Research Topics
Species | John Kenneth AmorySummaryAffiliation: University of Washington Country: USA Publications
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Publications
Pharmacokinetics of modified slow-release oral testosterone over 9 days in normal men with experimental hypogonadismAda Lee
Center for Research in Reproduction and Contraception, Divisions of General Internal Medicine and Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medical School, Seattle, WA, USA
J Androl 33:420-6. 2012..This formulation of oral testosterone may have efficacy for the treatment of testosterone deficiency...
Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamicsJohn Kenneth Amory
Department of Medicine, Division of General Internal Medicine and Endocrinology, Center for Research in Reproduction and Contraception, University of Washington, Seattle, WA 98195, USA
Cancer Chemother Pharmacol 64:641-5. 2009..We hypothesized that GIPET enhancement would allow for the safe oral dosing of acyline for the treatment of prostate cancer...
Male hormonal contraceptives: current status and future prospectsJohn K Amory
Department of Medicine, Center for Research in Reproduction and Contraception, University of Washington, Seattle, Washington 98195, USA
Treat Endocrinol 4:333-41. 2005....- Oral testosterone in oil plus dutasteride in men: a pharmacokinetic studyJohn K Amory
Center for Research in Reproduction and Contraception, Division of General Internal Medicine, University of Washington Medical School, Box 356429, 1959 NE Pacific Street, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 90:2610-7. 2005..T and D]. The administration of oral T or TE in oil combined with D results in unexpected and potentially therapeutic increases in serum T. Additional studies of this combination as a novel form of oral androgen therapy are warranted... - Male hormonal contraceptivesJ K Amory
Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington, Seattle, WA 98195, USA
Minerva Ginecol 58:215-26. 2006.... - Progress and prospects in male hormonal contraceptionJohn K Amory
Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Curr Opin Endocrinol Diabetes Obes 15:255-60. 2008..Male hormonal contraception is well tolerated and acceptable to most men. Unfortunately, testosterone-alone regimens fail to completely suppress spermatogenesis in all men, meaning that in some the potential for fertility remains... - Oral testosterone in oil: pharmacokinetic effects of 5alpha reduction by finasteride or dutasteride and food intake in menJohn K Amory
University of Washington, Box 356429, 1959 NE Pacific St, Seattle, WA 98195, USA
J Androl 27:72-8. 2006..Additional studies of the combination of oral T in oil with 5alpha-reductase inhibitors as a novel form of oral T therapy are warranted... - Clinical problem-solving. A jaundiced eyeJohn K Amory
Department of Internal Medicine, University of Washington, Seattle, WA 98195, USA
N Engl J Med 354:1516-20. 2006 - Contraceptive developments for menJohn K Amory
Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Drugs Today (Barc) 43:179-92. 2007.... - Drug insight: Recent advances in male hormonal contraceptionJohn K Amory
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Nat Clin Pract Endocrinol Metab 2:32-41. 2006..One of these testosterone and progestogen combination regimens might soon bring the promise of male hormonal contraception to fruition... - Pharmacokinetics and pharmacodynamics of oral testosterone enanthate plus dutasteride for 4 weeks in normal men: implications for male hormonal contraceptionJohn K Amory
Center for Research in Reproduction and Contraception, University of Washington, Box 356429, 1959 NE Pacific St, Seattle, WA 98195, USA
J Androl 29:260-71. 2008..The administration of 800 mg oral TE daily combined with dutasteride for 28 days significantly suppresses gonadotropins without untoward side effects and might have utility as part of a male hormonal contraceptive regimen... - Drug effects on spermatogenesisJohn K Amory
Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Drugs Today (Barc) 43:717-24. 2007..In this paper, we will review the drugs that are known to adversely impact spermatogenesis, and/or sperm function and detail what is known about the mechanisms through which these compounds impair fertility in men... - Miglustat has no apparent effect on spermatogenesis in normal menJ K Amory
