Research Topics
Genomes and Genes
Species | Arturo Alvarez-BuyllaSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Neurogenesis in adult subventricular zoneArturo Alvarez-Buylla
Department of Neurological Surgery, Brain Tumor Research Center, San Francisco, California 94143-0520, USA
J Neurosci 22:629-34. 2002- Identification of neural stem cells in the adult vertebrate brainArturo Alvarez-Buylla
Department of Neurosurgery Research, Brain Tumor Research Center, University of California, San Francisco, CA, 94143 USA
Brain Res Bull 57:751-8. 2002..The very same cells that give birth to new neurons also seem to nurture their maturation and support their function... - For the long run: maintaining germinal niches in the adult brainArturo Alvarez-Buylla
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143 USA
Neuron 41:683-6. 2004..The adult neurogenic niches can be viewed as "displaced" neuroepithelium, pockets of cells and local signals that preserve enough embryonic character to maintain neurogenesis for life... 
Cilia organize ependymal planar polarityZaman Mirzadeh
Department of Neurosurgery, University of California San Francisco, San Francisco, California 94143, USA
J Neurosci 30:2600-10. 2010..These results suggest that ependymal planar cell polarity is a multistep process initially organized by primary cilia in radial glia and then refined by motile cilia in ependymal cells...- Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulbMinoree Kohwi
Department of Neurological Surgery, Program in Developmental and Stem Cell Biology, University of California, San Francisco, California 94143, USA
J Neurosci 25:6997-7003. 2005..Our data show that SVZ neuroblasts are heterogeneous and that Pax6 is required in a cell-autonomous manner for the production of cells in the dopaminergic lineage... - Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiationJason E Long
Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 27:3230-43. 2007.... 
Intrinsically determined cell death of developing cortical interneuronsDerek G Southwell
Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA
Nature 491:109-13. 2012..Taken together, our findings indicate that interneuron cell death is determined intrinsically, either cell-autonomously or through a population-autonomous competition for survival signals derived from other interneurons...- Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cellsDaniel A Lim
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Street M779, San Francisco, California 94143, USA
Nature 458:529-33. 2009..These data support a model in which Mll1 is required to resolve key silenced bivalent loci in postnatal neural precursors to the actively transcribed state for the induction of neurogenesis, but not for gliogenesis... - Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cellsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, Brain Tumor Research Center, Developmental Stem Cell Biology Program, University of California, San Francisco, San Francisco, California 94143 0112, USA
J Comp Neurol 494:415-34. 2006..Ultrastructural analysis of this layer revealed a remarkable network of astrocytic and ependymal processes. This work provides a basic description of the organization of the adult human SVZ... - New neurons follow the flow of cerebrospinal fluid in the adult brainKazunobu Sawamoto
Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, CA 94143, USA
Science 311:629-32. 2006..Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons... - Regional astrocyte allocation regulates CNS synaptogenesis and repairHui Hsin Tsai
Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA
Science 337:358-62. 2012..Our findings demonstrate that region-restricted astrocyte allocation is a general CNS phenomenon and reveal intrinsic limitations of the astroglial response to injury... - A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitorsMinoree Kohwi
Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 27:6878-91. 2007..Our results suggest that some OB interneurons are derived from progenitors outside the LGE and that precursors expressing what has classically been considered a pallial transcription factor generate GABAergic interneurons... - Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic nicheChay T Kuo
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143, USA
Cell 127:1253-64. 2006..Our results show a self-repair mechanism in the mammalian brain and may have implications for both niche plasticity in other areas of stem cell biology and the therapeutic use of neural stem cells in neurodegenerative diseases... - Hedgehog signaling and primary cilia are required for the formation of adult neural stem cellsYoung Goo Han
Department of Neurological Surgery, Institute for Regeneration Medicine, University of California San Francisco, San Francisco, California 94143, USA
Nat Neurosci 11:277-84. 2008..We conclude that Shh signaling, acting through the primary cilia, has a critical role in the expansion and establishment of postnatal hippocampal progenitors... - Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identityRebecca A Ihrie
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 71:250-62. 2011..These results show that Shh is necessary and sufficient for the specification of adult ventral NSCs... - Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migrationNader Sanai
Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
Nature 427:740-4. 2004..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain... - Epidermal growth factor induces the progeny of subventricular zone type B cells to migrate and differentiate into oligodendrocytesOscar Gonzalez-Perez
Department of Neurological Surgery, Brain Tumor Research Center, Institute for Regeneration Medicine, University of California, San Francisco, California, USA
