D G Amaral

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Some observations on cortical inputs to the macaque monkey amygdala: an anterograde tracing study
    Lisa Stefanacci
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 451:301-23. 2002
  2. pmc Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders
    Sharifia Wills
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, 451 E Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA
    Brain Behav Immun 23:64-74. 2009
  3. pmc Emergence of stereotypies in juvenile monkeys (Macaca mulatta) with neonatal amygdala or hippocampus lesions
    M D Bauman
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, The M I N D Institute, University of California at Davis, CA 95817, USA
    Behav Neurosci 122:1005-15. 2008
  4. pmc Interest in infants by female rhesus monkeys with neonatal lesions of the amygdala or hippocampus
    J E Toscano
    Department of Psychiatry and Behavioral Sciences, 2230 Stockton Blvd Sacramento, CA 95817, USA
    Neuroscience 162:881-91. 2009
  5. pmc In search of cellular immunophenotypes in the blood of children with autism
    Paul Ashwood
    Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, United States of America
    PLoS ONE 6:e19299. 2011
  6. pmc Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism
    Sharifia Wills
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, 451 Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA
    Mol Autism 2:5. 2011
  7. ncbi request reprint The amygdala and autism: implications from non-human primate studies
    D G Amaral
    Department of Psychiatry and Behavioral Sciences and Center for Neuroscience, The M I N D Institute, University of California at Davis, Davis, CA 95817, USA
    Genes Brain Behav 2:295-302. 2003
  8. doi request reprint Neuroanatomy of autism
    David G Amaral
    The M I N D Institute, Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA
    Trends Neurosci 31:137-45. 2008
  9. pmc The promise and the pitfalls of autism research: an introductory note for new autism researchers
    David G Amaral
    Department of Psychiatry and Behavioral Sciences, The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA
    Brain Res 1380:3-9. 2011
  10. ncbi request reprint Topographic organization of projections from the amygdala to the visual cortex in the macaque monkey
    D G Amaral
    Department of Psychiatry, Center for Neuroscience, 1544 Newton Court, Davis, CA 95616, USA
    Neuroscience 118:1099-120. 2003

Research Grants

Detail Information

Publications71

  1. ncbi request reprint Some observations on cortical inputs to the macaque monkey amygdala: an anterograde tracing study
    Lisa Stefanacci
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 451:301-23. 2002
    ..Projections to the central nucleus are particularly prominent from these regions. These data are discussed in relation to the hierarchical processing of sensory information that occurs within the amygdaloid complex...
  2. pmc Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders
    Sharifia Wills
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, 451 E Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA
    Brain Behav Immun 23:64-74. 2009
    ....
  3. pmc Emergence of stereotypies in juvenile monkeys (Macaca mulatta) with neonatal amygdala or hippocampus lesions
    M D Bauman
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, The M I N D Institute, University of California at Davis, CA 95817, USA
    Behav Neurosci 122:1005-15. 2008
    ..We discuss these results in relation to the neurobiological basis of repetitive stereotypies in neurodevelopmental disorders, such as autism...
  4. pmc Interest in infants by female rhesus monkeys with neonatal lesions of the amygdala or hippocampus
    J E Toscano
    Department of Psychiatry and Behavioral Sciences, 2230 Stockton Blvd Sacramento, CA 95817, USA
    Neuroscience 162:881-91. 2009
    ..These findings suggest that neonatal damage to the amygdala, but not the hippocampus, impairs important precursors of non-human primate maternal behavior...
  5. pmc In search of cellular immunophenotypes in the blood of children with autism
    Paul Ashwood
    Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, United States of America
    PLoS ONE 6:e19299. 2011
    ..There has been substantial evidence for dysregulation of the immune system in autism...
  6. pmc Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism
    Sharifia Wills
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, 451 Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA
    Mol Autism 2:5. 2011
    ..abstract:..
  7. ncbi request reprint The amygdala and autism: implications from non-human primate studies
    D G Amaral
    Department of Psychiatry and Behavioral Sciences and Center for Neuroscience, The M I N D Institute, University of California at Davis, Davis, CA 95817, USA
    Genes Brain Behav 2:295-302. 2003
    ..1998). If the amygdala is pathological in subjects with autism, it may contribute to their abnormal fears and increased anxiety rather than their abnormal social behavior...
