Richard R Almon

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Corticosteroid-regulated genes in rat kidney: mining time series array data
    Richard R Almon
    Dept of Biological Sciences, SUNY at Buffalo, Buffalo, NY 14260, USA
    Am J Physiol Endocrinol Metab 289:E870-82. 2005
  2. ncbi request reprint A microarray analysis of the temporal response of liver to methylprednisolone: a comparative analysis of two dosing regimens
    Richard R Almon
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York 14260, USA
    Endocrinology 148:2209-25. 2007
  3. pmc Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle
    Richard R Almon
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Endocrinol 184:219-32. 2005
  4. pmc The genomic response of skeletal muscle to methylprednisolone using microarrays: tailoring data mining to the structure of the pharmacogenomic time series
    Richard R Almon
    Department of Biological Sciences, SUNY at Buffalo, Buffalo, NY 14260, USA
    Pharmacogenomics 5:525-52. 2004
  5. ncbi request reprint Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: comparative analysis of two dosing regimens
    Richard R Almon
    Department of Pharmaceutical Sciences State University of New York at Buffalo, Buffalo, New York 14260, USA
    Physiol Genomics 30:282-99. 2007
  6. ncbi request reprint In vivo multi-tissue corticosteroid microarray time series available online at Public Expression Profile Resource (PEPR)
    Richard R Almon
    Department of Biological Sciences, SUNY at Buffalo, Buffalo, NY 14260, USA
    Pharmacogenomics 4:791-9. 2003
  7. ncbi request reprint Gene arrays and temporal patterns of drug response: corticosteroid effects on rat liver
    Richard R Almon
    Department of Biological Sciences, SUNY at Buffalo, 107 Hochstetter Hall, Buffalo, NY 14260, USA
    Funct Integr Genomics 3:171-9. 2003
  8. pmc Circadian variations in rat liver gene expression: relationships to drug actions
    Richard R Almon
    Department of Biological Sciences, 107 Hochstetter Hall, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Pharmacol Exp Ther 326:700-16. 2008
  9. ncbi request reprint Pharmacodynamics and pharmacogenomics of diverse receptor-mediated effects of methylprednisolone in rats using microarray analysis
    Richard R Almon
    Department of Biological Sciences, State University of New York at Buffalo, 14260, USA
    J Pharmacokinet Pharmacodyn 29:103-29. 2002
  10. ncbi request reprint Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats
    Richard R Almon
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York 14260, USA
    J Endocrinol 200:331-46. 2009

Collaborators

Detail Information

Publications53

  1. pmc Corticosteroid-regulated genes in rat kidney: mining time series array data
    Richard R Almon
    Dept of Biological Sciences, SUNY at Buffalo, Buffalo, NY 14260, USA
    Am J Physiol Endocrinol Metab 289:E870-82. 2005
    ..This dataset, as well as similar datasets on liver and muscle, are available online in a format amenable to further analysis by others...
  2. ncbi request reprint A microarray analysis of the temporal response of liver to methylprednisolone: a comparative analysis of two dosing regimens
    Richard R Almon
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York 14260, USA
    Endocrinology 148:2209-25. 2007
    ..Examination of temporal profiles demonstrates that current perspectives on the mechanism of glucocorticoid action cannot entirely explain the temporal profiles of these regulated genes...
  3. pmc Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle
    Richard R Almon
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Endocrinol 184:219-32. 2005
    ..The results demonstrate the polygenic nature of transcriptional changes associated with insulin resistance that can provide a temporal scaffolding for translational and post-translational data as they become available...
  4. pmc The genomic response of skeletal muscle to methylprednisolone using microarrays: tailoring data mining to the structure of the pharmacogenomic time series
    Richard R Almon
    Department of Biological Sciences, SUNY at Buffalo, Buffalo, NY 14260, USA
    Pharmacogenomics 5:525-52. 2004
    ....
  5. ncbi request reprint Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: comparative analysis of two dosing regimens
    Richard R Almon
    Department of Pharmaceutical Sciences State University of New York at Buffalo, Buffalo, New York 14260, USA
    Physiol Genomics 30:282-99. 2007
    ..However, many genes did not exhibit steroid tolerance, indicating that present perspectives on the mechanism of glucocorticoid action cannot entirely explain all temporal profiles...