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Hum Reprod 22:702-7. 2007..This observation suggested that miglustat might have utility for fertility control in man. To ascertain the impact of miglustat on human spermatogenesis, we conducted a pilot study of miglustat administration in normal men... - Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin-suppressed normal men receiving various dosages of human chorionic gonadotropinJohn K Amory
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Fertil Steril 89:380-6. 2008..To determine if serum concentrations of testosterone precursors would correlate with intratesticular testosterone (ITT) concentration measured directly by testicular aspiration and allow for a less invasive means of inferring ITT... - Inhibiting sperm motility for male contraception: will the sperm tail be its "Achilles heel"?John K Amory
Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
Mol Interv 7:68-70. 2007..Future efforts directed towards effectively antagonizing the activities of these or other such targets will be required to completely impair sperm production, function, or both and create a usable male "pill.".. - Elevated end-of-treatment serum INSL3 is associated with failure to completely suppress spermatogenesis in men receiving male hormonal contraceptionJohn K Amory
Department of Medicine, University of Washington, 1959 NE Pacific, Seattle, WA 98195, USA
J Androl 28:548-54. 2007..INSL3 may play a role in preventing complete suppression of spermatogenesis in some men on hormonal contraceptive regimens. This finding suggests that INSL3 may be a potential target for male contraceptive development... - Testosterone/progestin regimens: a realistic option for male contraception?John K Amory
University of Washington, Division of General Internal Medicine, Box 356429, 1959 NE Pacific Street, Seattle, WA 98195 USA
Curr Opin Investig Drugs 5:1025-30. 2004..Significant suppression of spermatogenesis is observed in the remainder of individuals. These findings may soon result in the marketing of a safe, reversible and effective hormonal contraceptive for men... - Vasectomy by epithelial curettage without suture or cautery: a pilot study in humansJohn K Amory
Department of Medicine, Center for Research in Reproduction and Contraception, University of Washington School of Medicine, Seattle, WA 98195, USA
Asian J Androl 12:315-21. 2010..Epithelial curettage will require further refinement to determine if it is a viable form of vasectomy... - Endocrine regulation of testicular function in men: implications for contraceptive developmentJ K Amory
Population Center for Research in Reproduction, University of Washington, Seattle, WA, USA
Mol Cell Endocrinol 182:175-9. 2001..Recent promising trials of hormonal contraceptive combinations may soon bring the promise of male contraception to fruition... - Daily testosterone and gonadotropin levels are similar in azoospermic and nonazoospermic normal men administered weekly testosterone: implications for male contraceptive developmentJ K Amory
Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System and Department of Medicine, University of Washington School of Medicine, Seattle, USA
J Androl 22:1053-60. 2001..Innate differences in the testicle's ability to maintain spermatogenesis in a low-gonadotropin environment may explain persistent spermatogenesis in some men treated with androgen-based contraceptive regimens... - Testosterone release from a subcutaneous, biodegradable microcapsule formulation (Viatrel) in hypogonadal menJohn K Amory
Population Center for Research in Reproduction, Geriatric Research Education and Clinical Center, Veteran s Affairs Puget Sound Health Care System, Seattle, Washington, USA
J Androl 23:84-91. 2002..Subcutaneously administered testosterone microcapsules may provide a safe and convenient method for the long-term treatment of male hypogonadism or testosterone replacement in male contraceptive regimens... - Hyperthyroidism from autoimmune thyroiditis in a man with type 1 diabetes mellitus: a case reportJohn K Amory
Division of General Internal Medicine, Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA
J Med Case Reports 5:277. 2011..abstract:.. - Preoperative supraphysiological testosterone in older men undergoing knee replacement surgeryJohn K Amory
Department of Medicine, VA Puget Sound Health Care System, Seattle, Washington, USA
J Am Geriatr Soc 50:1698-701. 2002.... - Regulation of testicular function in men: implications for male hormonal contraceptive developmentJohn K Amory
