Research Topics
Genomes and Genes | David B AllisonSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Sexual dimorphism of adipose tissue distribution across the lifespan: a cross-sectional whole-body magnetic resonance imaging studyWei Shen
Obesity Research Center, St, Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, New York, NY, USA
Nutr Metab (Lond) 6:17. 2009..abstract:..- Bias in estimates of quantitative-trait-locus effect in genome scans: demonstration of the phenomenon and a method-of-moments procedure for reducing biasDavid B Allison
Department of Biostatistics and Center for Research on Clinical Nutrition, University of Alabama at Birmingham, 35294 0022, USA
Am J Hum Genet 70:575-85. 2002..Finally, limitations of the MOM approach are noted, and we discuss some alternative procedures that may also reduce bias... 
Two-stage testing in microarray analysis: what is gained?David B Allison
Department of Biostatistics, University of Alabama at Birmingham, USA
J Gerontol A Biol Sci Med Sci 57:B189-92. 2002..Therefore, investigators are encouraged to consider alternative analytic approaches...
Understanding the relationship between baseline BMI and subsequent weight change in antipsychotic trials: effect modification or regression to the mean?David B Allison
Department of Biostatistics, University of Alabama, Birmingham, AL, USA
Psychiatry Res 170:172-6. 2009..This class of drugs appears to cause similar weight gain in both high and low baseline BMI groups...- The PowerAtlas: a power and sample size atlas for microarray experimental design and researchGrier P Page
Department of Biostatistics, University of Alabama, Birmingham, AL, USA
BMC Bioinformatics 7:84. 2006..In addition, investigators frequently do not have pilot data to estimate the sample sizes required for microarray studies... - Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network studyYongjun Liu
Departments of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pharmacogenet Genomics 19:161-9. 2009..The apolipoproteins (APOA1/C3/A4/A5) are key components in modulating lipoprotein metabolism. It is unknown whether variants at the APOA1/C3/A4/A5 gene cluster are associated with lipid response to pharmacologic intervention... - Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB miceNengjun Yi
Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294, USA
J Lipid Res 45:2063-70. 2004..SPRET/Pt alleles of the QTL on each chromosome promote hepatic lipase activity. The proportion of phenotypic variance explained by the epistatic effect is higher than that explained by the main effect of the QTL on chromosome 7... - Detection of gene x gene interactions in genome-wide association studies of human population dataSolomon K Musani
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Hum Hered 63:67-84. 2007..Instead, a combination of approaches with the aim of balancing their specific strengths may be the optimal approach to investigate gene x gene interactions in human data... - Rank-based inverse normal transformations are increasingly used, but are they merited?T Mark Beasley
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Ryals Public Health Building, Suite 327, Birmingham, AL, 35294, USA
Behav Genet 39:580-95. 2009..Rigorous research evaluating the utility of INTs seems warranted... - A proposed metric for assessing the measurement quality of individual microarraysKyoungmi Kim
Department of Biostatistics, University of Alabama, Birmingham, Alabama, USA
BMC Bioinformatics 7:35. 2006..In some cases this may be manifested as systematic spatial variation on the surface of microarray in which expression measurements within an individual array may vary as a function of geographic position on the array surface... - New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random samplingHemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Genet Epidemiol 28:48-57. 2005..Both random sampling and extreme sampling schemes were investigated. A multinomial logistic joint test provides the highest overall power irrespective of sample size, allele frequency, heritability, and modes of inheritance... - Characterization of epistasis influencing complex spontaneous obesity in the BSB modelNengjun Yi
Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, Alabama 35294, USA
Genetics 167:399-409. 2004..Chromosomes 6 and 12 have not only main effects but also strong epistatic effects on plasma total cholesterol. Our results emphasize the importance of modeling epistasis for discovery of obesity genes... - No evidence for a major role of polymorphisms during bupropion treatmentJianfang Hu
Department of Biostatistics, Section on Statistical Genetics, Ryals Public Health Building, Suite 327, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA
Obesity (Silver Spring) 14:1863-7. 2006..Overall, our results do not support a major role for these five candidate genes in weight gain after smoking cessation... - Endocrine disruptors and obesity: an examination of selected persistent organic pollutants in the NHANES 1999-2002 dataMai A Elobeid
