Research Topics
| Aileen AndersonSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injuryHal X Nguyen
Physical Medicine and Rehabilitation, 1105 Gillespie Neuroscience Research Facility, University of California, Irvine, CA 92697 4292, USA
J Neuroinflammation 5:26. 2008..However, the expression/association of both early and terminal complement proteins by PMNs has not been fully characterized in vitro, and has not observed previously in vivo after traumatic spinal cord injury (SCI)...- Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNELA J Anderson
Institute for Brain Aging and Dementia, University of California, Irvine, 1113 Gillespie NRF, Irvine, CA 92697 4540, USA
Neurobiol Aging 21:511-24. 2000..This represents biochemical support for an apoptotic mechanism of cell death in DS and AD... - Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient?Aileen J Anderson
Sue and Bill Gross Stem Cell Center, 845 Health Science Road, UC Irvine, Irvine, CA 92697 1705, USA
Regen Med 6:367-406. 2011..Finally, we discuss strategies in the selection of animal models to maximize the predictive validity of preclinical safety and efficacy studies... - Upregulation of complement inhibitors in association with vulnerable cells following contusion-induced spinal cord injuryAileen J Anderson
Department of Physical Medicine and Rehabilitation, and the Reeve Irvine Center, University of California, Irvine, California, USA
J Neurotrauma 22:382-97. 2005.... - Activation of complement pathways after contusion-induced spinal cord injuryAileen J Anderson
Department of Physical Medicine and Rehabilitation, and the Reeve Irvine Center, University of California, Irvine, California 92696 4540, USA
J Neurotrauma 21:1831-46. 2004..Axonal staining by C1q and Factor B was also observed, suggesting a potential role for the complement cascade in demyelination or axonal degeneration. These data support the hypothesis that complement activation plays a role in SCI... - Mechanisms and pathways of inflammatory responses in CNS trauma: spinal cord injuryAileen J Anderson
Department of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine 92697 4540, USA
J Spinal Cord Med 25:70-9; discussion 80. 2002..This article details the innate and adaptive arms of the immune response, including cell-mediated and humoral pathways, and describes their relevance to the processes of degeneration and regeneration... - Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse modelDesirée L Salazar
Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America
PLoS ONE 5:e12272. 2010..We tested the ability of hCNS-SCns transplanted 30 days post SCI to survive, differentiate, migrate, and promote improved locomotor recovery... - Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injuryManuel D Galvan
Departments of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine, Irvine, California 92697 4292, USA
J Neurosci 28:13876-88. 2008..05). Together, these data suggest that initiation of the classical complement pathway via C1q is detrimental to recovery after SCI... - Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growthChristie Engesser-Cesar
Institute for Brain Aging and Dementia, University of California, Irvine, USA
Eur J Neurosci 25:1931-9. 2007..These observations suggest that improvement in function may be related to changes in serotonin fibers immediately caudal to the injury epicenter... - Comparison of immunopathology and locomotor recovery in C57BL/6, BUB/BnJ, and NOD-SCID mice after contusion spinal cord injurySabina Luchetti
Department of Physical Medicine and Rehabilitation, University of California Irvine, Irvine, California 92697 4540, USA
J Neurotrauma 27:411-21. 2010.... - Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recoveryMitra J Hooshmand
Department of Anatomy and Neurobiology, University of California Irvine, Irvine, CA, USA
PLoS ONE 4:e5871. 2009..However, the hypothesis that hCNS-SCns could alter the host microenvironment as an additional or alternative mechanism of recovery remained unexplored; we tested that hypothesis in the present study... - Voluntary wheel running improves recovery from a moderate spinal cord injuryChristie Engesser-Cesar
Institute for Brain Aging and Dementia, University of California, Irvine, California 92697 4540, USA
J Neurotrauma 22:157-71. 2005..05). Finally, fibronectin staining shows no significant difference in lesion size between the two groups. These data represent the first mouse model showing voluntary exercise improves recovery after SCI... - Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in miceRebecca A Nishi
CRF Spinal Cord Injury Core Research Facility, University of California, Irvine, California 92697 4540, USA
J Neurotrauma 24:674-89. 2007..These results give researchers more options in how to analyze spinal cord injuries in animal models... - Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injuryBrian J Cummings
Physical Medicine and Rehabilitation, University of California, Irvine, CA 92697, United States
Behav Brain Res 177:232-41. 2007..Critically, horizontal ladder beam testing discriminates between mice that score identically in terms of stepping frequency in open-field testing... - Exercise-induced gene expression changes in the rat spinal cordVictoria M Perreau
Institute for Brain Aging and Dementia, 1113 Gillespie N R F, University of California Irvine, Irvine, CA 92697, USA
Gene Expr 12:107-21. 2005..Taken together these data suggest cellular pathways through which exercise may promote recovery in the SCI population... - Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor functionBrian J Cummings
Department of Physical Medicine and Rehabilitation, University of California, Irvine, CA 92697, USA
Neurol Res 28:474-81. 2006.... - Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured miceBrian J Cummings
Department of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 102:14069-74. 2005..Glial fibrillary acidic protein-positive astrocytic differentiation was rare, and hCNS-SCns did not appear to contribute to the scar. These data suggest that hCNS-SCns may possess therapeutic potential for CNS injury and disease... - Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alphaHal X Nguyen
Department of Physical Medicine and Rehabilitation, University of California, Irvine, California, USA
J Neurochem 102:900-12. 2007.... - Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environmentKevin D Beck
Anatomy and Neurobiology, University of California, Irvine, CA 92697 4292, USA
Brain 133:433-47. 2010.... - Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal deathJoseph H Su
Institute for Brain Aging and Dementia, 1113 Gillespie Neuroscience Research Facility, University of California Irvine, 92697 4540, USA
Neurobiol Dis 12:182-93. 2003..These findings suggest that Fas-FasL interactions may contribute to mechanisms of neuronal loss and neuritic degeneration in AD... - Optimization of techniques for the maximal detection and quantification of Alzheimer's-related neuropathology with digital imagingBrian J Cummings
Institute for Brain Aging, University of California, Irvine, CA 92697-4540, USA
Neurobiol Aging 23:161-70. 2002..0). Because the latter treatments were often harsh on the tissue and more difficult to control, we recommend a standard tissue pretreatment of 99% formic acid for seven minutes for both beta-amyloid and tau-related pathology... - Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strainsD Michele Basso
Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
J Neurotrauma 23:635-59. 2006..05). The differing behavioral response to SCI suggests inherent genetic factors significantly impact locomotor recovery and must be considered in studies with inbred or genetically engineered mouse strains... - BDNF-induced facilitation of afferent-evoked responses in lamina II neurons is reduced after neonatal spinal cord contusion injurySandra M Garraway
Department of Neurobiology and Behavior, 550 Life Sciences Bldg, State University of New York, Stony Brook, New York 11794-5230, USA
J Neurophysiol 94:1798-804. 2005..It seems more likely that diminished trkB expression and enhanced expression of truncated trkB receptors in the contused cord play a significant role in determining the reduced effect of BDNF under these conditions...
Research Grants
- Mechanisms of Complement-Mediated Damage in SCIAileen Anderson; Fiscal Year: 2007....
- Mechanisms of SCI Recovery after hCNS Stem Cell GraftsAileen Anderson; Fiscal Year: 2007....