Department of Medicine, Population Center for Research in Reproduction, University of Washington, Box 356429, 1959 NE Pacific Street, Seattle, WA 98195, USA
J Steroid Biochem Mol Biol 85:357-61. 2003.... - Oral testosterone-triglyceride conjugate in rabbits: single-dose pharmacokinetics and comparison with oral testosterone undecanoateJ K Amory
Population Center for Research in Reproduction, University of Washington, Seattle, Washington, USA
J Androl 24:716-20. 2003..TTC may offer an alternative to the use of TU for oral testosterone therapy. Further testing of this compound is warranted... - George Washington's infertility: why was the father of our country never a father?John K Amory
Department of Medicine and the Population Center for Research in Human Reproduction, University of Washington School of Medicine, Seattle, Washington 98195, USA
Fertil Steril 81:495-9. 2004..The author also speculates as to the cause of Washington's infertility and its effect on the course of American history. Frank discussion of Washington's infertility might provide some comfort to men struggling with infertility today... - Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesisJohn K Amory
Department of Medicine, University of Washington School of Medicine and School of Pharmaceutics, Seattle, WA 98195, USA
J Androl 32:111-9. 2011..These findings suggest that ALDH1a2 is a promising target for the development of a reversible, nonhormonal male contraceptive... - The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy menJohn K Amory
Department of Medicine, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA 98195, USA
J Clin Endocrinol Metab 92:1659-65. 2007..Dutasteride and finasteride are 5alpha-reductase inhibitors (5ARIs) that dramatically reduce serum levels of dihydrotestosterone (DHT)... - Intratesticular testosterone concentrations comparable with serum levels are not sufficient to maintain normal sperm production in men receiving a hormonal contraceptive regimenAndrea D Coviello
Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
J Androl 25:931-8. 2004..Intratesticular androgenic bioactivity was higher than ITT during treatment, suggesting that other androgens may be prevalent in the low-ITT environment... - Acceptability of a combination testosterone gel and depomedroxyprogesterone acetate male contraceptive regimenJohn K Amory
Department of Medicine, University of Washington, Box 326429, Seattle, WA 98195, USA
Contraception 75:218-23. 2007.... - Combined transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in menVahid Mahabadi
Department of Medicine, Division of Endocrinology, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
J Clin Endocrinol Metab 94:2313-20. 2009..Nestorone (NES), a progestin without estrogenic or androgenic activity, when combined with T may be an excellent candidate for male contraception... - Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trialBradley D Anawalt
Department of Medicine, University of Washington School of Medicine, Seattle, WA 98108, USA
J Androl 26:405-13. 2005.... - A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young menKaren L Herbst
Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 89:5959-65. 2004..A twice monthly injection of acyline could be used as a potent suppressor of the GnRH axis to advance the development of a hormonal male contraceptive or for treatment of hormonally dependent disease... - Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosteroneJohn K Amory
Department of Medicine, Veterans Affairs-Puget Sound Health Care System, Seattle, WA 98195, USA
J Clin Endocrinol Metab 89:503-10. 2004..These findings have important implications for the prevention and treatment of osteoporosis in older men with low T levels... - The male contraceptive regimen of testosterone and levonorgestrel significantly increases lean mass in healthy young men in 4 weeks, but attenuates a decrease in fat mass induced by testosterone aloneKaren L Herbst
Population Center for Research in Reproduction, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 88:1167-73. 2003..These findings suggest that androgen-based male hormonal contraceptives might have favorable effects on body composition. The impact of these changes on cardiovascular risk in normal men needs further study... - Treatment of male infertility secondary to morbid obesityMara Y Roth
Division of Metabolism, Endocrinology and Nutrition, University of Washington School of Medicine, Seattle, WA 98195 6246, USA
