Research Topics
Species | Gail D AndersonSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Current oral and non-oral routes of antiepileptic drug deliveryGail D Anderson
Department of Pharmacy, University of Washington, Seattle, Washington, USA
Adv Drug Deliv Rev 64:911-8. 2012..There is a significant need for new non-oral formulations of the antiepileptic drugs when oral administration is not possible...
Sex differences in drug metabolism: cytochrome P-450 and uridine diphosphate glucuronosyltransferaseGail D Anderson
Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195, USA
J Gend Specif Med 5:25-33. 2002..However, genetics also controls the amount (or activity) of the enzymes. Sex-dependent differences have been demonstrated for several CYP isoenzymes and for UGT. Ethnicity also appears to play a role in the activity of these enzymes...- Pharmacokinetics of valerenic acid after single and multiple doses of valerian in older womenGail D Anderson
Department of Pharmacy, Schools of Pharmacy, University of Washington, Seattle, WA 98195, USA
Phytother Res 24:1442-6. 2010..In conclusion, large variability in the pharmacokinetics of valerenic acid may contribute to the inconsistencies in the effect of valerian as a sleep aid... - Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamicsGail D Anderson
Department of Pharmacy, University of Washington, Seattle, Washington, USA
J Womens Health (Larchmt) 14:19-29. 2005..This review highlights a few specific examples in each area in which sex differences in pharmacokinetics and pharmacodynamics are important and provides recommendations for additional needed research... - Effect of pregnancy on the pharmacokinetics of antihypertensive drugsGail D Anderson
Department of Pharmacy, University of Washington, Seattle, Washington, USA
Clin Pharmacokinet 48:159-68. 2009..Higher doses and altered dosage intervals may be needed for antihypertensive drugs used in pregnant women... - Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approachGail D Anderson
Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Clin Pharmacokinet 44:989-1008. 2005..However, because of the limitations, more clinical, evidence-based studies are needed to fully elucidate the effects of pregnancy on the pharmacokinetics of drugs... - Pharmacokinetics of valerenic acid after administration of valerian in healthy subjectsGail D Anderson
Department of Pharmacy, University of Washington, Seattle, 98195, USA
Phytother Res 19:801-3. 2005.... - Using pharmacokinetics to predict the effects of pregnancy and maternal-infant transfer of drugs during lactationGail D Anderson
University of Washington, School of Pharmacy, Health Science Building H 361H, Seattle, WA 98195 7630, USA
Expert Opin Drug Metab Toxicol 2:947-60. 2006..Knowledge of the protein binding properties of a drug can provide a quick and easy tool to estimate exposure of an infant to medication from breastfeeding... - Pharmacokinetic, pharmacodynamic, and pharmacogenetic targeted therapy of antiepileptic drugsGail D Anderson
Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Ther Drug Monit 30:173-80. 2008..Identification of experimental and clinical evidence linking functional changes associated with gene mutations to epilepsy syndromes will help provide new molecular targets for future AEDs... - Effect of time, injury, age and ethanol on interpatient variability in valproic acid pharmacokinetics after traumatic brain injuryGail D Anderson
Departments of Pharmacy and Neurological Surgery, Schools of Pharmacy and Medicine corrected University of Washington, Seattle, Washington 98195, USA
Clin Pharmacokinet 46:307-18. 2007..Valproic acid is a hepatically metabolised, low extraction-ratio drug. Therefore, unbound clearance (CL(u)) is equal to intrinsic or metabolic clearance... - Pharmacogenetics and enzyme induction/inhibition properties of antiepileptic drugsGail D Anderson
Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195, USA
Neurology 63:S3-8. 2004..The decreased induction and inhibition effects and the lack of significant genetic polymorphism of the newer AEDs allow increased ease of use and perhaps greater safety, especially for patients taking multiple medications... - Effect of valproate on hemostatic function in patients with traumatic brain injuryGail D Anderson
Department of Pharmacy, University of Washington, Box 357630, Seattle, WA 98195, USA
Epilepsy Res 57:111-9. 2003..To evaluate whether valproate (VPA) resulted in laboratory or clinical evidence of a change in bleeding-related measures associated with VPA therapy in patients sustaining a traumatic brain injury... - Optimizing pediatric dosing: a developmental pharmacologic approachGail D Anderson
Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Pharmacotherapy 29:680-90. 2009..Using a pharmacokinetics-based approach, rational predictions can be made for the effects of age on drugs that undergo similar pathways of elimination, even when specific pharmacokinetic data are limited or unavailable... - Children versus adults: pharmacokinetic and adverse-effect differencesGail D Anderson
Department of Pharmacy, University of Washington, Seattle 98195, USA
Epilepsia 43:53-9. 2002.... - Developmental pharmacokineticsGail D Anderson
Department of Pharmacy, University of Washington, Seattle, WA98195, USA
Semin Pediatr Neurol 17:208-13. 2010..Understanding the effects of age on pharmacokinetics can help to determine appropriate pediatric dosing in situations in which there is limited information... 