Stem Cells 27:2032-43. 2009..This expanded population could be used for the repair of white matter lesions... - Mosaic organization of neural stem cells in the adult brainFlorian T Merkle
Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California, San Francisco, San Francisco, CA 94143 0525, USA
Science 317:381-4. 2007..This suggests that rather than being plastic and homogeneous, neural stem cells are a restricted and diverse population of progenitors... - Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension"Nader Sanai
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143 0112, USA
Science 318:393; author reply 393. 2007.... - PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signalingErica L Jackson
Department of Neurological Surgery and Program in Developmental and Stem Cell Biology, University of California, San Francisco, San Francisco, California 94143, USA
Neuron 51:187-99. 2006..Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation... - Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartmentAnthony D Tramontin
Department of Neurosurgery Research, University of California, San Francisco, CA 94143, USA
Cereb Cortex 13:580-7. 2003..We propose that a VZ 'compartment' is retained postnatally and that this niche may be essential for stem cell function... - Radiation damage increases Purkinje neuron heterokaryons in neonatal cerebellumSilvia Espejel
Department of Neurological Surgery, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA
Ann Neurol 66:100-9. 2009..Here we investigated whether radiation plays a role in the formation of Purkinje neuron heterokaryons... - Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant miceScott C Baraban
Department of Neurological Surgery and Psychiatry, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:15472-7. 2009..Our findings suggest that MGE-derived interneurons could be used to ameliorate abnormal excitability and possibly act as an effective strategy in the treatment of epilepsy... - Cortical plasticity induced by inhibitory neuron transplantationDerek G Southwell
Department of Neurological Surgery and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Science 327:1145-8. 2010..These findings suggest that ocular dominance plasticity is regulated by the execution of a maturational program intrinsic to inhibitory neurons. By inducing plasticity, inhibitory neuron transplantation may facilitate brain repair... - Corridors of migrating neurons in the human brain and their decline during infancyNader Sanai
Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143, USA
Nature 478:382-6. 2011..Together, these findings reveal robust streams of tangentially migrating immature neurons in human early postnatal subventricular zone and cortex. These pathways represent potential targets of neurological injuries affecting neonates... - Neural stem cells in mammalian developmentFlorian T Merkle
Department of Neurological Surgery and Program in Developmental and Stem Cell Biology, University of California, San Francisco, Box 0525, HSW 1201A, San Francisco, California 94143, USA
Curr Opin Cell Biol 18:704-9. 2006..These advances challenge our traditional perceptions of glia and stem cells, and provide the foundation for understanding the molecular basis of mammalian NSC behavior... - Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brainZaman Mirzadeh
Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA
Cell Stem Cell 3:265-78. 2008..These results reveal that adult NSCs retain fundamental epithelial properties, including apical and basal compartmentalization, significantly reshaping our understanding of this adult neurogenic niche... - The glial nature of embryonic and adult neural stem cellsArnold Kriegstein
The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Neurology, University of California, San Francisco, California 94143 0525, USA
Annu Rev Neurosci 32:149-84. 2009..Identification of NSCs and IPCs is critical to understand brain development and adult neurogenesis and to develop new strategies for brain repair... - Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesisNathalie Spassky
Department of Neurological Surgery and Program in Developmental and Stem Cell Biology, University of California San Francisco, San Francisco, California 94143, USA
J Neurosci 25:10-8. 2005..The postmitotic nature of ependymal cells strongly suggests that these cells do not function as neural stem cells in the adult... - Composition and organization of the SCZ: a large germinal layer containing neural stem cells in the adult mammalian brainB Seri
Neurosurgery Department, University of California-San Francisco, San Francisco, CA 94143, USA
Cereb Cortex 16:i103-11. 2006..This study defines the organization and fate of cells born in a large germinal region of the adult forebrain... - Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned ratsVeronica Martinez-Cerdeno
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cell Stem Cell 6:238-50. 2010..Our data suggest that MGE cell transplantation into the striatum is a promising approach to investigate the potential benefits of remodeling basal ganglia circuitry in neurodegenerative diseases... - Lake-front property: a unique germinal niche by the lateral ventricles of the adult brainRebecca A Ihrie
Department of Neurosurgery and Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, USA
Neuron 70:674-86. 2011..The integration of emerging molecular and anatomical clues forecasts an exciting new understanding of how the germ of youth is actively maintained in the adult brain... - Cells in the astroglial lineage are neural stem cellsRebecca A Ihrie