  6. ncbi request reprint In vivo multi-tissue corticosteroid microarray time series available online at Public Expression Profile Resource (PEPR)
    Richard R Almon
    Department of Biological Sciences, SUNY at Buffalo, Buffalo, NY 14260, USA
    Pharmacogenomics 4:791-9. 2003
    ..Since the pharmacokinetic data and receptor model have been published, the results are amenable to PK/PD and pharmacogenomic evaluation...
  7. ncbi request reprint Gene arrays and temporal patterns of drug response: corticosteroid effects on rat liver
    Richard R Almon
    Department of Biological Sciences, SUNY at Buffalo, 107 Hochstetter Hall, Buffalo, NY 14260, USA
    Funct Integr Genomics 3:171-9. 2003
    ....
  8. pmc Circadian variations in rat liver gene expression: relationships to drug actions
    Richard R Almon
    Department of Biological Sciences, 107 Hochstetter Hall, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Pharmacol Exp Ther 326:700-16. 2008
    ..The expression levels of clock genes were also investigated in this study. Five clock genes exhibited circadian variation in the liver, and data suggest that these genes may also be regulated by corticosteroids...
  9. ncbi request reprint Pharmacodynamics and pharmacogenomics of diverse receptor-mediated effects of methylprednisolone in rats using microarray analysis
    Richard R Almon
    Department of Biological Sciences, State University of New York at Buffalo, 14260, USA
    J Pharmacokinet Pharmacodyn 29:103-29. 2002
    ..They also provide some insight into the advantages and limitations of microarray measurements in regard to the pharmacodynamics of drugs having complex, multi-faceted, and integrated mechanisms of action...
  10. ncbi request reprint Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats
    Richard R Almon
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York 14260, USA
    J Endocrinol 200:331-46. 2009
    ..In addition, the results suggest that chronic inflammation contributes significantly to the development of diabetes in the GK rats...
  11. pmc Pharmacogenomic responses of rat liver to methylprednisolone: an approach to mining a rich microarray time series
    Richard R Almon
    Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    AAPS J 7:E156-94. 2005
    ..Application of judiciously chosen filters is an effective tool for data mining of time series data sets. The remaining data can then be further analyzed by clustering and mathematical modeling techniques...
  12. pmc Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats
    Justin C Earp
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York 14260, USA
    J Pharmacol Exp Ther 326:532-45. 2008
    ..This small systems model integrates and quantitates multiple factors contributing to arthritis in rats...
  13. pmc Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle
    Richard R Almon
    Dept of Biological Sciences, State Univ of New York at Buffalo, Buffalo, NY 14260, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1031-47. 2008
    ..Examination of transcription factors involved in circadian control suggests that corticosterone may be the initiator of their rhythmic expression patterns in skeletal muscle...
  14. ncbi request reprint Application of scaling factors in simultaneous modeling of microarray data from diverse chips
    Zhenling Yao
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 565 Hochstetter Hall, Buffalo, NY 14260, USA
    Pharm Res 24:643-9. 2007
    ..However, differences in intensities of signals for different probe sets that represent the same gene on various types of Affymetrix chips make comparison of datasets complicated...
  15. ncbi request reprint Pharmacokinetics of methylprednisolone after intravenous and intramuscular administration in rats
    Anasuya Hazra
    Department of Pharmaceutical Sciences, University at Buffalo, State University of NY, Buffalo, NY 14260, USA
    Biopharm Drug Dispos 28:263-73. 2007
    ..m. and i.v. response profiles. The more convenient intramuscular dosing can replace the i.v. route without causing marked differences in pharmacodynamics...
  16. ncbi request reprint Modeling circadian rhythms of glucocorticoid receptor and glutamine synthetase expression in rat skeletal muscle
    Zhenling Yao
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, 565 Hochstetter Hall, Buffalo, New York 14260, USA
    Pharm Res 23:670-9. 2006
    ..This study examined changes in glucocorticoid receptor (GR) and glutamine synthetase (GS) expression in rat skeletal muscle in relation to plasma CS over a 24-h period...
  17. ncbi request reprint Assessing the dynamics of nuclear glucocorticoid-receptor complex: adding flexibility to gene expression modeling
    Anasuya Hazra
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, 565 Hochstetter Hall, Buffalo, NY 14260, USA
    J Pharmacokinet Pharmacodyn 34:333-54. 2007
    ..This more mechanistic model of GR dynamics can be applied to characterize profiles for a greater number of genes in liver...
