W L Alward

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Axenfeld-Rieger syndrome in the age of molecular genetics
    W L Alward
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Ophthalmol 130:107-15. 2000
  2. pmc Analysis of RNA splicing defects in PITX2 mutants supports a gene dosage model of Axenfeld-Rieger syndrome
    Nicole L Maciolek
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    BMC Med Genet 7:59. 2006
  3. ncbi request reprint Biomedicine. A new angle on ocular development
    Wallace L M Alward
    Department of Ophthalmology and Visual Sciences, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 299:1527-8. 2003
  4. ncbi request reprint Autosomal dominant iris hypoplasia is caused by a mutation in the Rieger syndrome (RIEG/PITX2) gene
    W L Alward
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City 52242, USA
    Am J Ophthalmol 125:98-100. 1998
  5. doi request reprint A history of gonioscopy
    Wallace L M Alward
    Department of Ophthalmology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Optom Vis Sci 88:29-35. 2011
  6. ncbi request reprint The genetics of open-angle glaucoma: the story of GLC1A and myocilin
    W L Alward
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City 52242 1091, USA
    Eye (Lond) 14:429-36. 2000
  7. pmc A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye
    D Y Nishimura
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Hum Genet 68:364-72. 2001
  8. ncbi request reprint Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension
    J H Fingert
    Departments of Ophthalmology and Pediatrics, and the Howard Hughes Medical Institute, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Invest Ophthalmol Vis Sci 42:145-52. 2001
  9. ncbi request reprint Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects
    R E Swiderski
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Dev Dyn 216:16-27. 1999
  10. ncbi request reprint The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25
    D Y Nishimura
    Department of Pediatrics, University of Iowa, Iowa City 52242, USA
    Nat Genet 19:140-7. 1998

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Axenfeld-Rieger syndrome in the age of molecular genetics
    W L Alward
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Ophthalmol 130:107-15. 2000
    ..To review the molecular genetics of Axenfeld-Rieger syndrome and related phenotypes and to discuss how this information might affect the way that we classify these disorders...
  2. pmc Analysis of RNA splicing defects in PITX2 mutants supports a gene dosage model of Axenfeld-Rieger syndrome
    Nicole L Maciolek
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    BMC Med Genet 7:59. 2006
    ..Several intronic PITX2 mutations have been reported in Axenfeld-Rieger patients but their effects on gene expression have not been tested...
  3. ncbi request reprint Biomedicine. A new angle on ocular development
    Wallace L M Alward
    Department of Ophthalmology and Visual Sciences, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 299:1527-8. 2003
  4. ncbi request reprint Autosomal dominant iris hypoplasia is caused by a mutation in the Rieger syndrome (RIEG/PITX2) gene
    W L Alward
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City 52242, USA
    Am J Ophthalmol 125:98-100. 1998
    ..To determine whether autosomal dominant iris hypoplasia is caused by mutations in the newly described gene for Rieger syndrome (RIEG/PITX2)...
  5. doi request reprint A history of gonioscopy
    Wallace L M Alward
    Department of Ophthalmology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Optom Vis Sci 88:29-35. 2011
    ..This article reviews the history of gonioscopy...
  6. ncbi request reprint The genetics of open-angle glaucoma: the story of GLC1A and myocilin
    W L Alward
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City 52242 1091, USA
    Eye (Lond) 14:429-36. 2000
    ..In the trabecular meshwork the production of myocilin can be induced by the application of topical corticosteroids. The exact function of myocilin in health and disease remains a mystery...
  7. pmc A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye
    D Y Nishimura
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Hum Genet 68:364-72. 2001
    ..Of particular interest is the fact that two families have a duplication of 6p25, involving the FOXC1 gene. These data suggest that both FOXC1 haploinsufficiency and increased gene dosage can cause anterior-chamber defects of the eye...
  8. ncbi request reprint Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension
    J H Fingert
    Departments of Ophthalmology and Pediatrics, and the Howard Hughes Medical Institute, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Invest Ophthalmol Vis Sci 42:145-52. 2001
    ..MYOC variations thought to be disease-causing also were found in 3% to 5% of POAG cases. The purpose of this study was to determine whether some variations in MYOC might be involved in steroid-induced ocular hypertension...