Department of Neurosurgery and Institute for Regeneration Medicine, University of California at San Francisco, San Francisco, CA, USA
Cell Tissue Res 331:179-91. 2008..The further characterization of these cells should eventually provide a body of knowledge central to the understanding of brain development and disease... - Sox1 marks an activated neural stem/progenitor cell in the hippocampusMonica Venere
Department of Urology, University of California, San Francisco, CA 94143, USA
Development 139:3938-49. 2012..These results demonstrate that Sox1 is expressed in an activated stem/progenitor population whose numbers decrease with age while maintaining a stable molecular program... - In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesisDaniel A Lim
Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California, San Francisco, CA 94143, USA
Mol Cell Neurosci 31:131-48. 2006.... - Radial glia give rise to adult neural stem cells in the subventricular zoneFlorian T Merkle
Department of Neurological Surgery, Developmental and Stem Cell Biology Program, Box 0525, University of California-San Francisco, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 101:17528-32. 2004..This study identifies and provides a method to genetically modify the lineage that links neonatal and adult neural stem cells... - Brain-derived neurotrophic factor signaling does not stimulate subventricular zone neurogenesis in adult mice and ratsRui P Galvão
Department of Neurological Surgery and Institute for Regeneration Medicine, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 28:13368-83. 2008..Our results indicate that TrkB is not essential for adult SVZ neurogenesis and do not support the current view that delivering BDNF to the SVZ can enhance adult neurogenesis... - Neural stem cells and the origin of gliomasNader Sanai
Department of Neurological Surgery, Brain Tumor Research Center, and the Developmental Stem Cell Biology Program, University of California, San Francisco, CA 94143, USA
N Engl J Med 353:811-22. 2005 - Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brainManuel Alvarez-Dolado
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 26:7380-9. 2006..Grafted MGE cells, therefore, can be used to modify neural circuits and selectively increase local inhibition. These findings could have important implications for reparative cell therapies for brain disorders... - The adult neural stem cell niche: lessons for future neural cell replacement strategiesDaniel A Lim
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Street, M779, Box 0112, San Francisco, CA 94143, USA
Neurosurg Clin N Am 18:81-92, ix. 2007..Lessons learned from these niches may allow one to manipulate NSCs better in culture for therapeutic transplantation and possibly even to mobilize endogenous precursors to repair diseased or injured brain... - Characterization of adult neural stem cells and their relation to brain tumorsErica L Jackson
Department of Neurological Surgery, Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, USA
Cells Tissues Organs 188:212-24. 2008..Indeed, activation of the PDGF or epidermal growth factor pathways in adult neural stem or progenitor cells confers tumor-like properties on these cells, lending support to this hypothesis... - Role of primary cilia in brain development and cancerYoung Goo Han
Department of Neurological Surgery, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0112, USA
Curr Opin Neurobiol 20:58-67. 2010..Understanding the multifaceted roles that primary cilia have in brain development will provide important insights into the mechanism of brain development and diseases... - Origin of oligodendrocytes in the subventricular zone of the adult brainBenedicte Menn
Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 26:7907-18. 2006..Our work identifies SVZ type B cells as progenitors of oligodendrocytes in normal and injured adult brain... - Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic painJoao M Braz
Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
Neuron 74:663-75. 2012..Our findings suggest that MGE-derived GABAergic interneurons overcome the spinal cord hyperexcitability that is a hallmark of nerve injury-induced neuropathic pain... - Distinct patterns of human medulloblastoma dissemination in the developing chick embryo nervous systemTene A Cage
Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0112, USA
Clin Exp Metastasis 29:371-80. 2012..This work supports an avian-human xenograft as a successful model to study patterns of MB dissemination. Our model provides a basis for manipulating cell signaling mechanisms to understand critical targets involved in MB dissemination... - miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cellsJoachim Silber
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
BMC Med 6:14. 2008..In this study, we investigated the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells... - Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrusBettina Seri
University of California, San Francisco, Department of Neurological Surgery and Program in Developmental and Stem Cell Research, San Francisco, California 94143, USA
J Comp Neurol 478:359-78. 2004..These observations provide a model of how the germinal zone of the adult hippocampus is organized and suggest a sequence of cellular stages in the generation of new granule neurons... - Stem Cells in the Land of the Rising Sun: ISSCR 2012Kathrin Plath
Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90024, USA Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA
Cell Stem Cell 11:607-14. 2012..Held in Japan, the meeting showcased recent discoveries and surveyed the remarkable progress that has been made in a decade of stem cell research... - Adult neural stem cells bridge their nicheLuis C Fuentealba
