Samson Amos

..The data obtained suggest that the aqueous extract of CI utilizes extracellular calcium pools to bring about contractile response and this effect might be mediated through the activation of potential-sensitive channels...

..In summary, these results suggest that c-Src, mitogen-activated protein kinase, and a composite activator protein 1 on the uPA promoter are responsible for EGF-induced uPA expression and GBM invasion...

..However, the extract did not affect contractions evoked by KCl, norepinephrine and 5-HT on the rat aorta. Pavetta crassipes contains biologically active substances that may be useful in the management of hypertension...

..crassipes contains biologically active substance(s) that might be acting centrally through the inhibition of dopaminergic pathway or a system linked to this pathway to mediate the observed pharmacological effects...

..Thus, a strategy of combining small molecule inhibitors of PKC-alpha and PI3K could provide a new treatment paradigm for glioblastomas...

..Taken together, our data demonstrate that PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastomas...

..Our results suggest that H-Ras increased uPA expression and activity via the Ras/Raf/MEK signaling pathway leading to enhanced cell invasion and this may contribute to increased invasive growth properties of astrocytomas...

..These results demonstrate that MMP-9 and PKC-alpha or PKC-delta may provide putative therapeutic targets for the control of PA dural invasion...

....

..It is suggested that methyl angolensate possesses some biologically active principles that are sedative in nature...

....

..These results suggest that beta-arrestin 1 dephosphorylation/inactivation is associated with aspects of the malignant behavior of glioblastomas...

..Elk-1 target genes involved in GBM proliferative responses have yet to be identified...

..The extract had an intraperitoneal (i.p.) LD(50) of 282.84+/-3.2 mg/kg in mice. These data corroborate the traditional use of this plant in the treatment of dysmenorrhea...

..Our data suggest PKM2 inhibition as a therapy for glioblastoma, with the potential for minimal toxicity to the brain...

..It also suggests that Ach mobilize Ca from some tightly bound or intracellular pool, whereas high K(+) and ID may mobilize Ca from some superficial or loosely-bound pool...

..This study demonstrates that inhibition of Ras methylation may provide a therapeutic target for the treatment of GBMs overexpressing EGFR...

..The oral LD50 values obtained were > 5000 mg/kg in both mice and rats. The results support the folkloric applications of Guiera senegalensis for the treatment of diarrhoea and ulcer in Nigerian herbal traditional medicine...

..It is suggested that the extract may contain biologically active components that may be useful against diarrhoea, thereby justifying its use in ethnomedical practice as an antidiarrhoeal agent...

..It is therefore suggested that methyl angolensate may exert its activity on gastrointestinal smooth muscle via serotonergic mechanisms...

..It was also found to attenuate apomorphine climbing in mice. The results suggest that the methanolic extract of Newbouldia laevis may contain principles that have sedative properties...

..These results suggest that the plant contain active constituents that may be useful against diarrhoea...

..Acetic acid-induced writhing, formalin and thermal (hot plate) tests were used. The extract (50 and 100 mg/kg, i.p.) showed a dose-dependent analgesic effect in all the tests used. Its i.p. LD50 in mice was 2236.07 mg/kg...

..05) against all the analgesic and anti-inflammatory models used. The LD(50) of the extract was estimated to be 513.80+/-33.92 mg/kg i.p. in mice. These results provide support for the use of the plant in relieving pain and fever...

..Acute toxicity test in mice established LD50 value (i.p.) of the extract to be 2000 mg/kg. Preliminary phytochemical screening of the extract gave positive test for flavonoids, tannins and saponins...

..05) when compared with the saline control group. The results suggest the presence of a potent anti-inflammatory and anti-nociceptive principle in the extract, which support the folkloric use of the plant in relieving rheumatic pains...

..The data obtained suggest that the aqueous extract of C. giganteum contains some biologically active principles with sedative activity...

..These results indicate the presence of psychoactive substances in the aqueous extract of the root bark of Nauclea latifolia...

..The results suggest that the extract may possess sedative principles with potential neuroleptic properties...

..The i.p. LD(50) in mice was 2735.61 and 5000 mg/kg orally. The results suggest that the aqueous extract of S. senegalensis contains some active principles, which may be sedative in nature...

..The results suggested that the crude aqueous extract of G. senegalensis possesses some biologically active principles that are sedative in nature...

..These results suggest that the extract contained some constituents that depress the central nervous system, which may not be due to neuromuscular blockade...

..It also failed to affect the motor coordination test. These results suggest that the extract contained an agent with neuropharmacological activity that may be sedative in nature...

..The results suggest that artemisinin possesses sedative property, which may be mediated via postsynaptic dopamine (D(2)) receptor in the CNS...

..The intraperitoneal LD50 in mice was found to be 1500 mg/kg. The aqueous extract of T. sessilifoliius possesses active components that may be mediating the observed biological activity through calcium mobilization...