Haptoglobin phenotype and apolipoprotein E polymorphism: relationship to posttraumatic seizures and neuropsychological functioning after traumatic brain injuryGail D Anderson
Department of Pharmacy, University of Washington, Box 357630, Seattle, WA 98195, USA
Epilepsy Behav 16:501-6. 2009..In contrast to our hypothesis, those with haptoglobin 1-1 (high-affinity binder of hemoglobin) scored somewhat worse on Verbal IQ and Tapping D at 1 and 12 months after injury...- Effects of cranberry juice on pharmacokinetics of beta-lactam antibiotics following oral administrationMeng Li
Department of Pharmacy, Health Science Complex H 361A, University of Washington, Seattle, WA 98195, USA
Antimicrob Agents Chemother 53:2725-32. 2009..These results suggest that the use of cranberry juice at usual quantities as prophylaxis for UTI is not likely to alter the pharmacokinetics of these two oral antibiotics... - A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomniaDiana M Taibi
Department of Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Box 357266, Seattle, WA 98195 7262, USA
Sleep Med 10:319-28. 2009..To test the effects of nightly valerian (Valeriana officinalis) extract to improve sleep of older women with insomnia... - Atenolol pharmacokinetics and excretion in breast milk during the first 6 to 8 months postpartumSara Eyal
University of Washington Department of Pharmacy, Seattle, WA 98195 7630, USA
J Clin Pharmacol 50:1301-9. 2010..Premature infants and those with kidney disease require further study. Infant exposure depends on maternal dose and decreases during the first 6 to 8 months postpartum... - Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trialNancy R Temkin
Department of Neurological Surgery, University of Washington, Seattle, USA
Lancet Neurol 6:29-38. 2007..We aimed to test whether treatment with magnesium favourably affects outcome in head-injured patients... - Is ethnicity associated with morphine's side effects in children? Morphine pharmacokinetics, analgesic response, and side effects in children having tonsillectomyNathalia Jimenez
Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA
Paediatr Anaesth 22:669-75. 2012..To examine whether morphine pharmacokinetics (PK) and/or genetic polymorphisms in opioid-related genes, underlie differences in analgesic response and side effects to morphine in Latino (L) vs non-Latino Caucasian (NL) children... - Ketorolac tromethamine: stereo-specific pharmacokinetics and single-dose use in postoperative infants aged 2-6 monthsAnne M Lynn
Department of Anesthesia and Pain Management, Seattle Children s Hospital, Seattle, WA 98105, USA
Paediatr Anaesth 21:325-34. 2011..We determined the postoperative pharmacokinetics (PK), safety, and analgesic effects of ketorolac in 14 infants (aged <6 months) receiving a single intravenous (IV) administration of racemic ketorolac or placebo... - Drug interaction potential of soy extract and Panax ginsengGail D Anderson
Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195, USA
J Clin Pharmacol 43:643-8. 2003..UGT2B15 was the only UGT significantly inhibited. Even though both soy extract and ginseng have been shown to activate CYP3A4 in vitro, there is a lack of an in vitro correlation with the in vivo effects... - Drug-drug interactions involving membrane transporters in the human kidneyMeng Li
University of Washington, Department of Pharmaceutics, School of Pharmacy, Seattle, 98195, USA
Expert Opin Drug Metab Toxicol 2:505-32. 2006..In particular, the review focuses on relating cloned renal drug transporters to clinically observed drug-drug interactions. The authors' opinion on the current status and future directions of research in these areas is also offered... - Gender differences in pharmacological responseGail D Anderson
Health Science Complex H 361A, University of Washington, Seatle, Washington 98195, USA