  9. ncbi request reprint Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects
    R E Swiderski
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Dev Dyn 216:16-27. 1999
    ..This is further supported by our studies showing that mutations in the FKHL7 gene were associated with defects in the anterior segment of the eye as well as atrial septal defects or mitral valve defects. Dev Dyn 1999;216:16-27...
  10. ncbi request reprint The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25
    D Y Nishimura
    Department of Pediatrics, University of Iowa, Iowa City 52242, USA
    Nat Genet 19:140-7. 1998
    ..Furthermore, FKHL7 was found to harbour mutations in patients diagnosed with Rieger anomaly (RA), Axenfeld anomaly (AA) and iris hypoplasia (IH). This study demonstrates that mutations in FKHL7 cause a spectrum of glaucoma phenotypes...
  11. ncbi request reprint Expression pattern and in situ localization of the mouse homologue of the human MYOC (GLC1A) gene in adult brain
    R E Swiderski
    Department of Pediatrics, University of Iowa, Room 440 EMRB, Iowa City, IA 52242, USA
    Brain Res Mol Brain Res 68:64-72. 1999
    ....
  12. pmc Characterization and comparison of the human and mouse GLC1A glaucoma genes
    J H Fingert
    Department of Ophthalmology, University of Iowa, Iowa City, Iowa 52242, USA
    Genome Res 8:377-84. 1998
    ..The comparison of the human and mouse GLC1A genes suggests that the mouse may be a useful model organism in studying the molecular pathophysiology of glaucoma...
  13. ncbi request reprint Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)
    W L Alward
    Department of Ophthalmology, University of Iowa, Iowa City 52242, USA
    N Engl J Med 338:1022-7. 1998
    ..The normal role of this protein and the mechanism by which mutations cause glaucoma are not known...
  14. ncbi request reprint Analysis of myocilin mutations in 1703 glaucoma patients from five different populations
    J H Fingert
    Department of Ophthalmology, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Hum Mol Genet 8:899-905. 1999
    ....
  15. ncbi request reprint Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome
    E V Semina
    f1partment of Pediatrics, University of Iowa, Iowa City 52242, USA
    Nat Genet 14:392-9. 1996
    ..RIEG characterization provides opportunities for understanding ocular, dental and umbilical development and the pleiotropic interactions of pituitary and limb morphogenesis...
  16. ncbi request reprint Linkage of autosomal dominant iris hypoplasia to the region of the Rieger syndrome locus (4q25)
    E Heon
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City 52242, USA
    Hum Mol Genet 4:1435-9. 1995
    ..These results suggest that autosomal dominant iris hypoplasia and Rieger syndrome are allelic...
  17. ncbi request reprint Identification of a gene that causes primary open angle glaucoma
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 275:668-70. 1997
    ..One of these mutations was also found in a control individual (0.2 percent). Identification of these mutations will aid in early diagnosis, which is essential for optimal application of existing therapies...
  18. ncbi request reprint A case-control comparison of the clinical characteristics of glaucoma and ocular hypertensive patients with and without the myocilin Gln368Stop mutation
    Thomas A Graul
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City 52242, USA
    Am J Ophthalmol 134:884-90. 2002
    ..To determine whether primary open-angle glaucoma (POAG) and ocular hypertensive (OHT) patients who harbor the myocilin Gln368Stop mutation differ in phenotype or clinical course from patients without the mutation...
  19. ncbi request reprint Rate of visual field loss and long-term visual outcome in primary open-angle glaucoma
    Y H Kwon
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City 52242, USA
    Am J Ophthalmol 132:47-56. 2001
    ..To evaluate long-term visual field outcome in primary open-angle glaucoma...
  20. ncbi request reprint Myocilin glaucoma
    John H Fingert
    Department of Ophthalmology, College of Medicine, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Surv Ophthalmol 47:547-61. 2002
    ..Clinical vignettes of POAG patients from four generations of a family harboring the TYR437HIS myocilin mutation are presented, highlighting the benefits of elucidating the genetics of glaucoma...
