Samson Amos

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Effect of the aqueous extract of Chrysanthellum indicum on calcium mobilization and activation of rat portal vein
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Garki, Abuja, Nigeria
    J Ethnopharmacol 88:57-62. 2003
  2. doi request reprint Epidermal growth factor receptor-mediated regulation of urokinase plasminogen activator expression and glioblastoma invasion via C-SRC/MAPK/AP-1 signaling pathways
    Samson Amos
    Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neuropathol Exp Neurol 69:582-92. 2010
  3. ncbi request reprint Hypotensive activity of the ethanol extract of Pavetta crassipes leaves
    Samson Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, Nigeria
    Biol Pharm Bull 26:1674-80. 2003
  4. ncbi request reprint Behavioural effect of Pavetta crassipes extract on rodents
    Samson Amos
    Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Nigeria
    Pharmacol Biochem Behav 77:751-9. 2004
  5. pmc Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion
    Samson Amos
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Cancer Res 67:10241-51. 2007
  6. pmc Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells
    Samson Amos
    Department of Pathology, University of Virginia Health System, Charlottesville 22908, USA
    J Biol Chem 280:7729-38. 2005
  7. pmc H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway
    Yunge Zhao
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Glia 56:917-24. 2008
  8. pmc Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line
    Isa M Hussaini
    Department of Pathology, 415 Lane Rd, Box 800904, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 170:356-65. 2007
  9. ncbi request reprint Matrix metalloproteinase-9, a potential biological marker in invasive pituitary adenomas
    Jian Gong
    Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA 22903, USA
    Pituitary 11:37-48. 2008
  10. ncbi request reprint Behavioural effects in rodents of methyl angolensate: a triterpenoid isolated from Entandrophragma angolense
    Samson Amos
    Department of Pharmacology, National Institute for Pharmaceutical Research and Development, Abuja, FCT, Nigeria
    Pharmacol Toxicol 91:71-6. 2002

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Effect of the aqueous extract of Chrysanthellum indicum on calcium mobilization and activation of rat portal vein
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Garki, Abuja, Nigeria
    J Ethnopharmacol 88:57-62. 2003
    ..The data obtained suggest that the aqueous extract of CI utilizes extracellular calcium pools to bring about contractile response and this effect might be mediated through the activation of potential-sensitive channels...
  2. doi request reprint Epidermal growth factor receptor-mediated regulation of urokinase plasminogen activator expression and glioblastoma invasion via C-SRC/MAPK/AP-1 signaling pathways
    Samson Amos
    Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neuropathol Exp Neurol 69:582-92. 2010
    ..In summary, these results suggest that c-Src, mitogen-activated protein kinase, and a composite activator protein 1 on the uPA promoter are responsible for EGF-induced uPA expression and GBM invasion...
  3. ncbi request reprint Hypotensive activity of the ethanol extract of Pavetta crassipes leaves
    Samson Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, Nigeria
    Biol Pharm Bull 26:1674-80. 2003
    ..However, the extract did not affect contractions evoked by KCl, norepinephrine and 5-HT on the rat aorta. Pavetta crassipes contains biologically active substances that may be useful in the management of hypertension...
  4. ncbi request reprint Behavioural effect of Pavetta crassipes extract on rodents
    Samson Amos
    Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Nigeria
    Pharmacol Biochem Behav 77:751-9. 2004
    ..crassipes contains biologically active substance(s) that might be acting centrally through the inhibition of dopaminergic pathway or a system linked to this pathway to mediate the observed pharmacological effects...
  5. pmc Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion
    Samson Amos
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Cancer Res 67:10241-51. 2007
    ..Thus, a strategy of combining small molecule inhibitors of PKC-alpha and PI3K could provide a new treatment paradigm for glioblastomas...
  6. pmc Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells
    Samson Amos
    Department of Pathology, University of Virginia Health System, Charlottesville 22908, USA
    J Biol Chem 280:7729-38. 2005
    ..Taken together, our data demonstrate that PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastomas...
  7. pmc H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway
    Yunge Zhao
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Glia 56:917-24. 2008
    ..Our results suggest that H-Ras increased uPA expression and activity via the Ras/Raf/MEK signaling pathway leading to enhanced cell invasion and this may contribute to increased invasive growth properties of astrocytomas...
  8. pmc Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line
    Isa M Hussaini
    Department of Pathology, 415 Lane Rd, Box 800904, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 170:356-65. 2007
    ..These results demonstrate that MMP-9 and PKC-alpha or PKC-delta may provide putative therapeutic targets for the control of PA dural invasion...