Nat Clin Pract Endocrinol Metab 4:415-9. 2008..5 kg/m(2)). Before referral to the clinic, the patient had been treated with testosterone therapy for 4 months for hypogonadism. This treatment had caused his initially low sperm concentration to fall to undetectable levels... - Klinefelter syndrome presenting as behavioral problems in a young adultAlexandra M Molnar
International Medicine Clinic, Harborview Medical Center, Box 359895, 325 9th Avenue, Seattle, WA 98104, USA
Nat Rev Endocrinol 6:707-12. 2010..A previous physical examination at school revealed the patient to have small, firm testicles which prompted further testing... - Nanomilled oral testosterone plus dutasteride effectively normalizes serum testosterone in normal men with induced hypogonadismStephanie T Page
Center for Research in Reproduction and Contraception, Division of General Internal Medicine and Endocrinology, Metabolism, and Nutrition, Department of Medicine, University of Washington Medical School, Seattle, WA, USA
J Androl 29:222-7. 2008..NmT allows for tablet formulation, and its pharmacokinetics were not affected by food, demonstrating the feasibility of oral nanomilled T as a promising and practical twice-daily therapy for the treatment of male hypogonadism... - Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a randomized-controlled trialStephanie T Page
Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine, Box 357138, 1959 NE Pacific Street, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 96:430-7. 2011..Exogenous androgens raise serum DHT concentrations, but their effects on the prostate are not clear... - The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young menJohn K Amory
Department of Medicine, University of Washington, Seattle, Washington, USA
J Urol 179:2333-8. 2008..Because androgens affect bone, lipids, hematopoiesis, prostate and sexual function, we determined the impact of 5alpha-reductase inhibitors on these end points... - Advances in male contraceptionStephanie T Page
Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
Endocr Rev 29:465-93. 2008.... - Intratesticular androgens and spermatogenesis during severe gonadotropin suppression induced by male hormonal contraceptive treatmentStephanie T Page
Department of Medicine, University of Washington, Seattle, Washington, USA
J Androl 28:734-41. 2007..Additional studies to identify factors involved in persistent spermatogenesis despite gonadotropin suppression are warranted... - Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppressionAndrea D Coviello
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 90:2595-602. 2005..Extensions of this study will allow determination of the ITT concentration threshold required to maintain spermatogenesis in man... - Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonistKaren L Herbst
Department of Medicine, Division of Metabolism, University of Washington, Seattle, WA 98195, USA
J Clin Endocrinol Metab 87:3215-20. 2002..Higher doses of acyline might be effective as depot injections for long-lasting gonadotropin suppression in hormone-dependent diseases and for use in male hormonal contraception regimens... - Testosterone administration to men increases hepatic lipase activity and decreases HDL and LDL size in 3 wkKaren L Herbst
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Am J Physiol Endocrinol Metab 284:E1112-8. 2003..Testosterone is therefore a potent stimulator of hepatic lipase activity, decreasing HDL-C, HDL(2), and HDL(3) as well as increasing LDL particle density changes, all associated with increased cardiovascular risk... - Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum TStephanie T Page
Wesley Woods Health Center, 1841 Clifton Road Northeast, Atlanta, Georgia 30329 5102, USA
J Clin Endocrinol Metab 90:1502-10. 2005.... - Testosterone administration suppresses adiponectin levels in menStephanie T Page
Department of Medicine, University of Washington Medical Center, Division of Endocrinology and Metabolism, 1959 NE Pacific, Box 357138, Seattle, WA 98195, USA
J Androl 26:85-92. 2005..Furthermore, supraphysiologic T administration results in decreased adiponectin levels. Our data support the hypothesis that T, its metabolites, or both directly suppress adipocyte production of adiponectin... - Comparative cognitive and subjective side effects of immediate-release oxycodone in healthy middle-aged and older adultsMonique M Cherrier
Department of Psychiatry, School of Medicine, University of Washington, Seattle, Washington, USA
