Aileen Anderson

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model
    Desirée L Salazar
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 5:e12272. 2010
  2. pmc Complement activation in the injured central nervous system: another dual-edged sword?
    Faith H Brennan
    The University of Queensland, School of Biomedical Sciences, St Lucia, Brisbane, QLD 4072, Australia
    J Neuroinflammation 9:137. 2012
  3. pmc Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury
    Hal X Nguyen
    Physical Medicine and Rehabilitation, 1105 Gillespie Neuroscience Research Facility, University of California, Irvine, CA 92697 4292, USA
    J Neuroinflammation 5:26. 2008
  4. pmc Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient?
    Aileen J Anderson
    Sue and Bill Gross Stem Cell Center, 845 Health Science Road, UC Irvine, Irvine, CA 92697 1705, USA
    Regen Med 6:367-406. 2011
  5. ncbi request reprint Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL
    A J Anderson
    Institute for Brain Aging and Dementia, University of California, Irvine, 1113 Gillespie NRF, Irvine, CA 92697 4540, USA
    Neurobiol Aging 21:511-24. 2000
  6. ncbi request reprint Upregulation of complement inhibitors in association with vulnerable cells following contusion-induced spinal cord injury
    Aileen J Anderson
    Department of Physical Medicine and Rehabilitation, and the Reeve Irvine Center, University of California, Irvine, California, USA
    J Neurotrauma 22:382-97. 2005
  7. ncbi request reprint Activation of complement pathways after contusion-induced spinal cord injury
    Aileen J Anderson
    Department of Physical Medicine and Rehabilitation, and the Reeve Irvine Center, University of California, Irvine, California 92696 4540, USA
    J Neurotrauma 21:1831-46. 2004
  8. ncbi request reprint Mechanisms and pathways of inflammatory responses in CNS trauma: spinal cord injury
    Aileen J Anderson
    Department of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine 92697 4540, USA
    J Spinal Cord Med 25:70-9; discussion 80. 2002
  9. pmc Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury
    Manuel D Galvan
    Departments of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine, Irvine, California 92697 4292, USA
    J Neurosci 28:13876-88. 2008
  10. pmc Comparison of immunopathology and locomotor recovery in C57BL/6, BUB/BnJ, and NOD-SCID mice after contusion spinal cord injury
    Sabina Luchetti
    Department of Physical Medicine and Rehabilitation, University of California Irvine, Irvine, California 92697 4540, USA
    J Neurotrauma 27:411-21. 2010

Research Grants

  1. Mechanisms of Complement-Mediated Damage in SCI
    Aileen Anderson; Fiscal Year: 2007
  2. Mechanisms of SCI Recovery after hCNS Stem Cell Grafts
    Aileen Anderson; Fiscal Year: 2007