  8. doi request reprint Neuroanatomy of autism
    David G Amaral
    The M I N D Institute, Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA
    Trends Neurosci 31:137-45. 2008
    ..Defined phenotypes in larger samples of children and well-characterized brain tissue will be necessary for clarification of the neuroanatomy of autism...
  9. pmc The promise and the pitfalls of autism research: an introductory note for new autism researchers
    David G Amaral
    Department of Psychiatry and Behavioral Sciences, The MIND Institute, University of California, Davis, Sacramento, CA 95817, USA
    Brain Res 1380:3-9. 2011
    ..This short article provides a brief overview of some of the achievements and some of the difficulties in conducting autism research...
  10. ncbi request reprint Topographic organization of projections from the amygdala to the visual cortex in the macaque monkey
    D G Amaral
    Department of Psychiatry, Center for Neuroscience, 1544 Newton Court, Davis, CA 95616, USA
    Neuroscience 118:1099-120. 2003
    ..These results suggest that the amygdala may have substantial modulatory control over sensory processing at all stages of the ventral-stream visual cortical hierarchy...
  11. ncbi request reprint The amygdala: is it an essential component of the neural network for social cognition?
    David G Amaral
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA 95616, USA
    Neuropsychologia 41:517-22. 2003
    ..However, our current answer to the question posed in the title of this paper is no!..
  12. pmc The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)
    David G Amaral
    Department of Psychiatry and Behavioral Sciences, The M I N D Institute and the California National Primate Research Center, UC Davis, Davis, CA, USA
    Prog Brain Res 163:3-22. 2007
    ..Together, this information provides essential information that can serve as an introduction to the dentate gyrus--a "dentate gyrus for dummies."..
  13. ncbi request reprint The amygdala, social behavior, and danger detection
    David G Amaral
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, The California National Primate Research Center, University of California Davis, Davis, California 95616, USA
    Ann N Y Acad Sci 1000:337-47. 2003
    ..This perspective predicts that hyperactivity of the amygdala would be associated with increased fear or anxiety and may contribute to disorders such as social phobia...
  14. ncbi request reprint The amygdala: is it an essential component of the neural network for social cognition?
    David G Amaral
    Department of Psychiatry, University of California, Davis, CA 95616, USA
    Neuropsychologia 41:235-40. 2003
    ..However, our current answer to the question posed in the title of this paper is no!..
  15. pmc Increased rate of amygdala growth in children aged 2 to 4 years with autism spectrum disorders: a longitudinal study
    Christine Wu Nordahl
    MIND Institute, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Arch Gen Psychiatry 69:53-61. 2012
    ..Precocious amygdala enlargement is commonly observed in young children with autism. However, the age at which abnormal amygdala enlargement begins and the relative growth trajectories of the amygdala and total brain remain unclear...
  16. ncbi request reprint The expression of social dominance following neonatal lesions of the amygdala or hippocampus in rhesus monkeys (Macaca mulatta)
    M D Bauman
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, California National Primate Research Center, Davis, CA, USA
    Behav Neurosci 120:749-60. 2006
    ..They were thus lower ranking on all indices of social dominance. The authors discuss these findings in relation to the role of the amygdala in the establishment of social rank and the regulation of aggression and fear...
  17. ncbi request reprint The effects of bilateral lesions of the amygdala on dyadic social interactions in rhesus monkeys (Macaca mulatta)
    N J Emery
    University of California, Davis, USA
    Behav Neurosci 115:515-44. 2001
    ..This is contrary to the idea that amygdalectomy produces a decrease in social interaction and increased aggression from conspecifics...
  18. ncbi request reprint Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions
    M D Prather
    Department of Psychiatry and Center for Neuroscience, University of California at Davis, 95616, USA
    Neuroscience 106:653-8. 2001
    ..Finally, amygdala lesions early in development have different effects on social behavior than lesions produced in adulthood...
  19. ncbi request reprint The development of social behavior following neonatal amygdala lesions in rhesus monkeys
    M D Bauman
    University of California Davis, Sacramento, CA 95817, USA
    J Cogn Neurosci 16:1388-411. 2004
    ..These findings are consistent with the view that the amygdala is not needed to develop fundamental aspects of social behavior and may be more related to the detection and avoidance of environmental dangers...
