Natalya M Ananyeva

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Role of the B domain in proteolytic inactivation of activated coagulation factor VIII by activated protein C and activated factor X
    Alexey V Khrenov
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Blood Coagul Fibrinolysis 17:379-88. 2006
  2. doi Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509
    Natalya M Ananyeva
    Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA
    Blood Coagul Fibrinolysis 19:543-55. 2008
  3. doi The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared within coagulation factor VIII
    Natalya M Ananyeva
    Center for Vascular and Inflammatory Diseases, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Blood Coagul Fibrinolysis 19:166-77. 2008
  4. ncbi Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII
    Andrey G Sarafanov
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Thromb Haemost 98:1170-81. 2007
  5. ncbi Identification of coagulation factor VIII A2 domain residues forming the binding epitope for low-density lipoprotein receptor-related protein
    Andrey G Sarafanov
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biochemistry 45:1829-40. 2006
  6. ncbi Factor VIIIa regulates substrate delivery to the intrinsic factor X-activating complex
    Mikhail A Panteleev
    Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland, USA
    FEBS J 273:374-87. 2006
  7. pmc Kinetics of Factor X activation by the membrane-bound complex of Factor IXa and Factor VIIIa
    Mikhail A Panteleev
    Laboratory of Physical Biochemistry of Blood, National Research Center for Hematology, Russian Academy of Medical Sciences, Novozykovskii pr 4a, Moscow, 125167, Russia
    Biochem J 381:779-94. 2004
  8. ncbi Inhibitors in hemophilia A: mechanisms of inhibition, management and perspectives
    Natalya M Ananyeva
    Department of Biochemistry, J Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
    Blood Coagul Fibrinolysis 15:109-24. 2004
  9. ncbi Effect of factor VIII on tissue factor-initiated spatial clot growth
    Mikhail V Ovanesov
    Laboratory of Physical Biochemistry of Blood, Russian Academy of Medical Sciences, Moscow, Russia
    Thromb Haemost 89:235-42. 2003
  10. ncbi Factor VIII - novel insights into form and function
    Evgueni L Saenko
    Department of Biochemistry, Holland Laboratory, American Red Cross, Rockville, USA
    Br J Haematol 119:323-31. 2002