  18. ncbi request reprint Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats
    Rohini Ramakrishnan
    Department of Pharmaceutical Sciences, 565 Hochstetter Hall, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Pharmacokinet Pharmacodyn 29:1-24. 2002
    ..The extent and duration of steroid exposure play a critical role in mediating steroid effects and advanced PK/PD models provide unique insights into controlling factors...
  19. doi request reprint Mathematical modeling of corticosteroid pharmacogenomics in rat muscle following acute and chronic methylprednisolone dosing
    Zhenling Yao
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York 14260, USA
    Mol Pharm 5:328-39. 2008
    ..Pharmacokinetic/pharmacodynamic (PK/PD) modeling provides a quantitative tool for elucidating the complexities of CS pharmacogenomics in skeletal muscle...
  20. pmc Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action
    Siddharth Sukumaran
    Dept of Biological Sciences, 107 Hochstetter Hall, State Univ of New York at Buffalo, Buffalo, NY 14260, USA
    J Appl Physiol (1985) 110:1732-47. 2011
    ....
  21. ncbi request reprint Modeling of corticosteroid pharmacogenomics in rat liver using gene microarrays
    Jin Y Jin
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, 565 Hochstetter Hall, State University of New York at Buffalo, 14260, USA
    J Pharmacol Exp Ther 307:93-109. 2003
    ..These PK/PD models provide quantitation of CS pharmacogenomics and new hypotheses regarding understanding of diverse mechanisms of CS receptor-gene mediated action...
  22. pmc Pharmacokinetic/pharmacodynamic modeling of corticosterone suppression and lymphocytopenia by methylprednisolone in rats
    Zhenling Yao
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 565 Hochstetter Hall, Buffalo, NY 14260, USA
    J Pharm Sci 97:2820-32. 2008
    ..Rats and humans differ in lymphocyte responses with humans showing full recovery of baselines. Modeling provides a valuable tool in quantitative assessment of dual, complex drug responses...
  23. pmc Differential muscle gene expression as a function of disease progression in Goto-Kakizaki diabetic rats
    Jing Nie
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    Mol Cell Endocrinol 338:10-7. 2011
    ..Furthermore, we demonstrate here the presence of chronic inflammation evident both systemically and in the musculature, despite the absence of obesity...
  24. pmc Adipose tissue deficiency and chronic inflammation in diabetic Goto-Kakizaki rats
    Bai Xue
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York, United States of America
    PLoS ONE 6:e17386. 2011
    ..This study demonstrates an age specific failure to accumulate adipose tissue in the GK rat and the presence of chronic inflammation in adipose tissue from these animals...
  25. pmc Evidence for a glucocorticoid receptor beta splice variant in the rat and its physiological regulation in liver
    Debra C Dubois
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    Steroids 78:312-20. 2013
    ..A modest up-regulation in GRβ expression was observed only in animals having chronically elevated plasma insulin concentrations. However the expression of GRβ was significantly lower than that of GRα in all cases...
  26. ncbi request reprint Modeling receptor/gene-mediated effects of corticosteroids on hepatic tyrosine aminotransferase dynamics in rats: dual regulation by endogenous and exogenous corticosteroids
    Anasuya Hazra
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Pharmacokinet Pharmacodyn 34:643-67. 2007
    ....
  27. ncbi request reprint Modeling of corticosteroid effects on hepatic low-density lipoprotein receptors and plasma lipid dynamics in rats
    Anasuya Hazra
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, 565 Hochstetter Hall, State University of New York at Buffalo, Buffalo, New York, 14260, USA
    Pharm Res 25:769-80. 2008
    ..This study examines methylprednisolone (MPL) effects on the dynamics of hepatic low-density lipoprotein receptor (LDLR) mRNA and plasma lipids associated with increased risks for atherosclerosis...
  28. pmc Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology
    Siddharth Sukumaran
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    Physiol Genomics 42:141-52. 2010
    ....
  29. pmc Mechanistic modeling of the effects of glucocorticoids and circadian rhythms on adipokine expression
    Siddharth Sukumaran
    Department of Biological Sciences, State University of New York, Buffalo, NY 14260, USA
    J Pharmacol Exp Ther 337:734-46. 2011
    ..This small systems model quantitatively describes, integrates, and provides additional insights into various factors controlling adipokine gene expression...