  20. pmc Neonatal amygdala lesions alter responsiveness to objects in juvenile macaques
    E Bliss-Moreau
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA
    Neuroscience 178:123-32. 2011
    ..Taken together, these findings suggest that early damage to the amygdala, like damage sustained during adulthood, permanently compromises emotional processing...
  21. pmc Context-specific social behavior is altered by orbitofrontal cortex lesions in adult rhesus macaques
    B A Babineau
    Department of Psychiatry and Behavioral Sciences, University of California Davis, Davis, CA 95616, USA
    Neuroscience 179:80-93. 2011
    ..Behavioral alterations were more apparent during the initial interactions between animals. We discuss these findings in relation to the role of the orbitofrontal cortex in context dependent modulation of social behavior...
  22. ncbi request reprint The development of mother-infant interactions after neonatal amygdala lesions in rhesus monkeys
    M D Bauman
    Department of Psychiatry and Behavioral Sciences, and Center for Neuroscience, University of California at Davis, Davis, California 95616, USA
    J Neurosci 24:711-21. 2004
    ..These results are consistent with the view that the amygdala is not essential for fundamental aspects of social behavior but is necessary to evaluate potentially dangerous situations and to coordinate appropriate behavioral responses...
  23. ncbi request reprint Macaque monkey retrosplenial cortex: II. Cortical afferents
    Yasushi Kobayashi
    Department of Psychiatry, Center for Neuroscience, California National Primate Research Center, and The M I N D Institute, University of California, Davis, Davis, California 95616, USA
    J Comp Neurol 466:48-79. 2003
    ..The posterior cingulate cortex, in contrast, may be more highly associated with visuospatial functions...
  24. pmc Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey
    M D Bauman
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA, USA
    Transl Psychiatry 3:e278. 2013
    ..White matter volume increases appeared to be driving the brain differences in the IgG-ASD offspring and these differences were most pronounced in the frontal lobes. ..
  25. ncbi request reprint Distribution of GABAergic cells and fibers in the hippocampal formation of the macaque monkey: an immunohistochemical and in situ hybridization study
    A L Jongen-Relo
    Department of Psychiatry and Center for Neuroscience, University of California Davis, 95616, USA
    J Comp Neurol 408:237-71. 1999
    ..The in situ hybridization preparations largely confirmed the distribution of GABAergic neurons in all fields of the hippocampal formation...
  26. pmc Effects of neonatal amygdala or hippocampus lesions on resting brain metabolism in the macaque monkey: a microPET imaging study
    Christopher J Machado
    Department of Psychiatry and Behavioral Sciences, The California National Primate Research Center, 2825 50th Street, UC Davis, Sacramento, CA 95817, USA
    Neuroimage 39:832-46. 2008
    ..These observations raise the possibility that behavioral alterations in animals with neonatal lesions may be due to the intended damage, to consequent brain reorganization or to a combination of both factors...
  27. ncbi request reprint Brief report: methods for acquiring structural MRI data in very young children with autism without the use of sedation
    Christine Wu Nordahl
    M I N D Institute and Department of Psychiatry and Behavioral Sciences, University of California at Davis, 2805 50th Street, Sacramento, CA, 95817, USA
    J Autism Dev Disord 38:1581-90. 2008
    ..Scanning very young children with autism, typical development, and developmental delays without the use of sedation or anesthesia was possible in the majority of cases...
  28. ncbi request reprint Cortical folding abnormalities in autism revealed by surface-based morphometry
    Christine Wu Nordahl
    The Medical Investigation of Neurodevelopmental Disorders Institute and the Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California 95817, USA
    J Neurosci 27:11725-35. 2007
    ..These findings are consistent with evidence of an altered trajectory of early brain development in autism, and they identify several regions that may have abnormal patterns of connectivity in individuals with autism...
  29. ncbi request reprint Amygdalectomy and responsiveness to novelty in rhesus monkeys (Macaca mulatta): generality and individual consistency of effects
    William A Mason
    Department of Psychology and California National Primate Research Center, University of California Davis, 95615, USA
    Emotion 6:73-81. 2006
    ....
  30. ncbi request reprint Role of the primate amygdala in fear-potentiated startle: effects of chronic lesions in the rhesus monkey
    Elena A Antoniadis
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California 95616, USA
    J Neurosci 27:7386-96. 2007
    ..These findings are discussed in relation to the role of the amygdala in emotional learning and in cross-species comparisons of emotional behavior...
