David M Allman

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Characterization of marginal zone B cell precursors
    Bhaskar Srivastava
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadephia, 19104, USA
    J Exp Med 202:1225-34. 2005
  2. pmc The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7
    Juli P Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 196:705-11. 2002
  3. pmc Transcriptional repression of Gata3 is essential for early B cell commitment
    Anupam Banerjee
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Immunity 38:930-42. 2013
  4. pmc Peripheral B cell subsets
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Curr Opin Immunol 20:149-57. 2008
  5. ncbi request reprint B cell development and receptor diversity during aging
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
    Curr Opin Immunol 17:463-7. 2005
  6. ncbi request reprint Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation
    D Allman
    Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 167:6834-40. 2001
  7. ncbi request reprint The aging of early B-cell precursors
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Immunol Rev 205:18-29. 2005
  8. ncbi request reprint Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells
    David Allman
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Immunol Rev 197:147-60. 2004
  9. ncbi request reprint Common lymphoid progenitors, early B-lineage precursors, and IL-7: characterizing the trophic and instructive signals underlying early B cell development
    David Allman
    Department of Pathology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Immunol Res 27:131-40. 2003
  10. ncbi request reprint The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
    Juli P Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 171:2326-30. 2003

Research Grants

  1. Aging of Early B Cell Precursors
    David M Allman; Fiscal Year: 2010
  2. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David M Allman; Fiscal Year: 2010
  3. Aging of Early B Cell Precursors
    David Allman; Fiscal Year: 2009
  4. Aging of Early B Cell Precursors
    David Allman; Fiscal Year: 2007
  5. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2007
  6. Aging of Early B Cell Precursors
    David Allman; Fiscal Year: 2006
  7. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2006
  8. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David Allman; Fiscal Year: 2006
  9. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2005
  10. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David Allman; Fiscal Year: 2002