J Pain 10:1038-50. 2009..Therefore, clinicians should not avoid prescribing oral opioids to older adults based on the belief that older adults are at higher risk for side effects than younger adults... - Clinical problem-solving. Lost in transcriptionRobert M Kalus
Division of General Internal Medicine, Department of Internal Medicine, University of Washington, Seattle 98104, USA
N Engl J Med 355:1487-91. 2006 - Persistent intraprostatic androgen concentrations after medical castration in healthy menStephanie T Page
University of Washington Medical Center, Division of Metabolism, Endocrinology and Nutrition, Box 357138, 1959 NE Pacific, Seattle, WA 98195
J Clin Endocrinol Metab 91:3850-6. 2006..Studies of men with prostate cancer have suggested that prostatic androgens are preserved in the setting of castration. Tissue androgens might stimulate prostate growth, producing adverse clinical consequences... - Testosterone gel combined with depomedroxyprogesterone acetate is an effective male hormonal contraceptive regimen and is not enhanced by the addition of a GnRH antagonistStephanie T Page
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 91:4374-80. 2006.... - Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolitesStephanie T Page
Department of Medicine, University of Washington, Seattle, WA, USA
Am J Physiol Endocrinol Metab 290:E856-63. 2006..In addition, sex steroids suppress NK cell proliferation. This study supports a complex physiological role for T and/or its metabolites in immune regulation... - Computer-based order entry decreases duration of indwelling urinary catheterization in hospitalized patientsPaul B Cornia
Primary and Specialty Medicine Service, Veterans Affairs Puget Sound Health Care System, and the Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Am J Med 114:404-7. 2003 - TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthoodElena Gianetti
Harvard Center for Reproductive Sciences and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 95:2857-67. 2010.... - Male hormonal contraception: suppression of spermatogenesis by injectable testosterone undecanoate alone or with levonorgestrel implants in chinese menYou-Lun Gui
Shanghai Institute of Planned Parenthood Research, 2140 Xie Tu Rd, Shanghai 200032, China
J Androl 25:720-7. 2004..The combination of high-dose TU every 2 months and LNG implants is a promising candidate for future large-scale efficacy studies of hormonal male contraception in Chinese men... - Novel male hormonal contraceptive combinations: the hormonal and spermatogenic effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonistKati L Matthiesson
Prince Henry s Institute of Medical Research and Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, P O Box 5152, Clayton, Victoria 3168, Australia
J Clin Endocrinol Metab 90:91-7. 2005.... - Effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist on spermatogenesis and intratesticular steroid levels in normal menKati L Matthiesson
Prince Henry s Institute of Medical Research, Monash University, Monash Medical Center, Clayton, Victoria 3168, Australia
J Clin Endocrinol Metab 90:5647-55. 2005..Combination of a GnRH antagonist (acyline), types I and II, 5alpha-reductase inhibitor (dutasteride) or levonorgestrel (LNG) with testosterone (T) treatment may augment the suppression of spermatogenesis and intratesticular (iT) steroids... - Oral erythromycin and the risk of sudden deathJohn K Amory
N Engl J Med 352:301-4; author reply 301-4. 2005 - Case 15-2004: cancer therapy and sperm bankingJohn K Amory
N Engl J Med 351:510; author reply 510. 2004 - 10th Summit Meeting consensus: recommendations for regulatory approval for hormonal male contraceptionPertti Aaltonen
Schering AG, Berlin, Germany
J Androl 28:362-3. 2007 - Neuroprotection is associated with beta-adrenergic receptor antagonists during cardiac surgery: evidence from 2,575 patientsDavid W Amory
Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Duke University Heart Center, Durham, NC 27710, USA
J Cardiothorac Vasc Anesth 16:270-7. 2002..A prospective randomized trial is needed to verify this potentially important neuroprotective strategy in cardiac surgery...
Research Grants
- Oral Androgen Administration and Function in ManJOHN AMORY; Fiscal Year: 2007..Matsumoto M.D., Director, Clinical Research Unit VA-Puget Sound and Professor of Medicine, University of Washington School of Medicine will co-mentor this award. ..