  9. ncbi request reprint Matrix metalloproteinase-9, a potential biological marker in invasive pituitary adenomas
    Jian Gong
    Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA 22903, USA
    Pituitary 11:37-48. 2008
    ....
  10. ncbi request reprint Behavioural effects in rodents of methyl angolensate: a triterpenoid isolated from Entandrophragma angolense
    Samson Amos
    Department of Pharmacology, National Institute for Pharmaceutical Research and Development, Abuja, FCT, Nigeria
    Pharmacol Toxicol 91:71-6. 2002
    ..It is suggested that methyl angolensate possesses some biologically active principles that are sedative in nature...
  11. doi request reprint Anticonvulsant properties of saponins from Ficus platyphylla stem bark
    Ben A Chindo
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P M B 21, Abuja, Nigeria
    Brain Res Bull 78:276-82. 2009
    ....
  12. doi request reprint Dephosphorylation of beta-arrestin 1 in glioblastomas
    James W Mandell
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22903, USA
    J Neuropathol Exp Neurol 68:535-41. 2009
    ..These results suggest that beta-arrestin 1 dephosphorylation/inactivation is associated with aspects of the malignant behavior of glioblastomas...
  13. ncbi request reprint The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway
    R M Uht
    Department of Pathology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Oncogene 26:2885-93. 2007
    ..Elk-1 target genes involved in GBM proliferative responses have yet to be identified...
  14. ncbi request reprint Pharmacological effects of the aqueous extract of Neorautanenia mitis in rodents
    H O Vongtau
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P M B 21, Abuja, Nigeria
    J Ethnopharmacol 72:207-14. 2000
    ..The extract had an intraperitoneal (i.p.) LD(50) of 282.84+/-3.2 mg/kg in mice. These data corroborate the traditional use of this plant in the treatment of dysmenorrhea...
  15. pmc Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells
    Benjamin Kefas
    Division of Neuro Oncology, Neurology Department, University of Virginia Health System, Old Medical School, Room 4818, 21 Hospital Drive, Charlottesville, VA 22908, USA
    Neuro Oncol 12:1102-12. 2010
    ..Our data suggest PKM2 inhibition as a therapy for glioblastoma, with the potential for minimal toxicity to the brain...
  16. ncbi request reprint Smooth muscle contraction induced by Indigofera dendroides leaf extracts may involve calcium mobilization via potential sensitive channels
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria
    Phytother Res 17:792-6. 2003
    ..It also suggests that Ach mobilize Ca from some tightly bound or intracellular pool, whereas high K(+) and ID may mobilize Ca from some superficial or loosely-bound pool...
  17. ncbi request reprint Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells
    S Amos
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Cell Death Differ 13:642-51. 2006
    ..This study demonstrates that inhibition of Ras methylation may provide a therapeutic target for the treatment of GBMs overexpressing EGFR...
  18. ncbi request reprint Anti-diarrhoeal and ulcer-protective effects of the aqueous root extract of Guiera senegalensis in rodents
    S O Aniagu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P M B 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 97:549-54. 2005
    ..The oral LD50 values obtained were > 5000 mg/kg in both mice and rats. The results support the folkloric applications of Guiera senegalensis for the treatment of diarrhoea and ulcer in Nigerian herbal traditional medicine...
  19. ncbi request reprint Evaluation of the antidiarrhoeal effects of Zizyphus spina-christi stem bark in rats
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P M B 21 Abuja, FCT, Nigeria
    Acta Trop 87:245-50. 2003
    ..It is suggested that the extract may contain biologically active components that may be useful against diarrhoea, thereby justifying its use in ethnomedical practice as an antidiarrhoeal agent...
  20. ncbi request reprint Spasmolytic activity of methyl angolensate: a triterpenoid isolated from Entandrophragma angolense
    A Orisadipe
    Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development, Garki, Abhuja, Nigeria
    Biol Pharm Bull 24:364-7. 2001
    ..It is therefore suggested that methyl angolensate may exert its activity on gastrointestinal smooth muscle via serotonergic mechanisms...
  21. ncbi request reprint Sedative effects of the methanolic leaf extract of Newbouldia laevis in mice and rats
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Garki, Abuja, Nigeria
    Boll Chim Farm 141:471-5. 2002
    ..It was also found to attenuate apomorphine climbing in mice. The results suggest that the methanolic extract of Newbouldia laevis may contain principles that have sedative properties...
  22. ncbi request reprint The efficacy of Sphaeranthus senegalensis Vaill extract against diarrhoea in rats
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, PMB 21 Abuja, Nigeria
    J Ethnopharmacol 95:173-6. 2004
    ..These results suggest that the plant contain active constituents that may be useful against diarrhoea...