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Int J Environ Res Public Health 7:2988-3005. 2010..Hence, BMI and WC are associated with POPs levels, making the chemicals plausible contributors to the obesity epidemic... - The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J miceDaniel L Smith
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
Obesity (Silver Spring) 18:995-9. 2010..247 g; P = 0.57). Contrary to previous research, MOS supplementation had no discernable effect on body weight gain or composition during this 12-week study, challenging the potential use of MOS as a CRM or body composition enhancer... - Principal component analysis of quantitative trait loci for immune response to adenovirus in miceSolomon K Musani
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, AL 35294 0007, USA
Hereditas 143:189-97. 2006..01 and 31.01 cM) and 15 (29.21, 36.01, and 56.31 cM). These results illustrate the use of principal component analysis in mapping QTLs using multiple correlated traits... - Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear modelDavid T Redden
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS Genet 2:e137. 2006.... - Bayesian analyses of multiple epistatic QTL models for body weight and body composition in miceNengjun Yi
Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294, USA
Genet Res 87:45-60. 2006..Several main and epistatic effects were shared by the body composition and body weight traits, suggesting that pleiotropy plays an important role in growth and obesity... - Mapping multiple quantitative trait Loci for ordinal traitsNengjun Yi
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Behav Genet 34:3-15. 2004..To this end, we provide a unified approach to mapping multiple QTL for continuous, binary, and ordinal traits. Utility and flexibility of the method are demonstrated using simulated data... - Optimal allocation of replicates for measurement evaluation studiesStanislav O Zakharkin
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA
Genomics Proteomics Bioinformatics 4:196-202. 2006..Therefore, it is recommended to use two technical replicates for each biological replicate if the goal is to evaluate the reproducibility of measurements... - Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of childrenYann C Klimentidis
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
Hum Genomics 5:79-89. 2011..Importantly, we have implicated this region in the early development of diabetes-related phenotypes, and in the genetic aetiology of population differences in these phenotypes... - HDBStat!: a platform-independent software suite for statistical analysis of high dimensional biology dataPrinal Trivedi
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
BMC Bioinformatics 6:86. 2005..HDBStat! provides statisticians and biologists a flexible and easy-to-use interface to analyze complex microarray data using a variety of methods for data preprocessing, quality control analysis and hypothesis testing... - Intramyocellular lipid and insulin resistance: differential relationships in European and African AmericansKatherine H Ingram
Department of Biostatistics, University of Alabama, Birmingham, Alabama, USA
Obesity (Silver Spring) 19:1469-75. 2011..These results highlight ethnic differences in the determinants of insulin sensitivity and in the pathogenesis of the metabolic syndrome trait cluster... - Joint tests for quantitative trait loci in experimental crossesT Mark Beasley
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
Genet Sel Evol 36:601-19. 2004..Joint tests were generally more powerful for one-tailed selection under both backcross and F2 intercross situations. However, joint tests cannot be recommended for one-tailed selective genotyping if segregation distortion is suspected... - Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)David B Allison
Department of Biostatistics, School of Public Health and Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 20:330-42. 2012..75/23 patients, and 33.6% of 15/92 patients. PHEN/TPM CR demonstrated dose-dependent effects on weight and metabolic variables in the direction expected to be beneficial with no evidence of serious adverse events induced by treatment... - Randomized controlled trial of chewing gum for weight lossJames M Shikany
Division of Preventive Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 20:547-52. 2012..Analyses including completers only produced essentially the same results. We conclude that chewing gum on a regular schedule for 8 weeks did not facilitate weight loss in these overweight and obese adults... - Microarray data analysis: from disarray to consolidation and consensusDavid B Allison
Section on Statistical Genetics, Department of Biostatistics, Ryals Public Health Building, 1665 University Avenue, University of Alabama at Birmingham, Alabama 35294 0022, USA
