Victor Ambros

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. doi The evolution of our thinking about microRNAs
    Victor Ambros
    University of Massachusetts Medical School Department of Molecular Medicine, 373 Plantation Street, B2 306, Worcester, Massachusetts 01605, USA
    Nat Med 14:1036-40. 2008
  2. ncbi MicroRNAs: genetically sensitized worms reveal new secrets
    Victor Ambros
    Department of Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
    Curr Biol 20:R598-600. 2010
  3. pmc MicroRNAs and developmental timing
    Victor Ambros
    UMass Medical School, Molecular Medicine, 373 Plantation St, Worcester, MA 01605, USA
    Curr Opin Genet Dev 21:511-7. 2011
  4. pmc Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans
    Xantha Karp
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Development 139:2177-86. 2012
  5. pmc Effect of life history on microRNA expression during C. elegans development
    Xantha Karp
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    RNA 17:639-51. 2011
  6. pmc The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans
    Xantha Karp
    University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genetics 187:345-53. 2011
  7. pmc A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
    Christopher M Hammell
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:18668-73. 2009
  8. pmc mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts
    Molly Hammell
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 306, Worcester, Massachusetts 01605, USA
    Nat Methods 5:813-9. 2008
  9. pmc nhl-2 Modulates microRNA activity in Caenorhabditis elegans
    Christopher M Hammell
    University of Massachusetts Medical School, Worcester, 01605, USA
    Cell 136:926-38. 2009
  10. pmc The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans
    Maria C Ow
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 22:2520-34. 2008