Detail Information

Publications16

  1. ncbi Role of the B domain in proteolytic inactivation of activated coagulation factor VIII by activated protein C and activated factor X
    Alexey V Khrenov
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Blood Coagul Fibrinolysis 17:379-88. 2006
    ..We suggest that differences in proteolytic inactivation may contribute to differences between BDD-rFVIII and pd-FVIII in assaying and in clinical use...
  2. doi Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509
    Natalya M Ananyeva
    Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA
    Blood Coagul Fibrinolysis 19:543-55. 2008
    ..We conclude that interaction of factor VIII with the members of the low-density lipoprotein receptor family follows the general mode, requires dissociation of factor VIII from von Willebrand factor, and is activation sensitive...
  3. doi The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared within coagulation factor VIII
    Natalya M Ananyeva
    Center for Vascular and Inflammatory Diseases, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Blood Coagul Fibrinolysis 19:166-77. 2008
    ..A functional role of FVIII/VLDLR interaction may be related to regulation of intrinsic Xase activity...
  4. ncbi Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII
    Andrey G Sarafanov
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Thromb Haemost 98:1170-81. 2007
    ..We conclude that A2 interacts with LRP via multiple binding sites spanning CR 3-8 in cluster II and CR 23-29 in cluster IV, and the minimal A2-binding unit of LRP is formed by two adjacent CR...
  5. ncbi Identification of coagulation factor VIII A2 domain residues forming the binding epitope for low-density lipoprotein receptor-related protein
    Andrey G Sarafanov
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biochemistry 45:1829-40. 2006
    ..This further confirms the importance of the mutated residues for interaction of A2 with LRP and suggests the existence of an LRP-dependent mechanism for removing A2 as a product of dissociation of activated fVIII from the circulation...
  6. ncbi Factor VIIIa regulates substrate delivery to the intrinsic factor X-activating complex
    Mikhail A Panteleev
    Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland, USA
    FEBS J 273:374-87. 2006
    ..The obtained results reveal formation of high-affinity fVIIIa-fX complexes on phospholipid membranes and suggest their role in regulating fX activation by anchoring and delivering fX to the enzymatic complex...
  7. pmc Kinetics of Factor X activation by the membrane-bound complex of Factor IXa and Factor VIIIa
    Mikhail A Panteleev
    Laboratory of Physical Biochemistry of Blood, National Research Center for Hematology, Russian Academy of Medical Sciences, Novozykovskii pr 4a, Moscow, 125167, Russia
    Biochem J 381:779-94. 2004
    ..The approach of the present study can be applied to research of other membrane-dependent enzymic reactions...
  8. ncbi Inhibitors in hemophilia A: mechanisms of inhibition, management and perspectives
    Natalya M Ananyeva
    Department of Biochemistry, J Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
    Blood Coagul Fibrinolysis 15:109-24. 2004
    ....
  9. ncbi Effect of factor VIII on tissue factor-initiated spatial clot growth
    Mikhail V Ovanesov
    Laboratory of Physical Biochemistry of Blood, Russian Academy of Medical Sciences, Moscow, Russia
    Thromb Haemost 89:235-42. 2003
    ..05 U/ml fVIII restored the normal clot growth rate (44.9 +/- 2.5 microm/min) at high but not at low fibroblast density. Our results indicate that the functioning of the intrinsic tenase complex is critical for normal spatial clot growth...
  10. ncbi Factor VIII - novel insights into form and function
    Evgueni L Saenko
    Department of Biochemistry, Holland Laboratory, American Red Cross, Rockville, USA
    Br J Haematol 119:323-31. 2002
  11. ncbi Intrinsic pathway of blood coagulation contributes to thrombogenicity of atherosclerotic plaque
    Natalya M Ananyeva
    Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    Blood 99:4475-85. 2002
    ..Our data predict that the intrinsic pathway significantly enhances thrombogenicity of atherosclerotic lesions after removal of the endothelial layer and exposure of SMCs and macrophages to blood flow...
  12. pmc Spatial propagation and localization of blood coagulation are regulated by intrinsic and protein C pathways, respectively
    Mikhail A Panteleev
    Laboratory of Physical Biochemistry of Blood, National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, Russia
    Biophys J 90:1489-500. 2006
    ..2 mm. These results identify roles of specific coagulation pathways at different stages of spatial clot formation (initiation, elongation, and termination) and provide a possible basis for their therapeutic targeting...
  13. ncbi Development of improved factor VIII molecules and new gene transfer approaches for hemophilia A
    Evgueni L Saenko
    Department of Biochemistry, Holland Laboratory, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Curr Gene Ther 3:27-41. 2003
    ..Collectively, these proposed advances represent promising prophylactic strategies toward long-term correction of the coagulation defect in this progressively debilitating, life-threatening disease...
  14. ncbi Coagulation pathways in atherothrombosis
    Alexey V Khrenov
    Department of Biochemistry, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    Trends Cardiovasc Med 12:317-24. 2002
    ..The present review discusses contribution of the extrinsic and intrinsic pathways of blood coagulation in thrombogenicity of atherosclerotic plaque and factors determining the overall procoagulant/anticoagulant balance...
  15. ncbi Hemophilia A--from basic science to clinical practice
    Jens Klinge
    Hospital for Children and Adolescents, University of Erlangen, Erlangen, Germany
    Semin Thromb Hemost 28:309-22. 2002
    ..We also analyze the main concepts and scientific priorities in the gene-therapeutic approach for treatment of hemophilia A...
  16. ncbi Expression of factor VIII in recombinant and transgenic systems
    Serguei Soukharev
    Department of Plasma Derivatives, Holland Laboratory, American Red Cross, 15601 Crabbs Branch Way, Rockville, Maryland 20855, USA
    Blood Cells Mol Dis 28:234-48. 2002
    ..Finally, we present a brief characterization of commercial recombinant FVIII products currently available on the market for hemophilia A treatment...