  31. pmc Bilateral neurotoxic amygdala lesions in rhesus monkeys (Macaca mulatta): consistent pattern of behavior across different social contexts
    Christopher J Machado
    Department of Psychiatry and Behavioral Sciences, The M I N D Institute, University of California, Davis, Sacramento, CA 95817, USA
    Behav Neurosci 122:251-66. 2008
    ..The authors concluded that the amygdala contributes to social inhibition and that this function transcends various social contexts...
  32. ncbi request reprint Perirhinal and parahippocampal cortices of the macaque monkey: projections to the neocortex
    Pierre Lavenex
    Department of Psychiatry, Center for Neuroscience and California Regional Primate Research Center, UC Davis, Davis, California 95616, USA
    J Comp Neurol 447:394-420. 2002
    ..In all areas receiving heavy projections, the projections extend throughout most cortical layers, largely avoiding layer IV. We discuss these findings in relation to current theories of memory consolidation...
  33. ncbi request reprint The amygdala, autism and anxiety
    David G Amaral
    Department of Psychiatry, Center for Neuroscience, University of California Davis, Davis, CA 95616, USA
    Novartis Found Symp 251:177-87; discussion 187-97, 281-97. 2003
    ..If the amygdala is pathological in subjects with autism, it may contribute to their abnormal fears and increased anxiety rather than their abnormal social behaviour...
  34. ncbi request reprint Nonphosphorylated high-molecular-weight neurofilament expression suggests early maturation of the monkey subiculum
    Pierre Lavenex
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, California National Primate Research Center and M I N D Institute, University of California at Davis, Sacramento, California 95817, USA
    Hippocampus 14:797-801. 2004
    ....
  35. ncbi request reprint The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages
    Cynthia Mills Schumann
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience and the M I N D Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis, Sacramento, California 95817, USA
    J Neurosci 24:6392-401. 2004
    ..The cause of amygdala and hippocampal abnormalities in autism is currently unknown...
  36. ncbi request reprint Perirhinal and parahippocampal cortices of the macaque monkey: Intrinsic projections and interconnections
    Pierre Lavenex
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, California National Primate Research Center and M I N D Institute, University of California, Davis, Davis, California 95616, USA
    J Comp Neurol 472:371-94. 2004
    ..We discuss the functional implications of the organization of these extensive networks of intrinsic, associational projections...
  37. doi request reprint Neonatal amygdala or hippocampus lesions influence responsiveness to objects
    Eliza Bliss-Moreau
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
    Dev Psychobiol 52:487-503. 2010
    ..At 18 months of age, both amygdala-lesioned and hippocampus-lesioned animals were judged to be less fearful than controls during the testing procedure. Implications for understanding the neurobiology of emotional behavior are discussed...
  38. ncbi request reprint Spatial relational learning persists following neonatal hippocampal lesions in macaque monkeys
    Pierre Lavenex
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, California National Primate Research Center, The M I N D Institute, University of California at Davis, 2805 50th St, Sacramento, California 95817, USA
    Nat Neurosci 10:234-9. 2007
    ..Our experiments suggest that early hippocampal damage leads to functional brain reorganization that enables spatial information to be acquired through the use of brain regions that normally do not subserve this function...
  39. pmc The nonhuman primate amygdala is necessary for the acquisition but not the retention of fear-potentiated startle
    Elena A Antoniadis
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA
    Biol Psychiatry 65:241-8. 2009
    ..However, a second group of monkeys, which received the lesion after training, successfully demonstrated fear-potentiated startle learned prior to the lesion...
  40. ncbi request reprint Stereological analysis of amygdala neuron number in autism
    Cynthia Mills Schumann
    Department of Psychiatry and Behavioral Sciences and the M I N D Institute, University of California, Davis, Sacramento, California 95817, USA
    J Neurosci 26:7674-9. 2006
    ..It will be important to determine in future studies whether neuron loss in the amygdala is a consistent characteristic of autism and whether cell loss occurs in other brain regions as well...
