L Altshuler

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The impact of antidepressant discontinuation versus antidepressant continuation on 1-year risk for relapse of bipolar depression: a retrospective chart review
    L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    J Clin Psychiatry 62:612-6. 2001
  2. ncbi request reprint Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study
    Lori L Altshuler
    Department of Psychiatry, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    J Clin Psychiatry 70:450-7. 2009
  3. pmc Regional brain changes in bipolar I depression: a functional magnetic resonance imaging study
    Lori Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    Bipolar Disord 10:708-17. 2008
  4. doi request reprint The Pregnancy Depression Scale (PDS): a screening tool for depression in pregnancy
    Lori L Altshuler
    Mood Disorders Research Program, Department of Psychiatry and Biobehavioral Sciences, University of California, PO Box 957057, Los Angeles, CA 90095 7057, USA
    Arch Womens Ment Health 11:277-85. 2008
  5. ncbi request reprint Increased amygdala activation during mania: a functional magnetic resonance imaging study
    Lori Altshuler
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095 7057, USA
    Am J Psychiatry 162:1211-3. 2005
  6. ncbi request reprint Executive function and employment status among veterans with bipolar disorder
    Lori Altshuler
    Department of Psychiatry, West Los Angeles Healthcare Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, University of California, CA 90095 7057, USA
    Psychiatr Serv 58:1441-7. 2007
  7. ncbi request reprint The Life Functioning Questionnaire (LFQ): a brief, gender-neutral scale assessing functional outcome
    Lori Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, 300 UCLA Medical Plaza, Mood Disorders Research Program, Los Angeles 90095, USA
    Psychiatry Res 112:161-82. 2002
  8. ncbi request reprint Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study
    Lori L Altshuler
    Department of Psychiatry, Los Angeles, California, USA
    Biol Psychiatry 58:763-9. 2005
  9. ncbi request reprint A relationship between neurocognitive impairment and functional impairment in bipolar disorder: a pilot study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Medical Center, Los Angeles, CA, USA
    Psychiatry Res 157:289-93. 2008
  10. ncbi request reprint Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants
    Lori L Altshuler
    Dept of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095 7057
    Am J Psychiatry 163:313-5. 2006

Research Grants

  1. RELAPSE AND PREDICTORS OF DEPRESSION IN PREGNANCY
    Lori Altshuler; Fiscal Year: 1999
  2. Bipolar II Depression: Lithium, SSRI or the Combination
    Lori Altshuler; Fiscal Year: 2006
  3. Risk and Predictors of Postpartum Depression
    Lori Altshuler; Fiscal Year: 2007
  4. Bipolar II Depression: Lithium, SSRI or the Combination
    Lori Altshuler; Fiscal Year: 2007
  5. Mapping Brain Structure to Function in Bipolar Disorder
    Lori Altshuler; Fiscal Year: 2007
  6. FMRI IN BIPOLAR ILLNESS
    Lori Altshuler; Fiscal Year: 2007
  7. Bipolar II Depression: Lithium, SSRI or the Combination
    Lori Altshuler; Fiscal Year: 2008
  8. FMRI IN BIPOLAR ILLNESS
    Lori Altshuler; Fiscal Year: 2008
  9. Bipolar II Depression: Lithium, SSRI or the Combination
    Lori Altshuler; Fiscal Year: 2009
  10. Mapping Brain Structure to Function in Euthymic Subjects with Bipolar Disorder
    Lori Altshuler; Fiscal Year: 2009

Collaborators

Detail Information

Publications85

  1. ncbi request reprint The impact of antidepressant discontinuation versus antidepressant continuation on 1-year risk for relapse of bipolar depression: a retrospective chart review
    L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    J Clin Psychiatry 62:612-6. 2001
    ....
  2. ncbi request reprint Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study
    Lori L Altshuler
    Department of Psychiatry, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    J Clin Psychiatry 70:450-7. 2009
    ..To assess long-term outcome in bipolar disorder, subjects were prospectively followed after receiving acute treatment for bipolar depression...