  23. ncbi request reprint Antinociceptive activity of Zizyphus spina-christi root bark extract
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P.M.B. 21, Garki, Abuja, Nigeria
    Fitoterapia 72:344-50. 2001
    ..Acetic acid-induced writhing, formalin and thermal (hot plate) tests were used. The extract (50 and 100 mg/kg, i.p.) showed a dose-dependent analgesic effect in all the tests used. Its i.p. LD50 in mice was 2236.07 mg/kg...
  24. ncbi request reprint Pharmacological evidence favouring the folkloric use of Diospyros mespiliformis Hochst in the relief of pain and fever
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, PMB 21, Abuja, Nigeria
    J Ethnopharmacol 82:191-5. 2002
    ..05) against all the analgesic and anti-inflammatory models used. The LD(50) of the extract was estimated to be 513.80+/-33.92 mg/kg i.p. in mice. These results provide support for the use of the plant in relieving pain and fever...
  25. ncbi request reprint Evaluation of methanolic extract of Ficus platyphylla on gastrointestinal activity
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P M B 21, Abuja, Nigeria
    Indian J Exp Biol 39:63-7. 2001
    ..Acute toxicity test in mice established LD50 value (i.p.) of the extract to be 2000 mg/kg. Preliminary phytochemical screening of the extract gave positive test for flavonoids, tannins and saponins...
  26. ncbi request reprint Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, PMB 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 84:169-73. 2003
    ..05) when compared with the saline control group. The results suggest the presence of a potent anti-inflammatory and anti-nociceptive principle in the extract, which support the folkloric use of the plant in relieving rheumatic pains...
  27. ncbi request reprint Central inhibitory activity of the aqueous extract of Crinum giganteum
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area P M B 21, Garki, Abuja, FCT, Nigeria
    Fitoterapia 74:23-8. 2003
    ..The data obtained suggest that the aqueous extract of C. giganteum contains some biologically active principles with sedative activity...
  28. ncbi request reprint Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P M B 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 97:53-7. 2005
    ..These results indicate the presence of psychoactive substances in the aqueous extract of the root bark of Nauclea latifolia...
  29. ncbi request reprint Central nervous system activity of the methanol extract of Ficus platyphylla stem bark
    B A Chindo
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, P M B 21, Abuja, FCT, Nigeria
    J Ethnopharmacol 85:131-7. 2003
    ..The results suggest that the extract may possess sedative principles with potential neuroleptic properties...
  30. ncbi request reprint Neuropharmacological effect of the aqueous extract of Sphaeranthus senegalensis in mice
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, PMB 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 78:33-7. 2001
    ..The i.p. LD(50) in mice was 2735.61 and 5000 mg/kg orally. The results suggest that the aqueous extract of S. senegalensis contains some active principles, which may be sedative in nature...
  31. ncbi request reprint Behavioral effects of the aqueous extract of Guiera senegalensis in mice and rats
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, FCT, Nigeria
    Phytomedicine 8:356-61. 2001
    ..The results suggested that the crude aqueous extract of G. senegalensis possesses some biologically active principles that are sedative in nature...
  32. ncbi request reprint Effect of Zizyphus spina-christi Willd aqueous extract on the central nervous system in mice
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P M B 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 79:13-6. 2002
    ..These results suggest that the extract contained some constituents that depress the central nervous system, which may not be due to neuromuscular blockade...
  33. ncbi request reprint Neuropharmacological screening of Diospyros mespiliformis in mice
    B Adzu
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, PMB 21, Abuja, Nigeria
    J Ethnopharmacol 83:139-43. 2002
    ..It also failed to affect the motor coordination test. These results suggest that the extract contained an agent with neuropharmacological activity that may be sedative in nature...
  34. ncbi request reprint Postsynaptic dopamine (D(2))-mediated behavioural effects of high acute doses of artemisinin in rodents
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development NIPRD, Idu Industrial Area, P M B 21, Abuja, Garki, Nigeria
    Brain Res Bull 62:255-60. 2003
    ..The results suggest that artemisinin possesses sedative property, which may be mediated via postsynaptic dopamine (D(2)) receptor in the CNS...
  35. ncbi request reprint Effect of the aqueous extract of African mistletoe, Tapinanthus sessilifolius (P. Beauv) van Tiegh leaf on gastrointestinal muscle activity
    F D Tarfa
    National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P M B 21, Garki Abuja, Nigeria
    Indian J Exp Biol 40:571-4. 2002
    ..The intraperitoneal LD50 in mice was found to be 1500 mg/kg. The aqueous extract of T. sessilifoliius possesses active components that may be mediating the observed biological activity through calcium mobilization...