  41. ncbi request reprint Acoustic startle reflex in rhesus monkeys: a review
    Michael Davis
    Yerkes Regional Primate Research Center, Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30322, USA
    Rev Neurosci 19:171-85. 2008
    ..The opportunity now emerges to link concepts developed in rodents to the more complex neuroanatomical and cognitive processes common to monkeys and humans...
  42. pmc Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism
    Loren A Martin
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, California National Primate Research Center and The MIND Institute, University of California Davis, 2825 50th Street, Sacramento, CA 95817, USA
    Brain Behav Immun 22:806-16. 2008
    ..This research raises the prospect of prenatal evaluation for neurodevelopmental risk factors and the potential for preventative therapeutics...
  43. ncbi request reprint Morphological characteristics and electrophysiological properties of CA1 pyramidal neurons in macaque monkeys
    K L Altemus
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, California National Primate Research Center, CA, USA
    Neuroscience 136:741-56. 2005
    ..Quantitative studies of the primate brain are critical in order to extrapolate information derived from rodent studies into better understanding of the normal and pathological function of the human hippocampus...
  44. ncbi request reprint The distribution of serotonergic fibers in the macaque monkey amygdala: an immunohistochemical study using antisera to 5-hydroxytryptamine
    M D Bauman
    Department of Psychiatry and Behavioral Sciences, The M I N D Institute and the California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA
    Neuroscience 136:193-203. 2005
    ..The present study provides evidence that the serotonergic system can have substantial influence on the ongoing activity of the amygdaloid complex...
  45. doi request reprint Intrinsic connections of the macaque monkey hippocampal formation: II. CA3 connections
    Hideki Kondo
    Department of Psychiatry and Behavioral Sciences, M I N D Institute, Center for Neuroscience and the California National Primate Research Center, University of California, Davis, Davis, California 95816, USA
    J Comp Neurol 515:349-77. 2009
    ..Interestingly, radial, transverse, and longitudinal gradients of CA3 fiber distribution, so clear in the rat, are much more subtle in the nonhuman primate brain...
  46. ncbi request reprint The primate amygdala and the neurobiology of social behavior: implications for understanding social anxiety
    David G Amaral
    Department of Psychiatry, Center for Neuroscience, California Regional Primate Research Center, University of California, 1544 Newton Court, Davis, CA 95616, USA
    Biol Psychiatry 51:11-7. 2002
    ..Finally, recent data from developmental studies raise the possibility that, at least at some developmental stages, fear in social contexts may be subserved by different brain regions than fear of inanimate objects...
  47. ncbi request reprint Investigation of neuroanatomical differences between autism and Asperger syndrome
    Linda J Lotspeich
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Arch Gen Psychiatry 61:291-8. 2004
    ....
  48. ncbi request reprint Hippocampal lesion prevents spatial relational learning in adult macaque monkeys
    Pamela Banta Lavenex
    Department of Psychiatry and Behavioral Sciences, California National Primate Research Center, The Medical Investigation of Neurodevelopmental Disorders Institute, University of California, Davis, Sacramento, California 95817, USA
    J Neurosci 26:4546-58. 2006
    ....
  49. ncbi request reprint The organization of projections from the amygdala to visual cortical areas TE and V1 in the macaque monkey
    Jennifer L Freese
    The M I N D Institute, Department of Psychiatry and Behavioral Sciences, University of California, 95616, USA
    J Comp Neurol 486:295-317. 2005
    ..These feedback-like projections from the amygdala have the potential of modulating key areas of the visual processing system...
  50. pmc A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder
    Julia A Scott
    Department of Psychiatry and Behavioral Sciences, University of California, Davis, M I N D Institute, Sacramento, California, USA
    Autism Res 2:246-57. 2009
    ..These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders...
  51. pmc Stereological estimation of the number of neurons in the human amygdaloid complex
    Cynthia Mills Schumann
    Department of Psychiatry and Behavioral Sciences, Medical Investigation of Neurodevelopmental Disorders Institute, University of California, Davis, Sacramento, California 95817, USA
    J Comp Neurol 491:320-9. 2005
    ..To facilitate these types of analyses, this paper provides a detailed anatomical description of the methods used to define subdivisions of the human amygdaloid complex...
  52. ncbi request reprint Magnetic resonance imaging of the post-mortem autistic brain
    C M Schumann
    The MIND Institute, Department of Psychiatry, University of California, Davis 95616, USA
    J Autism Dev Disord 31:561-8. 2001
    ..We describe our procedures for carrying out post-mortem MRI of the human brain...