  3. pmc Regional brain changes in bipolar I depression: a functional magnetic resonance imaging study
    Lori Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    Bipolar Disord 10:708-17. 2008
    ..To investigate neural activity in prefrontal cortex and amygdala during bipolar depression...
  4. doi request reprint The Pregnancy Depression Scale (PDS): a screening tool for depression in pregnancy
    Lori L Altshuler
    Mood Disorders Research Program, Department of Psychiatry and Biobehavioral Sciences, University of California, PO Box 957057, Los Angeles, CA 90095 7057, USA
    Arch Womens Ment Health 11:277-85. 2008
    ..We present a well-validated, brief scale to screen pregnant women for clinical depression. Whether this study will generalize to women who do not have a history of major depression remains to be studied...
  5. ncbi request reprint Increased amygdala activation during mania: a functional magnetic resonance imaging study
    Lori Altshuler
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095 7057, USA
    Am J Psychiatry 162:1211-3. 2005
    ..This study sought to investigate neural activity in the amygdala during episodes of mania...
  6. ncbi request reprint Executive function and employment status among veterans with bipolar disorder
    Lori Altshuler
    Department of Psychiatry, West Los Angeles Healthcare Center, Department of Veterans Affairs Greater Los Angeles Healthcare System, University of California, CA 90095 7057, USA
    Psychiatr Serv 58:1441-7. 2007
    ....
  7. ncbi request reprint The Life Functioning Questionnaire (LFQ): a brief, gender-neutral scale assessing functional outcome
    Lori Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, 300 UCLA Medical Plaza, Mood Disorders Research Program, Los Angeles 90095, USA
    Psychiatry Res 112:161-82. 2002
    ..The LFQ provides a reliable, consistent and valid assessment of function at work and home in both male and female patients with a mood disorder...
  8. ncbi request reprint Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study
    Lori L Altshuler
    Department of Psychiatry, Los Angeles, California, USA
    Biol Psychiatry 58:763-9. 2005
    ..Specifically, we sought to evaluate activation in the lateral orbitofrontal cortex, a brain region that is normally activated during activities that require response inhibition...
  9. ncbi request reprint A relationship between neurocognitive impairment and functional impairment in bipolar disorder: a pilot study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Medical Center, Los Angeles, CA, USA
    Psychiatry Res 157:289-93. 2008
    ..Poor verbal memory and executive function were associated with functional impairment, suggesting that functional disability may be restricted to a subgroup of cognitively impaired bipolar patients...
  10. ncbi request reprint Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants
    Lori L Altshuler
    Dept of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095 7057
    Am J Psychiatry 163:313-5. 2006
    ..The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder...
  11. ncbi request reprint Neurocognitive function in clinically stable men with bipolar I disorder or schizophrenia and normal control subjects
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 56:560-9. 2004
    ..The degree and pattern of impairment between psychiatric groups have rarely been compared, especially when subjects are psychiatrically stable...
  12. ncbi request reprint Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up
    Lori Altshuler
    Stanley Bipolar Treatment Network, USA
    Am J Psychiatry 160:1252-62. 2003
    ..This study examined the effect of antidepressant discontinuation or continuation on depressive relapse risk among bipolar subjects successfully treated for an acute depressive episode...
  13. ncbi request reprint Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder
    Lori L Altshuler
    VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Bipolar Disord 12:541-9. 2010
    ..Specifically, it is not known whether differences in the density and/or volume of neurons or glial cells contribute to tissue volume changes seen on magnetic resonance images...
  14. ncbi request reprint Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute of Neuroscience and Human Behavior, UCLA, USA
    Am J Psychiatry 167:708-15. 2010
    ..The authors assessed gender differences in the proportion of clinical visits spent depressed, manic, or euthymic in patients with bipolar disorder...
  15. ncbi request reprint Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  16. ncbi request reprint Does thyroid supplementation accelerate tricyclic antidepressant response? A review and meta-analysis of the literature
    L L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, USA
    Am J Psychiatry 158:1617-22. 2001
    ....