  21. doi request reprint Variance owing to observer, repeat imaging, and fundus camera type on cup-to-disc ratio estimates by stereo planimetry
    Young H Kwon
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA
    J Glaucoma 18:305-10. 2009
    ..To determine and compare variance components in linear cup-to-disc ratio (LCDR) estimates by computer-assisted planimetry by human experts, and automated machine algorithm (digital automated planimetry)...
  22. pmc Automated segmentation of the optic disc from stereo color photographs using physiologically plausible features
    Michael D Abramoff
    Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Invest Ophthalmol Vis Sci 48:1665-73. 2007
    ..To evaluate a novel automated segmentation algorithm for cup-to-disc segmentation from stereo color photographs of patients with glaucoma for the measurement of glaucoma progression...
  23. pmc Automated segmentation of the cup and rim from spectral domain OCT of the optic nerve head
    Michael D Abramoff
    Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Invest Ophthalmol Vis Sci 50:5778-84. 2009
    ....
  24. ncbi request reprint The C677T variant in the methylenetetrahydrofolate reductase gene is not associated with disease in cohorts of pseudoexfoliation glaucoma and primary open-angle glaucoma patients from Iowa
    John H Fingert
    Department of Ophthalmology and Visual Sciences, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Ophthalmic Genet 27:39-41. 2006
  25. ncbi request reprint Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma
    Wallace L M Alward
    Department of Ophthalmology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Ophthalmol 136:904-10. 2003
    ..To investigate the association of sequence variations in the optineurin (OPTN) gene in patients with open-angle glaucoma...
  26. ncbi request reprint Retinal synthesis and deposition of complement components induced by ocular hypertension
    Markus H Kuehn
    Department of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Exp Eye Res 83:620-8. 2006
    ..The results show that complement activation occurs in the retina that has been subjected to elevated IOP, and may have implications in pathophysiology of glaucoma...
  27. ncbi request reprint Variations in the myocilin gene in patients with open-angle glaucoma
    Wallace L M Alward
    Department of Ophthalmology, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    Arch Ophthalmol 120:1189-97. 2002
    ..To determine the prevalence and associated phenotype of myocilin (MYOC) coding sequence variations and a specific promoter polymorphism (MYOC.mt1) in patients with glaucoma and glaucoma suspects...
  28. ncbi request reprint Rate of optic disc cup progression in treated primary open-angle glaucoma
    Young H Kwon
    Department of Ophthalmology and Visual Sciences, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
    J Glaucoma 12:409-16. 2003
    ..To quantitatively evaluate the rate of cup-to-disc ratio progression in treated patients with primary open-angle glaucoma and to identify clinical factors associated with cup progression...
  29. ncbi request reprint A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene
    Robert A Honkanen
    Department of Ophthalmology, Howard Hughes Medical Institute, The University of Iowa, Iowa City, Iowa, USA
    Am J Ophthalmol 135:368-75. 2003
    ..In this report, we clinically characterize the spectrum of ocular and systemic manifestations in one family resulting from a previously reported point mutation (Phe112Ser) in FOXC1...
  30. ncbi request reprint Progressive axial myopia in a juvenile patient with traumatic glaucoma
    Thomas A Graul
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA
    Am J Ophthalmol 133:700-2. 2002
    ..To report a case of progressive axial myopia associated with traumatic glaucoma in a juvenile patient with no systemic disease...
  31. ncbi request reprint Atypical pigment dispersion syndrome in a child
    Michael A Grassi
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Ophthalmol 137:753-6. 2004
    ..To describe the features of atypical pigment dispersion in a child...
  32. ncbi request reprint Familial cavitary optic disk anomalies: clinical features of a large family with examples of progressive optic nerve head cupping
    Robert A Honkanen
    Department of Ophthalmology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Ophthalmol 143:788-794. 2007
    ..To describe a multigenerational family with autosomal dominant inheritance of cavitary optic nerve head (ONH) anomalies and abnormal ONH vasculature...