  53. pmc Synaptic organization of projections from the amygdala to visual cortical areas TE and V1 in the macaque monkey
    Jennifer L Freese
    MIND Institute, Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, University of California, Davis, 95616, USA
    J Comp Neurol 496:655-67. 2006
    ..We conclude from these observations that the amygdaloid complex provides an excitatory input to areas TE and V1 that primarily influences spiny, probably pyramidal, neurons in these cortices...
  54. ncbi request reprint How do rhesus monkeys ( Macaca mulatta) scan faces in a visual paired comparison task?
    Katalin M Gothard
    Department of Psychiatry, University of California Davis, 2230 Stokton Blvd, Sacramento, CA 95817, USA
    Anim Cogn 7:25-36. 2004
    ..These studies indicate that non-human primates carry out the visual analysis of complex images such as faces in a characteristic and quantifiable manner...
  55. ncbi request reprint Hippocampal size positively correlates with verbal IQ in male children
    Cynthia Mills Schumann
    Department of Psychiatry and Behavioral Sciences and M I N D Institute, University of California, Davis, CA 95817, USA
    Hippocampus 17:486-93. 2007
    ..Given the substantial evidence for environmentally induced changes in hippocampal structure, an unresolved issue is whether this relationship reflects genetically determined individual variation or learning induced plasticity...
  56. pmc Intrinsic connections of the macaque monkey hippocampal formation: I. Dentate gyrus
    Hideki Kondo
    Department of Psychiatry and Behavioral Sciences, The MIND Institute, The Center for Neuroscience, University of California, Davis, Davis, California 95817, USA
    J Comp Neurol 511:497-520. 2008
    ..Such extensive longitudinal connections have the potential for integrating information across much of the rostrocaudal extent of the dentate gyrus...
  57. ncbi request reprint Perirhinal and parahippocampal cortices of the macaque monkey: cytoarchitectonic and chemoarchitectonic organization
    Wendy A Suzuki
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Comp Neurol 463:67-91. 2003
    ..We discuss these findings in the context of the results of previous tract-tracing studies...
  58. ncbi request reprint Morphological and electrophysiological characteristics of layer V neurons of the rat lateral entorhinal cortex
    Bassam N Hamam
    Department of Neurology and Neurosurgery, Montreal Neurological Institute and McGill University, Montreal, Quebec H3A 2B4, Canada
    J Comp Neurol 451:45-61. 2002
    ..Layer V of the entorhinal cortex may undertake very complex operations beyond acting as a relay station of hippocampal processed information to the neocortex...
  59. ncbi request reprint Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the entorhinal cortex in the macaque monkey
    Asla Pitkanen
    A I Virtanen Institute, University of Kuopio, Finland
    Hippocampus 12:186-205. 2002
    ..The accessory basal nucleus provides a light projection to the same regions of the entorhinal cortex innervated by the lateral and basal nuclei...
  60. ncbi request reprint Macaque monkey retrosplenial cortex: III. Cortical efferents
    Yasushi Kobayashi
    Department of Anatomy and Neurobiology, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    J Comp Neurol 502:810-33. 2007
    ....
  61. ncbi request reprint Dendritic morphology, local circuitry, and intrinsic electrophysiology of principal neurons in the entorhinal cortex of macaque monkeys
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Comp Neurol 470:317-29. 2004
    ..The interspecies differences revealed by this study may influence information processing and pathophysiological processes in the primate entorhinal cortex. J. Comp. Neurol. 470:317-329, 2004...
  62. ncbi request reprint Functional neuroanatomy of the medial temporal lobe memory system
    Wendy A Suzuki
    Center for Neural Science, New York University, New York, NY 10003, USA
    Cortex 40:220-2. 2004
  63. ncbi request reprint EEG sharp waves and sparse ensemble unit activity in the macaque hippocampus
    William E Skaggs
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurophysiol 98:898-910. 2007
    ....
  64. ncbi request reprint Entorhinal cortex lesions disrupt the relational organization of memory in monkeys
    Cindy A Buckmaster
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 24:9811-25. 2004
    ..Together, the findings support the conclusion that the primate hippocampal system critically enables the relational organization of declarative memory...