  17. ncbi request reprint Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study
    W G van Gorp
    Department of Psychiatry, Cornell University Medical College, White Plains, NY, USA
    Arch Gen Psychiatry 55:41-6. 1998
    ..Few studies of the neurocognitive performance of patients with bipolar disorder have been performed while patients are in the euthymic state...
  18. ncbi request reprint Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder
    S L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Am J Psychiatry 158:420-6. 2001
    ..Therefore, the authors assessed comorbid lifetime and current axis I disorders in 288 patients with bipolar disorder and the relationships of these comorbid disorders to selected demographic and historical illness variables...
  19. ncbi request reprint Antidepressant medications, mood and male fertility
    V Hendrick
    UCLA Neuropsychiatric Institute and Hospital 90095, USA
    Psychoneuroendocrinology 25:37-51. 2000
    ....
  20. ncbi request reprint Predictors of work adjustment in bipolar I patients: a naturalistic longitudinal follow-up
    C Hammen
    Department of Psychology, UCLA 90095, USA
    J Consult Clin Psychol 68:220-5. 2000
    ..The results highlight the need to study functional outcomes in patients, especially because they appear only modestly associated with clinical status...
  21. ncbi request reprint Efficacy of lithium vs. valproate in the treatment of mania in the elderly: a retrospective study
    S T Chen
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine, USA
    J Clin Psychiatry 60:181-6. 1999
    ..This retrospective study was conducted to assess the efficacy of lithium and valproate and associated serum levels in the treatment of mania in elderly patients...
  22. ncbi request reprint Reliability of medial temporal lobe volume measurements using reformatted 3D images
    G Bartzokis
    West Los Angeles VA Medical Center, Research Service, CA 90073, USA
    Psychiatry Res 82:11-24. 1998
    ..Image contrast is an additional important factor since the reformatted T1 weighted images used in this study, which have suboptimal CSF/brain contrast, worsened measurement accuracy in the temporal horn...
  23. ncbi request reprint Efficacy and response time to sertraline versus fluoxetine in the treatment of unipolar major depressive disorder
    R A Suri
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, USA
    J Clin Psychiatry 61:942-6. 2000
    ..Few studies have compared the treatment efficacy of the 2 selective serotonin reuptake inhibitors sertraline and fluoxetine...
  24. ncbi request reprint Enabling the diagnosis of occult psychiatric illness in the emergency department: a randomized, controlled trial of the computerized, self-administered PRIME-MD diagnostic system
    D L Schriger
    University of California Los Angeles Emergency Medical Center, Department of Psychiatry, and School of Medicine, Los Angeles, CA, USA
    Ann Emerg Med 37:132-40. 2001
    ....
  25. ncbi request reprint Gabapentin in the acute treatment of refractory bipolar disorder
    L L Altshuler
    UCLA Mood Disorders Research Program, UCLA Medical Plaza, CA 90095 7057, USA
    Bipolar Disord 1:61-5. 1999
    ..We systematically assessed the response rate in bipolar patients being treated adjunctively with gabapentin for manic symptoms, depressive symptoms, or rapid cycling not responsive to standard treatments...
  26. ncbi request reprint The impact of depression and fluoxetine treatment on obstetrical outcome
    R Suri
    Department of Psychiatry, UCLA Neuropsychiatric Institute and Hospital, Los Angeles, CA, U S A
    Arch Womens Ment Health 7:193-200. 2004
    ..This study prospectively followed women over the course of pregnancy to assess the impact of depression and/or antidepressant treatment on obstetrical outcome...
  27. ncbi request reprint Use of sertraline, paroxetine and fluvoxamine by nursing women
    V Hendrick
    Department of Psychiatry, UCLA Neuropsychiatric Institute and Hospital, Los Angeles, California 90095, USA
    Br J Psychiatry 179:163-6. 2001
    ..No adverse sequelae occurred in any infant. CONCLUSIONS: This study shows that paroxetine, fluvoxamine and sertraline produce minimal exposure to infants when taken by nursing mothers...
