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Genomes and Genes | Namasivayam AmbalavananSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Titanium oxide nanoparticle instillation induces inflammation and inhibits lung development in miceNamasivayam Ambalavanan
Univ of Alabama at Birmingham, 176F Suite 9380, 619 South 20 St, Birmingham, AL 35233
Am J Physiol Lung Cell Mol Physiol 304:L152-61. 2013....
Cytokines and posthemorrhagic ventricular dilation in premature infantsNamasivayam Ambalavanan
Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Am J Perinatol 29:731-40. 2012....- Outcome trajectories in extremely preterm infantsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
Pediatrics 130:e115-25. 2012..Our objective was to develop serial predictions of outcome by using prognostic factors available over the course of NICU hospitalization... - Survey of vitamin A supplementation for extremely-low-birth-weight infants: is clinical practice consistent with the evidence?Namasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, 619 South 20th Street, Birmingham, AL 35249, USA
J Pediatr 145:304-7. 2004.... - Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lungNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Am J Physiol Lung Cell Mol Physiol 295:L86-95. 2008..These data support the conclusion that TGF-beta plays an important role in hypoxia-induced pulmonary vascular adaptation and IAD in the newborn animal model... - Nitric oxide administration using an oxygen hood: a pilot trialNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 4:e4312. 2009..Our objective in this study was to determine feasibility of iNO by oxygen hood in neonates with elevated alveolar-arterial oxygen gradients (A-aDO(2))... - Endothelin-A receptor blockade inhibits the effects of hypoxia on the newborn lung vasculatureNamasivayam Ambalavanan
Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, USA
ScientificWorldJournal 6:669-70. 2006..These results indicate that endothelin-A receptor blockade is of potential therapeutic significance in neonates with pulmonary hypertension and abnormal pulmonary arterial remodeling... - Ventilatory strategies in the prevention and management of bronchopulmonary dysplasiaNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Semin Perinatol 30:192-9. 2006..There is a lack of evidence-based guidelines on management of infants with established BPD. Optimization of clinical care practices and ancillary therapies need to be combined with ventilatory strategies to prevent and manage BPD... - Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathyNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Pediatrics 118:2084-93. 2006..The goals were to identify predictor variables and to develop scoring systems and classification trees to predict death/disability or death in infants with hypoxic-ischemic encephalopathy... - Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failureN Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
J Perinatol 28:420-6. 2008..To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure... - Endothelin-1 mediates hypoxia-induced increases in vascular collagen in the newborn mouse lungNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Pediatr Res 61:559-64. 2007..ET-AR blockade reduces collagen fiber area but not mRNA, and does not decrease elastin despite reducing its expression... - Prediction of death for extremely low birth weight neonatesNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama, Birmingham, AL 35249, USA
Pediatrics 116:1367-73. 2005.... - Role of matrix metalloproteinase-2 in newborn mouse lungs under hypoxic conditionsNamasivayam Ambalavanan
Department of Pediatrics, Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Pediatr Res 63:26-32. 2008..We conclude that hypoxia reduces the postnatal MMP-2 increase in the lung, which may contribute to abnormal pulmonary arterial remodeling and impaired alveolarization... - A comparison of three vitamin A dosing regimens in extremely-low-birth-weight infantsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama, USA
J Pediatr 142:656-61. 2003.... - Endothelin-A receptor blockade prevents and partially reverses neonatal hypoxic pulmonary vascular remodelingNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Burmingham, Alabama 35233, USA
Pediatr Res 57:631-6. 2005..Development of this newborn mouse model of HPVR facilitates investigation of mechanisms underlying this important and severe disease entity in human infants... - Vitamin A supplementation for extremely low birth weight infants: outcome at 18 to 22 monthsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama, Birmingham, Alabama 35249, USA