Department of Neurological Surgery and Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Cell Stem Cell 10:698-708. 2012..NSCs in the adult brain stretch into physiologically distinct compartments of their niche. We propose how adult NSCs' morphology may allow these cells to integrate multiple signaling pathways arising from unique locations of their niche... - Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytesManuel Alvarez-Dolado
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143-0520, USA
Nature 425:968-73. 2003..These observations provide the first in vivo evidence for cell fusion of BMDCs with neurons and cardiomyocytes, raising the possibility that cell fusion may contribute to the development or maintenance of these key cell types... - Developing cell transplantation for temporal lobe epilepsyR Mark Richardson
Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
Neurosurg Focus 24:E17. 2008..These issues are reviewed, with a focus on those factors most likely to influence clinically applicable results... - Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloningBernard Lo
Program in Medical Ethics, Department of Medicine, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
Cell Stem Cell 6:16-20. 2010..Professional standards and laws that ban human reproductive cloning by somatic cell nuclear transfer should be revised to also forbid it by other methods, such as iPSCs via tetraploid complementation... - Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zoneKazuhide Adachi
Department of Physiology, Keio University School of Medicine, Tokyo, Japan
Stem Cells 25:2827-36. 2007..These results suggest that beta-catenin signaling plays a role in the proliferation of progenitor cells in the SVZ of the adult mouse brain... - Maturation and death of adult-born olfactory bulb granule neurons: role of olfactionLeopoldo Petreanu
The Rockefeller University, New York, New York 10021, USA
J Neurosci 22:6106-13. 2002..This selection mechanism might allow the construction of specific OB circuits based on olfactory experience and suggests possible functions of OB cell replacement... - Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cellsNoritaka Masahira
Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8787, Japan
Dev Biol 293:358-69. 2006..These findings demonstrate that motoneurons and oligodendrocytes are not the only cell types originating from this domain... - Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesisFiona Doetsch
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 22:2255-64. 2002..We conclude that cell-cycle regulation of SVZ adult progenitors is remarkably cell-type specific, with p27Kip1 being a key regulator of the cell division of the transit-amplifying progenitors... - EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cellsFiona Doetsch
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Neuron 36:1021-34. 2002..Furthermore, purified C cells are 53-fold enriched for neurosphere generation. We conclude that transit-amplifying cells retain stem cell competence under the influence of growth factors... - Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brainErik M Shapiro
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Neuroimage 32:1150-7. 2006..This work demonstrates that in vivo cell labeling of progenitor cells for MRI is possible and enables the serial, non-invasive visualization of endogenous progenitor/precursor cell migration... - Origin and function of olfactory bulb interneuron diversityPierre Marie Lledo
Laboratory of Perception and Memory, Pasteur Institute, CNRS URA 2182, Paris Cedex, France
Trends Neurosci 31:392-400. 2008..The mosaic organization of the SVZ offers a unique opportunity to understand the origin of interneuron diversity and how this assortment of neurons contributes to plasticity of postnatal olfactory circuits... - Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastomaUlrich Schüller
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 14:123-34. 2008..Thus, oncogenic Hh signaling promotes medulloblastoma from lineage-restricted granule cell progenitors... - Becoming a new neuron in the adult olfactory bulbAlan Carleton
Pasteur Institute, Laboratory of Perception and Memory, CNRS UMR 2182, 25 rue du Dr Roux, 75015 Paris, France
Nat Neurosci 6:507-18. 2003..Our results show that newly born cells recruited into the olfactory bulb become neurons, and a unique sequence of events leads to their functional integration... - Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodentsAngela Gritti
Institute for Stem Cell Research, Department of Biotechnology, San Raffaele Hospital, 20132 Milan, Italy
J Neurosci 22:437-45. 2002..These findings demonstrate that stem cells are not confined to the forebrain periventricular region and indicate that stem cells endowed with different functional characteristics occur at different levels of the SVZ-RE pathway... - Telomerase activity in the subventricular zone of adult miceGregg L Caporaso
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Mol Cell Neurosci 23:693-702. 2003..We conclude that telomerase is active in neural precursor cells of the adult mouse and suggest that its regulation is an important parameter for cellular proliferation to occur in the mammalian brain... - Sonic hedgehog controls stem cell behavior in the postnatal and adult brainVeronica Palma
The Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
Development 132:335-44. 2005.... - Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortexHynek Wichterle
The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 100:727-32. 2003..In addition, we propose that chemotactic guidance cues superimposed over the permissive corridor facilitate efficient dorsal migration of MGE cells...