  65. ncbi request reprint Reactive plasticity in the dentate gyrus following bilateral entorhinal cortex lesions in cynomolgus monkeys
    Jul Lea Shamy
    Fishberg Department of Neuroscience and Alfred B and Gundren J Kastor Neurobiology Aging Laboratories, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Comp Neurol 502:192-201. 2007
    ....
  66. pmc Offering to share: how to put heads together in autism neuroimaging
    Matthew K Belmonte
    Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853 4401, USA
    J Autism Dev Disord 38:2-13. 2008
    ..A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on...
  67. ncbi request reprint Entorhinal cortex of the monkey: VII. intrinsic connections
    James J Chrobak
    Department of Psychology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Comp Neurol 500:612-33. 2007
    ..Our findings are discussed with reference to the role of interlaminar connections in mediating physiological interactions between the neocortex and the hippocampus...
  68. ncbi request reprint Postnatal development of the primate hippocampal formation
    Pierre Lavenex
    Institute of Physiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
    Dev Neurosci 29:179-92. 2007
    ....
  69. ncbi request reprint Hippocampal volume is preserved and fails to predict recognition memory impairment in aged rhesus monkeys (Macaca mulatta)
    Jul Lea T Shamy
    Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mt Sinai School of Medicine, One Gustave, L Levy Place, Box 1065, NY 10029 6574, USA
    Neurobiol Aging 27:1405-15. 2006
    ..These findings confirm and extend the conclusion of recent post-mortem histological analyses demonstrating that normal cognitive aging occurs independently of gross structural deterioration in the primate hippocampus...
  70. pmc Entorhinal cortex of the monkey: IV. Topographical and laminar organization of cortical afferents
    Ricardo Insausti
    Laboratory of Human Neuroanatomy, Department of Health Sciences and CRIB, School of Medicine, University of Castilla La Mancha, 02006 Albacete, Spain
    J Comp Neurol 509:608-41. 2008
    ....
  71. ncbi request reprint Neural and behavioral substrates of mood and mood regulation
    Richard J Davidson
    Department of Psychology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Biol Psychiatry 52:478-502. 2002
    ..Training interdisciplinary clinical scientists who meaningfully draw upon both behavioral and neuroscientific literatures and methods is critically required for the realization of these goals...

Research Grants36

  1. ANATOMY OF THE PRIMATE AMYGDALOID COMPLEX
    David G Amaral; Fiscal Year: 2010
    ..This work provides essential normative data to study influences like circulating hormones or social experience on amygdala maturation. ..
  2. FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL FORMATION
    David Amaral; Fiscal Year: 1999
    ..Taken together, these studies will provide important new information concerning the functional organization of memory systems in the rat and monkey brains. ..
  3. FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL FORMATION
    David Amaral; Fiscal Year: 2004
    ..These data will provide essential information on the functional organization of the primate hippocampal formation with implications for studies of normal memory and human disorders such as epilepsy and autism. ..
  4. Neurobiology of Social Behavior
    David Amaral; Fiscal Year: 2007
    ..abstract_text> ..
  5. Interdisciplinary Investigation of Biological Signatures of Autism Subtypes
    David Amaral; Fiscal Year: 2009
    ..We already have strong evidence for at least an autoimmune type of autism and this research will lead to more effective efforts at preventing future cases of autism and treating existing children with autism. ..
  6. ANATOMY OF THE PRIMATE AMYGDALOID COMPLEX
    David Amaral; Fiscal Year: 2006
    ..This work provides essential normative data to study influences like circulating hormones or social experience on amygdala maturation. ..
  7. FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL FORMATION
    David Amaral; Fiscal Year: 2003
    ..These data will provide essential information on the functional organization of the primate hippocampal formation with implications for studies of normal memory and human disorders such as epilepsy and autism. ..
  8. FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL FORMATION
    David Amaral; Fiscal Year: 2002
    ..These data will provide essential information on the functional organization of the primate hippocampal formation with implications for studies of normal memory and human disorders such as epilepsy and autism. ..
  9. ANATOMY OF THE PRIMATE AMYGDALOID COMPLEX
    David Amaral; Fiscal Year: 2007
    ..This work provides essential normative data to study influences like circulating hormones or social experience on amygdala maturation. ..