Pediatrics 115:e249-54. 2005..89). As with postnatal steroids or other interventions, it is important to ensure that there are no longer-term adverse effects that outweigh neonatal benefits... - Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infantsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Pediatrics 123:1132-41. 2009..The goal was to develop multivariate logistic regression models for the outcome of bronchopulmonary dysplasia and/or death at postmenstrual age of 36 weeks by using clinical and cytokine data from the first 28 days... - Identification of extremely premature infants at high risk of rehospitalizationNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249 7335, USA
Pediatrics 128:e1216-25. 2011..Extremely low birth weight infants often require rehospitalization during infancy. Our objective was to identify at the time of discharge which extremely low birth weight infants are at higher risk for rehospitalization... - Bronchopulmonary dysplasia: new insightsNamasivayam Ambalavanan
Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, 620 South 20th Street, Birmingham, AL 35233, USA
Clin Perinatol 31:613-28. 2004..Future therapeutic interventions are likely to target one or more of these abnormalities in lung development, maturation, and response to injury... - Intercenter differences in bronchopulmonary dysplasia or death among very low birth weight infantsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Pediatrics 127:e106-16. 2011.... - Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodelingYiu Fai Chen
Vascular Biology and Hypertension Program, Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, 35296, USA
Life Sci 79:1357-65. 2006.... - Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodelingYiu Fai Chen
Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Dept of Medicine, Univ of Alabama at Birmingham, UAB Station, Birmingham, AL 35294 0007, USA
J Appl Physiol 100:564-71. 2006.... - Predicting time to hospital discharge for extremely preterm infantsSusan R Hintz
Department of Pediatrics, Division of Neonatology, Stanford University School of Medicine and Lucile Packard Children s Hospital, Palo Alto, CA 94304, USA
Pediatrics 125:e146-54. 2010..Accurate models for predicting time to hospital discharge could aid in resource planning, family counseling, and stimulate quality-improvement initiatives... - Endothelin-A receptor blockade in porcine pulmonary hypertensionNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Pediatr Res 52:913-21. 2002..Differences in response to ET(A) blockade in pulmonary hypertension may be seen depending on the etiology (hypoxia versus infection-associated), and the specific ET(A) antagonist used... - Cytokines and neurodevelopmental outcomes in extremely low birth weight infantsWaldemar A Carlo
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 7335, USA
J Pediatr 159:919-25.e3. 2011.... - Hypoxia-induced inhibition of lung development is attenuated by the peroxisome proliferator-activated receptor-γ agonist rosiglitazoneTeodora Nicola
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Am J Physiol Lung Cell Mol Physiol 301:L125-34. 2011..PPAR-γ agonists may be of potential therapeutic significance in attenuating TGF-β signaling and improving alveolar development... - Impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infantsEdward F Bell
Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
Pediatrics 126:222-31. 2010.... - Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposureNelida Olave
Department of Pediatrics, Univ of Alabama at Birmingham, Birmingham, AL 35249, USA
Am J Physiol Lung Cell Mol Physiol 302:L857-65. 2012..ETAR blockade improves function but not development of the hypoxic newborn lung. Reduction of ET-1 via inhibition of TGF-β signaling indicates that TGF-β is upstream of ET-1 during hypoxia-induced signaling in the newborn lung... - Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infantsMatthew M Laughon
Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599 7596, USA
Am J Respir Crit Care Med 183:1715-22. 2011.... - Outcome of term infants using apgar scores at 10 minutes following hypoxic-ischemic encephalopathyAbbot R Laptook
Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island 02906, USA
Pediatrics 124:1619-26. 2009..The objective of this study was to determine whether Apgar scores at 10 minutes are associated with death or disability in early childhood after perinatal hypoxic-ischemic encephalopathy... - Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signalingKaizheng Gong
Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, 35294, USA
Am J Physiol Lung Cell Mol Physiol 301:L899-907. 2011..These data provide strong evidence that activation of TGF-β/Smad signaling, via transcriptional suppression of PPAR-γ expression, mediates chronic hypoxia-induced downregulation of PPAR-γ expression in lung... - Vitamin A and retinoic acid act synergistically to increase lung retinyl esters during normoxia and reduce hyperoxic lung injury in newborn miceMasheika L James