  28. ncbi request reprint MRI-based measurements of temporal lobe and ventricular structures in patients with bipolar I and bipolar II disorders
    P Hauser
    Department of Psychiatry, University of Maryland Medical Center and Psychiatry Service, Baltimore VA Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA
    J Affect Disord 60:25-32. 2000
    ..Also there have been no quantitative MRI studies of bipolar II patients. The present study measured temporal lobe and ventricular structures in both bipolar I and bipolar II patients, as well as control subjects...
  29. ncbi request reprint The use of psychotropic medications during breast-feeding
    V K Burt
    Women's Life Center, UCLA Neuropsychiatric Institute and Hospital, Los Angeles, CA 90095-6968, USA
    Am J Psychiatry 158:1001-9. 2001
    ..In this way, an informed decision can be made. When psychotropic medication is used during breast-feeding, it is strongly recommended that the infant's pediatrician be involved in monitoring the infant...
  30. ncbi request reprint Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression
    M Bauer
    Neuropsychiatric Institute and Hospital, University of California Los Angeles, CA, USA
    Mol Psychiatry 10:456-69. 2005
    ..We conclude that bipolar depressed patients have abnormal function in prefrontal and limbic brain areas. L-T(4) may improve mood by affecting circuits involving these areas, which have been previously implicated in affective disorders...
  31. ncbi request reprint Relapse of depression during pregnancy following antidepressant discontinuation: a preliminary prospective study
    L S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Womens Ment Health 7:217-21. 2004
    ..Pregnancy has frequently been referred to as a time of emotional well-being for patients. However, systematic data about the risk for relapse of depression during pregnancy are sparse...
  32. ncbi request reprint Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk
    V Hendrick
    UCLA Neuropsychiatric Institute and Hospital, Los Angeles, California 90095, USA
    Biol Psychiatry 50:775-82. 2001
    ..In nursing women taking 20 mg/day or less of fluoxetine, infant serum concentrations were typically low...
  33. ncbi request reprint Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
    JAMA 295:499-507. 2006
    ..However, systematic delineation of risk of relapse in women who maintain or discontinue pharmacological treatment during pregnancy is necessary...
  34. ncbi request reprint Brain ferritin iron may influence age- and gender-related risks of neurodegeneration
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Aging 28:414-23. 2007
    ..We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases...
  35. ncbi request reprint Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  36. ncbi request reprint Estrogen and response to sertraline in postmenopausal women with major depressive disorder: a pilot study
    Natalie L Rasgon
    Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, 410 Quarry Road, Room 2368, Palo Alto, CA 94305 5723, USA
    J Psychiatr Res 41:338-43. 2007
    ..Pilot study examining the effects of estrogen therapy (ET) on antidepressant response in postmenopausal women with major depressive disorder (MDD)...
  37. ncbi request reprint Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  38. ncbi request reprint Longitudinal evaluation of reproductive function in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, 401 Quarry Road, Palo Alto, Ca 94305 5723 Stanford, California, United States
    J Affect Disord 89:217-25. 2005
    ..We assessed reproductive endocrine and metabolic markers in women treated for bipolar disorder over a 2-year time period, controlling for valproate use...
  39. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  40. ncbi request reprint Atypical antipsychotics in the treatment of schizophrenia during pregnancy and the postpartum
    Deborah Yaeger
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA 90073, USA
    Am J Psychiatry 163:2064-70. 2006
  41. pmc Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium
    Lara C Foland
    Laboratory of Neuroimaging, Department of Neurology, University of California, UCLA School of Medicine, Los Angeles, California, USA
    Neuroreport 19:221-4. 2008
    ..Our findings may help to explain previous inconsistencies in the bipolar literature...
