Research Topics
Species | David M AllmanSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturationD Allman
Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 167:6834-40. 2001....- Common lymphoid progenitors, early B-lineage precursors, and IL-7: characterizing the trophic and instructive signals underlying early B cell developmentDavid Allman
Department of Pathology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
Immunol Res 27:131-40. 2003.... - The aging of early B-cell precursorsDavid Allman
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Immunol Rev 205:18-29. 2005..Finally, we present a model in which the age-associated loss of early B-cell precursors is linked to suboptimal function of key transcriptional regulators of very early B-cell development... - B cell development and receptor diversity during agingDavid Allman
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
Curr Opin Immunol 17:463-7. 2005..On the basis of these studies we propose a model in which the aging of very early B cell progenitors results in shifts in the peripheral B cell repertoire and, consequently, changes in mature B cell function... - Peripheral B cell subsetsDavid Allman
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Curr Opin Immunol 20:149-57. 2008.... - Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cellsDavid Allman
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
Immunol Rev 197:147-60. 2004..In addition, we attempt to initiate a resolution of current controversies surrounding transitional B-cell subsets and offer an alternative model of peripheral B-cell maturation and the follicular versus marginal zone decision... - Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1David J Izon
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Immunity 16:231-43. 2002..These data suggest that a balance of inductive Notch1 signals and inhibitory signals mediated through Deltex1 and other modulators regulate T-B lineage commitment... - The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursorsJuli P Miller
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
J Immunol 171:2326-30. 2003..Collectively, these data indicate that aging results in a previously unappreciated decline in the earliest stages of B cell development... - Keeping track of pro-B cells: a new model for the effects of IL-7 during B cell developmentJohn G Monroe
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Eur J Immunol 34:2642-6. 2004..We also discuss the implications of recent data that have led to a new model for this process... - Early T lineage progenitors: new insights, but old questions remainAvinash Bhandoola
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 171:5653-8. 2003 - Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cellsJuli P Miller
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 269 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
Semin Immunol 17:321-9. 2005.... - Transcriptional regulation of early B cell developmentDaniel L Northrup
Department of Pathology and Laboratory Medicine, 230 John Morgan Building, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, 19104 6082, PA, USA
Immunol Res 42:106-17. 2008..Furthermore, because aging leads to a decline in early B cell development and reduced IL-7 responsiveness, this work establishes a conceptual framework for understanding how and why aging leads to the loss of early B cell precursors... - Mastermind critically regulates Notch-mediated lymphoid cell fate decisionsIvan Maillard
Division of Hematology Oncology, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
Blood 104:1696-702. 2004..These results suggest a critical role for MAMLs during Notch-mediated cell fate decisions in vivo and indicate that DNMAML1, but not Deltex1, can be used to interfere with the function of multiple Notch family members... - Thymopoiesis independent of common lymphoid progenitorsDavid Allman
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6160, USA
Nat Immunol 4:168-74. 2003..We conclude that ETPs can develop via a CLP-independent pathway... - An invitation to T and more: notch signaling in lymphopoiesisDavid Allman
Department of Pathology and Laboratory Medicine, The Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center, Philadelphia 19104, USA
Cell 109:S1-11. 2002..During lymphoid development, Notch influences a series of cell fate decisions involving multipotent progenitors. This review focuses on current views and lingering uncertainties about Notch function in lymphoid cells... - Instructing B cell fates on the fringeDavid Allman
Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
Immunity 30:175-7. 2009..In this issue of Immunity, Tan et al. (2009) show that modification of Notch2 by Fringe enzymes is critical to maturing B cells for accessing DL1 on vascular endothelial cells... - The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7Juli P Miller
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Exp Med 196:705-11. 2002..These findings challenge previous notions regarding the point in B cell development affected by the loss of IL-7R signaling and suggest that IL-7 plays a key and requisite role during the earliest phases of B cell development... - Models for peripheral B cell development and homeostasisBhaskar Srivastava
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6082, USA
Semin Immunol 17:175-82. 2005..We will also discuss current controversies over the identity of precursor cells for MZ and follicular B cells, and propose a potentially unifying model for precursor-product relationships in peripheral B cell maturation... - Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathwayDuonan Yu
Departments of Pathobiology, Pathology and Laboratory Medicine, and Animal Biology, University of Pennsylvania, Philadelphia, PA 19104 6051, USA
Blood 101:1950-5. 2003..Our data demonstrate that some Myc target cells are bipotent B-lymphoid/myeloid progenitors with the astonishing capacity to undergo successive rounds of lineage switching... - Development and selection of edited B cells in B6.56R miceDebora R Sekiguchi
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