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Pediatr Res 67:591-7. 2010..We conclude that the VARA combination has synergistic effects on lung retinyl ester concentrations and on the attenuation of hyperoxia-induced lung injury in newborn mice, possibly by modulation of inflammatory mediators... - T cell cytokines and the risk of blood stream infection in extremely low birth weight infantsRobert L Schelonka
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
Cytokine 53:249-55. 2011..Altered maturation of regulatory and inflammatory cytokines may increase the risk of serious infection in this population... - Approach to infants born at 22 to 24 weeks' gestation: relationship to outcomes of more-mature infantsP Brian Smith
Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
Pediatrics 129:e1508-16. 2012..We sought to determine if a center's approach to care of premature infants at the youngest gestational ages (22-24 weeks' gestation) is associated with clinical outcomes among infants of older gestational ages (25-27 weeks' gestation)... - Maternal age, multiple birth, and extremely low birth weight infantsBetty R Vohr
Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI, USA
J Pediatr 154:498-503.e2. 2009..To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers... - Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 monthsConrad R Cole
Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
Pediatrics 122:e573-82. 2008.... - Loss of Thy-1 inhibits alveolar development in the newborn mouse lungTeodora Nicola
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Am J Physiol Lung Cell Mol Physiol 296:L738-50. 2009..Thy-1(-/-) mice given 1D11 had improved alveolar development and lung function. These data support the hypothesis that hypoxia, by reducing Thy-1, increases TGF-beta activation, and thereby inhibits normal alveolar development... - Prospective analysis of pulmonary hypertension in extremely low birth weight infantsRamachandra Bhat
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249 7335, USA
Pediatrics 129:e682-9. 2012..The objective was to determine the prevalence of pulmonary hypertension among ELBW infants by screening echocardiography and evaluate subsequent outcomes... - Bias in reported neurodevelopmental outcomes among extremely low birth weight survivorsLisa Castro
Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Pediatrics 114:404-10. 2004..The purpose of this study was to investigate possible bias in the evaluation of neurodevelopment and somatic growth at 18 to 22 months' postmenstrual age among extremely low birth weight (ELBW) survivors (401-1000 g at birth)... - Evaluation of a pumpless lung assist device in hypoxia-induced pulmonary hypertension in juvenile pigletsGeorge T El-Ferzli
Division of Neonatology, Department of Pediatrics, 525 New Hillman Building, 619 South 19th Street, University of Alabama, Birmingham, AL 35233, USA
Pediatr Res 66:677-81. 2009..05). Other hemodynamic variables remained stable. The novel LAD shows feasibility and efficacy in improving gas exchange and reducing PAPs in a juvenile animal model of hypoxia-induced pulmonary hypertension... 
PaCO2 and neurodevelopment in extremely low birth weight infantsLara A McKee
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Pediatr 155:217-21.e1. 2009..To determine the relationship between PaCO2 in the first 4 days of life and neurodevelopment at 18 to 22 months...- Survival and morbidity outcomes for very low birth weight infants with Down syndromeNansi S Boghossian
University of Iowa Health Care, Department of Pediatrics, 200 Hawkins Dr, Iowa City, IA 52242, USA
Pediatrics 126:1132-40. 2010.... - A pumpless lung assist device reduces mechanical ventilation-induced lung injury in juvenile pigletsGeorge T El-Ferzli
Division of Neonatology, Department of Pediatrics, 525 New Hillman Bldg, 619 South 19th Street, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Pediatr Res 66:671-6. 2009..The novel pumpless low-resistance LAD has shown feasibility and potential to decrease ventilator-induced lung injury in a juvenile animal model... - Developmental regulation of NO-mediated VEGF-induced effects in the lungVineet Bhandari
Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, New Haven, CT 06520 8057, USA
Am J Respir Cell Mol Biol 39:420-30. 2008..This opens up the possibility of selective manipulation of any VEGF-based intervention using NO inhibitors for maximal potential clinical benefit... - Early nutrition mediates the influence of severity of illness on extremely LBW infantsRichard A Ehrenkranz
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Pediatr Res 69:522-9. 2011.... - Acute kidney injury and renal replacement therapy independently predict mortality in neonatal and pediatric noncardiac patients on extracorporeal membrane oxygenationDavid J Askenazi
Department of Pediatrics, University of Alabama at Birmingham, School of Public Health, Birmingham, AL, USA