  42. pmc Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania
    Lara C Foland
    Laboratory of Neuroimaging, Department of Neurology, University of California, Los Angeles, CA, USA
    Psychiatry Res 162:27-37. 2008
    ..These findings, taken in context with previous fMRI studies of bipolar mania, suggest that reductions in inhibitory frontal activity in these patients may lead to an increased reactivity of the amygdala...
  43. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  44. ncbi request reprint Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
    ..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder...
  45. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
    ..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue...
  46. ncbi request reprint Modal subcomponents of metabolic syndrome in patients with bipolar disorder
    Jeffrey Cardenas
    Department of Psychiatry, UCLA Mood Disorders Research Program, David Geffen School of Medicine at UCLA, Los Angeles, United States
    J Affect Disord 106:91-7. 2008
    ..The metabolic syndrome is a growing global public health problem...
  47. ncbi request reprint A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:426-34. 2007
    ..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD...
  48. ncbi request reprint The poor prognosis of childhood-onset bipolar disorder
    Gabriele S Leverich
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Pediatr 150:485-90. 2007
    ..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness...
  49. pmc Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, United States
    Schizophr Res 93:13-22. 2007
    ..Atypical antipsychotics have been shown to have a wide spectrum of efficacy across multiple psychiatric diseases and to be particularly efficacious in treatment resistant cases of disorders such as schizophrenia...
  50. ncbi request reprint Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism
    Eric Levander
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    J Affect Disord 101:211-7. 2007
    ..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)...
  51. ncbi request reprint Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
    ..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole...
  52. ncbi request reprint New findings from the Bipolar Collaborative Network: clinical implications for therapeutics
    Robert M Post
    Penn State College of Medicine, Hershey, PA, USA
    Curr Psychiatry Rep 8:489-97. 2006
    ..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss...
  53. ncbi request reprint Free T4 index and clinical outcome in patients with depression
    Osama Abulseoud
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Affect Disord 100:271-7. 2007
    ..This study evaluated baseline thyroid function and its relationship to rapidity of treatment response as measured by hospital length of stay (HLOS)...
  54. ncbi request reprint Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence
    James W McKowen
    UCLA Mood Disorders Research Program, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7057, USA
    Bipolar Disord 7:377-81. 2005
    ..This report evaluates preliminary data of alcohol consumption patterns utilizing the Alcohol Timeline Followback (TLFB) method in actively drinking patients with bipolar disorder...
  55. ncbi request reprint The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9121, USA
    J Clin Psychiatry 66:870-86. 2005
    ..The guidelines for evaluating possible medications, the criteria for selection and ranking, and the updated algorithms are described...
  56. ncbi request reprint Placental passage of antidepressant medications
    Victoria Hendrick
    Mood Disorders Research Program, UCLA Neuropsychiatric Institute and Hospital, University of California Los Angeles, 300 Medical Plaza, Suite 2345, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:993-6. 2003
    ..This study determined the placental transfer of antidepressants and their metabolites...
  57. ncbi request reprint Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  58. ncbi request reprint Weight gain in breastfed infants of mothers taking antidepressant medications
    Victoria Hendrick
    Department of Psychiatry and Behavioral Sciences, UCLA Neuropsychiatric Institute and Hospital, Los Angeles, CA 90095, USA
    J Clin Psychiatry 64:410-2. 2003
    ..Little is known about the physical development of infants who are exposed to antidepressant medications through breast milk...
  59. ncbi request reprint Acceleration and augmentation strategies for treating bipolar depression
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA
    Biol Psychiatry 53:691-700. 2003
    ..This review will define three types of common combination strategies--adjunctive, acceleration and augmentation--and discuss the limited literature of controlled studies reported on acceleration and augmentation approaches...
  60. ncbi request reprint Treating acute mania
    Mark A Frye
    UCLA Bipolar Disorder Research Program, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, USA
    J Fam Pract . 2003
  61. ncbi request reprint Tiagabine in treatment refractory bipolar disorder: a clinical case series
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Bipolar Disord 4:283-9. 2002
    ..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments...
