S An

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization
    S An
    Departments of Medicine and Microbiology Immunology, University of California, San Francisco, California 94143 0711, USA
    Mol Pharmacol 54:881-8. 1998
  2. ncbi Molecular identification and characterization of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate
    S An
    Department of Medicine, University of California, San Francisco 94143 0711, USA
    Ann N Y Acad Sci 905:25-33. 2000
  3. ncbi Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids
    S An
    Department of Medicine, University of California, San Francisco 94143, USA
    FEBS Lett 417:279-82. 1997
  4. ncbi Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5
    S An
    Department of Medicine, University of California, San Francisco, California 94143 0711, USA
    J Biol Chem 275:288-96. 2000
  5. ncbi Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate
    S An
    Department of Medicine, University of California, San Francisco 94143 0711, USA
    J Cell Biochem Suppl 30:147-57. 1998
  6. ncbi Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid
    S An
    Department of Medicine, University of California Medical Center, San Francisco 94143 0711, USA
    Biochem Biophys Res Commun 231:619-22. 1997
  7. ncbi Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors
    S An
    Department of Medicine, University of California, San Francisco, California 94143 0711, USA
    Mol Pharmacol 55:787-94. 1999
  8. ncbi Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
    S An
    Departments of Medicine and Microbiology Immunology, University of California, San Francisco, California 94143 0711, USA
    J Biol Chem 273:7906-10. 1998
  9. ncbi Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2
    J Yang
    Department of Medicine, University of California, San Francisco 94143 0711
    Biochem Biophys Res Commun 198:999-1006. 1994
  10. ncbi Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing
    H Lee
    Department of Medicine, University of California Medical Center, San Francisco, California 94143 0711, USA
    Am J Physiol Cell Physiol 278:C612-8. 2000