  30. ncbi request reprint Modeling glucocorticoid-mediated fetal lung maturation: I. Temporal patterns of corticosteroids in rat pregnancy
    Mahesh N Samtani
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 14260, USA
    J Pharmacol Exp Ther 317:117-26. 2006
    ..These temporal steroid profiles in the fetal circulation will be used to drive the PD effects reported in a companion paper and an optimal steroid regimen will be proposed...
  31. pmc Pharmacokinetics, pharmacodynamics and toxicities of methotrexate in healthy and collagen-induced arthritic rats
    Dong Yang Liu
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA
    Biopharm Drug Dispos 34:203-14. 2013
    ..16) but sensitive (IC(50d) = 0.712 nm) effectiveness on paw edema. The higher dose produced toxicity. The proposed model offers improved understanding of the effects of methotrexate on rheumatoid arthritis...
  32. pmc Population pharmacokinetic-pharmacodynamic-disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis
    Dongyang Liu
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14260, USA
    J Pharmacokinet Pharmacodyn 38:769-86. 2011
    ..Anakinra has modest effects (I ( max ) = 0.28) on paw edema in CIA rats. The profiles are well-described by our PK/PD/DIS model which provides a basis for future mechanism-based assessment of anakinra dynamics in rheumatoid arthritis...
  33. pmc Modeling corticosteroid effects in a rat model of rheumatoid arthritis II: mechanistic pharmacodynamic model for dexamethasone effects in Lewis rats with collagen-induced arthritis
    Justin C Earp
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York 14260, USA
    J Pharmacol Exp Ther 326:546-54. 2008
    ..TNF-alpha seemed to primarily influence edema, whereas IL-6 contributed the most to bone loss. Lower doses of corticosteroids may be sufficient to suppress the cytokines most relevant to bone erosion...
  34. ncbi request reprint Receptor/gene-mediated pharmacodynamic effects of methylprednisolone on phosphoenolpyruvate carboxykinase regulation in rat liver
    Jin Y Jin
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA
    J Pharmacol Exp Ther 309:328-39. 2004
    ..The model provides quantitation of multiple controlling factors regulating PEPCK and presents insights into its function in glucose metabolism...
  35. pmc Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats
    Jing Fang
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Pharmacokinet Pharmacodyn 38:293-316. 2011
    ..These mechanism-based PD models provide further insights into the multi-factor control of this essential metabolic system...
  36. pmc Glucocorticoid effects on adiponectin expression
    Siddharth Sukumaran
    Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, USA
    Vitam Horm 90:163-86. 2012
    ..In addition, methods to gain better insights pertaining to the regulation of adiponectin expression are discussed...
  37. pmc Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats
    Yanguang Cao
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    Biopharm Drug Dispos 33:285-91. 2012
    ..Such CL/F decreased with age in both diabetic and normal rats. The effect of diabetes on SA pharmacokinetics may necessitate increased dosing in the future usage of SS in diabetes...
  38. pmc Quantitative dynamic models of arthritis progression in the rat
    Justin C Earp
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, SUNY, 565 Hochstetter Hall, Buffalo, New York 14260, USA
    Pharm Res 26:196-203. 2009
    ..This comparison employs mathematical disease progression models to identify a rat model of arthritis with the least inter-animal variability and features lending to better study designs...
  39. ncbi request reprint Pharmacodynamics and pharmacogenomics of methylprednisolone during 7-day infusions in rats
    Rohini Ramakrishnan
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 14260, USA
    J Pharmacol Exp Ther 300:245-56. 2002
    ..Our results exemplify the importance of biological signal transduction variables in controlling receptor/gene-mediated steroid responses during chronic dosing...
  40. pmc Pharmacokinetic/pharmacodynamic modeling of methylprednisolone effects on iNOS mRNA expression and nitric oxide during LPS-induced inflammation in rats
    Siddharth Sukumaran
    Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 565 Hochstetter Hall, Buffalo, New York 14260, USA
    Pharm Res 29:2060-9. 2012
    ..We assess the effects of methylprednisolone (MPL) on these processes during endotoxin-induced acute inflammation and provide a mechanism-based model to quantitatively describe them...
  41. doi request reprint Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats
    Cornelia B Landersdorfer
    Department of Pharmaceutical Sciences, State University of New York, Buffalo, New York 14260, USA
    J Pharmacol Exp Ther 328:644-51. 2009
    ..Our mechanism-based model explains intrinsic reasons for differences in growth, food intake, and leptin concentrations among these two strains of rats...