Int Rev Neurobiol 83:1-10. 2008..There are still large gaps in our knowledge of sex differences in clinical pharmacology and significantly more research is needed... - Rufinamide: a new anti-epileptic medicationShahin Hakimian
University of Washington, Regional Epilepsy Center, Harborview Medical Center, Seattle, WA 98104, USA
Expert Opin Pharmacother 8:1931-40. 2007..Rufinamide has shown promise as adjunctive treatment for Lennox-Gastaut syndrome and may have some role in localization related epilepsies as well... - Postoperative ketorolac tromethamine use in infants aged 6-18 months: the effect on morphine usage, safety assessment, and stereo-specific pharmacokineticsAnne M Lynn
Department of Anesthesia and Pain Management, Children s Hospital and Regional Medical Center, University of Washington School of Medicine, Seattle, Washington 98105, USA
Anesth Analg 104:1040-51, tables of contents. 2007.... - Pharmacokinetics and pharmacodynamics of atenolol during pregnancy and postpartumMary F Hebert
Department of Pharmacy, University of Washington, Seattle, WA 98195-7630, USA
J Clin Pharmacol 45:25-33. 2005..Atenolol administration did not appear to change the pattern of the increase in cardiac output and the decrease in total peripheral resistance, which normally occurs during pregnancy... - Valproic acid, but not lamotrigine, suppresses seizure-induced c-fos and c-Jun mRNA expressionPatricia Szot
Mental Illness Research Education and Clinical Center MIRECC, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
Brain Res Mol Brain Res 135:285-9. 2005..The consequence of this suppression of IEGs following a generalized seizure may be viewed either as a neuroprotective or detrimental effect upon the brain... - Ginkgo biloba: evaluation of CYP2C9 drug interactions in vitro and in vivoMichael A Mohutsky
Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, USA
Am J Ther 13:24-31. 2006.... - Inhaled beta-2 adrenergic receptor agonists and primary cardiac arrestRozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98101, USA
Am J Med 113:711-6. 2002..We sought to investigate if short-acting, inhaled beta2-adrenergic receptor agonists were associated with higher risk of primary cardiac arrest in patients with asthma or chronic obstructive pulmonary disease (COPD)... - Optimal prevention of seizures induced by high-dose busulfanAndrea L Eberly
Department of Pharmacy, University of Washington, Seattle, WA 98195, USA
Pharmacotherapy 28:1502-10. 2008..The second-generation antiepileptic drug levetiracetam possesses the characteristics of optimal prophylaxis for busulfan-induced seizures, and early data of its efficacy are promising, although further study is needed... - Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transportersMeng Li
Department of Pharmaceutics, University of Washington, H272J, Health Sciences Building, Seattle, WA 98195-7610, USA
Drug Metab Dispos 34:547-55. 2006..2 muM for cefaclor. hPepT2, and to a lesser extent hPepT1, may play an important role in apical transport of amoxicillin and cefaclor in the renal tubule. hOAT1, in contrast, is not involved in basolateral uptake of these antibiotics... - The effect of progesterone dose on gene expression after traumatic brain injuryGail D Anderson
Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
J Neurotrauma 28:1827-43. 2011..GO analysis identified genes for the low-dose treatment involved in positive regulation of cell proliferation, innate immune response, positive regulation of anti-apoptosis, and blood vessel remodeling... - Time course of lamotrigine de-induction: impact of step-wise withdrawal of carbamazepine or phenytoinGail D Anderson
Department of Pharmacy, University of Washington, Seattle, USA
Epilepsy Res 49:211-7. 2002..Importantly, these data suggest that LTG concentrations would not be expected to increase until the concomitant inducer is almost completely removed... - Onset of action and seizure control in Lennox-Gaustaut syndrome: focus on rufinamideRussell P Saneto
