Research Topics
Genomes and GenesSpecies | Kimberly H AllisonSummaryAffiliation: University of Washington Country: USA Publications
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Publications
PAX2 loss by immunohistochemistry occurs early and often in endometrial hyperplasiaKimberly H Allison
Department of Pathology, University of Washington Medical Center Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Int J Gynecol Pathol 31:151-159. 2012..However, it is not useful in distinguishing between these diagnostic categories...
Diagnosing endometrial hyperplasia: why is it so difficult to agree?Kimberly H Allison
Department of Pathology, University of Washington Medical Center, Seattle, WA, USA
Am J Surg Pathol 32:691-8. 2008..Although obtaining additional tissue may increase diagnostic reproducibility, differences in interpretation of key histologic features like cytologic atypia remain major factors contributing to diagnostic disagreement...
Radiographically occult, diffuse intrasinusoidal hepatic metastases from primary breast carcinomas: a clinicopathologic study of 3 autopsy casesKimberly H Allison
Department of Pathology, University of Washington School of Medicine, Seattle, USA
Arch Pathol Lab Med 128:1418-23. 2004..Rarely, metastatic carcinoma can diffusely infiltrate hepatic sinusoids, a pattern of metastasis that may be missed on imaging studies, and can result in liver failure...- Atypical ductal hyperplasia on vacuum-assisted breast biopsy: suspicion for ductal carcinoma in situ can stratify patients at high risk for upgradeKimberly H Allison
Department of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
Hum Pathol 42:41-50. 2011..04). In conclusion, qualitative features of atypical ductal hyperplasia on core biopsy such as suspicion for ductal carcinoma in situ may help stratify patients at the highest risk for upgrade... - Immunohistochemical markers in endometrial hyperplasia: is there a panel with promise? A reviewKimberly H Allison
Department of Pathology, University of Washington Medical Center, 1959 NE Pacific, Box 356100, Seattle, WA 98195, USA
Appl Immunohistochem Mol Morphol 16:329-43. 2008..The goal of this literature review was to identify studies on endometrial hyperplasia (EH) that describe markers with potential to predict response to progestin therapy or potential for progression to invasive disease... - Epithelioid trophoblastic tumor: review of a rare neoplasm of the chorionic-type intermediate trophoblastKimberly H Allison
Division of Anatomic Pathology, University of Washington Medical Center, 1959 NE Pacific St, Room BB 220, Box 356100, Seattle, WA 98195, USA
Arch Pathol Lab Med 130:1875-7. 2006..The clinical behavior of this rare form of gestational trophoblastic disease is difficult to predict. Although most cases follow a benign course following resection, there is a potential for metastatic disease... - Defining an appropriate threshold for the diagnosis of serous borderline tumor of the ovary: when is a full staging procedure unnecessary?Kimberly H Allison
Department of Anatomic Pathology, University of Washington Medical Center, Seattle, Washington 98195, USA
Int J Gynecol Pathol 27:10-7. 2008..5-cm borderline change... - Risk of upgrade of atypical ductal hyperplasia after stereotactic breast biopsy: effects of number of foci and complete removal of calcificationsJennifer R Kohr
Department of Radiology, University of Washington Medical Center, Seattle, Wash, USA
Radiology 255:723-30. 2010.... - Biomarkers of progestin therapy resistance and endometrial hyperplasia progressionKristen Upson
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Am J Obstet Gynecol 207:36.e1-8. 2012..We sought to identify biomarkers associated with progestin therapy resistance and persistence/progression of endometrial hyperplasia... - Complex hyperplasia with and without atypia: clinical outcomes and implications of progestin therapySusan D Reed
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98115, USA
Obstet Gynecol 116:365-73. 2010..We evaluated women with complex and atypical endometrial hyperplasia, comparing those prescribed progestin with those not prescribed progestin... - Is surgical excision necessary for focal atypical ductal hyperplasia found at stereotactic vacuum-assisted breast biopsy?Peter R Eby
Department of Radiology, University of Washington Medical Center, 1959 NE Pacific, Seattle, WA 98195, USA
Ann Surg Oncol 15:3232-8. 2008.... - Frequency, upgrade rates, and characteristics of high-risk lesions initially identified with breast MRIRoberta M Strigel
Department of Radiology, University of Washington Medical Center, Seattle, WA, USA
AJR Am J Roentgenol 195:792-8. 2010.... - In vivo assessment of ductal carcinoma in situ grade: a model incorporating dynamic contrast-enhanced and diffusion-weighted breast MR imaging parametersHabib Rahbar
Department of Radiology and Pathology, University of Washington, Seattle, WA 98109 1023, USA
Radiology 263:374-82. 2012..To develop a model incorporating dynamic contrast material-enhanced (DCE) and diffusion-weighted (DW) magnetic resonance (MR) imaging features to differentiate high-nuclear-grade (HNG) from non-HNG ductal carcinoma in situ (DCIS) in vivo... - Impact and outcomes of routine microstaging of sentinel lymph nodes in breast cancer: significance of the pN0(i+) and pN1mi categoriesMatthew S Pugliese
Surgical Residency, Swedish Medical Center, 747 Broad Way, Seattle, WA 98122, USA
Ann Surg Oncol 16:113-20. 2009..However, the clinical significance of these categories is debated in the literature... - Lobular in-situ neoplasia on breast core needle biopsy: imaging indication and pathologic extent can identify which patients require excisional biopsyMara H Rendi
Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA
Ann Surg Oncol 19:914-21. 2012..The surgical management of lobular in-situ neoplasia (LN) identified by core needle biopsy (CNB) is currently variable. Our institution has routinely excised LN on CNB since 2003, allowing for an unbiased assessment of upgrade rates... - Frequency and upgrade rates of atypical ductal hyperplasia diagnosed at stereotactic vacuum-assisted breast biopsy: 9-versus 11-gaugePeter R Eby