Nat Rev Genet 7:55-65. 2006..Many are special cases of more general models, and points of consensus are emerging about the general approaches that warrant use and elaboration... - Is dietary fat "fattening"? A comprehensive research synthesisJames M Shikany
Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, MT610 Birmingham, AL 35294, USA
Crit Rev Food Sci Nutr 50:699-715. 2010..General recommendations to reduce dietary fat to promote weight loss or maintenance in all circumstances may merit reconsideration... - An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African AmericansJames M Kelley
University of Alabama at Birmingham, Birmingham, AL, USA
PLoS Genet 5:e1000424. 2009..An African ancestry-specific genetic variant of CTLA4 appears to be associated with protection from RA in African Americans. This finding may explain, in part, the relatively low prevalence of RA in black African populations... - Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regionsYann C Klimentidis
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, 1665 University Blvd, RPHB 327, Birmingham, AL 35294, USA
Hum Genet 129:407-18. 2011..Our findings suggest that there is an evolutionary genetic basis for population differences in these traits, and we have identified potential group-specific genetic risk factors... - Fruit and vegetable pricing by demographic factors in the Birmingham, Alabama, metropolitan area, 2004-2005Jamy D Ard
University of Alabama at Birmingham, 1675 University Blvd, Webb 441, Birmingham, AL 35294, USA
Prev Chronic Dis 7:A78. 2010..Because the contextual environment influences food outlet type and availability, we wanted to determine whether neighborhood demographics were associated with prices of fruits and vegetables... - Prediction of expected years of life using whole-genome markersGustavo de Los Campos
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 7:e40964. 2012.... - BMI and headache among women: results from 11 epidemiologic datasetsScott W Keith
Section on Statistical Genetics and Clinical Nutrition Research Center, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
Obesity (Silver Spring) 16:377-83. 2008..To evaluate the association between BMI (kg/m(2)) and headaches among women... - Missing data in randomized clinical trials for weight loss: scope of the problem, state of the field, and performance of statistical methodsMai A Elobeid
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 4:e6624. 2009..Herein, we meta-analytically evaluate the extent of missing data, the frequency with which various analytic methods are employed to accommodate dropouts, and the performance of multiple statistical methods... - Haplotyping methods for pedigreesGuimin Gao
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Ala, USA
Hum Hered 67:248-66. 2009..We explore the connections among these methods, and describe the challenges that remain to be addressed... - Obesity among those with mental disorders: a National Institute of Mental Health meeting reportDavid B Allison
University of Alabama at Birmingham, Birmingham, Alabama, USA
Am J Prev Med 36:341-50. 2009.... - Intramyocellular lipid content is lower with a low-fat diet than with high-fat diets, but that may not be relevant for healthMarie Pierre St-Onge
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Clin Nutr 86:1316-22. 2007..Fat deposition in muscle has been found to be related to metabolic risk... - Sample size in obesity trials: patient perspective versus current practiceDavid B Allison
Department of Nutrition Sciences and the Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Med Decis Making 30:68-75. 2010..To evaluate patient opinions on acceptable risks in exchange for a given degree of weight loss and their implications for sample size determination in obesity randomized clinical trials (RCTs)... - The effects of intentional weight loss as a latent variable problemChristopher S Coffey
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Stat Med 24:941-54. 2005.... - Sources of variation in Affymetrix microarray experimentsStanislav O Zakharkin
University of Alabama, Birmingham, Alabama, USA
BMC Bioinformatics 6:214. 2005..The objectives of this study were: (1) to estimate relative magnitudes of different sources of variation and (2) to evaluate agreement between biological and technical replicates... - Genes and biochemical pathways in human skeletal muscle affecting resting energy expenditure and fuel partitioningXuxia Wu
Dept of Nutrition Sciences, The Univ of Alabama at Birmingham, 1675 University Blvd, Birmingham, AL 35294 3360, USA
J Appl Physiol 110:746-55. 2011..Individual variations in whole body REE and RQ are regulated by differential expressions of specific genes and pathways intrinsic to skeletal muscle... - Bayesian model selection for genome-wide epistatic quantitative trait loci analysisNengjun Yi
Department of Biostatistics, University of Alabama, Birmingham 35294, USA
Genetics 170:1333-44. 2005..We illustrate the proposed method by detecting new epistatic QTL for obesity in a backcross of CAST/Ei mice onto M16i... - Myths, presumptions, and facts about obesityKrista Casazza
