Affiliation: University of Texas Southwestern Medical Center
- DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumorsJames F Amatruda
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
BMC Cancer 13:313. 2013..Aberrant DNA methylation is a prominent feature of many cancers, and may be especially relevant in germ cell tumors (GCTs) due to the extensive epigenetic reprogramming that occurs in the germ line during normal development...
- Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate developmentDaniel Verduzco
Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, MC 8534, Dallas, TX 75390, USA
Mol Cancer Res 10:1451-61. 2012..Checkpoint activation in cdc25a mutants occurs despite the absence of increased DNA damage, highlighting the role of Cdc25 proteins to balance constitutive ATM activity during early embryonic development...
- TUMOR SUPPRESSORS HEMATOPOIESIS AND LEUKEMIAJAMES AMATRUDA; Fiscal Year: 2003..These proteins will be potential therapeutic targets for the treatment of aplastic anemia, myelodysplasia and leukemia in humans. ..
- Generation and Rapid Mapping of Low-Penetrance Disease Alleles in ZebrafishJames F Amatruda; Fiscal Year: 2010..In this proposal we describe methods to significantly increase the efficiency of cancer gene discovery in zebrafish and the generation of zebrafish that accurately model human cancers. ..