  42. pmc Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action
    Siddharth Sukumaran
    Department of Biological Sciences, State University of New York at Buffalo, 14260, United States
    Adv Drug Deliv Rev 62:904-17. 2010
    ..Understanding the regulation of circadian rhythms in gene expression plays an important role in both optimizing the dosing time for existing drugs and in the development of new therapeutics targeting the molecular clock...
  43. pmc Effects of high fat feeding on liver gene expression in diabetic goto-kakizaki rats
    Richard R Almon
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY, USA Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA New York State Center of Excellence in Bioinformatics and Life Sciences
    Gene Regul Syst Bio 6:151-68. 2012
    ..In addition, compensatory mechanisms by which WKY animals on HFD resisted the development of diabetes were identified, thus illustrating the complexity of diabetes disease progression...
  44. pmc Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats
    Yanguang Cao
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York, Buffalo, NY 14260, USA
    J Pharmacol Exp Ther 339:896-904. 2011
    ..Modeling results suggest that salsalate reduces weight gain by enhancing metabolic rate and energy expenditure in both GK and Wister-Kyoto rats...
  45. pmc Mechanism-based disease progression modeling of type 2 diabetes in Goto-Kakizaki rats
    Wei Gao
    Department of Pharmaceutical Sciences, State University of New York, 565 Hochstetter Hall, Buffalo, NY, USA
    J Pharmacokinet Pharmacodyn 38:143-62. 2011
    ..The model could be extended to incorporate other biomarkers and effects of various anti-diabetic drugs...
  46. pmc Meta-modeling of methylprednisolone effects on glucose regulation in rats
    Jing Fang
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, United States of America
    PLoS ONE 8:e81679. 2013
    ..This advanced mechanistic model provides unique insights into the contributions of major tissues and quantitative hypotheses for the multi-factor control of a complex metabolic system. ..
  47. ncbi request reprint Modeling glucocorticoid-mediated fetal lung maturation: II. Temporal patterns of gene expression in fetal rat lung
    Mahesh N Samtani
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 14260, USA
    J Pharmacol Exp Ther 317:127-38. 2006
    ..The simulations illustrate that administering smaller quantities of steroids over extended periods that produce sustained steroid exposure might be the optimal approach for designing dose-sparing antenatal corticosteroid therapy...
  48. pmc Mechanistic population modeling of diabetes disease progression in Goto-Kakizaki rat muscle
    Jing Nie
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    Biopharm Drug Dispos 32:50-63. 2011
    ..19-fold. The model indicated that corticosterone had a moderate effect and PDK4 was more sensitive to free fatty acid than insulin fluxes, which was in good agreement with the literature data...
  49. pmc Pharmacokinetic-pharmacodynamic disease progression model for effect of etanercept in Lewis rats with collagen-induced arthritis
    Hoi Kei Lon
    Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14260, USA
    Pharm Res 28:1622-30. 2011
    ..To develop a pharmacokinetic-pharmacodynamic disease progression (PK/PD/DIS) model to characterize the effect of etanercept in collagen-induced arthritis (CIA) rats on rheumatoid arthritis (RA) progression...
  50. ncbi request reprint Quantitation of expressed message for inducible nitric oxide synthase
    Richard R Almon
    Department of Biological Sciences, State University of New York, Buffalo, New York 14260, USA
    Methods Enzymol 359:445-52. 2002
    ..NOS2 presents a particular problem in this regard because of the high conservation of sequence with NOS1 and NOS3, as well as the existence of both multiple genes and splice variants, which may be of experimental importance...
  51. pmc The PEPR GeneChip data warehouse, and implementation of a dynamic time series query tool (SGQT) with graphical interface
    Josephine Chen
    Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Nucleic Acids Res 32:D578-81. 2004
    ..cnmcresearch.org/pgadatatable.asp)...
  52. ncbi request reprint Expression profiling and pharmacogenomics of muscle and muscle disease
    Eric P Hoffman
    Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Curr Opin Pharmacol 3:309-16. 2003
    ..Muscle is also important in drug metabolism and adverse events, and the application of single nucleotide polymorphism association studies in muscle pharmacogenomics is a field of expected future growth...
  53. ncbi request reprint Context specific transcription factor prediction
    Eric Yang
    Biomedical Engineering Department, Rutgers University, Piscataway, NJ 08854, USA
    Ann Biomed Eng 35:1053-67. 2007
    ....