Shrikant Anant

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi request reprint Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor
    Cate Moriasi
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Anticancer Agents Med Chem 12:1221-38. 2012
  2. pmc Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism
    Sripathi M Sureban
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Nanobiotechnology 9:40. 2011
  3. pmc Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects
    Zhiyun He
    Department of Medicine, Lanzhou University Second Hospital, Gansu Province, China
    Am J Physiol Gastrointest Liver Physiol 301:G929-37. 2011
  4. pmc CDK-4 inhibitor P276 sensitizes pancreatic cancer cells to gemcitabine-induced apoptosis
    Dharmalingam Subramaniam
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Cancer Ther 11:1598-608. 2012
  5. pmc RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells
    Dharmalingam Subramaniam
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e16958. 2011
  6. pmc 3,5-bis(2,4-difluorobenzylidene)-4-piperidone, a novel compound that affects pancreatic cancer growth and angiogenesis
    Dharmalingam Subramaniam
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Mol Cancer Ther 10:2146-56. 2011
  7. pmc Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells
    Gaurav Kaushik
    Department of Surgery, University of Kansas Medical Center, Kansas City, KS, USA
    Am J Surg 204:868-73. 2012
  8. pmc Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells
    Sivapriya Ponnurangam
    Department of Molecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Cancer Ther 11:963-72. 2012
  9. pmc Critical roles of Notch and Wnt/β-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection
    Ishfaq Ahmed
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Infect Immun 80:3107-21. 2012
  10. pmc Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling
    Dharmalingam Subramaniam
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 7:e30590. 2012

Research Grants

  1. Dietary Prevention of Cancer
    Shrikant Anant; Fiscal Year: 2007
  2. RNA Binding Protein CUGBP2 in Intestinal Epithelium
    Shrikant Anant; Fiscal Year: 2010
  3. Dietary Prevention of Cancer
    Shrikant Anant; Fiscal Year: 2010
  4. RNA Binding Proteins in Cancer
    Shrikant Anant; Fiscal Year: 2010
  5. Dietary Prevention of Cancer
    Shrikant Anant; Fiscal Year: 2010

Collaborators

  • Dharmalingam Subramaniam
  • Shahid Umar
  • Aravind Sugumar
  • Prateek Sharma
  • Satish Ramalingam
  • Sivapriya Ponnurangam
  • Zhiyun He
  • Cate Moriasi
  • Gaurav Kaushik
  • Joshua M V Mammen
  • Ishfaq Ahmed
  • Youcheng Zhang
  • Sripathi M Sureban
  • Parthasarthy Rangarajan
  • Lijun Xia
  • Prabhu Rammamoorthy
  • Piero Protti
  • Parthasarathy Chandrakesan
  • Ossama Tawfik
  • Shanjana Awasthi
  • Courtney W Houchen
  • Panayotis Pantazis
  • Dongfeng Qu
  • Russell G Postier
  • RAMA P RAMANUJAM
  • Randal May
  • Fadee G Mondalek
  • Animesh Dhar

Detail Information

Publications10

  1. ncbi request reprint Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor
    Cate Moriasi
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Anticancer Agents Med Chem 12:1221-38. 2012
    ....
  2. pmc Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism
    Sripathi M Sureban
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Nanobiotechnology 9:40. 2011
    ..To measure let-7a and miR-144 expression in vitro, HCT116 cells were transfected with plasmids encoding the firefly luciferase gene with let-7a and miR-144 miRNA binding sites in the 3'UTR...
  3. pmc Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects
    Zhiyun He
    Department of Medicine, Lanzhou University Second Hospital, Gansu Province, China
    Am J Physiol Gastrointest Liver Physiol 301:G929-37. 2011
    ..These data demonstrate that honokiol is highly effective in radiosensitizing colorectal cancer cells, especially those with a mismatch repair defect...
  4. pmc CDK-4 inhibitor P276 sensitizes pancreatic cancer cells to gemcitabine-induced apoptosis
    Dharmalingam Subramaniam
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Cancer Ther 11:1598-608. 2012
    ..Taken together, these data suggest that P276-Gem combination is a novel potent therapeutic agent that can target the Akt-mTOR signaling pathway to inhibit both tumor growth and angiogenesis...
  5. pmc RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells
    Dharmalingam Subramaniam
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e16958. 2011
    ..Here, we have determined that curcumin modulates the expression of RNA binding protein CUGBP2 to inhibit pancreatic cancer growth...
  6. pmc 3,5-bis(2,4-difluorobenzylidene)-4-piperidone, a novel compound that affects pancreatic cancer growth and angiogenesis
    Dharmalingam Subramaniam
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Mol Cancer Ther 10:2146-56. 2011
    ..Taken together, these data suggest that DiFiD is a novel potent therapeutic agent that can target different aspects of the Notch signaling pathway to inhibit both tumor growth and angiogenesis...
  7. pmc Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells
    Gaurav Kaushik
    Department of Surgery, University of Kansas Medical Center, Kansas City, KS, USA
    Am J Surg 204:868-73. 2012
    ..Therefore, developing new therapies with low toxicity is of utmost importance. Honokiol is a natural compound that recently has shown promise as an effective anticancer agent...
  8. pmc Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells
    Sivapriya Ponnurangam
    Department of Molecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Cancer Ther 11:963-72. 2012
    ..These studies warrant further clinical evaluation for the combination of honokiol and IR for treating colon cancers...
  9. pmc Critical roles of Notch and Wnt/β-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection
    Ishfaq Ahmed
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Infect Immun 80:3107-21. 2012
    ..Thus, the balancing act between cell proliferation and mucus production to restore barrier integrity seems to depend upon the interplay between the Wnt/β-catenin and Notch pathways in the TMCH model...
  10. pmc Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling
    Dharmalingam Subramaniam
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 7:e30590. 2012
    ..Here, we have determined that curcumin inhibits esophageal cancer growth via a mechanism mediated through the Notch signaling pathway...

Research Grants10

  1. Dietary Prevention of Cancer
    Shrikant Anant; Fiscal Year: 2007
    ..Together these studies should provide insight into the cancer process and how curcumin suppresses the risk and proliferation of colon cancer, and of no less importance, why curcumin is of great value as a food supplement. ..
  2. RNA Binding Protein CUGBP2 in Intestinal Epithelium
    Shrikant Anant; Fiscal Year: 2010
    ..We are in the process of identifying how the gene expressing CUGBP2 is silenced in cancer cells so that we can determine ways to reverse the process. This might stop or slow down the tumorigenesis. ..
  3. Dietary Prevention of Cancer
    Shrikant Anant; Fiscal Year: 2010
    ..We expect that the work will lead to a better understanding of the tumorigenesis process and identify novel methods to stop or slow down tumorigenesis. ..
  4. RNA Binding Proteins in Cancer
    Shrikant Anant; Fiscal Year: 2010
    ..We expect that the work will lead to a better understanding of the tumorigenesis process which should subsequently lead to novel methods to stop or slow down tumorigenesis. ..
  5. Dietary Prevention of Cancer
    Shrikant Anant; Fiscal Year: 2010
    ..We expect that the work will lead to a better understanding of the tumorigenesis process and identify novel methods to stop or slow down tumorigenesis. ..