Namasivayam Ambalavanan

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Titanium oxide nanoparticle instillation induces inflammation and inhibits lung development in mice
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, 176F Suite 9380, 619 South 20 St, Birmingham, AL 35233, USA
    Am J Physiol Lung Cell Mol Physiol 304:L152-61. 2013
  2. pmc Cytokines and posthemorrhagic ventricular dilation in premature infants
    Namasivayam Ambalavanan
    Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Am J Perinatol 29:731-40. 2012
  3. pmc Outcome trajectories in extremely preterm infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Pediatrics 130:e115-25. 2012
  4. pmc Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failure
    N Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    J Perinatol 28:420-6. 2008
  5. ncbi request reprint Prediction of death for extremely low birth weight neonates
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama, Birmingham, AL 35249, USA
    Pediatrics 116:1367-73. 2005
  6. ncbi request reprint Ventilatory strategies in the prevention and management of bronchopulmonary dysplasia
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Semin Perinatol 30:192-9. 2006
  7. ncbi request reprint Endothelin-A receptor blockade inhibits the effects of hypoxia on the newborn lung vasculature
    Namasivayam Ambalavanan
    Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, USA
    ScientificWorldJournal 6:669-70. 2006
  8. pmc Role of matrix metalloproteinase-2 in newborn mouse lungs under hypoxic conditions
    Namasivayam Ambalavanan
    Department of Pediatrics, Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Res 63:26-32. 2008
  9. ncbi request reprint Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 118:2084-93. 2006
  10. pmc Identification of extremely premature infants at high risk of rehospitalization
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249 7335, USA
    Pediatrics 128:e1216-25. 2011

Research Grants

Collaborators

Detail Information

Publications78

  1. pmc Titanium oxide nanoparticle instillation induces inflammation and inhibits lung development in mice
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, 176F Suite 9380, 619 South 20 St, Birmingham, AL 35233, USA
    Am J Physiol Lung Cell Mol Physiol 304:L152-61. 2013
    ....
  2. pmc Cytokines and posthemorrhagic ventricular dilation in premature infants
    Namasivayam Ambalavanan
    Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Am J Perinatol 29:731-40. 2012
    ....
  3. pmc Outcome trajectories in extremely preterm infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Pediatrics 130:e115-25. 2012
    ..Our objective was to develop serial predictions of outcome by using prognostic factors available over the course of NICU hospitalization...
  4. pmc Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failure
    N Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    J Perinatol 28:420-6. 2008
    ..To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure...
  5. ncbi request reprint Prediction of death for extremely low birth weight neonates
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama, Birmingham, AL 35249, USA
    Pediatrics 116:1367-73. 2005
    ....
  6. ncbi request reprint Ventilatory strategies in the prevention and management of bronchopulmonary dysplasia
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Semin Perinatol 30:192-9. 2006
    ..There is a lack of evidence-based guidelines on management of infants with established BPD. Optimization of clinical care practices and ancillary therapies need to be combined with ventilatory strategies to prevent and manage BPD...
  7. ncbi request reprint Endothelin-A receptor blockade inhibits the effects of hypoxia on the newborn lung vasculature
    Namasivayam Ambalavanan
    Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, USA
    ScientificWorldJournal 6:669-70. 2006
    ..These results indicate that endothelin-A receptor blockade is of potential therapeutic significance in neonates with pulmonary hypertension and abnormal pulmonary arterial remodeling...
  8. pmc Role of matrix metalloproteinase-2 in newborn mouse lungs under hypoxic conditions
    Namasivayam Ambalavanan
    Department of Pediatrics, Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Res 63:26-32. 2008
    ..We conclude that hypoxia reduces the postnatal MMP-2 increase in the lung, which may contribute to abnormal pulmonary arterial remodeling and impaired alveolarization...
  9. ncbi request reprint Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 118:2084-93. 2006
    ..The goals were to identify predictor variables and to develop scoring systems and classification trees to predict death/disability or death in infants with hypoxic-ischemic encephalopathy...
  10. pmc Identification of extremely premature infants at high risk of rehospitalization
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249 7335, USA
    Pediatrics 128:e1216-25. 2011
    ..Extremely low birth weight infants often require rehospitalization during infancy. Our objective was to identify at the time of discharge which extremely low birth weight infants are at higher risk for rehospitalization...