Pediatr Crit Care Med 12:e1-6. 2011..AKI and RRT portend poor outcomes independent of comorbidities and illness severity in several critically ill populations... - Mortality and morbidity by month of birth of neonates admitted to an academic neonatal intensive care unitThomas D Soltau
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
Pediatrics 122:e1048-52. 2008..It is possible that variation in clinical expertise of housestaff affects important clinical outcomes in infants in ICUs... - Antenatal consent in the SUPPORT trial: challenges, costs, and representative enrollmentWade D Rich
Department of Pediatrics, School of Medicine, University of California, San Diego, California, USA
Pediatrics 126:e215-21. 2010.... - Perinatal systemic inflammatory response syndrome and retinopathy of prematurityBeena G Sood
Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
Pediatr Res 67:394-400. 2010..We conclude that perinatal inflammation may be involved in the pathogenesis of ROP... - Baseline values of candidate urine acute kidney injury biomarkers vary by gestational age in premature infantsDavid J Askenazi
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Pediatr Res 70:302-6. 2011..We conclude that urine values of candidate AKI biomarkers are higher in the most premature infants. These findings should be considered when designing and analyzing biomarker studies in newborn with AKI... - Clinical data predict neurodevelopmental outcome better than head ultrasound in extremely low birth weight infantsEduardo Broitman
University of Alabama at Birmingham, Birmingham, Alabama, USA
J Pediatr 151:500-5, 505.e1-2. 2007..To determine the relative contribution of clinical data versus head ultrasound scanning (HUS) in predicting neurodevelopmental impairment (NDI) in extremely low birth weight infants... - Feasibility of nitric oxide administration by oxygen hood in neonatal pulmonary hypertensionNamasivayam Ambalavanan
Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, 35249-6098, USA
J Perinatol 22:50-6. 2002..NO administration could be performed without detectable environmental leakage. CONCLUSION: Hood NO administration is feasible and shows hemodynamic efficacy in neonatal piglets with pulmonary hypertension... - Urine biomarkers predict acute kidney injury in newbornsDavid J Askenazi
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Pediatr 161:270-5.e1. 2012..To identify urine biomarkers predictive of acute kidney injury (AKI) in infants admitted to level 2 and 3 neonatal intensive care units with birth weight >2000 g and 5-minute Apgar score ≤ 7... - Gastric residuals and their relationship to necrotizing enterocolitis in very low birth weight infantsBridget Arnold Cobb
Department of Pediatrics, University of Alabama at Birmingham School of Medicine, 35249, USA
Pediatrics 113:50-3. 2004..However, there was overlap with the normal control subjects. Of the gastric residual data, the maximum residual seems to be the best predictor for NEC in the subsequent days... - Urine biomarkers predict acute kidney injury and mortality in very low birth weight infantsDavid J Askenazi
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Pediatr 159:907-12.e1. 2011..To test the hypothesis that noninvasive urinary biomarkers may improve early identification, differentiate causes, and predict outcomes of acute kidney injury (AKI) in very low birth weight subjects... - Accuracy of a novel system for oxygen delivery to small childrenMatthew Coghill
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pediatrics 128:e382-7. 2011..Entrainment devices may provide an accurate and precise concentration of oxygen when used at the flow rates appropriate for infants and small children... - Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infantsC Michael Cotten
Department of Pediatrics, Duke University, Durham, NC 27710, USA
Pediatrics 123:58-66. 2009.... - TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestineAkhil Maheshwari
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Gastroenterology 140:242-53. 2011..We investigated whether NEC occurs in the preterm intestine due to incomplete noninflammatory differentiation of intestinal macrophages, which increases the risk of a severe mucosal inflammatory response to bacterial products... - Acute kidney injury is independently associated with mortality in very low birthweight infants: a matched case-control analysisDavid J Askenazi
Division of Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Pediatr Nephrol 24:991-7. 2009..90, 95% CI 1.10-3.27). After confounding variables had been controlled for, AKI was independently associated with mortality in VLBW infants. Further prospective multi-center studies are needed to determine whether this association exists... - Both extremes of arterial carbon dioxide pressure and the magnitude of fluctuations in arterial carbon dioxide pressure are associated with severe intraventricular hemorrhage in preterm infantsJorge Fabres
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