  62. ncbi request reprint Subsyndromal depression is associated with functional impairment in patients with bipolar disorder
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    J Clin Psychiatry 63:807-11. 2002
    ..The purpose of this study was to assess whether a relationship exists between mild depressive symptoms and overall functioning in subjects with bipolar disorder...
  63. ncbi request reprint Impact of axis II comorbidity on the course of bipolar illness in men: a retrospective chart review
    Joanne H Kay
    Greater Los Angeles VA Healthcare System, West Los Angeles VA Medical Center, Department of Psychiatry, Los Angeles, CA, USA
    Bipolar Disord 4:237-42. 2002
    ..The purpose of this study was to investigate whether the presence of comorbid personality disorder influences the course of bipolar illness...
  64. ncbi request reprint Olanzapine versus divalproex in the treatment of acute mania
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Am J Psychiatry 159:1011-7. 2002
    ..The effects of olanzapine and divalproex for the treatment of mania were compared in a large randomized clinical trial...
  65. ncbi request reprint Mania and attention deficit hyperactivity disorder in a prepubertal child: diagnostic and treatment challenges
    Rosanne C State
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Am J Psychiatry 159:918-25. 2002
  66. ncbi request reprint Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women
    Natalie L Rasgon
    Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, USA
    J Clin Psychiatry 63:45-8. 2002
    ..Fluctuating estrogen levels accompany the perimenopausal transition. Thus, estrogen replacement therapy (ERT) has been proposed as a potentially effective treatment for mood disorders occurring during perimenopause...
  67. ncbi request reprint The use of SSRIs in depressive disorders specific to women
    Lori L Altshuler
    Department of Psychiatry, UCLA Neuropsychiatric Institute and Hospital, Los Angeles, Calif, USA
    J Clin Psychiatry 63:3-8. 2002
  68. ncbi request reprint High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure
    Ralph W Kupka
    Altrecht Centre for Mental Health Care and University Medical Centre Utrecht, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands
    Biol Psychiatry 51:305-11. 2002
    ..We assessed the prevalence of thyroperoxidase antibodies (TPO-Abs) and thyroid failure in outpatients with bipolar disorder compared with two control groups...
  69. ncbi request reprint Depression in women with polycystic ovary syndrome: clinical and biochemical correlates
    Natalie L Rasgon
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Mood Disorders Research Program, 300 Medical Plaza, Suite 1544, Los Angeles, CA 90095 7057, USA
    J Affect Disord 74:299-304. 2003
    ..We assessed the prevalence of mood disturbance among women with prospectively documented polycystic ovary syndrome (PCOS)...
  70. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  71. ncbi request reprint Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  72. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...
  73. ncbi request reprint Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  74. ncbi request reprint Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depression
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:611-6. 2005
    ..These subanalyses compare treatment-emergent mania rates in bipolar I depressed patients treated with olanzapine, placebo, or olanzapine/fluoxetine combination...
  75. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  76. pmc Peripheral thyroid hormones and response to selective serotonin reuptake inhibitors
    Michael Gitlin
    Department of Psychiatry, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Psychiatry Neurosci 29:383-6. 2004
    ..To examine the relation between baseline measurements of thyroid function and response to selective serotonin reuptake inhibitors (SSRIs) and to consider the effect of these antidepressants on thyroid hormone levels...
  77. ncbi request reprint Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania
    Rosanne C State
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, Calif, USA
    J Clin Psychiatry 65:1057-63. 2004
    ..This study was conducted to evaluate comparative response rates to lithium and divalproex sodium in adolescent mania with and without this comorbidity...
  78. ncbi request reprint Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network
    Willem A Nolen
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Psychiatry 161:1447-54. 2004
    ..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder...
  79. ncbi request reprint Unmet needs in bipolar depression
    Mark A Frye
    UCLA Bipolar Disorder Research Program, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Depress Anxiety 19:199-208. 2004
    ....