  11. pmc Endothelin-A receptor blockade prevents and partially reverses neonatal hypoxic pulmonary vascular remodeling
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Burmingham, Alabama 35233, USA
    Pediatr Res 57:631-6. 2005
    ..Development of this newborn mouse model of HPVR facilitates investigation of mechanisms underlying this important and severe disease entity in human infants...
  12. pmc Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Am J Physiol Lung Cell Mol Physiol 295:L86-95. 2008
    ..These data support the conclusion that TGF-beta plays an important role in hypoxia-induced pulmonary vascular adaptation and IAD in the newborn animal model...
  13. pmc Nitric oxide administration using an oxygen hood: a pilot trial
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 4:e4312. 2009
    ..Our objective in this study was to determine feasibility of iNO by oxygen hood in neonates with elevated alveolar-arterial oxygen gradients (A-aDO(2))...
  14. pmc Intercenter differences in bronchopulmonary dysplasia or death among very low birth weight infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 127:e106-16. 2011
    ....
  15. ncbi request reprint A comparison of three vitamin A dosing regimens in extremely-low-birth-weight infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama, USA
    J Pediatr 142:656-61. 2003
    ....
  16. pmc Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Pediatrics 123:1132-41. 2009
    ..The goal was to develop multivariate logistic regression models for the outcome of bronchopulmonary dysplasia and/or death at postmenstrual age of 36 weeks by using clinical and cytokine data from the first 28 days...
  17. pmc Endothelin-1 mediates hypoxia-induced increases in vascular collagen in the newborn mouse lung
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Pediatr Res 61:559-64. 2007
    ..ET-AR blockade reduces collagen fiber area but not mRNA, and does not decrease elastin despite reducing its expression...
  18. ncbi request reprint Vitamin A supplementation for extremely low birth weight infants: outcome at 18 to 22 months
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama, Birmingham, Alabama 35249, USA
    Pediatrics 115:e249-54. 2005
    ..89). As with postnatal steroids or other interventions, it is important to ensure that there are no longer-term adverse effects that outweigh neonatal benefits...
  19. ncbi request reprint Bronchopulmonary dysplasia: new insights
    Namasivayam Ambalavanan
    Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, 620 South 20th Street, Birmingham, AL 35233, USA
    Clin Perinatol 31:613-28. 2004
    ..Future therapeutic interventions are likely to target one or more of these abnormalities in lung development, maturation, and response to injury...
  20. ncbi request reprint Survey of vitamin A supplementation for extremely-low-birth-weight infants: is clinical practice consistent with the evidence?
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, 619 South 20th Street, Birmingham, AL 35249, USA
    J Pediatr 145:304-7. 2004
    ....
  21. ncbi request reprint Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling
    Yiu Fai Chen
    Vascular Biology and Hypertension Program, Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, 35296, USA
    Life Sci 79:1357-65. 2006
    ....
  22. ncbi request reprint Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling
    Yiu Fai Chen
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Dept of Medicine, Univ of Alabama at Birmingham, UAB Station, Birmingham, AL 35294 0007, USA
    J Appl Physiol (1985) 100:564-71. 2006
    ....
  23. pmc Predicting time to hospital discharge for extremely preterm infants
    Susan R Hintz
    Department of Pediatrics, Division of Neonatology, Stanford University School of Medicine and Lucile Packard Children s Hospital, Palo Alto, CA 94304, USA
    Pediatrics 125:e146-54. 2010
    ..Accurate models for predicting time to hospital discharge could aid in resource planning, family counseling, and stimulate quality-improvement initiatives...
  24. ncbi request reprint Endothelin-A receptor blockade in porcine pulmonary hypertension
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Res 52:913-21. 2002
    ..Differences in response to ET(A) blockade in pulmonary hypertension may be seen depending on the etiology (hypoxia versus infection-associated), and the specific ET(A) antagonist used...
  25. pmc Cytokines and neurodevelopmental outcomes in extremely low birth weight infants
    Waldemar A Carlo
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 7335, USA
    J Pediatr 159:919-25.e3. 2011
    ....
  26. pmc VARA attenuates hyperoxia-induced impaired alveolar development and lung function in newborn mice
    Masheika L James
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Am J Physiol Lung Cell Mol Physiol 304:L803-12. 2013
    ....
  27. doi request reprint Fluid overload and mortality are associated with acute kidney injury in sick near-term/term neonate
    David J Askenazi
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Nephrol 28:661-6. 2013
    ..Acute kidney injury (AKI) is common and portends mortality in several neonatal cohorts. Fluid overload is independently associated with poor outcomes in children and adults but has not been extensively studied in neonates...
  28. pmc Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling
    Kaizheng Gong
    Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Lung Cell Mol Physiol 301:L899-907. 2011
    ..These data provide strong evidence that activation of TGF-β/Smad signaling, via transcriptional suppression of PPAR-γ expression, mediates chronic hypoxia-induced downregulation of PPAR-γ expression in lung...
  29. pmc Vitamin A and retinoic acid act synergistically to increase lung retinyl esters during normoxia and reduce hyperoxic lung injury in newborn mice
    Masheika L James
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Pediatr Res 67:591-7. 2010
    ..We conclude that the VARA combination has synergistic effects on lung retinyl ester concentrations and on the attenuation of hyperoxia-induced lung injury in newborn mice, possibly by modulation of inflammatory mediators...
  30. pmc Hypoxia-induced inhibition of lung development is attenuated by the peroxisome proliferator-activated receptor-γ agonist rosiglitazone
    Teodora Nicola
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Am J Physiol Lung Cell Mol Physiol 301:L125-34. 2011
    ..PPAR-γ agonists may be of potential therapeutic significance in attenuating TGF-β signaling and improving alveolar development...
  31. pmc Impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infants
    Edward F Bell
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Pediatrics 126:222-31. 2010
    ....
  32. pmc Histological characteristics of the fetal inflammatory response associated with neurodevelopmental impairment and death in extremely preterm infants
    Ariel A Salas
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    J Pediatr 163:652-7.e1-2. 2013
    ..To test the hypothesis that increasing severity of the fetal inflammatory response (FIR) would have a dose-dependent relationship with severe neurodevelopmental impairment or death in extremely preterm infants...
  33. pmc Loss of Thy-1 inhibits alveolar development in the newborn mouse lung
    Teodora Nicola
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Am J Physiol Lung Cell Mol Physiol 296:L738-50. 2009
    ..Thy-1(-/-) mice given 1D11 had improved alveolar development and lung function. These data support the hypothesis that hypoxia, by reducing Thy-1, increases TGF-beta activation, and thereby inhibits normal alveolar development...
  34. pmc Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure
    Nelida Olave
    Department of Pediatrics, Univ of Alabama at Birmingham, Birmingham, AL 35249, USA
    Am J Physiol Lung Cell Mol Physiol 302:L857-65. 2012
    ..ETAR blockade improves function but not development of the hypoxic newborn lung. Reduction of ET-1 via inhibition of TGF-β signaling indicates that TGF-β is upstream of ET-1 during hypoxia-induced signaling in the newborn lung...
  35. pmc Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infants
    Matthew M Laughon
    Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599 7596, USA
    Am J Respir Crit Care Med 183:1715-22. 2011
    ....
  36. pmc Outcome of term infants using apgar scores at 10 minutes following hypoxic-ischemic encephalopathy
    Abbot R Laptook
    Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, Rhode Island 02906, USA
    Pediatrics 124:1619-26. 2009
    ..The objective of this study was to determine whether Apgar scores at 10 minutes are associated with death or disability in early childhood after perinatal hypoxic-ischemic encephalopathy...
  37. pmc Individual and center-level factors affecting mortality among extremely low birth weight infants
    Brandon W Alleman
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Pediatrics 132:e175-84. 2013
    ..To examine factors affecting center differences in mortality for extremely low birth weight (ELBW) infants...
  38. pmc ABO blood group is associated with response to inhaled nitric oxide in neonates with respiratory failure
    George T El-Ferzli
    Department of Pediatrics, Centers for Free Radical Biology and Pulmonary Injury Repair Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e45164. 2012
    ..It is not known why only some infants respond to iNO. Adults and children with blood groups B or AB do not respond as well to iNO as those with blood groups O/A...
  39. pmc T cell cytokines and the risk of blood stream infection in extremely low birth weight infants
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
    Cytokine 53:249-55. 2011
    ..Altered maturation of regulatory and inflammatory cytokines may increase the risk of serious infection in this population...
  40. pmc Approach to infants born at 22 to 24 weeks' gestation: relationship to outcomes of more-mature infants
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
    Pediatrics 129:e1508-16. 2012
    ..We sought to determine if a center's approach to care of premature infants at the youngest gestational ages (22-24 weeks' gestation) is associated with clinical outcomes among infants of older gestational ages (25-27 weeks' gestation)...
  41. pmc Maternal age, multiple birth, and extremely low birth weight infants
    Betty R Vohr
    Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Pediatr 154:498-503.e2. 2009
    ..To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers...
  42. pmc Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months
    Conrad R Cole
    Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
    Pediatrics 122:e573-82. 2008
    ....
  43. pmc Prospective analysis of pulmonary hypertension in extremely low birth weight infants
    Ramachandra Bhat
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249 7335, USA
    Pediatrics 129:e682-9. 2012
    ..The objective was to determine the prevalence of pulmonary hypertension among ELBW infants by screening echocardiography and evaluate subsequent outcomes...
  44. pmc Survival and morbidity outcomes for very low birth weight infants with Down syndrome
    Nansi S Boghossian
    University of Iowa Health Care, Department of Pediatrics, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Pediatrics 126:1132-40. 2010
    ....
  45. pmc Evaluation of a pumpless lung assist device in hypoxia-induced pulmonary hypertension in juvenile piglets
    George T El-Ferzli
    Division of Neonatology, Department of Pediatrics, 525 New Hillman Building, 619 South 19th Street, University of Alabama, Birmingham, AL 35233, USA
    Pediatr Res 66:677-81. 2009
    ..05). Other hemodynamic variables remained stable. The novel LAD shows feasibility and efficacy in improving gas exchange and reducing PAPs in a juvenile animal model of hypoxia-induced pulmonary hypertension...
  46. doi request reprint PaCO2 and neurodevelopment in extremely low birth weight infants
    Lara A McKee
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Pediatr 155:217-21.e1. 2009
    ..To determine the relationship between PaCO2 in the first 4 days of life and neurodevelopment at 18 to 22 months...
  47. ncbi request reprint Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors
    Lisa Castro
    Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Pediatrics 114:404-10. 2004
    ..The purpose of this study was to investigate possible bias in the evaluation of neurodevelopment and somatic growth at 18 to 22 months' postmenstrual age among extremely low birth weight (ELBW) survivors (401-1000 g at birth)...
  48. doi request reprint Mortality and morbidity by month of birth of neonates admitted to an academic neonatal intensive care unit
    Thomas D Soltau
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Pediatrics 122:e1048-52. 2008
    ..It is possible that variation in clinical expertise of housestaff affects important clinical outcomes in infants in ICUs...
  49. pmc Developmental regulation of NO-mediated VEGF-induced effects in the lung
    Vineet Bhandari
    Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, New Haven, CT 06520 8057, USA
    Am J Respir Cell Mol Biol 39:420-30. 2008
    ..This opens up the possibility of selective manipulation of any VEGF-based intervention using NO inhibitors for maximal potential clinical benefit...
  50. pmc Antenatal consent in the SUPPORT trial: challenges, costs, and representative enrollment
    Wade D Rich
    Department of Pediatrics, School of Medicine, University of California, San Diego, California, USA
    Pediatrics 126:e215-21. 2010
    ....
  51. doi request reprint Acute kidney injury and renal replacement therapy independently predict mortality in neonatal and pediatric noncardiac patients on extracorporeal membrane oxygenation
    David J Askenazi
    Department of Pediatrics, University of Alabama at Birmingham, School of Public Health, Birmingham, AL, USA
    Pediatr Crit Care Med 12:e1-6. 2011
    ..AKI and RRT portend poor outcomes independent of comorbidities and illness severity in several critically ill populations...
  52. pmc A pumpless lung assist device reduces mechanical ventilation-induced lung injury in juvenile piglets
    George T El-Ferzli
    Division of Neonatology, Department of Pediatrics, 525 New Hillman Bldg, 619 South 19th Street, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Res 66:671-6. 2009
    ..The novel pumpless low-resistance LAD has shown feasibility and potential to decrease ventilator-induced lung injury in a juvenile animal model...
  53. pmc Early nutrition mediates the influence of severity of illness on extremely LBW infants
    Richard A Ehrenkranz
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Pediatr Res 69:522-9. 2011
    ....
  54. pmc Perinatal systemic inflammatory response syndrome and retinopathy of prematurity
    Beena G Sood
    Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    Pediatr Res 67:394-400. 2010
    ..We conclude that perinatal inflammation may be involved in the pathogenesis of ROP...
  55. pmc Clinical data predict neurodevelopmental outcome better than head ultrasound in extremely low birth weight infants
    Eduardo Broitman
    University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Pediatr 151:500-5, 505.e1-2. 2007
    ..To determine the relative contribution of clinical data versus head ultrasound scanning (HUS) in predicting neurodevelopmental impairment (NDI) in extremely low birth weight infants...
  56. pmc Baseline values of candidate urine acute kidney injury biomarkers vary by gestational age in premature infants
    David J Askenazi
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Pediatr Res 70:302-6. 2011
    ..We conclude that urine values of candidate AKI biomarkers are higher in the most premature infants. These findings should be considered when designing and analyzing biomarker studies in newborn with AKI...
  57. ncbi request reprint Feasibility of nitric oxide administration by oxygen hood in neonatal pulmonary hypertension
    Namasivayam Ambalavanan
    Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, 35249 6098, USA
    J Perinatol 22:50-6. 2002
    ..To test the hemodynamic efficacy and feasibility of nitric oxide (NO) administration by oxygen hood in neonatal pulmonary hypertension...
  58. doi request reprint Extremely low birth weight and infant mortality rates in the United States
    Carissa Lau
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249 7335, USA
    Pediatrics 131:855-60. 2013
    ..The purpose of this study was to determine the contributions of birth weight and gestational age subgroups to the IMR and NMR in the United States...
  59. doi request reprint Nano-TiO₂ particles impair adhesion of airway epithelial cells to fibronectin
    Sotirios G Zarogiannis
    Department of Anesthesiology, University of Alabama at Birmingham, 35294 Birmingham, AL, USA
    Respir Physiol Neurobiol 185:454-60. 2013
    ..In conclusion, short-term exposure of H441 cells to nano-TiO(2) appears to reduce adherence to fibronectin due to oxidative stress and activation of ERK1/2...
  60. pmc TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine
    Akhil Maheshwari
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Gastroenterology 140:242-53. 2011
    ..We investigated whether NEC occurs in the preterm intestine due to incomplete noninflammatory differentiation of intestinal macrophages, which increases the risk of a severe mucosal inflammatory response to bacterial products...
  61. pmc Urine biomarkers predict acute kidney injury in newborns
    David J Askenazi
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Pediatr 161:270-5.e1. 2012
    ..To identify urine biomarkers predictive of acute kidney injury (AKI) in infants admitted to level 2 and 3 neonatal intensive care units with birth weight >2000 g and 5-minute Apgar score ≤ 7...
  62. ncbi request reprint Gastric residuals and their relationship to necrotizing enterocolitis in very low birth weight infants
    Bridget Arnold Cobb
    Department of Pediatrics, University of Alabama at Birmingham School of Medicine, 35249, USA
    Pediatrics 113:50-3. 2004
    ..To determine the characteristics of gastric residuals in very low birth weight (VLBW; <or=1500 g birth weight) infants with and without necrotizing enterocolitis (NEC)...
  63. ncbi request reprint Retinol-binding protein, transthyretin, and C-reactive protein in extremely low birth weight (ELBW) infants
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35246, USA
    J Perinatol 25:714-9. 2005
    ..Vitamin A deficiency reduces retinol binding protein (RBP) but not transthyretin (TTR), while inflammation reduces both RBP and TTR and increases C-reactive protein (CRP), an acute phase reactant...
  64. ncbi request reprint Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonates
    Namasivayam Ambalavanan
    Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Pediatr Res 53:240-4. 2003
    ..We conclude that elevated bFGF levels in the preterm trachea correlate with BPD/death and markers of cell injury and apoptosis but not with chorioamnionitis. We speculate that bFGF may play a role in the development of BPD...
  65. pmc Accuracy of a novel system for oxygen delivery to small children
    Matthew Coghill
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatrics 128:e382-7. 2011
    ..Entrainment devices may provide an accurate and precise concentration of oxygen when used at the flow rates appropriate for infants and small children...
  66. pmc Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants
    C Michael Cotten
    Department of Pediatrics, Duke University, Durham, NC 27710, USA
    Pediatrics 123:58-66. 2009
    ....
  67. doi request reprint Acute kidney injury is independently associated with mortality in very low birthweight infants: a matched case-control analysis
    David J Askenazi
    Division of Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Nephrol 24:991-7. 2009
    ..90, 95% CI 1.10-3.27). After confounding variables had been controlled for, AKI was independently associated with mortality in VLBW infants. Further prospective multi-center studies are needed to determine whether this association exists...
  68. doi request reprint Urine biomarkers predict acute kidney injury and mortality in very low birth weight infants
    David J Askenazi
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Pediatr 159:907-12.e1. 2011
    ..To test the hypothesis that noninvasive urinary biomarkers may improve early identification, differentiate causes, and predict outcomes of acute kidney injury (AKI) in very low birth weight subjects...
  69. ncbi request reprint Both extremes of arterial carbon dioxide pressure and the magnitude of fluctuations in arterial carbon dioxide pressure are associated with severe intraventricular hemorrhage in preterm infants
    Jorge Fabres
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
    Pediatrics 119:299-305. 2007
    ..The goal was to test the hypothesis that extremes of PaCO2 during the first 4 days after birth are associated with severe intraventricular hemorrhage (grades 3 and 4)...
  70. pmc Acute kidney injury in critically ill newborns: what do we know? What do we need to learn?
    David J Askenazi
    Division of Pediatric Nephrology, University of Alabama at Birmingham, 1600 7th Ave So, ACC 516, Birmingham, AL, 35233, USA
    Pediatr Nephrol 24:265-74. 2009
    ..Early biomarkers of AKI need to be explored in critically ill neonates. Infants with AKI need to be followed for sequelae after AKI...
  71. doi request reprint Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy
    Donald F Meyn
    Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Pediatr 157:334-6. 2010
    ..3) but fewer clinical seizures in cooled infants who received prophylactic phenobarbital (15% vs 82% P < .0001)...
  72. pmc SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation
    T Scott Isbell
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Med 14:773-7. 2008
    ..These results demonstrate that SNO-Hb is not essential for the physiologic coupling of erythrocyte deoxygenation with increased NO bioactivity in vivo...
  73. doi request reprint Acute kidney injury reduces survival in very low birth weight infants
    Rajesh Koralkar
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA
    Pediatr Res 69:354-8. 2011
    ..4 (95% CI 0.95-6.04). AKI is associated with mortality in VLBW infants. Efforts to prevent and ameliorate the impact of AKI may improve the outcomes in this vulnerable population...
  74. ncbi request reprint The mismatch between evidence and practice. Common therapies in search of evidence
    Namasivayam Ambalavanan
    Division of Neonatology, Department of Pediatrics, 525 New Hillman Building, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Clin Perinatol 30:305-31. 2003
    ..Patients are better served by guidelines that recommend only strategies that are supported by strong evidence and recommend further research when the evidence is inadequate...
  75. ncbi request reprint Vitamin A combined with retinoic acid increases retinol uptake and lung retinyl ester formation in a synergistic manner in neonatal rats
    A Catharine Ross
    Department of Nutritional Sciences, Pennsylvania State University, University Park, 16802, USA
    J Lipid Res 47:1844-51. 2006
    ..In conclusion, VARA, a 10:1 nutrient-metabolite combination, increased lung RE significantly compared with VA alone and could be a promising therapeutic option for enhancing the delivery of VA to the lungs...
  76. pmc Retinoic acid combined with vitamin A synergizes to increase retinyl ester storage in the lungs of newborn and dexamethasone-treated neonatal rats
    A Catharine Ross
    Department of Nutritional Sciences and Huck Institute for Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Neonatology 92:26-32. 2007
    ..We previously showed that the nutrient-metabolite combination VARA (molar ratio 10 vitamin A to 1 RA), synergistically increased REs in the lungs of 1-week-old rats, compared to vitamin A or RA alone...
  77. pmc Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion
    Ira Adams-Chapman
    Department of Pediatrics Division of Neonatology, Emory University School of Medicine, 46 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
    Pediatrics 121:e1167-77. 2008
    ..We aimed to evaluate neurodevelopmental and growth outcomes among extremely low birth weight infants who had severe intraventricular hemorrhage that required shunt insertion compared with infants without shunt insertion...
  78. ncbi request reprint Permissive hypercapnia during mechanical ventilation of neonates
    Rune Toms
    Indian Pediatr 41:775-8. 2004

Research Grants8

  1. C-Reactive Protein in Extremely Low Birth Weight Neonates
    Namasivayam Ambalavanan; Fiscal Year: 2007
    ....
  2. MMP-2 in Neonatal Hypoxic Pulmonary Vascular Remodeling
    Namasivayam Ambalavanan; Fiscal Year: 2007
    ..Determination of the mechanisms of ECM protein deposition in the neonatal pulmonary vasculature will provide essential information on normal pulmonary vascular development and lead to the development of new therapies for HPVR. ..
  3. TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNG
    Namasivayam Ambalavanan; Fiscal Year: 2010
    ....
  4. TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNG
    Namasivayam Ambalavanan; Fiscal Year: 2009
    ....