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Species | Victor AmbrosSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
MicroRNAs and developmental timingVictor Ambros
UMass Medical School, Molecular Medicine, 373 Plantation St, Worcester, MA 01605, USA
Curr Opin Genet Dev 21:511-7. 2011....
MicroRNAs: genetically sensitized worms reveal new secretsVictor Ambros
Department of Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
Curr Biol 20:R598-600. 2010....
The evolution of our thinking about microRNAsVictor Ambros
University of Massachusetts Medical School Department of Molecular Medicine, 373 Plantation Street, B2-306, Worcester, Massachusetts 01605, USA
Nat Med 14:1036-40. 2008- Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegansXantha Karp
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Development 139:2177-86. 2012..These results illustrate how the employment of alternative genetic regulatory pathways can provide for the robust progression of progenitor cell fates in the face of temporary developmental quiescence... - Effect of life history on microRNA expression during C. elegans developmentXantha Karp
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
RNA 17:639-51. 2011..Hence these microRNAs could function to regulate gene expression programs appropriate for different life history options in the developing worm... - The developmental timing regulator HBL-1 modulates the dauer formation decision in Caenorhabditis elegansXantha Karp
University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genetics 187:345-53. 2011..We propose that dynamic interactions between genes that regulate stage-specific cell fate decisions and those that regulate dauer formation promote the robustness of developmental outcomes to changing environmental conditions... - A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegansChristopher M Hammell
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 106:18668-73. 2009..We propose that this feedback loop functions to ensure robustness of cell fate decisions and to coordinate cell fate with developmental arrest... - mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcriptsMolly Hammell
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 306, Worcester, Massachusetts 01605, USA
Nat Methods 5:813-9. 2008..MirWIP can be used to capture all known conserved miRNA-mRNA target relationships in Caenorhabditis elegans at a lower false-positive rate than can the current standard methods... - nhl-2 Modulates microRNA activity in Caenorhabditis elegansChristopher M Hammell
University of Massachusetts Medical School, Worcester, 01605, USA
Cell 136:926-38. 2009.... - The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegansMaria C Ow
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 22:2520-34. 2008..Therefore, the FLH-1 and FLH-2 proteins likely play a more general role in regulating gene expression in embryos... - The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegansAllison L Abbott
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Dev Cell 9:403-14. 2005..These results indicate that let-7 family microRNAs function in combination to affect both early and late developmental timing decisions... - Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosisNicholas S Sokol
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Genes Dev 22:1591-6. 2008..This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior... - The regulation of genes and genomes by small RNAsVictor Ambros
Dartmouth Medical School, Hanover, NH 03755, USA
Development 134:1635-41. 2007.... - Potent effect of target structure on microRNA functionDang Long
Wadsworth Center, New York State Department of Health, 150 New Scotland Avenue, Albany, New York 12208, USA
Nat Struct Mol Biol 14:287-94. 2007..elegans and Drosophila melanogaster. These findings indicate a potent effect of target structure on target recognition by miRNAs and establish a structure-based framework for genome-wide identification of animal miRNA targets... - The 2006 Genetics Society of America Medal. Victor AmbrosGeraldine Seydoux
Genetics 172:721-2. 2006 - Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegansRosalind C Lee
Dartmouth Medical School, Department of Genetics, Hanover, New Hamphsire 03755, USA
RNA 12:589-97. 2006..elegans. Microarray expression profiling of RNAi-defective mutant worms further suggests diverse endogenous RNAi pathways for silencing different sets of genes... - The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA bindingMarta Hristova
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Mol Cell Biol 25:11059-72. 2005..These results reinforce the conclusion that lin-14 encodes a novel class of transcription factor... - MicroRNAs and other tiny endogenous RNAs in C. elegansVictor Ambros
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Curr Biol 13:807-18. 2003..We employed cDNA sequencing and comparative genomics to identify additional C. elegans small RNAs with properties similar to miRNAs and siRNAs... - MicroRNA pathways in flies and worms: growth, death, fat, stress, and timingVictor Ambros
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Cell 113:673-6. 2003..In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing... - Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activityLorenzo F Sempere
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Dev Biol 259:9-18. 2003.... - Role of microRNAs in plant and animal developmentJames C Carrington
Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
Science 301:336-8. 2003..miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets... - Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiationLorenzo F Sempere
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Genome Biol 5:R13. 2004..lin-4, let-7 and other miRNA genes are conserved in mammals, and their potential functions in mammalian development are under active study... - A short history of a short RNARosalind Lee
Department of Genetics Dartmouth Medical School Hanover, New Hampshire 03755, USA
Cell 116:S89-92, 1 p following S96. 2004 - The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrinAnita S R Pepper
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Development 131:2049-59. 2004..Our findings suggest that the LIN-46 protein acts as a scaffold for a multiprotein assembly that controls developmental timing, and expand the known roles of gephyrin-related proteins to development... - Identification of microRNAs and other tiny noncoding RNAs by cDNA cloningVictor Ambros
Department of Genetics, Dartmouth Medical School, Hanover, NH, USA
Methods Mol Biol 265:131-58. 2004..Northern blot hybridization is used to confirm the expression of small RNAs in vivo... - The functions of animal microRNAsVictor Ambros
Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
Nature 431:350-5. 2004.... - Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growthNicholas S Sokol
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Genes Dev 19:2343-54. 2005..Thus, DmiR-1 is not required for the formation or physiological function of the larval musculature, but is required for the dramatic post-mitotic growth of larval muscle... - Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAiMarkus Kuhlmann
Abt Genetik, Universitat Kassel, Heinrich Plett Str 40, 34132 Kassel, Germany
Nucleic Acids Res 33:6405-17. 2005..The data show that DNA methylation plays a crucial role in epigenetic gene silencing in Dictyostelium but that different, partially overlapping mechanisms control transposon silencing... - Developmental biology. Encountering microRNAs in cell fate signalingXantha Karp
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Science 310:1288-9. 2005 - A uniform system for microRNA annotationVictor Ambros
Dartmouth Medical School Department of Genetics, Hanover, New Hampshire 03755, USA
RNA 9:277-9. 2003..Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families...