Collaborators

Detail Information

Publications22

  1. ncbi Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization
    S An
    Departments of Medicine and Microbiology Immunology, University of California, San Francisco, California 94143 0711, USA
    Mol Pharmacol 54:881-8. 1998
    ....
  2. ncbi Molecular identification and characterization of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate
    S An
    Department of Medicine, University of California, San Francisco 94143 0711, USA
    Ann N Y Acad Sci 905:25-33. 2000
    ..From these experimental approaches, important lessons can be learned and applied to future studies of signal transduction of lysophospholipid receptors...
  3. ncbi Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids
    S An
    Department of Medicine, University of California, San Francisco 94143, USA
    FEBS Lett 417:279-82. 1997
    ..H218 and Edg3 expressed in Xenopus oocytes conferred responsiveness to S1P and dihydro-S1P in agonist-triggered 45Ca2+ efflux. Therefore, H218 and Edg3 are functional receptors for S1P and perhaps other closely related lysosphingolipids...
  4. ncbi Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5
    S An
    Department of Medicine, University of California, San Francisco, California 94143 0711, USA
    J Biol Chem 275:288-96. 2000
    ..Thus, specific G protein-coupled receptors Edg3 and Edg5 account for, at least in part, S1P-induced cell proliferation, survival, and related signaling events...
  5. ncbi Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate
    S An
    Department of Medicine, University of California, San Francisco 94143 0711, USA
    J Cell Biochem Suppl 30:147-57. 1998
    ..This review summarizes our current understanding of signaling pathways critical for cellular responses to LPA and S1P and of recent progress in the molecular biological analyses of the Edg receptors...
  6. ncbi Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid
    S An
    Department of Medicine, University of California Medical Center, San Francisco 94143 0711, USA
    Biochem Biophys Res Commun 231:619-22. 1997
    ..Recently, the mouse counterpart of Edg2 protein also was identified as a receptor for LPA (Hecht et al., 1996, J. Cell Biol. 135, 1071). Therefore, it is concluded that the human Edg2 protein functions as a cellular receptor for LPA...
  7. ncbi Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors
    S An
    Department of Medicine, University of California, San Francisco, California 94143 0711, USA
    Mol Pharmacol 55:787-94. 1999
    ..Although these results did not dismiss that S1P may function as an intracellular second messenger in other settings, they definitively proved that S1P can mobilize Ca2+ as an extracellular ligand for G protein-coupled receptors...
  8. ncbi Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
    S An
    Departments of Medicine and Microbiology Immunology, University of California, San Francisco, California 94143 0711, USA
    J Biol Chem 273:7906-10. 1998
    ..The existence and distinctive tissue expression of structurally different subtypes of LPA receptors may provide one basis for tissue-specific functions and permit independent regulation of each subtype of LPA receptor...
  9. ncbi Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2
    J Yang
    Department of Medicine, University of California, San Francisco 94143 0711
    Biochem Biophys Res Commun 198:999-1006. 1994
    ..6 nM and native specificity. In contrast to the reliance of EP2Rs on increases in the intracellular concentration of cyclic AMP ([cAMP]i) for cellular signaling, EP3Rs transduce both decreases in [cAMP]i and modest increases in [Ca++]i...
  10. ncbi Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing
    H Lee
    Department of Medicine, University of California Medical Center, San Francisco, California 94143 0711, USA
    Am J Physiol Cell Physiol 278:C612-8. 2000
    ..Thus LPA and S1P affect endothelial cell functions through signaling pathways activated by distinct GPCRs and may contribute to the healing of wounded vasculatures...
  11. ncbi Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2
    S An
    Department of Medicine, University of California, San Francisco 94143 0724
    Biochem Biophys Res Commun 197:263-70. 1993
    ..That most EP2 receptor mRNA is in lung, kidney, intestinal, glandular and immune tissues, is consistent with functional responses...
  12. ncbi Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue
    S An
    Department of Medicine, University of California, San Francisco 94143 0711, USA
    FEBS Lett 375:121-4. 1995
    ..Northern analysis revealed that they are expressed prominently in the lung. Although the ligands for GPR12A and GPR6C.1 are unknown, their similarity suggests that they are receptors for ligands of similar or identical chemical nature...
  13. ncbi Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals
    S An
    Department of Medicine, University of California, San Francisco 94143 0711
    Biochemistry 33:14496-502. 1994
    ..The dual signal transduction pathways and distinctive tissue distribution of isoforms of the EP3 receptor are consistent with its mediation of diverse functions of PGE2...
  14. ncbi Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate
    E J Goetzl
    Departments of Medicine and Microbiology Immunology, University of California Medical Center, San Francisco, California 94143 0711, USA
    FASEB J 12:1589-98. 1998
    ..These ubiquitous LPL mediators of cellular growth, differentiation, and activities thus act directly through complex subfamilies of GPCRs and by regulating expression of biologically critical proteins...
  15. ncbi Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases
    E J Goetzl
    Department of Medicine, University of California Medical Center, San Francisco 94143 0711, USA
    FASEB J 9:1051-8. 1995
    ....
  16. ncbi Identification and characterization of a melanin-concentrating hormone receptor
    S An
    Tularik, Inc, Two Corporate Drive, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 98:7576-81. 2001
    ..This discovery is important for a full understanding of MCH biology and the development of potential therapeutics for diseases involving MCH, including obesity...
  17. ncbi Endothelial differentiation gene-2 receptor is involved in lysophosphatidic acid-dependent control of 3T3F442A preadipocyte proliferation and spreading
    C Pages
    INSERM U317, Institut Louis Bugnard, , CHU Rangueil, Batiment L3, 31403, Toulouse cedex 04, France
    J Biol Chem 276:11599-605. 2001
    ..Results demonstrate the significant contribution of the EDG-2 receptor in the biological responses generated by LPA in 3T3F442A preadipocytes...
  18. ncbi Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins
    R T Windh
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 274:27351-8. 1999
    ..These studies represent the first characterization of S1P receptor activity through G proteins directly and establish fundamental differences in coupling...
  19. ncbi SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils
    E R Chapman
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510
    J Biol Chem 269:27427-32. 1994
    ..We conclude that SNAP-25 can interact with both syntaxin and synaptobrevin and that binding may be mediated by alpha-helical domains that form intermolecular coiled-coil structures...
  20. ncbi Fatty acylation of synaptotagmin in PC12 cells and synaptosomes
    E R Chapman
    Howard Hughes Medical Institute, New Haven, Connecticut, USA
    Biochem Biophys Res Commun 225:326-32. 1996
    ..In addition, hydroxylamine-induced mobility shifts were also apparent for synaptotagmins II and III, suggesting that posttranslational palmitoylation via thioester bonds may be a general modification of all synaptotagmins...
  21. ncbi The secretory granule protein syncollin binds to syntaxin in a Ca2(+)-sensitive manner
    J M Edwardson
    Department of Pharmacology, University of Cambridge, United Kingdom
    Cell 90:325-33. 1997
    ..We suggest that syncollin acts as a Ca2(+)-sensitive regulator of exocytosis in exocrine tissues...
  22. ncbi Expression profiling of radiation-induced genes in radiodermatitis of hairless mice
    Y S Lee
    Department of Dermatology, School of Medicine, Chungnam National University, Dajeon, and Department of Radiation Oncology, Chosun University Hospital, Gwangju, Korea
    Br J Dermatol 154:829-38. 2006
    ..CONCLUSIONS: These results demonstrate the complexity of the transcriptional profile of the radiation response, providing important clues on which to base further investigations of the molecular events underlying radiodermatitis...