  33. ncbi request reprint Long-term results of eyes with penetrating keratoplasty and glaucoma drainage tube implant
    Y H Kwon
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA
    Ophthalmology 108:272-8. 2001
    ..However, the success of corneal grafts is low (55%) at 3 years. Postsurgical complications are not uncommon and are associated with poor glaucoma outcome. Other clinical factors are associated with poor graft outcome...
  34. ncbi request reprint Diurnal fluctuation and concordance of intraocular pressure in glaucoma suspects and normal tension glaucoma patients
    Lesya M Shuba
    Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Glaucoma 16:307-12. 2007
    ..The study objective was to determine the concordance of intraocular pressure (IOP) in glaucoma suspects (GS) and normal tension glaucoma (NTG) patients...
  35. doi request reprint Escalation of glaucoma therapy after deep lamellar endothelial keratoplasty
    George R Wandling
    Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, USA
    Cornea 29:991-5. 2010
    ..To determine the prevalence and risk factors for escalation of glaucoma therapy after deep lamellar endothelial keratoplasty (DLEK)...
  36. ncbi request reprint Concordance of diurnal intraocular pressure between fellow eyes in primary open-angle glaucoma
    Robert B Dinn
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa 52242, USA
    Ophthalmology 114:915-20. 2007
    ..To study the concordance of diurnal intraocular pressure (IOP) between fellow eyes in primary open-angle glaucoma (POAG)...
  37. ncbi request reprint Progressive iris changes in a case of Axenfeld-Rieger syndrome
    Robert Honkanen
    Department of Ophthalmology, SUNY at Stony Brook, NY 11794, USA
    Arch Ophthalmol 124:1793. 2006
  38. pmc Familial cavitary optic disk anomalies: identification of a novel genetic locus
    John H Fingert
    Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Ophthalmol 143:795-800. 2007
    ..To identify the chromosomal location of the gene involved in the pathogenesis of cavitary optic disk anomalies in a large pedigree with autosomal dominant inheritance of disease...
  39. ncbi request reprint Rate and pattern of visual field decline in primary open-angle glaucoma
    Mary Lucy M Pereira
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA
    Ophthalmology 109:2232-40. 2002
    ..To study the rate and pattern of visual field decline in primary open-angle glaucoma...
  40. pmc Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome
    Colleen M Trantow
    Department of Molecular Physiology, University of Iowa, Iowa City, Iowa 52242, USA
    Invest Ophthalmol Vis Sci 50:1205-14. 2009
    ..The purpose of this study was to determine the anatomic basis for Lyst-mediated transillumination defects, test whether Lyst mutant mice develop other features of XFS, and describe the molecular basis of the beige mutation...
  41. ncbi request reprint Gonioscopy in primary angle closure glaucoma
    Christina A Bruno
    Department of Ophthalmology and Visual Sciences, The University of Michigan, Ann Arbor, MI 48015, USA
    Semin Ophthalmol 17:59-68. 2002
    ..Finally, there is a discussion about the pathology associated with the closed angle, with emphasis on the appearance of iris bombé, plateau iris, and the distinction between iris processes and peripheral anterior synechiae...
  42. ncbi request reprint LOXL1 mutations are associated with exfoliation syndrome in patients from the midwestern United States
    John H Fingert
    Am J Ophthalmol 144:974-975. 2007
  43. ncbi request reprint Macular degeneration and glaucoma-like optic nerve head cupping
    Wallace L M Alward
    Am J Ophthalmol 138:135-6. 2004
  44. ncbi request reprint No association between variations in the WDR36 gene and primary open-angle glaucoma
    John H Fingert
    Arch Ophthalmol 125:434-6. 2007
  45. ncbi request reprint Heritable features of the optic disc: a novel twin method for determining genetic significance
    Alex W Hewitt
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
    Invest Ophthalmol Vis Sci 48:2469-75. 2007
    ..Numerous genetic diseases and environmental stimuli affect optic nerve morphology. The purpose of this study was to identify the principal heritable components of visible optic nerve head structures in a population-based sample of twins...
  46. ncbi request reprint Gonioscopy.org: a video Atlas
    Matthew B Goren
    Compr Ophthalmol Update 8:285-6. 2007