WILLIAM ALTEMEIER

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Ischemia-reperfusion lung injury is attenuated in MyD88-deficient mice
    William A Altemeier
    Center for Lung Biology, University of Washington, Seattle, WA, United States of America Department of Medicine, University of Washington, Seattle, WA, United States of America
    PLoS ONE 8:e77123. 2013
  2. pmc Lipopolysaccharide-induced lung injury is independent of serum vitamin D concentration
    Lindy S Klaff
    Center for Lung Biology, Department of Medicine, University of Washington, Seattle, WA, USA
    PLoS ONE 7:e49076. 2012
  3. pmc Fas-deficient mice have impaired alveolar neutrophil recruitment and decreased expression of anti-KC autoantibody:KC complexes in a model of acute lung injury
    Sucheol Gil
    The Center for Lung Biology, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, 850 Republican Street, Box 351082, Seattle, WA 98109, USA
    Respir Res 13:91. 2012
  4. pmc Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction
    D Shane O'Mahony
    Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Crit Care 10:R136. 2006
  5. pmc Mechanical ventilation modulates Toll-like receptor-3-induced lung inflammation via a MyD88-dependent, TLR4-independent pathway: a controlled animal study
    Carrie D Chun
    Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    BMC Pulm Med 10:57. 2010
  6. ncbi request reprint Fas (CD95) induces macrophage proinflammatory chemokine production via a MyD88-dependent, caspase-independent pathway
    William A Altemeier
    Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98105 6522, USA
    J Leukoc Biol 82:721-8. 2007
  7. ncbi request reprint Hyperoxia in the intensive care unit: why more is not always better
    William A Altemeier
    Department of Medicine, University of Washington, Seattle, Washington 98195 6522, USA
    Curr Opin Crit Care 13:73-8. 2007
  8. ncbi request reprint Pseudomonal pericarditis complicating cystic fibrosis
    W A Altemeier
    Department of Medicine, University of Washington, Seattle, USA
    Pediatr Pulmonol 27:62-4. 1999
  9. ncbi request reprint Fractal nature of regional ventilation distribution
    W A Altemeier
    University of Washington, Seattle, Washington 98195 6522, USA
    J Appl Physiol (1985) 88:1551-7. 2000
  10. ncbi request reprint Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin
    William A Altemeier
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle 98195 6522, USA
    Am J Physiol Lung Cell Mol Physiol 287:L533-42. 2004