Department of Radiology, University of Washington Medical Center, Seattle, WA, USA
AJR Am J Roentgenol 192:229-34. 2009.... - The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutationsBarbara M Norquist
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA
Cancer 116:5261-71. 2010..BRCA1 or BRCA2 (BRCA1/2)-mutated ovarian carcinomas may originate in the fallopian tube. The authors of this report investigated alterations in BRCA1/2 tubal epithelium to define the molecular pathogenesis of these carcinomas... - Nonmalignant Breast Lesions: ADCs of Benign and High-Risk Subtypes Assessed as False-Positive at Dynamic Enhanced MR ImagingSana Parsian
Departments of Radiology and Pathology, University of Washington School of Medicine, Seattle Cancer Care Alliance, 825 Eastlake Ave E, G3 200, Seattle, WA 98109 1023
Radiology 265:696-706. 2012..RSNA, 2012 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12112672/-/DC1... - Intratumoral T cells, tumor-associated macrophages, and regulatory T cells: association with p53 mutations, circulating tumor DNA and survival in women with ovarian cancerChirag A Shah
University of Washington Medical Center, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Seattle, Washington 98195, USA
Gynecol Oncol 109:215-9. 2008..Forty percent of women with ovarian cancer have circulating free tumor DNA. We sought to determine if the tumor immune infiltrate varied based on tumor p53 mutation status or presence of circulating tumor DNA... - Endogenous versus tumor-specific host response to breast carcinoma: a study of stromal response in synchronous breast primaries and biopsy site changesJulie M Wu
Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
Clin Cancer Res 17:437-46. 2011..The purpose of this study is to elucidate the basis of this stromal response--whether they are elicited by individual tumors or whether they represent an endogenous host reaction produced by the patient... - Feasibility study of FDG PET as an indicator of early response to aromatase inhibitors and trastuzumab in a heterogeneous group of breast cancer patientsBrenda F Kurland
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
EJNMMI Res 2:34. 2012..abstract:.. - Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosisKimberly H Allison
Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
Am J Clin Pathol 124:685-92. 2005..However, identification of a benign precursor or origin from a nerve may be the most definitive way to properly classify these rare lesions... - Alternate molecular genetic pathways in ovarian carcinomas of common histological typesJulia Willner
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
Hum Pathol 38:607-13. 2007..Mutations in p53, PIK3CA, PTEN, and CTNNB1 account for most EC tumors; most CC remain unexplained. EC/CC histology is a favorable prognostic factor... - Frequency of HER2 heterogeneity by fluorescence in situ hybridization according to CAP expert panel recommendations: time for a new look at how to report heterogeneityKimberly H Allison
Department of Pathology, University of Washington Medical Center, Seattle, 98195, USA
Am J Clin Pathol 136:864-71. 2011..Further definition of optimal criteria with clinical relevance is needed before HER2 heterogeneity reporting is adopted in routine practice... - Achieving 95% cross-methodological concordance in HER2 testing: causes and implications of discordant casesErin E Grimm
University of Washington Medical Center, Seattle, WA 98195, USA
Am J Clin Pathol 134:284-92. 2010..Focusing on issues with HER2 immunohistochemical interpretation can improve concordance rates for immunohistochemically positive cases, but biologic reasons may explain some discordant immunohistochemically negative cases... - FOXP3+ regulatory T-cells are abundant in vulvar Paget's disease and are associated with recurrenceJoshua Z Press
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195, USA
Gynecol Oncol 120:296-9. 2011..To characterize clinical features of vulvar Paget's disease, and examine the quantity of immunosuppressive regulatory T-cells in vulvar Paget's tissue... - Accuracy of intraoperative imprint cytology of sentinel lymph nodes in breast cancerMatthew S Pugliese
Department of Surgery, Comprehensive Breast Cancer Program, Swedish Cancer Institute, Seattle, WA, USA
Am J Surg 192:516-9. 2006..IC allowed 49 (55%) of these patients to undergo synchronous completion of ALND. No unnecessary completion ALNDs were performed. The sensitivity of IC decreased with decreasing size of the metastasis... - Diffusion tensor magnetic resonance imaging of the normal breastSavannah C Partridge
Department of Radiology, University of Washington, Seattle, WA 98195, USA
Magn Reson Imaging 28:320-8. 2010..The objective of this study was to evaluate diffusion anisotropy of the breast parenchyma and assess the range and repeatability of diffusion tensor imaging (DTI) parameters in normal breast tissue... - Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic targetSandra D Bohling
Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195 6100, USA
Mod Pathol 21:1527-32. 2008..These results argue that regulatory T cells may play a role in inducing immune tolerance to higher grade, more aggressive breast carcinomas, and are a potential therapeutic target for these cancers... - Tumor metabolism and blood flow as assessed by positron emission tomography varies by tumor subtype in locally advanced breast cancerJennifer M Specht
Medical Oncology and Nuclear Medicine, Department of Medicine, University of Washington, Seattle, Washington 98109, USA
Clin Cancer Res 16:2803-10. 2010..This analysis examines tumor metabolism and perfusion by tumor subtype... - Angiosarcoma involving the gastrointestinal tract: a series of primary and metastatic casesKimberly H Allison
Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
Am J Surg Pathol 28:298-307. 2004..Immunohistochemistry with vascular markers, CK20, and S-100 protein may be helpful in differentiating angiosarcoma from carcinoma and melanoma...