  80. ncbi request reprint Reintroduction of antidepressant therapy across pregnancy in women who previously discontinued treatment. A preliminary retrospective study
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychother Psychosom 73:255-8. 2004
    ..Pregnancy has frequently been described as a time of emotional well-being conferring 'protection' against psychiatric disorders. However, data to support this impression are sparse...
  81. ncbi request reprint Clinical and legal correlates of inmates with bipolar disorder at time of criminal arrest
    Cameron D Quanbeck
    Department of Psychiatry, Forensic Division, University of California Davis, 2230 Stockton Boulevard, Sacramento, CA 95817, USA
    J Clin Psychiatry 65:198-203. 2004
    ....
  82. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
    ..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
  83. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  84. ncbi request reprint Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Compr Psychiatry 44:263-9. 2003
    ..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort...
  85. ncbi request reprint Early physical and sexual abuse associated with an adverse course of bipolar illness
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892 1272, USA
    Biol Psychiatry 51:288-97. 2002
    ..There is growing awareness of the association between physical and sexual abuse and subsequent development of psychopathology, but little is known, however, about their relationship to the longitudinal course of bipolar disorder...

Research Grants24

  1. RELAPSE AND PREDICTORS OF DEPRESSION IN PREGNANCY
    Lori Altshuler; Fiscal Year: 1999
    ..Delineating of these subgroups provides an opportunity to screen for women "at risk" for relapse and allows for thoughtful treatment plan. ..
  2. Bipolar II Depression: Lithium, SSRI or the Combination
    Lori Altshuler; Fiscal Year: 2006
    ..We also hypothesize that the frequency of side effects will be significantly less in patients on SSRI monotherapy. Thus, secondary aims include assessment of patient satisfaction, which may affect compliance in the clinical setting. ..
  3. Risk and Predictors of Postpartum Depression
    Lori Altshuler; Fiscal Year: 2007
    ..AItshuler, Dr. Hendrick), and the Emory Women's Mental Health Program at Emory University School of Medicine (Dr. Stowe). ..
  4. Bipolar II Depression: Lithium, SSRI or the Combination
    Lori Altshuler; Fiscal Year: 2007
    ..We also hypothesize that the frequency of side effects will be significantly less in patients on SSRI monotherapy. Thus, secondary aims include assessment of patient satisfaction, which may affect compliance in the clinical setting. ..
  5. Mapping Brain Structure to Function in Bipolar Disorder
    Lori Altshuler; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. FMRI IN BIPOLAR ILLNESS
    Lori Altshuler; Fiscal Year: 2007
    ..S. population. The neurophysiologic basis of this disorder remains unknown. Elucidating the functional neuroanatomic underpinnings of this disorder is a critical first step in developing targeted treatment. ..
  7. Bipolar II Depression: Lithium, SSRI or the Combination
    Lori Altshuler; Fiscal Year: 2008
    ..We also hypothesize that the frequency of side effects will be significantly less in patients on SSRI monotherapy. Thus, secondary aims include assessment of patient satisfaction, which may affect compliance in the clinical setting. ..
  8. FMRI IN BIPOLAR ILLNESS
    Lori Altshuler; Fiscal Year: 2008
    ..S. population. The neurophysiologic basis of this disorder remains unknown. Elucidating the functional neuroanatomic underpinnings of this disorder is a critical first step in developing targeted treatment. ..
  9. Bipolar II Depression: Lithium, SSRI or the Combination
    Lori Altshuler; Fiscal Year: 2009
    ..We also hypothesize that the frequency of side effects will be significantly less in patients on SSRI monotherapy. Thus, secondary aims include assessment of patient satisfaction, which may affect compliance in the clinical setting. ..
  10. Mapping Brain Structure to Function in Euthymic Subjects with Bipolar Disorder
    Lori Altshuler; Fiscal Year: 2009
    ..We hope to clarify whether gray and/or white matter structural deficits are associated with the reduction in neural activity seen in fMRI and in turn clarify the neural/biologic underpinnings of bipolar disorder. ..