J Immunol 176:6879-87. 2006..H chain editing is also observed and is increased in spontaneous as compared with LPS hybridomas. A subset of spontaneous hybridomas appears to lack H chain expression... - Resolution of unique Sca-1highc-Kit- lymphoid-biased progenitors in adult bone marrowBenjamin C Harman
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 181:7514-24. 2008..Moreover, these findings suggest that hematopoietic stem cells in adults generate an array of lymphoid-biased progenitor populations characterized by distinct gene expression and cytokine response profiles... - Characterization of marginal zone B cell precursorsBhaskar Srivastava
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadephia, 19104, USA
J Exp Med 202:1225-34. 2005..These observations challenge previous models of peripheral B cell maturation, and suggest that MZ B cells develop by way of CD21/35(high) CD23(+) intermediates... - pERKing up the BLIMP in plasma cell differentiationDavid M Allman
University of Pennsylvania School of Medicine, John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
Sci Signal 4:pe21. 2011.... - Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changesVargheese Chennathukuzhi
Center for Research on Reproduction and Women s Health, School of Medicine, Department of Biology, University of Pennsylvania, 1310 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
Mol Cell Biol 23:6419-34. 2003..Behavioral abnormalities were also seen. Compared to littermates, the TB-RBP-null mice appeared docile and exhibited reduced Rota-Rod performance... - Akt1 and Akt2 promote peripheral B-cell maturation and survivalMarco Calamito
Department of Pathology and Laboratory of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
Blood 115:4043-50. 2010..Altogether, these studies show that Akt signaling plays a key role in peripheral B-cell maturation and survival... - Generation of peripheral B cells occurs via two spatially and temporally distinct pathwaysRobert Coleman Lindsley
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Blood 109:2521-8. 2007..These observations indicate that the first step in B-cell maturation occurs in both the BM and the periphery and suggest that recently formed B cells exit the BM as a heterogeneous pool of immature and semimature B cells... - Ikaros is required for plasmacytoid dendritic cell differentiationDavid Allman
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
Blood 108:4025-34. 2006..These studies suggest that Ikaros controls pDC differentiation by silencing a large array of genes... - Regulation of peripheral B cell maturationMatthew D Thomas
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6082, USA
Cell Immunol 239:92-102. 2006..We pay particular attention to the role of the Baff cytokine family and the Notch receptor-ligand family and their unique roles in promoting B cell survival and differentiation into follicular and marginal zone B cells... - Notch signaling in hematopoiesis and early lymphocyte developmentDavid Allman
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104-6160, USA
Immunol Rev 187:75-86. 2002..In committed progenitors, Notch signaling plays a key role in determining lymphoid cell fates. This review focuses on recent developments to understand the role of Notch signaling in early events in hematopoiesis... - Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activationMatthew Thomas
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
Blood 109:3342-50. 2007..These data suggest that the BCR and CD40 signaling pathways collaborate with the Notch pathway to optimize B-cell activation... - Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitorsBenjamin C Harman
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, 230 John Morgan Bldg, Philadelphia, 19104, USA
Blood 108:878-85. 2006..These data suggest that PDCs arise exclusively from early myeloid progenitors and that promiscuous low-level expression of lymphoid-associated genes is a general feature of PDC progenitors among CMPs... - Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignanciesPatrick A Zweidler-McKay
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 611 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104-6160, USA
Blood 106:3898-906. 2005..These results suggest that therapies capable of activating Notch/Hes1 signaling may have therapeutic potential in a wide range of human B-cell malignancies... - Connecting the dots: revealing the interactions of lymphocyte development and homeostasis in the immunobiology of agingMichael P Cancro
Semin Immunol 17:319-20. 2005 - Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged miceJoseph E Labrie
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave. N, Worcester 01655, USA
J Exp Med 200:411-23. 2004..Together, these observations suggest that extrinsic factors in the bone marrow that decline with age are largely responsible for less efficient V(D)J recombination in pro-B cells and diminished progression to the pre-B cell stage... - Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signalsAlison M Michie
Division of Cancer Sciences and Molecular Pathology, Section of Experimental Haematology, Royal Infirmary, University of Glasgow, Glasgow, UK
Int Immunol 19:1421-30. 2007..Taken together, these studies demonstrate that constitutive Notch signalling can bypass beta-selection during early T-cell development by inducing pre-TCR-like signals within a T-cell-promoting environment...
Research Grants
- Effect of aging on lymphoid stem cellsDavid Allman; Fiscal Year: 2002..In Aim 3, we will establish BM chimeras to determine whether age-associated decreases in frequencies of CLPs reflect cell autonomous versus environmental defects. ..
- MECHANISMS OF LYMPHOID LINEAGE COMMITMENTDavid M Allman; Fiscal Year: 2010....
- MECHANISMS OF LYMPHOID LINEAGE COMMITMENTDavid Allman; Fiscal Year: 2009....
- Aging of Early B Cell PrecursorsDavid Allman; Fiscal Year: 2007..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
- Development of plasmacytoid dendritic cellsDavid Allman; Fiscal Year: 2007..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
- MECHANISMS OF LYMPHOID LINEAGE COMMITMENTDavid Allman; Fiscal Year: 2006..abstract_text> ..
- ONTOGENY OF PLASMACYTOID DENDRITIC CELLSDavid Allman; Fiscal Year: 2003..abstract_text> ..
- Aging of Early B Cell PrecursorsDavid M Allman; Fiscal Year: 2010..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..