JAMES AMATRUDA

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors
    James F Amatruda
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    BMC Cancer 13:313. 2013
  2. pmc Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development
    Daniel Verduzco
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, MC 8534, Dallas, TX 75390, USA
    Mol Cancer Res 10:1451-61. 2012

Research Grants

Collaborators

  • Daniel Verduzco
  • Abhay A Shukla
  • Elisabeth Kodym
  • Brian A Skaug
  • Jennifer Shepard Dovey

Detail Information

Publications2

  1. pmc DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors
    James F Amatruda
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    BMC Cancer 13:313. 2013
    ..Aberrant DNA methylation is a prominent feature of many cancers, and may be especially relevant in germ cell tumors (GCTs) due to the extensive epigenetic reprogramming that occurs in the germ line during normal development...
  2. pmc Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development
    Daniel Verduzco
    Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, MC 8534, Dallas, TX 75390, USA
    Mol Cancer Res 10:1451-61. 2012
    ..Checkpoint activation in cdc25a mutants occurs despite the absence of increased DNA damage, highlighting the role of Cdc25 proteins to balance constitutive ATM activity during early embryonic development...

Research Grants4

  1. TUMOR SUPPRESSORS HEMATOPOIESIS AND LEUKEMIA
    JAMES AMATRUDA; Fiscal Year: 2003
    ..These proteins will be potential therapeutic targets for the treatment of aplastic anemia, myelodysplasia and leukemia in humans. ..
  2. Generation and Rapid Mapping of Low-Penetrance Disease Alleles in Zebrafish
    James F Amatruda; Fiscal Year: 2010
    ..In this proposal we describe methods to significantly increase the efficiency of cancer gene discovery in zebrafish and the generation of zebrafish that accurately model human cancers. ..