Collaborators

Detail Information

Publications36

  1. pmc Characterization of marginal zone B cell precursors
    Bhaskar Srivastava
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadephia, 19104, USA
    J Exp Med 202:1225-34. 2005
    ..These observations challenge previous models of peripheral B cell maturation, and suggest that MZ B cells develop by way of CD21/35(high) CD23(+) intermediates...
  2. pmc The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7
    Juli P Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 196:705-11. 2002
    ..These findings challenge previous notions regarding the point in B cell development affected by the loss of IL-7R signaling and suggest that IL-7 plays a key and requisite role during the earliest phases of B cell development...
  3. pmc Transcriptional repression of Gata3 is essential for early B cell commitment
    Anupam Banerjee
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Immunity 38:930-42. 2013
    ..Furthermore, EBF1 binding to Gata3 regulatory sites induced repressive histone modifications across this region. These data identify a transcriptional circuit critical for B cell lineage commitment...
  4. pmc Peripheral B cell subsets
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Curr Opin Immunol 20:149-57. 2008
    ....
  5. ncbi request reprint B cell development and receptor diversity during aging
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
    Curr Opin Immunol 17:463-7. 2005
    ..On the basis of these studies we propose a model in which the aging of very early B cell progenitors results in shifts in the peripheral B cell repertoire and, consequently, changes in mature B cell function...
  6. ncbi request reprint Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation
    D Allman
    Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 167:6834-40. 2001
    ....
  7. ncbi request reprint The aging of early B-cell precursors
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Immunol Rev 205:18-29. 2005
    ..Finally, we present a model in which the age-associated loss of early B-cell precursors is linked to suboptimal function of key transcriptional regulators of very early B-cell development...
  8. ncbi request reprint Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells
    David Allman
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Immunol Rev 197:147-60. 2004
    ..In addition, we attempt to initiate a resolution of current controversies surrounding transitional B-cell subsets and offer an alternative model of peripheral B-cell maturation and the follicular versus marginal zone decision...
  9. ncbi request reprint Common lymphoid progenitors, early B-lineage precursors, and IL-7: characterizing the trophic and instructive signals underlying early B cell development
    David Allman
    Department of Pathology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Immunol Res 27:131-40. 2003
    ....
  10. ncbi request reprint The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
    Juli P Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 171:2326-30. 2003
    ..Collectively, these data indicate that aging results in a previously unappreciated decline in the earliest stages of B cell development...
  11. ncbi request reprint Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1
    David J Izon
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Immunity 16:231-43. 2002
    ..These data suggest that a balance of inductive Notch1 signals and inhibitory signals mediated through Deltex1 and other modulators regulate T-B lineage commitment...
  12. pmc Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes
    Vargheese Chennathukuzhi
    Center for Research on Reproduction and Women s Health, School of Medicine, Department of Biology, University of Pennsylvania, 1310 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
    Mol Cell Biol 23:6419-34. 2003
    ..Behavioral abnormalities were also seen. Compared to littermates, the TB-RBP-null mice appeared docile and exhibited reduced Rota-Rod performance...
  13. ncbi request reprint Early T lineage progenitors: new insights, but old questions remain
    Avinash Bhandoola
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 171:5653-8. 2003
  14. ncbi request reprint Keeping track of pro-B cells: a new model for the effects of IL-7 during B cell development
    John G Monroe
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Immunol 34:2642-6. 2004
    ..We also discuss the implications of recent data that have led to a new model for this process...
  15. doi request reprint Transcriptional regulation of early B cell development
    Daniel L Northrup
    Department of Pathology and Laboratory Medicine, 230 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, 19104 6082, PA, USA
    Immunol Res 42:106-17. 2008
    ..Furthermore, because aging leads to a decline in early B cell development and reduced IL-7 responsiveness, this work establishes a conceptual framework for understanding how and why aging leads to the loss of early B cell precursors...
  16. ncbi request reprint Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cells
    Juli P Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 269 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    Semin Immunol 17:321-9. 2005
    ....
  17. ncbi request reprint Thymopoiesis independent of common lymphoid progenitors
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6160, USA
    Nat Immunol 4:168-74. 2003
    ..We conclude that ETPs can develop via a CLP-independent pathway...
  18. ncbi request reprint Mastermind critically regulates Notch-mediated lymphoid cell fate decisions
    Ivan Maillard
    Division of Hematology Oncology, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Blood 104:1696-702. 2004
    ..These results suggest a critical role for MAMLs during Notch-mediated cell fate decisions in vivo and indicate that DNMAML1, but not Deltex1, can be used to interfere with the function of multiple Notch family members...
  19. ncbi request reprint An invitation to T and more: notch signaling in lymphopoiesis
    David Allman
    Department of Pathology and Laboratory Medicine, The Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Cell 109:S1-11. 2002
    ..During lymphoid development, Notch influences a series of cell fate decisions involving multipotent progenitors. This review focuses on current views and lingering uncertainties about Notch function in lymphoid cells...
  20. ncbi request reprint Development and selection of edited B cells in B6.56R mice
    Debora R Sekiguchi
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
    J Immunol 176:6879-87. 2006
    ..H chain editing is also observed and is increased in spontaneous as compared with LPS hybridomas. A subset of spontaneous hybridomas appears to lack H chain expression...
  21. ncbi request reprint Instructing B cell fates on the fringe
    David Allman
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Immunity 30:175-7. 2009
    ..In this issue of Immunity, Tan et al. (2009) show that modification of Notch2 by Fringe enzymes is critical to maturing B cells for accessing DL1 on vascular endothelial cells...
  22. ncbi request reprint Resolution of unique Sca-1highc-Kit- lymphoid-biased progenitors in adult bone marrow
    Benjamin C Harman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 181:7514-24. 2008
    ..Moreover, these findings suggest that hematopoietic stem cells in adults generate an array of lymphoid-biased progenitor populations characterized by distinct gene expression and cytokine response profiles...
  23. ncbi request reprint Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway
    Duonan Yu
    Departments of Pathobiology, Pathology and Laboratory Medicine, and Animal Biology, University of Pennsylvania, Philadelphia, PA 19104 6051, USA
    Blood 101:1950-5. 2003
    ..Our data demonstrate that some Myc target cells are bipotent B-lymphoid/myeloid progenitors with the astonishing capacity to undergo successive rounds of lineage switching...
  24. ncbi request reprint Models for peripheral B cell development and homeostasis
    Bhaskar Srivastava
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Semin Immunol 17:175-82. 2005
    ..We will also discuss current controversies over the identity of precursor cells for MZ and follicular B cells, and propose a potentially unifying model for precursor-product relationships in peripheral B cell maturation...
  25. doi request reprint pERKing up the BLIMP in plasma cell differentiation
    David M Allman
    University of Pennsylvania School of Medicine, John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Sci Signal 4:pe21. 2011
    ....
  26. ncbi request reprint Generation of peripheral B cells occurs via two spatially and temporally distinct pathways
    Robert Coleman Lindsley
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 109:2521-8. 2007
    ..These observations indicate that the first step in B-cell maturation occurs in both the BM and the periphery and suggest that recently formed B cells exit the BM as a heterogeneous pool of immature and semimature B cells...
  27. pmc Ikaros is required for plasmacytoid dendritic cell differentiation
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
    Blood 108:4025-34. 2006
    ..These studies suggest that Ikaros controls pDC differentiation by silencing a large array of genes...
  28. ncbi request reprint Regulation of peripheral B cell maturation
    Matthew D Thomas
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    Cell Immunol 239:92-102. 2006
    ..We pay particular attention to the role of the Baff cytokine family and the Notch receptor-ligand family and their unique roles in promoting B cell survival and differentiation into follicular and marginal zone B cells...
  29. pmc Akt1 and Akt2 promote peripheral B-cell maturation and survival
    Marco Calamito
    Department of Pathology and Laboratory of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Blood 115:4043-50. 2010
    ..Altogether, these studies show that Akt signaling plays a key role in peripheral B-cell maturation and survival...
  30. ncbi request reprint Notch signaling in hematopoiesis and early lymphocyte development
    David Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
    Immunol Rev 187:75-86. 2002
    ..In committed progenitors, Notch signaling plays a key role in determining lymphoid cell fates. This review focuses on recent developments to understand the role of Notch signaling in early events in hematopoiesis...
  31. ncbi request reprint Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation
    Matthew Thomas
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    Blood 109:3342-50. 2007
    ..These data suggest that the BCR and CD40 signaling pathways collaborate with the Notch pathway to optimize B-cell activation...
  32. pmc Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitors
    Benjamin C Harman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, 230 John Morgan Bldg, Philadelphia, 19104, USA
    Blood 108:878-85. 2006
    ..These data suggest that PDCs arise exclusively from early myeloid progenitors and that promiscuous low-level expression of lymphoid-associated genes is a general feature of PDC progenitors among CMPs...
  33. pmc Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies
    Patrick A Zweidler-McKay
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 611 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Blood 106:3898-906. 2005
    ..These results suggest that therapies capable of activating Notch/Hes1 signaling may have therapeutic potential in a wide range of human B-cell malignancies...
  34. pmc Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice
    Joseph E Labrie
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave N, Worcester 01655, USA
    J Exp Med 200:411-23. 2004
    ..Together, these observations suggest that extrinsic factors in the bone marrow that decline with age are largely responsible for less efficient V(D)J recombination in pro-B cells and diminished progression to the pre-B cell stage...
  35. ncbi request reprint Connecting the dots: revealing the interactions of lymphocyte development and homeostasis in the immunobiology of aging
    Michael P Cancro
    Semin Immunol 17:319-20. 2005
  36. ncbi request reprint Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals
    Alison M Michie
    Division of Cancer Sciences and Molecular Pathology, Section of Experimental Haematology, Royal Infirmary, University of Glasgow, Glasgow, UK
    Int Immunol 19:1421-30. 2007
    ..Taken together, these studies demonstrate that constitutive Notch signalling can bypass beta-selection during early T-cell development by inducing pre-TCR-like signals within a T-cell-promoting environment...