Department of Nutrition Sciences, of Alabama at Birmingham, Birmingham, USA
N Engl J Med 368:446-54. 2013.... - Weighted multiple hypothesis testing proceduresGuolian Kang
University of Alabama at Birmingham, Birmingham, AL 35294, USA
Stat Appl Genet Mol Biol 8:Article23. 2009..All proposed procedures control the FWER well and are useful when prior information is available to estimate the weights... - Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principlesHemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Hum Hered 66:67-86. 2008.... - Calorie restriction: what recent results suggest for the future of ageing researchDaniel L Smith
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Eur J Clin Invest 40:440-50. 2010..Thus, the search for substances that can reproduce the beneficial physiologic responses of CR without a requisite calorie intake reduction, termed CR mimetics (CRMs), has gained momentum... - The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixtureDavid T Redden
Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, USA
Behav Genet 36:678-86. 2006.... - Bayesian model choice and search strategies for mapping interacting quantitative trait LociNengjun Yi
Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294, USA
Genetics 165:867-83. 2003..Utility and flexibility of the method are demonstrated using both simulated data and a real data set. Sensitivity of posterior inference to prior specifications of the number and genetic effects of QTL is investigated... - Telomere dynamics in rhesus monkeys: no apparent effect of caloric restrictionDaniel L Smith
University of Alabama at Birmingham, Main Campus, Birmingham, AL 35294 3360, USA
J Gerontol A Biol Sci Med Sci 66:1163-8. 2011..002) and sex (p = .003; p = .042), but not calorie restriction (p = .884; p = .766). Despite an age-dependent shortening of TL in leukocytes and skin, calorie restriction did not significantly affect TL dynamics in these samples... - Conjectures on some curious connections among social status, calorie restriction, hunger, fatness, and longevityKathryn A Kaiser
Office of Energetics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Ann N Y Acad Sci 1264:1-12. 2012..Second, we examine models of the interactions between caloric restriction, body composition, and longevity. Finally, we put forth a relational model of the influences of differing environmental cues on body composition and longevity... - A generalized sequential Bonferroni procedure using smoothed weights for genome-wide association studies incorporating information on Hardy-Weinberg disequilibrium among casesGuimin Gao
Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
Hum Hered 73:1-13. 2012.... - Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension studyW Timothy Garvey
Department of Nutrition Sciences, UAB Diabetes Research and Training Center, University of Alabama at Birmingham, 35294 3360, USA
Am J Clin Nutr 95:297-308. 2012.... - Obesity: person and populationMark B Cope
Department of Nutrition Sciences, University of Alabama at Birmingham, Ryals Public Health Building 327, 1665 University Boulevard, Birmingham, AL 35294, USA
Obesity (Silver Spring) 14:156S-159S. 2006..If we are to make pervasive and enduring changes to population adiposity levels, it is likely that we will need to make pervasive and enduring changes to the ways in which we live across the lifespan... - Comparison of linear weighting schemes for perfect match and mismatch gene expression levels from microarray dataT Mark Beasley
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Am J Pharmacogenomics 5:197-205. 2005..However, the PM-only model demonstrates superior power in an overwhelming majority of realistic situations, which provides theoretical support for the current trend to employ PM-only models in microarray data analyzes... - Effect of dairy supplementation on body composition and insulin resistance in miceMaria S Johnson
Department of Nutrition Sciences, University of Alabama at Birmingham, Alabama, USA
Nutrition 23:836-43. 2007..This study examined whether yogurt supplementation attenuated the weight gain and insulin resistance in mice fed a moderate-fat diet... - Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated resultsDavid T Redden
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Alabama 35294 0022, USA
Cancer Epidemiol Biomarkers Prev 14:1384-9. 2005.... - Applications of Bayesian statistical methods in microarray data analysisDongyan Yang
Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Am J Pharmacogenomics 4:53-62. 2004..Bayesian methods will undoubtedly become more common in the future because of their great utility in microarray analysis... - Mapping interacting QTL for count phenotypes using hierarchical Poisson and binomial models: an application to reproductive traits in miceJun Li