  11. Bipolar II Depression: Lithium, SSRI or the Combination
    Lori L Altshuler; Fiscal Year: 2010
    ..We also hypothesize that the frequency of side effects will be significantly less in patients on SSRI monotherapy. Thus, secondary aims include assessment of patient satisfaction, which may affect compliance in the clinical setting. ..
  12. Risk and Predictors of Postpartum Depression
    Lori Altshuler; Fiscal Year: 2006
    ..AItshuler, Dr. Hendrick), and the Emory Women's Mental Health Program at Emory University School of Medicine (Dr. Stowe). ..
  13. Risk and Predictors of Postpartum Depression
    Lori Altshuler; Fiscal Year: 2005
    ..Cohen, Nonacs and Otto), the Women's Life Center and Mood Disorders Research Program at UCLA (Dr. AItshuler, Dr. Hendrick), and the Emory Women's Mental Health Program at Emory University School of Medicine (Dr. Stowe). ..
  14. DETERMINANTS OF FUNCTIONAL RECOVERY IN BIPOLAR ILLNESS
    Lori Altshuler; Fiscal Year: 2000
    ..abstract_text> ..
  15. RELAPSE AND PREDICTORS OF DEPRESSION IN PREGNANCY
    Lori Altshuler; Fiscal Year: 2000
    ..Delineating of these subgroups provides an opportunity to screen for women "at risk" for relapse and allows for thoughtful treatment plan. ..
  16. RELAPSE AND PREDICTORS OF DEPRESSION IN PREGNANCY
    Lori Altshuler; Fiscal Year: 2001
    ..Delineating of these subgroups provides an opportunity to screen for women "at risk" for relapse and allows for thoughtful treatment plan. ..
  17. DETERMINANTS OF FUNCTIONAL RECOVERY IN BIPOLAR ILLNESS
    Lori Altshuler; Fiscal Year: 2001
    ..abstract_text> ..
  18. RELAPSE AND PREDICTORS OF DEPRESSION IN PREGNANCY
    Lori Altshuler; Fiscal Year: 2002
    ..Delineating of these subgroups provides an opportunity to screen for women "at risk" for relapse and allows for thoughtful treatment plan. ..
  19. DETERMINANTS OF FUNCTIONAL RECOVERY IN BIPOLAR ILLNESS
    Lori Altshuler; Fiscal Year: 2002
    ..abstract_text> ..
  20. Risk and Predictors of Postpartum Depression
    Lori Altshuler; Fiscal Year: 2003
    ..Cohen, Nonacs and Otto), the Women's Life Center and Mood Disorders Research Program at UCLA (Dr. AItshuler, Dr. Hendrick), and the Emory Women's Mental Health Program at Emory University School of Medicine (Dr. Stowe). ..
  21. RELAPSE AND PREDICTORS OF DEPRESSION IN PREGNANCY
    Lori Altshuler; Fiscal Year: 2003
    ..Delineating of these subgroups provides an opportunity to screen for women "at risk" for relapse and allows for thoughtful treatment plan. ..
  22. DETERMINANTS OF FUNCTIONAL RECOVERY IN BIPOLAR ILLNESS
    Lori Altshuler; Fiscal Year: 2003
    ..abstract_text> ..
  23. Risk and Predictors of Postpartum Depression
    Lori Altshuler; Fiscal Year: 2004
    ..Cohen, Nonacs and Otto), the Women's Life Center and Mood Disorders Research Program at UCLA (Dr. AItshuler, Dr. Hendrick), and the Emory Women's Mental Health Program at Emory University School of Medicine (Dr. Stowe). ..
  24. Mapping Brain Structure to Function in Euthymic Subjects with Bipolar Disorder
    Lori L Altshuler; Fiscal Year: 2010
    ..We hope to clarify whether gray and/or white matter structural deficits are associated with the reduction in neural activity seen in fMRI and in turn clarify the neural/biologic underpinnings of bipolar disorder. ..