Research Grants19

  1. Aging of Early B Cell Precursors
    David M Allman; Fiscal Year: 2010
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  2. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David M Allman; Fiscal Year: 2010
    ....
  3. Aging of Early B Cell Precursors
    David Allman; Fiscal Year: 2009
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  4. Aging of Early B Cell Precursors
    David Allman; Fiscal Year: 2007
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  5. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2007
    ..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
  6. Aging of Early B Cell Precursors
    David Allman; Fiscal Year: 2006
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  7. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2006
    ..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
  8. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David Allman; Fiscal Year: 2006
    ..abstract_text> ..
  9. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2005
    ..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
  10. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David Allman; Fiscal Year: 2002
    ..abstract_text> ..
  11. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2004
    ..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
  12. ONTOGENY OF PLASMACYTOID DENDRITIC CELLS
    David Allman; Fiscal Year: 2003
    ..abstract_text> ..
  13. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David Allman; Fiscal Year: 2003
    ..abstract_text> ..
  14. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David Allman; Fiscal Year: 2009
    ....
  15. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David Allman; Fiscal Year: 2004
    ..abstract_text> ..
  16. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David Allman; Fiscal Year: 2005
    ..abstract_text> ..
  17. Effect of aging on lymphoid stem cells
    David Allman; Fiscal Year: 2002
    ..In Aim 3, we will establish BM chimeras to determine whether age-associated decreases in frequencies of CLPs reflect cell autonomous versus environmental defects. ..