Division of Pediatric Neurology, Seattle Children s Hospital University of Washington, Seattle, Washington, USA
Ther Clin Risk Manag 5:271-80. 2009..Our focus will be on the role of the new medication rufinamide in seizure reduction in patients with Lennox-Gaustaut syndrome... - Digoxin therapy and the risk of primary cardiac arrest in patients with congestive heart failure: effect of mild-moderate renal impairmentThomas D Rea
Cardiovascular Health Research Unit, University of Washington, Department of Medicine, Metropolitan Park, 1730 Minor Avenue, East Tower, Seattle, WA 98101, USA
J Clin Epidemiol 56:646-50. 2003..The cardiac safety of digoxin therapy for congestive heart failure (CHF) is a source of concern, especially among those with renal impairment... - Position statement on the coverage of anticonvulsant drugs for the treatment of epilepsy: what's the problem with generic antiepileptic drugs? A call to actionJohn W Miller
Neurology 69:1806-8. 2007 - Treatment of epilepsy in women of reproductive age: pharmacokinetic considerationsJames W McAuley
The Ohio State University College of Pharmacy, 500 West 12th Avenue, Columbus, OH 43210, USA
Clin Pharmacokinet 41:559-79. 2002..Many groups have turned their attention to women's issues in epilepsy and have developed clinical practice guidelines. Although the future holds promise in this area, many questions and the need for progress remain... - The effect of valproic acid on drug and steroid glucuronidation by expressed human UDP-glucuronosyltransferasesBrian T Ethell
Department of Molecular and Cellular Pathology, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, Scotland, Dundee, UK
Biochem Pharmacol 65:1441-9. 2003..No significant inhibition of UGT1A1 or UGT1A6 by valproic acid was observed. These data indicate that valproic acid inhibition of glucuronidation reactions is not always due to simple competitive inhibition of substrates... - Magnesium for neuroprotection after traumatic brain injuryH Richard Winn
Lancet Neurol 6:478-9. 2007 - Pioglitazone: effect on CYP3A4 activitySandra N Nowak
Wayne State University, Department of Pharmacy Practice, Detroit, Michigan, USA
J Clin Pharmacol 42:1299-302. 2002..Thus, administration of pioglitazone should not result in clinically significant effects on the pharmacokinetics of other CYP3A4 substrates... - Voltage-dependent block of N-methyl-D-aspartate receptors by the novel anticonvulsant dibenzylamine, a bioactive constituent of L-(+)-beta-hydroxybutyrateSean D Donevan
Pfizer Global Research and Development, Ann Arbor, Michigan, USA
Epilepsia 44:1274-9. 2003..In addition, we provide additional evidence that DBA is responsible for the anticonvulsant activity of L-BHB, and that this action may be mediated in part by voltage-dependent blockade of NMDA receptors... - Nicotinamide treatment reduces behavioral impairments and provides cortical protection after fluid percussion injury in the ratMichael R Hoane
Restorative Neuroscience Laboratory, Department of Psychology, Southern Illinois University, Carbondale, Illinois 62901, USA
J Neurotrauma 23:1535-48. 2006..This data suggests that nicotinamide has substantial preclinical efficacy for TBI, and there appears to be some differences in the ability of the doses to improve performance in the MWM... - Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?Gail D Anderson
Epilepsia 48:2372-4. 2007 - Acetoacetate, acetone, and dibenzylamine (a contaminant in l-(+)-beta-hydroxybutyrate) exhibit direct anticonvulsant actions in vivoJong M Rho
Department of Pediatrics, ZC 4482, University of California at Irvine Medical Center, Bldg 2, 3rd Floor, 101 The City Drive S, Orange, CA 92868, USA
Epilepsia 43:358-61. 2002..To investigate whether ketone bodies are directly anticonvulsant...
Research Grants
- Pharmacological Optimization of Poly-Drug Therapy in Traumatic Brain InjuryMichael R Hoane; Fiscal Year: 2010..This study will help to identify combinations of drugs that could be used to prevent the long-term effects. ..