  10. FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL FORMATION
    David Amaral; Fiscal Year: 2009
    ..Our findings will have broad implications for the study of normal memory processes, including infantile amnesia, as well as human neurodevelopmental and genetic disorders, such as autism, schizophrenia and epilepsy...
  11. FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL FORMATION
    David Amaral; Fiscal Year: 2006
    ..Our findings will have broad implications for the study of normal memory processes, including infantile amnesia, as well as human neurodevelopmental and genetic disorders, such as autism, schizophrenia and epilepsy...
  12. ANATOMY OF THE PRIMATE AMYGDALOID COMPLEX
    David Amaral; Fiscal Year: 2009
    ..This work provides essential normative data to study influences like circulating hormones or social experience on amygdala maturation. ..
  13. ANATOMY OF THE PRIMATE AMYGDALOID COMPLEX
    David Amaral; Fiscal Year: 2009
    ..This work provides essential normative data to study influences like circulating hormones or social experience on amygdala maturation. ..
  14. FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL FORMATION
    David Amaral; Fiscal Year: 2007
    ..Our findings will have broad implications for the study of normal memory processes, including infantile amnesia, as well as human neurodevelopmental and genetic disorders, such as autism, schizophrenia and epilepsy...
  15. NEUROBIOLOGY OF PRIMATE SOCIAL BEHAVIOR
    David Amaral; Fiscal Year: 1999
    ..These studies will provide important insights into the neurobiology of normal social behavior and may contribute to an understanding of pathologies of social communication in disorders such as autism. ..
  16. FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL FORMATION
    David Amaral; Fiscal Year: 2000
    ..These data will provide essential information on the functional organization of the primate hippocampal formation with implications for studies of normal memory and human disorders such as epilepsy and autism. ..
  17. NEUROBIOLOGY OF PRIMATE SOCIAL BEHAVIOR
    David Amaral; Fiscal Year: 2000
    ..These studies will provide important insights into the neurobiology of normal social behavior and may contribute to an understanding of pathologies of social communication in disorders such as autism. ..
  18. ANATOMY OF THE PRIMATE AMYGDALOID COMPLEX
    David Amaral; Fiscal Year: 2000
    ....
  19. ANATOMY OF THE PRIMATE AMYGDALOID COMPLEX
    David Amaral; Fiscal Year: 2001
    ....
  20. NEUROBIOLOGY OF PRIMATE SOCIAL BEHAVIOR
    David Amaral; Fiscal Year: 2001
    ..These studies will provide important insights into the neurobiology of normal social behavior and may contribute to an understanding of pathologies of social communication in disorders such as autism. ..
  21. FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL FORMATION
    David Amaral; Fiscal Year: 2001
    ..These data will provide essential information on the functional organization of the primate hippocampal formation with implications for studies of normal memory and human disorders such as epilepsy and autism. ..
  22. NEUROBIOLOGY OF PRIMATE SOCIAL BEHAVIOR
    David Amaral; Fiscal Year: 2002
    ..These studies will provide important insights into the neurobiology of normal social behavior and may contribute to an understanding of pathologies of social communication in disorders such as autism. ..
  23. TRAINING PROGRAM IN SYSTEMS NEUROSCIENCE
    David Amaral; Fiscal Year: 2002
    ..abstract_text> ..
  24. ANATOMY OF THE PRIMATE AMYGDALOID COMPLEX
    David Amaral; Fiscal Year: 2002
    ....
  25. ANATOMY OF THE PRIMATE AMYGDALOID COMPLEX
    David Amaral; Fiscal Year: 2003
    ....
  26. ANATOMY OF THE PRIMATE AMYGDALOID COMPLEX
    David Amaral; Fiscal Year: 2004
    ....
  27. FUNCTIONAL ORGANIZATION OF THE HIPPOCAMPAL FORMATION
    David Amaral; Fiscal Year: 2005
    ..Our findings will have broad implications for the study of normal memory processes, including infantile amnesia, as well as human neurodevelopmental and genetic disorders, such as autism, schizophrenia and epilepsy. ..
  28. Interdisciplinary Investigation of Biological Signatures of Autism Subtypes
    JUDY A VAN DE WATER; Fiscal Year: 2010
    ..We already have strong evidence for at least an autoimmune type of autism and this research will lead to more effective efforts at preventing future cases of autism and treating existing children with autism. ..