Pediatrics 119:299-305. 2007..The goal was to test the hypothesis that extremes of PaCO2 during the first 4 days after birth are associated with severe intraventricular hemorrhage (grades 3 and 4)... - Acute kidney injury in critically ill newborns: what do we know? What do we need to learn?David J Askenazi
Division of Pediatric Nephrology, University of Alabama at Birmingham, 1600 7th Ave So, ACC 516, Birmingham, AL, 35233, USA
Pediatr Nephrol 24:265-74. 2009..Early biomarkers of AKI need to be explored in critically ill neonates. Infants with AKI need to be followed for sequelae after AKI... - Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonatesNamasivayam Ambalavanan
Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
Pediatr Res 53:240-4. 2003..We conclude that elevated bFGF levels in the preterm trachea correlate with BPD/death and markers of cell injury and apoptosis but not with chorioamnionitis. We speculate that bFGF may play a role in the development of BPD... - Retinol-binding protein, transthyretin, and C-reactive protein in extremely low birth weight (ELBW) infantsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35246, USA
J Perinatol 25:714-9. 2005..Lower TTR and maintained RBP/TTR ratios suggest inflammation rather than vitamin A deficiency as the cause for lower serum vitamin A levels in ELBW infants.... - Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathyDonald F Meyn
Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA
J Pediatr 157:334-6. 2010..3) but fewer clinical seizures in cooled infants who received prophylactic phenobarbital (15% vs 82% P < .0001)... - SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilationT Scott Isbell
Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nat Med 14:773-7. 2008..These results demonstrate that SNO-Hb is not essential for the physiologic coupling of erythrocyte deoxygenation with increased NO bioactivity in vivo... - Acute kidney injury reduces survival in very low birth weight infantsRajesh Koralkar
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA
Pediatr Res 69:354-8. 2011..4 (95% CI 0.95-6.04). AKI is associated with mortality in VLBW infants. Efforts to prevent and ameliorate the impact of AKI may improve the outcomes in this vulnerable population... - The mismatch between evidence and practice. Common therapies in search of evidenceNamasivayam Ambalavanan
Division of Neonatology, Department of Pediatrics, 525 New Hillman Building, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Clin Perinatol 30:305-31. 2003..Patients are better served by guidelines that recommend only strategies that are supported by strong evidence and recommend further research when the evidence is inadequate... - Retinoic acid combined with vitamin A synergizes to increase retinyl ester storage in the lungs of newborn and dexamethasone-treated neonatal ratsA Catharine Ross
Department of Nutritional Sciences and Huck Institute for Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
Neonatology 92:26-32. 2007..We previously showed that the nutrient-metabolite combination VARA (molar ratio 10 vitamin A to 1 RA), synergistically increased REs in the lungs of 1-week-old rats, compared to vitamin A or RA alone... - Vitamin A combined with retinoic acid increases retinol uptake and lung retinyl ester formation in a synergistic manner in neonatal ratsA Catharine Ross
Department of Nutritional Sciences, Pennsylvania State University, University Park, 16802, USA
J Lipid Res 47:1844-51. 2006..In conclusion, VARA, a 10:1 nutrient-metabolite combination, increased lung RE significantly compared with VA alone and could be a promising therapeutic option for enhancing the delivery of VA to the lungs... - Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertionIra Adams-Chapman
Department of Pediatrics Division of Neonatology, Emory University School of Medicine, 46 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
Pediatrics 121:e1167-77. 2008..We aimed to evaluate neurodevelopmental and growth outcomes among extremely low birth weight infants who had severe intraventricular hemorrhage that required shunt insertion compared with infants without shunt insertion... - Permissive hypercapnia during mechanical ventilation of neonatesRune Toms
Indian Pediatr 41:775-8. 2004
Research Grants
- C-Reactive Protein in Extremely Low Birth Weight NeonatesNamasivayam Ambalavanan; Fiscal Year: 2007....
- MMP-2 in Neonatal Hypoxic Pulmonary Vascular RemodelingNamasivayam Ambalavanan; Fiscal Year: 2007..Determination of the mechanisms of ECM protein deposition in the neonatal pulmonary vasculature will provide essential information on normal pulmonary vascular development and lead to the development of new therapies for HPVR. ..
- TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNGNamasivayam Ambalavanan; Fiscal Year: 2010....
- TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNGNamasivayam Ambalavanan; Fiscal Year: 2009....