Collaborators

Detail Information

Publications31

  1. doi The evolution of our thinking about microRNAs
    Victor Ambros
    University of Massachusetts Medical School Department of Molecular Medicine, 373 Plantation Street, B2 306, Worcester, Massachusetts 01605, USA
    Nat Med 14:1036-40. 2008
  2. ncbi MicroRNAs: genetically sensitized worms reveal new secrets
    Victor Ambros
    Department of Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
    Curr Biol 20:R598-600. 2010
    ....
  3. pmc MicroRNAs and developmental timing
    Victor Ambros
    UMass Medical School, Molecular Medicine, 373 Plantation St, Worcester, MA 01605, USA
    Curr Opin Genet Dev 21:511-7. 2011
    ....
  4. pmc Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans
    Xantha Karp
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Development 139:2177-86. 2012
    ..These results illustrate how the employment of alternative genetic regulatory pathways can provide for the robust progression of progenitor cell fates in the face of temporary developmental quiescence...
  5. pmc Effect of life history on microRNA expression during C. elegans development
    Xantha Karp
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    RNA 17:639-51. 2011
    ..Hence these microRNAs could function to regulate gene expression programs appropriate for different life history options in the developing worm...
  6. pmc The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegans
    Xantha Karp
    University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genetics 187:345-53. 2011
    ..We propose that dynamic interactions between genes that regulate stage-specific cell fate decisions and those that regulate dauer formation promote the robustness of developmental outcomes to changing environmental conditions...
  7. pmc A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
    Christopher M Hammell
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:18668-73. 2009
    ..We propose that this feedback loop functions to ensure robustness of cell fate decisions and to coordinate cell fate with developmental arrest...
  8. pmc mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts
    Molly Hammell
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 306, Worcester, Massachusetts 01605, USA
    Nat Methods 5:813-9. 2008
    ..MirWIP can be used to capture all known conserved miRNA-mRNA target relationships in Caenorhabditis elegans at a lower false-positive rate than can the current standard methods...
  9. pmc nhl-2 Modulates microRNA activity in Caenorhabditis elegans
    Christopher M Hammell
    University of Massachusetts Medical School, Worcester, 01605, USA
    Cell 136:926-38. 2009
    ....
  10. pmc The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans
    Maria C Ow
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 22:2520-34. 2008
    ..Therefore, the FLH-1 and FLH-2 proteins likely play a more general role in regulating gene expression in embryos...
  11. ncbi Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression
    Anna Y Zinovyeva
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Genet 10:e1004286. 2014
    ....
  12. ncbi The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans
    Allison L Abbott
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Dev Cell 9:403-14. 2005
    ..These results indicate that let-7 family microRNAs function in combination to affect both early and late developmental timing decisions...
  13. pmc Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Genes Dev 22:1591-6. 2008
    ..This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior...
  14. ncbi The regulation of genes and genomes by small RNAs
    Victor Ambros
    Dartmouth Medical School, Hanover, NH 03755, USA
    Development 134:1635-41. 2007
    ....
  15. ncbi Potent effect of target structure on microRNA function
    Dang Long
    Wadsworth Center, New York State Department of Health, 150 New Scotland Avenue, Albany, New York 12208, USA
    Nat Struct Mol Biol 14:287-94. 2007
    ..elegans and Drosophila melanogaster. These findings indicate a potent effect of target structure on target recognition by miRNAs and establish a structure-based framework for genome-wide identification of animal miRNA targets...
  16. pmc The 2006 Genetics Society of America Medal. Victor Ambros
    Geraldine Seydoux
    Genetics 172:721-2. 2006
  17. pmc Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans
    Rosalind C Lee
    Dartmouth Medical School, Department of Genetics, Hanover, New Hamphsire 03755, USA
    RNA 12:589-97. 2006
    ..elegans. Microarray expression profiling of RNAi-defective mutant worms further suggests diverse endogenous RNAi pathways for silencing different sets of genes...
  18. ncbi MicroRNAs and other tiny endogenous RNAs in C. elegans
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Curr Biol 13:807-18. 2003
    ..We employed cDNA sequencing and comparative genomics to identify additional C. elegans small RNAs with properties similar to miRNAs and siRNAs...
  19. ncbi MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Cell 113:673-6. 2003
    ..In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing...
  20. ncbi Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
    Lorenzo F Sempere
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Dev Biol 259:9-18. 2003
    ....
  21. ncbi Role of microRNAs in plant and animal development
    James C Carrington
    Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
    Science 301:336-8. 2003
    ..miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets...
  22. pmc Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
    Lorenzo F Sempere
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Genome Biol 5:R13. 2004
    ..lin-4, let-7 and other miRNA genes are conserved in mammals, and their potential functions in mammalian development are under active study...
  23. ncbi A short history of a short RNA
    Rosalind Lee
    Department of Genetics Dartmouth Medical School Hanover, New Hampshire 03755, USA
    Cell 116:S89-92, 1 p following S96. 2004
  24. ncbi The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin
    Anita S R Pepper
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Development 131:2049-59. 2004
    ..Our findings suggest that the LIN-46 protein acts as a scaffold for a multiprotein assembly that controls developmental timing, and expand the known roles of gephyrin-related proteins to development...
  25. ncbi Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning
    Victor Ambros
    Department of Genetics, Dartmouth Medical School, Hanover, NH, USA
    Methods Mol Biol 265:131-58. 2004
    ..Northern blot hybridization is used to confirm the expression of small RNAs in vivo...
  26. ncbi The functions of animal microRNAs
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
    Nature 431:350-5. 2004
    ....
  27. pmc Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genes Dev 19:2343-54. 2005
    ..Thus, DmiR-1 is not required for the formation or physiological function of the larval musculature, but is required for the dramatic post-mitotic growth of larval muscle...
  28. pmc Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi
    Markus Kuhlmann
    Abt Genetik, Universitat Kassel, Heinrich Plett Str 40, 34132 Kassel, Germany
    Nucleic Acids Res 33:6405-17. 2005
    ..The data show that DNA methylation plays a crucial role in epigenetic gene silencing in Dictyostelium but that different, partially overlapping mechanisms control transposon silencing...
  29. ncbi Developmental biology. Encountering microRNAs in cell fate signaling
    Xantha Karp
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Science 310:1288-9. 2005
  30. pmc The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding
    Marta Hristova
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Mol Cell Biol 25:11059-72. 2005
    ..These results reinforce the conclusion that lin-14 encodes a novel class of transcription factor...
  31. pmc A uniform system for microRNA annotation
    Victor Ambros
    Dartmouth Medical School Department of Genetics, Hanover, New Hampshire 03755, USA
    RNA 9:277-9. 2003
    ..Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families...