V B Andela

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB
    Valentine B Andela
    Center for Musculoskeletal Research, University of Rochester Medical Center, NY 14620, USA
    Biochem Biophys Res Commun 297:237-41. 2002
  2. pmc The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids
    Valentine B Andela
    Department of Orthopaedics and The James P, Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, New York, 14642, USA
    Mol Cancer 3:8. 2004
  3. ncbi request reprint Functional antagonism between NF-kappaB and nuclear receptors: implications in carcinogenesis and strategies for optimal cancer chemopreventive interventions
    V B Andela
    The James P Wilmot Cancer Center and the Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Curr Cancer Drug Targets 4:337-44. 2004
  4. ncbi request reprint Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists
    Valentine B Andela
    The James P Wilmot Cancer Center and the Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue Box 665 Rochester, NY 14642, USA
    FEBS Lett 579:1765-9. 2005
  5. ncbi request reprint Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB
    Valentine B Andela
    Center for Musculoskeletal Research, University of Rochester Medical Center, 575 Elmwood Avenue, 1 7534, Rochester, NY 14642, USA
    Cancer Lett 194:37-43. 2003
  6. pmc An immunohistochemical analysis to evaluate an inverse correlation between Runx2/Cbfa1 and NF kappa B in human osteosarcoma
    V B Andela
    The James P Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, NY 14642, USA
    J Clin Pathol 58:328-30. 2005
  7. ncbi request reprint A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival
    Valentine B Andela
    The James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEBS Lett 579:6814-20. 2005
  8. ncbi request reprint Correspondence Re S. S. Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62:2708-14. Re K. Sawada et al., Alendronate inhibits lysophosphatidic acid-induced migration of huma
    Valentine B Andela
    Cancer Res 64:2934-5; author reply 2935-6. 2004

Detail Information

Publications8

  1. ncbi request reprint Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB
    Valentine B Andela
    Center for Musculoskeletal Research, University of Rochester Medical Center, NY 14620, USA
    Biochem Biophys Res Commun 297:237-41. 2002
    ..These results point to the negative regulation of osteoblast differentiation by NFkappaB, with implications in the pathogenesis and progression of osteosarcomas...
  2. pmc The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids
    Valentine B Andela
    Department of Orthopaedics and The James P, Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, New York, 14642, USA
    Mol Cancer 3:8. 2004
    ....
  3. ncbi request reprint Functional antagonism between NF-kappaB and nuclear receptors: implications in carcinogenesis and strategies for optimal cancer chemopreventive interventions
    V B Andela
    The James P Wilmot Cancer Center and the Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Curr Cancer Drug Targets 4:337-44. 2004
    ..Finally, strategies for optimal chemopreventive interventions with NR ligands are discussed...
  4. ncbi request reprint Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists
    Valentine B Andela
    The James P Wilmot Cancer Center and the Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue Box 665 Rochester, NY 14642, USA
    FEBS Lett 579:1765-9. 2005
    ..These findings, suggest that inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists...
  5. ncbi request reprint Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB
    Valentine B Andela
    Center for Musculoskeletal Research, University of Rochester Medical Center, 575 Elmwood Avenue, 1 7534, Rochester, NY 14642, USA
    Cancer Lett 194:37-43. 2003
    ..Our results are consistent with the putative role of retinoids and cAMP in the malignant reversion of tumor cells and illustrative of the binary nature of transcriptional programs that modulate malignant progression...
  6. pmc An immunohistochemical analysis to evaluate an inverse correlation between Runx2/Cbfa1 and NF kappa B in human osteosarcoma
    V B Andela
    The James P Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, NY 14642, USA
    J Clin Pathol 58:328-30. 2005
    ..This observation suggests that there is an inverse relation between a transcription factor associated with malignant progression and chemoresistance (NF kappa B) and an osteoblast differentiating transcription factor (Runx2/Cbfa1)...
  7. ncbi request reprint A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival
    Valentine B Andela
    The James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEBS Lett 579:6814-20. 2005
    ..Accordingly, mI-kappaB-Line 1 cells are markedly sensitized to pharmacologic inhibition of beta-oxidative respiration. These findings are indicative of compensatory changes that could undermine anti-cancer therapies targeting NF-kappaB...
  8. ncbi request reprint Correspondence Re S. S. Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62:2708-14. Re K. Sawada et al., Alendronate inhibits lysophosphatidic acid-induced migration of huma
    Valentine B Andela
    Cancer Res 64:2934-5; author reply 2935-6. 2004