Valentine B Andela

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival
    Valentine B Andela
    The James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEBS Lett 579:6814-20. 2005
  2. ncbi Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB
    Valentine B Andela
    Center for Musculoskeletal Research, University of Rochester Medical Center, 575 Elmwood Avenue, 1 7534, Rochester, NY 14642, USA
    Cancer Lett 194:37-43. 2003
  3. ncbi Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB
    Valentine B Andela
    Center for Musculoskeletal Research, University of Rochester Medical Center, NY 14620, USA
    Biochem Biophys Res Commun 297:237-41. 2002
  4. ncbi The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids
    Valentine B Andela
    Department of Orthopaedics and The James P, Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, New York, 14642, USA
    Mol Cancer 3:8. 2004
  5. ncbi Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists
    Valentine B Andela
    The James P Wilmot Cancer Center and the Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue Box 665 Rochester, NY 14642, USA
    FEBS Lett 579:1765-9. 2005
  6. ncbi NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone
    Valentine B Andela
    Department of Orthopaedics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Clin Orthop Relat Res . 2003

Collaborators

Detail Information

Publications6

  1. ncbi A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival
    Valentine B Andela
    The James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEBS Lett 579:6814-20. 2005
    ..Accordingly, mI-kappaB-Line 1 cells are markedly sensitized to pharmacologic inhibition of beta-oxidative respiration. These findings are indicative of compensatory changes that could undermine anti-cancer therapies targeting NF-kappaB...
  2. ncbi Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB
    Valentine B Andela
    Center for Musculoskeletal Research, University of Rochester Medical Center, 575 Elmwood Avenue, 1 7534, Rochester, NY 14642, USA
    Cancer Lett 194:37-43. 2003
    ..Our results are consistent with the putative role of retinoids and cAMP in the malignant reversion of tumor cells and illustrative of the binary nature of transcriptional programs that modulate malignant progression...
  3. ncbi Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB
    Valentine B Andela
    Center for Musculoskeletal Research, University of Rochester Medical Center, NY 14620, USA
    Biochem Biophys Res Commun 297:237-41. 2002
    ..These results point to the negative regulation of osteoblast differentiation by NFkappaB, with implications in the pathogenesis and progression of osteosarcomas...
  4. ncbi The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids
    Valentine B Andela
    Department of Orthopaedics and The James P, Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, New York, 14642, USA
    Mol Cancer 3:8. 2004
    ....
  5. ncbi Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists
    Valentine B Andela
    The James P Wilmot Cancer Center and the Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue Box 665 Rochester, NY 14642, USA
    FEBS Lett 579:1765-9. 2005
    ..These findings, suggest that inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists...
  6. ncbi NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone
    Valentine B Andela
    Department of Orthopaedics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Clin Orthop Relat Res . 2003
    ..mIkappaB cells. These in vitro experiments suggest NFkappaB as an important target to prevent prostate cancer bone metastasis and provide a rationale for further study of this transcription factor in metastatic disease...