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Genet Res (Camb) 92:13-23. 2010..The proposed statistical models and methods provide valuable tools for detecting multiple interacting QTLs for complex count phenotypes... - Testing for differences in distribution tails to test for differences in 'maximum' lifespanGuimin Gao
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
BMC Med Res Methodol 8:49. 2008..However, a limitation of these tests is that they do not consider how much above the threshold any particular observation is... - Beyond missing heritability: prediction of complex traitsRobert Makowsky
Department of Biostatistics, University of Alabama at Birmingham, Alabama, United States of America
PLoS Genet 7:e1002051. 2011..While such R(2) values vastly exceed what has been previously reported using a reduced number of pre-selected markers (<0.10), given the heritability of the trait (∼ 0.80), substantial room for improvement remains... - Effects of a reimbursement incentive on enrollment in a weight control programW Scott Butsch
Department of Nutrition Sciences, University of Alabama at Birmingham, Webb 439, 1675 University Blvd, Birmingham, AL 35294 3360, USA
Obesity (Silver Spring) 15:2733-8. 2007..The objective was to examine the effect of offering a reimbursement incentive on the percentage of inquirers who enrolled in a weight control program and on weight loss and program attendance among enrollees... - Mapping quantitative trait loci affecting variation in Drosophila triacylglycerol storageMaria De Luca
Department of Environmental Health Sciences, University of Alabama, Birmingham, AL 35294, USA
Obes Res 13:1596-605. 2005..The objective of our study was to identify quantitative trait loci (QTLs) that contribute to variation in triacylglycerol (TAG) storage in two D. melanogaster laboratory strains... - Metformin supplementation and life span in Fischer-344 ratsDaniel L Smith
Department of Biostatistics, Ryals Public Health Building, Suite 414, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, USA
J Gerontol A Biol Sci Med Sci 65:468-74. 2010..05) compared with control... - Snack chips fried in corn oil alleviate cardiovascular disease risk factors when substituted for low-fat or high-fat snacksMarie Pierre St-Onge
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Clin Nutr 85:1503-10. 2007..The perception that all high-fat snacks are unhealthy may be wrong... - Can rodent longevity studies be both short and powerful?Henry T Robertson
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
J Gerontol A Biol Sci Med Sci 66:279-86. 2011..4 times as many rodents will often have equivalent or greater power. Cost calculations suggest that shorter studies will be more expensive but perhaps not so much to not be worth the reduced time... - Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progressionAndrzej B Popławski
Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
Eur J Hum Genet 18:560-8. 2010..Frequent genetic differences between primary tumors and metastases in breast cancer also question, at least to some extent, the role of primary tumors as a surrogate subject of study for the systemic disease... - An empirical Bayes method for updating inferences in analysis of quantitative trait loci using information from related genome scansKui Zhang
Department of Biostatistics, Section of Statistical Genetics, University of Alabama, Birmingham 35294, USA
Genetics 173:2283-96. 2006..In the face of marked heterogeneity among studies, the empirical Bayes method outperforms the comparator... - Marker genotypes and population admixture and their association with body weight, height and relative body mass in United States federal bison herdsSolomon K Musani
Section on Statistical Genetics, Department of Biostatistics, University of Alabama, Alabama 35294, USA
Genetics 174:775-83. 2006..Individual loci contributed approximately 2.0% of variation in weight, height, and BMI, which confirms the utility and potential importance of adjusting for population stratification... - A simple significance test for quantile regressionDavid T Redden
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Stat Med 23:2587-97. 2004.... - Epistemological issues in omics and high-dimensional biology: give the people what they wantTapan S Mehta
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Physiol Genomics 28:24-32. 2006..The shift from family-wise error rate control to false discovery rate estimation and to assessment of ranking and other forms of stability will be portrayed as illustrative of approaches to this challenge... - Predicting genetic predisposition in humans: the promise of whole-genome markersGustavo de Los Campos
University of Alabama at Birmingham, 35294, USA
Nat Rev Genet 11:880-6. 2010..We propose that alternative approaches, which are largely borrowed from animal breeding, provide potential for advances. We review selected methods and discuss the challenges and opportunities ahead... - Attitudes and beliefs associated with leisure-time physical activity among African American adultsOlivia Affuso
Department of Epidemiology, University of Alabama at Birmingham 35294 0013, USA
