Research Topics
| MARION ANDERSSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Putting bioactivation reactions to work: Targeting antioxidants to mitochondriaM W Anders
Department of Pharmacology and Physiology, Mitochondrial Research and Innovation Group, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Chem Biol Interact 192:8-13. 2011..These results demonstrate the feasibility of exploiting bioactivation reactions for targeted drug delivery...
Mitochondria: new drug targets for oxidative stress-induced diseasesM W Anders
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
Expert Opin Drug Metab Toxicol 2:71-9. 2006..Future studies will undoubtedly exploit the unique biophysical and biochemical properties of mitochondria, including mitochondrial activation of prodrugs, for the targeted delivery of cytoprotective agents...- Formation and toxicity of anesthetic degradation productsM W Anders
Department of Pharmacology and Physiology, University of Rochester Medical Center, New York 14642, USA
Annu Rev Pharmacol Toxicol 45:147-76. 2005..The elucidation of the mechanisms of formation and bioactivation of degradation products has allowed for the safe use of anesthetics that may undergo degradation in the anesthesia circuit... 
Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acidZ Tong
Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
Biochem J 331:371-4. 1998..These results demonstrate that the glutathione-dependent oxygenation of DCA to glyoxylic acid is catalysed by a Zeta-class glutathione transferase...- Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking alpha-haloalkanoic acidsW B Anderson
Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, New York 14642, USA
Chem Res Toxicol 12:1144-9. 1999..These data show that the observed DCA-induced decrease in the level of DCA metabolism is caused by the inactivation of GSTZ... - Targeting antioxidants to mitochondria: a new therapeutic directionShey Shing Sheu
Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
Biochim Biophys Acta 1762:256-65. 2006.... - Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophilesWayne B Anderson
Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, New York 14642, USA
Chem Res Toxicol 17:650-62. 2004..The reaction of glyoxylate with cellular macromolecules may be associated with the multiorgan toxicity of DCA... - Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiencyHoffman B M Lantum
Department of Pharmacology, University of Rochester Medical Center, Rochester, New York, 14642, USA
Toxicol Sci 74:192-202. 2003..These data indicate that DCA-induced inactivation of GSTZ1-1 leads to formation of an MAA-derived intermediate, MA, that may be a mediator and biomarker for DCA-associated toxicities... - Nephrotoxicity of chlorofluoroacetic acid in ratsHoffman B M Lantum
Department of Pharmacology and Physiology and Laboratory of Animal Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, New York 14642, USA
Toxicol Sci 70:261-8. 2002..2 mmol DFA/kg/day for 5 days had normal urine volumes but showed proximal and distal tubular damage; fluoride excretion was not elevated. The mechanism of DFA-induced nephrotoxicity is not known but appears to differ from that of CFA... - Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacidsZ Tong
Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, New York 14642, USA
Chem Res Toxicol 11:1332-8. 1998..Elimination of glutathione from the hemithioacetal would give glyoxylic acid... - Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1)Hoffman B M Lantum
Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, New York 14642, USA
Chem Res Toxicol 15:957-63. 2002.... - Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zetaWayne B Anderson
Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, New York 14642, USA
Chem Res Toxicol 15:1387-97. 2002..These findings explain the DCA-induced inactivation of GSTZ1-1 observed in humans and rats... - Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: a prodrug strategy for targeting cytoprotective antioxidants to mitochondriaKurt S Roser
Mitochondrial Research and Innovation Group, Department of Anesthesiology, Rochester, NY 14642, USA
Bioorg Med Chem 18:1441-8. 2010..These results demonstrate that mitochondrial beta-oxidation is a potentially useful delivery system for targeting antioxidants to mitochondria... - Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissuesHoffman B M Lantum
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
Drug Metab Dispos 30:616-25. 2002..These findings indicate that the DCA-induced inactivation of GSTZ1-1 in different tissues may result in multiorgan disorders that may be associated with perturbed tyrosine metabolism... - Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product compound A in human, nonhuman primate, and rat kidney cytosol and mitochondriaR A Iyer
University of Rochester, Department of Pharmacology, New York 14642, USA
Anesthesiology 85:1454-61. 1996..These experiments were designed to test the hypothesis that cysteine S-conjugates of compound A undergo beta-lyase-dependent biotransformation... - Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450Lin Xu
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14624, USA
Chem Res Toxicol 17:767-75. 2004..These results show that the major pathway for the biotransformation of N-EtFOSE is N-dealkylation to give FOSA. The biotransformation of FOSA to PFOS explains the observation that PFOS is found in animals given N-EtFOSE... - Calcium, ATP, and ROS: a mitochondrial love-hate trianglePaul S Brookes
University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, NY 14642, USA
Am J Physiol Cell Physiol 287:C817-33. 2004..Overall, a "two-hit" hypothesis is developed, in which Ca(2+) plus another pathological stimulus can bring about mitochondrial dysfunction... - Acivicin-induced alterations in renal and hepatic glutathione concentrations and in gamma-glutamyltransferase activitiesHoffman B M Lantum
Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Biochem Pharmacol 67:1421-6. 2004.... - Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetoneHoffman B M Lantum
Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, New York 14642, USA
Chem Res Toxicol 15:707-16. 2002.... - Structure-activity relationship for the biotransformation of haloalkenes by rat liver microsomal glutathione transferase 1Larry J Jolivette
Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
Chem Res Toxicol 15:1036-41. 2002..73 eV and that cGST catalyzed the reaction of glutathione with haloalkenes with E(LUMO) values more negative than -0.06 eV... - Chemical toxicology of reactive intermediates formed by the glutathione-dependent bioactivation of halogen-containing compoundsM W Anders
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 214642, USA
Chem Res Toxicol 21:145-59. 2008.... - Computational and experimental studies on the distribution of addition and substitution products of the microsomal glutathione transferase 1-catalyzed conjugation of glutathione with fluoroalkenesLarry J Jolivette
Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Box 711, Rochester, New York 14642, USA
Chem Res Toxicol 16:137-44. 2003..The results show that this computational model accurately predicted the distribution of the addition and substitution products that result from the MGST1-catalyzed reaction of glutathione with these fluoroalkenes... - Glutathione-dependent bioactivation of haloalkanes and haloalkenesM W Anders
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
Drug Metab Rev 36:583-94. 2004..With all of these compounds, the formation of reactive intermediates is associated with their observed toxicity...
Research Grants
- METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONSMARION ANDERS; Fiscal Year: 2000....
- METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONSMARION ANDERS; Fiscal Year: 2004..Hence, DCA may also find use in the management of HT-1. It is, therefore, important to explore the mechanism by which DCA and other dihaloacetates inactivate GSTZ1-1. ..