Collaborators

Detail Information

Publications20

  1. pmc Ischemia-reperfusion lung injury is attenuated in MyD88-deficient mice
    William A Altemeier
    Center for Lung Biology, University of Washington, Seattle, WA, United States of America Department of Medicine, University of Washington, Seattle, WA, United States of America
    PLoS ONE 8:e77123. 2013
    ..We conclude that MyD88-dependent signaling through multiple receptors is important in the pathogenesis of acute lung inflammation and injury following ischemia and reperfusion...
  2. pmc Lipopolysaccharide-induced lung injury is independent of serum vitamin D concentration
    Lindy S Klaff
    Center for Lung Biology, Department of Medicine, University of Washington, Seattle, WA, USA
    PLoS ONE 7:e49076. 2012
    ..Vitamin D deficiency modestly impairs neutrophil chemotaxis; however, it does not affect lung injury or its resolution in an LPS model of acute lung injury...
  3. pmc Fas-deficient mice have impaired alveolar neutrophil recruitment and decreased expression of anti-KC autoantibody:KC complexes in a model of acute lung injury
    Sucheol Gil
    The Center for Lung Biology, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, 850 Republican Street, Box 351082, Seattle, WA 98109, USA
    Respir Res 13:91. 2012
    ..In this study we test the hypothesis that a functioning Fas/FasL system is required for the development of lung injury in mechanically ventilated mice...
  4. pmc Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction
    D Shane O'Mahony
    Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Crit Care 10:R136. 2006
    ....
  5. pmc Mechanical ventilation modulates Toll-like receptor-3-induced lung inflammation via a MyD88-dependent, TLR4-independent pathway: a controlled animal study
    Carrie D Chun
    Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    BMC Pulm Med 10:57. 2010
    ....
  6. ncbi request reprint Fas (CD95) induces macrophage proinflammatory chemokine production via a MyD88-dependent, caspase-independent pathway
    William A Altemeier
    Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98105 6522, USA
    J Leukoc Biol 82:721-8. 2007
    ..Furthermore, Fas-induced chemokine release was not dependent on either IL-1 receptor signaling or on caspase activity. We conclude that MyD88 plays an integral role in Fas-induced macrophage-mediated inflammation...
  7. ncbi request reprint Hyperoxia in the intensive care unit: why more is not always better
    William A Altemeier
    Department of Medicine, University of Washington, Seattle, Washington 98195 6522, USA
    Curr Opin Crit Care 13:73-8. 2007
    ..This review identifies relevant new findings regarding hyperoxic lung injury in the context of providing guidance for future clinical studies...
  8. ncbi request reprint Pseudomonal pericarditis complicating cystic fibrosis
    W A Altemeier
    Department of Medicine, University of Washington, Seattle, USA
    Pediatr Pulmonol 27:62-4. 1999
    ..This is a previously unreported complication in cystic fibrosis prior to lung transplantation...
  9. ncbi request reprint Fractal nature of regional ventilation distribution
    W A Altemeier
    University of Washington, Seattle, Washington 98195 6522, USA
    J Appl Physiol (1985) 88:1551-7. 2000
    ..Efficient gas exchange is preserved, despite ventilation and perfusion heterogeneity, through close correlation. One potential explanation is the similar geometry of bronchial and vascular structures...
  10. ncbi request reprint Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin
    William A Altemeier
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle 98195 6522, USA
    Am J Physiol Lung Cell Mol Physiol 287:L533-42. 2004
    ..We conclude that moderate volume ventilation strategies augment the innate immune response to bacterial products in the lung and may play a role in the development of acute lung injury in patients with sepsis...
  11. ncbi request reprint Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation
    William A Altemeier
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle 98195 6522, USA
    J Immunol 175:3369-76. 2005
    ..We conclude that MV with conventional tidal volumes enhanced the transcriptional response to LPS and promoted development of ALI...
  12. ncbi request reprint Effect of posture on regional gas exchange in pigs
    William A Altemeier
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98195 6522, USA
    J Appl Physiol (1985) 97:2104-11. 2004
    ..These mismatched changes reduced alveolar oxygen tension primarily in the dorsocaudal lung region...
  13. pmc Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes
    Teal S Hallstrand
    Division of Pulmonary and Critical Care, Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e8583. 2010
    ..The objective of this study was to identify genes differentially expressed in EIB and to understand the function of these genes in the biology of asthma...
  14. pmc Positive end-expiratory pressure alters the severity and spatial heterogeneity of ventilator-induced lung injury: an argument for cyclical airway collapse
    Scott E Sinclair
    Department of Medicine, University of Tennessee, TN, USA
    J Crit Care 24:206-11. 2009
    ..We hypothesized that mechanical ventilation in the absence of positive end-expiratory pressure (PEEP) causes VILI to be more severe and regionally variable as compared with PEEP = 8 cm H(2)O...
  15. pmc Noninjurious mechanical ventilation activates a proinflammatory transcriptional program in the lung
    Sina A Gharib
    Center for Lung Biology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Physiol Genomics 37:239-48. 2009
    ....
  16. ncbi request reprint Computational identification of key biological modules and transcription factors in acute lung injury
    Sina A Gharib
    Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Respir Crit Care Med 173:653-8. 2006
    ..Mechanical ventilation augments the acute lung injury (ALI) caused by bacterial products. The molecular pathogenesis of this synergistic interaction remains incompletely understood...
  17. ncbi request reprint Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia
    Shireesha Dhanireddy
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98103, USA
    Lab Invest 86:790-9. 2006
    ....
  18. pmc PKR-dependent CHOP induction limits hyperoxia-induced lung injury
    Tricia I Lozon
    Center for Lung Biology, University of Washington, Seattle, USA
    Am J Physiol Lung Cell Mol Physiol 300:L422-9. 2011
    ..We conclude that hyperoxia increases CHOP expression via an ER stress-independent, PKR-dependent pathway and that increased CHOP expression protects against hyperoxia-induced lung injury...
  19. ncbi request reprint Typical symptons and atypical radiographic findings in a case of chronic eosinophilic pneumonia
    Andrew M Luks
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle 98195 6522, USA
    Respir Care 51:764-7. 2006
  20. ncbi request reprint Augmented lung injury due to interaction between hyperoxia and mechanical ventilation
    Scott E Sinclair
    Departments of Medicine and Physiology, University of Tennessee, Memphis, TN 38163, USA
    Crit Care Med 32:2496-501. 2004
    ..Mechanical overdistension and hyperoxia can independently cause lung injury, yet little is known about their combined effects. We hypothesized that hyperoxia exacerbates lung injury caused by large tidal volume ventilation...

Research Grants5

  1. Immunomodulatory Effects of Mechanical Ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2007
    ....
  2. Mechanisms of innate immune response modulation by mechanical ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2009
    ....
  3. Mechanisms of innate immune response modulation by mechanical ventilation
    William A Altemeier; Fiscal Year: 2010
    ..This project will help identify mechanisms by which mechanical ventilation support causes lung injury;thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
  4. Mechanisms of innate immune response modulation by mechanical ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2009
    ..This project will help identify mechanisms by which mechanical ventilation support causes lung injury; thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..