Daniel H Anderson
Affiliation: University of California
- An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferaseD H Anderson
UCLA DOE Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, CA 90095 1570, USA
J Mol Biol 307:671-81. 2001..Based on the trehalose-bound structure, we suggest a new class of antituberculous drugs, made by connecting two trehalose molecules by an amphipathic linker...
- Granulysin crystal structure and a structure-derived lytic mechanismDaniel H Anderson
Howard Hughes Medical Institute, 5 748 MacDonald, Box 951662, Los Angeles, CA 90095 1662, USA
J Mol Biol 325:355-65. 2003..The loosely packed core facilitates a hinge or scissors motion towards exposure of hydrophobic surface that we propose tunnels the granulysin into the fracturing target membrane...
- Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnesJamie E McInturff
Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
J Invest Dermatol 125:256-63. 2005..acnes-stimulated cytokine release. Taken together, these data suggest that granulysin peptides may be useful as topical therapeutic agents, providing alternatives to current acne therapies...
- The TB structural genomics consortium: providing a structural foundation for drug discoveryCelia W Goulding
Bioscience Division, Mail Stop M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Curr Drug Targets Infect Disord 2:121-41. 2002..The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts...