JAMES AMATRUDA

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Effect of vascular cadherin knockdown on zebrafish vasculature during development
    Ian C Mitchell
    Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e8807. 2010
  2. pmc A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis
    Stefanie W Leacock
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8534, USA
    Dis Model Mech 5:95-106. 2012
  3. pmc Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms
    Vinita A Hajeri
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8534, USA
    Dis Model Mech 5:33-7. 2012
  4. pmc DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors
    James F Amatruda
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    BMC Cancer 13:313. 2013
  5. pmc Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development
    Daniel Verduzco
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, MC 8534, Dallas, TX 75390, USA
    Mol Cancer Res 10:1451-61. 2012

Collaborators

  • Daniel Verduzco
  • Stefanie W Leacock
  • Vinita A Hajeri
  • Ian C Mitchell
  • Audrey N Basse
  • Abhay A Shukla
  • Elisabeth Kodym
  • Garvin L Chandler
  • Brian A Skaug
  • Anne M Kirk
  • Dinesh Rakheja
  • Jennifer Shepard Dovey
  • Fiemu E Nwariaku
  • Lance S Terada
  • Timothy S Brown

Detail Information

Publications6

  1. pmc Effect of vascular cadherin knockdown on zebrafish vasculature during development
    Ian C Mitchell
    Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e8807. 2010
    ..Vascular endothelial cadherin (VE-cad) is essential for endothelial barrier integrity and vascular sprouting. However, the role of this important protein in cardiovascular development is only recently becoming apparent...
  2. pmc A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis
    Stefanie W Leacock
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8534, USA
    Dis Model Mech 5:95-106. 2012
    ..These results indicate that functional targets of EWS-FLI1 that mediate tumorigenesis are conserved from zebrafish to human and provide a novel context in which to study the function of this fusion oncogene...
  3. pmc Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms
    Vinita A Hajeri
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8534, USA
    Dis Model Mech 5:33-7. 2012
    ..We further discuss experimental approaches by which the concept of synthetic lethality can be applied to the zebrafish to understand the functions of specific genes...
  4. pmc DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors
    James F Amatruda
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    BMC Cancer 13:313. 2013
    ..Aberrant DNA methylation is a prominent feature of many cancers, and may be especially relevant in germ cell tumors (GCTs) due to the extensive epigenetic reprogramming that occurs in the germ line during normal development...
  5. pmc Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development
    Daniel Verduzco
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, MC 8534, Dallas, TX 75390, USA
    Mol Cancer Res 10:1451-61. 2012
    ..Checkpoint activation in cdc25a mutants occurs despite the absence of increased DNA damage, highlighting the role of Cdc25 proteins to balance constitutive ATM activity during early embryonic development...

Research Grants4

  1. Generation and Rapid Mapping of Low-Penetrance Disease Alleles in Zebrafish
    JAMES AMATRUDA; Fiscal Year: 2009
    ..In this proposal we describe methods to significantly increase the efficiency of cancer gene discovery in zebrafish and the generation of zebrafish that accurately model human cancers. ..
  2. TUMOR SUPPRESSORS HEMATOPOIESIS AND LEUKEMIA
    JAMES AMATRUDA; Fiscal Year: 2003
    ..These proteins will be potential therapeutic targets for the treatment of aplastic anemia, myelodysplasia and leukemia in humans. ..
  3. Generation and Rapid Mapping of Low-Penetrance Disease Alleles in Zebrafish
    James F Amatruda; Fiscal Year: 2010
    ..In this proposal we describe methods to significantly increase the efficiency of cancer gene discovery in zebrafish and the generation of zebrafish that accurately model human cancers. ..