Detail Information

Publications24

  1. pmc Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model
    Desirée L Salazar
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 5:e12272. 2010
    ..We tested the ability of hCNS-SCns transplanted 30 days post SCI to survive, differentiate, migrate, and promote improved locomotor recovery...
  2. pmc Complement activation in the injured central nervous system: another dual-edged sword?
    Faith H Brennan
    The University of Queensland, School of Biomedical Sciences, St Lucia, Brisbane, QLD 4072, Australia
    J Neuroinflammation 9:137. 2012
    ....
  3. pmc Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury
    Hal X Nguyen
    Physical Medicine and Rehabilitation, 1105 Gillespie Neuroscience Research Facility, University of California, Irvine, CA 92697 4292, USA
    J Neuroinflammation 5:26. 2008
    ..However, the expression/association of both early and terminal complement proteins by PMNs has not been fully characterized in vitro, and has not observed previously in vivo after traumatic spinal cord injury (SCI)...
  4. pmc Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient?
    Aileen J Anderson
    Sue and Bill Gross Stem Cell Center, 845 Health Science Road, UC Irvine, Irvine, CA 92697 1705, USA
    Regen Med 6:367-406. 2011
    ..Finally, we discuss strategies in the selection of animal models to maximize the predictive validity of preclinical safety and efficacy studies...
  5. ncbi request reprint Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL
    A J Anderson
    Institute for Brain Aging and Dementia, University of California, Irvine, 1113 Gillespie NRF, Irvine, CA 92697 4540, USA
    Neurobiol Aging 21:511-24. 2000
    ..This represents biochemical support for an apoptotic mechanism of cell death in DS and AD...
  6. ncbi request reprint Upregulation of complement inhibitors in association with vulnerable cells following contusion-induced spinal cord injury
    Aileen J Anderson
    Department of Physical Medicine and Rehabilitation, and the Reeve Irvine Center, University of California, Irvine, California, USA
    J Neurotrauma 22:382-97. 2005
    ....
  7. ncbi request reprint Activation of complement pathways after contusion-induced spinal cord injury
    Aileen J Anderson
    Department of Physical Medicine and Rehabilitation, and the Reeve Irvine Center, University of California, Irvine, California 92696 4540, USA
    J Neurotrauma 21:1831-46. 2004
    ..Axonal staining by C1q and Factor B was also observed, suggesting a potential role for the complement cascade in demyelination or axonal degeneration. These data support the hypothesis that complement activation plays a role in SCI...
  8. ncbi request reprint Mechanisms and pathways of inflammatory responses in CNS trauma: spinal cord injury
    Aileen J Anderson
    Department of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine 92697 4540, USA
    J Spinal Cord Med 25:70-9; discussion 80. 2002
    ..This article details the innate and adaptive arms of the immune response, including cell-mediated and humoral pathways, and describes their relevance to the processes of degeneration and regeneration...
  9. pmc Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury
    Manuel D Galvan
    Departments of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine, Irvine, California 92697 4292, USA
    J Neurosci 28:13876-88. 2008
    ..05). Together, these data suggest that initiation of the classical complement pathway via C1q is detrimental to recovery after SCI...
  10. pmc Comparison of immunopathology and locomotor recovery in C57BL/6, BUB/BnJ, and NOD-SCID mice after contusion spinal cord injury
    Sabina Luchetti
    Department of Physical Medicine and Rehabilitation, University of California Irvine, Irvine, California 92697 4540, USA
    J Neurotrauma 27:411-21. 2010
    ....
  11. pmc Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery
    Mitra J Hooshmand
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, CA, USA
    PLoS ONE 4:e5871. 2009
    ..However, the hypothesis that hCNS-SCns could alter the host microenvironment as an additional or alternative mechanism of recovery remained unexplored; we tested that hypothesis in the present study...
  12. ncbi request reprint Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth
    Christie Engesser-Cesar
    Institute for Brain Aging and Dementia, University of California, Irvine, USA
    Eur J Neurosci 25:1931-9. 2007
    ..These observations suggest that improvement in function may be related to changes in serotonin fibers immediately caudal to the injury epicenter...
  13. pmc Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injury
    Brian J Cummings
    Physical Medicine and Rehabilitation, University of California, Irvine, CA 92697, United States
    Behav Brain Res 177:232-41. 2007
    ..Critically, horizontal ladder beam testing discriminates between mice that score identically in terms of stepping frequency in open-field testing...
  14. ncbi request reprint Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice
    Rebecca A Nishi
    CRF Spinal Cord Injury Core Research Facility, University of California, Irvine, California 92697 4540, USA
    J Neurotrauma 24:674-89. 2007
    ..These results give researchers more options in how to analyze spinal cord injuries in animal models...
  15. ncbi request reprint Voluntary wheel running improves recovery from a moderate spinal cord injury
    Christie Engesser-Cesar
    Institute for Brain Aging and Dementia, University of California, Irvine, California 92697 4540, USA
    J Neurotrauma 22:157-71. 2005
    ..05). Finally, fibronectin staining shows no significant difference in lesion size between the two groups. These data represent the first mouse model showing voluntary exercise improves recovery after SCI...
  16. ncbi request reprint Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function
    Brian J Cummings
    Department of Physical Medicine and Rehabilitation, University of California, Irvine, CA 92697, USA
    Neurol Res 28:474-81. 2006
    ....
  17. ncbi request reprint Exercise-induced gene expression changes in the rat spinal cord
    Victoria M Perreau
    Institute for Brain Aging and Dementia, 1113 Gillespie N R F, University of California Irvine, Irvine, CA 92697, USA
    Gene Expr 12:107-21. 2005
    ..Taken together these data suggest cellular pathways through which exercise may promote recovery in the SCI population...
  18. pmc Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice
    Brian J Cummings
    Department of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:14069-74. 2005
    ..Glial fibrillary acidic protein-positive astrocytic differentiation was rare, and hCNS-SCns did not appear to contribute to the scar. These data suggest that hCNS-SCns may possess therapeutic potential for CNS injury and disease...
  19. pmc Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment
    Kevin D Beck
    Anatomy and Neurobiology, University of California, Irvine, CA 92697 4292, USA
    Brain 133:433-47. 2010
    ....
  20. ncbi request reprint Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha
    Hal X Nguyen
    Department of Physical Medicine and Rehabilitation, University of California, Irvine, California, USA
    J Neurochem 102:900-12. 2007
    ....
  21. ncbi request reprint Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death
    Joseph H Su
    Institute for Brain Aging and Dementia, 1113 Gillespie Neuroscience Research Facility, University of California Irvine, 92697 4540, USA
    Neurobiol Dis 12:182-93. 2003
    ..These findings suggest that Fas-FasL interactions may contribute to mechanisms of neuronal loss and neuritic degeneration in AD...
  22. ncbi request reprint Optimization of techniques for the maximal detection and quantification of Alzheimer's-related neuropathology with digital imaging
    Brian J Cummings
    Institute for Brain Aging, University of California, Irvine, CA 92697 4540, USA
    Neurobiol Aging 23:161-70. 2002
    ..0). Because the latter treatments were often harsh on the tissue and more difficult to control, we recommend a standard tissue pretreatment of 99% formic acid for seven minutes for both beta-amyloid and tau-related pathology...
  23. ncbi request reprint Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:635-59. 2006
    ..05). The differing behavioral response to SCI suggests inherent genetic factors significantly impact locomotor recovery and must be considered in studies with inbred or genetically engineered mouse strains...
  24. ncbi request reprint BDNF-induced facilitation of afferent-evoked responses in lamina II neurons is reduced after neonatal spinal cord contusion injury
    Sandra M Garraway
    Department of Neurobiology and Behavior, 550 Life Sciences Bldg, State University of New York, Stony Brook, New York 11794 5230, USA
    J Neurophysiol 94:1798-804. 2005
    ..It seems more likely that diminished trkB expression and enhanced expression of truncated trkB receptors in the contused cord play a significant role in determining the reduced effect of BDNF under these conditions...

Research Grants10

  1. Mechanisms of Complement-Mediated Damage in SCI
    Aileen Anderson; Fiscal Year: 2007
    ....
  2. Mechanisms of SCI Recovery after hCNS Stem Cell Grafts
    Aileen Anderson; Fiscal Year: 2007
    ....