Ethn Dis 21:63-7. 2011..We sought to discover the extent to which health attitudes and beliefs are associated with leisure-time physical activity in this population... - Natural selection among Eurasians at genomic regions associated with HIV-1 controlYann C Klimentidis
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
BMC Evol Biol 11:173. 2011.... - Stochastic search variable selection for identifying multiple quantitative trait lociNengjun Yi
Department of Biostatistics, University of Alabama, Birmingham 35294 0022, USA
Genetics 164:1129-38. 2003..The results demonstrate that the proposed method works well under typical situations of most QTL studies in terms of number of markers and marker density... - Nonreplication in genetic association studies of obesity and diabetes researchDavid T Redden
Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Nutr 133:3323-6. 2003..Recommendations to improve future association studies are presented... - A design and statistical perspective on microarray gene expression studies in nutrition: the need for playful creativity and scientific hard-mindednessGrier P Page
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Nutrition 19:997-1000. 2003.... - Association of African genetic admixture with resting metabolic rate and obesity among womenJose R Fernandez
Department of Nutrition Sciences and the Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Obes Res 11:904-11. 2003.... - Treatment and prevention of obesity: what works, what doesn't work, and what might workDavid B Allison
Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Alabama 35294 0022, USA
Lipids 38:147-55. 2003..Perhaps, with continued efforts at enhancing treatments, we will see incremental advances in the treatment and prevention of obesity... - The impact of weight gain on quality of life among persons with schizophreniaDavid B Allison
Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, Suite 327 Ryals Public Health Building, University of Alabama at Birmingham, 1665 University Avenue, Birmingham, AL 35294, USA
Psychiatr Serv 54:565-7. 2003..Clinicians should consider the effect of weight gain on quality of life when prescribing antipsychotics and should help patients adopt weight maintenance behaviors... - Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescentsJose R Fernandez
Section on Statistical Genetics, Department of Biostatistics, Clinical Nutrition Research Center, University of Alabama at Birmingham, 35294 3360, USA
J Pediatr 145:439-44. 2004..To describe and provide estimates of the distribution of waist circumference (WC) according to percentiles in African-, European-, and Mexican-American children, and to test for group differences at different percentiles... - Is GAD2 on chromosome 10p12 a potential candidate gene for morbid obesity?Hemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham 35294, USA
Nutr Rev 63:315-9. 2005..Also discussed are additional research questions that merit inquiry when further evaluating this genetic variant as a putative contributor to human obesity... - Dietary restraint and disinhibition do not affect accuracy of 24-hour recall in a multiethnic populationJamy D Ard
Nutrition Sciences and Medicine, Department of Medicine, University of Alabama, Birmingham, USA
J Am Diet Assoc 106:434-7. 2006..Disinhibition was not related to intake or accuracy. Dietetics professionals should consider dietary restraint a possible reason for a lower than expected estimate of energy intake when using 24-hour recalls... - Is percentage body fat differentially related to body mass index in Hispanic Americans, African Americans, and European Americans?Jose R Fernandez
Obesity Research Center, St Luke s Roosevelt Hospital and the Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, USA
Am J Clin Nutr 77:71-5. 2003.... - Obesity as a disease: a white paper on evidence and arguments commissioned by the Council of the Obesity SocietyDavid B Allison
Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 16:1161-77. 2008 - Improving the power of sib pair quantitative trait loci detection by phenotype winsorizationJose R Fernandez
Department of Nutrition Sciences, Division of Physiology and Metabolism, The University of Alabama at Birmingham, 35294 3360, USA
Hum Hered 53:59-67. 2002..We evaluated the robustness and power of reducing the influence of subjects with extreme phenotypic values by Winsorizing non-normal distributions in three versions of Haseman-Elston regression-based methods of QTL linkage analysis... - Divergence in popular diets relative to diets consumed by Americans, and implications for diet selectionJames M Shikany
Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, USA
MedGenMed 9:8. 2007..We hypothesized that because most of these diets differ greatly from the way most Americans spontaneously eat, the choice of a WLD may be less critical than the decision to adopt any WLD... - Beneficial influences of systemic cooperation and sociological behavior on longevityJohn D Mountz
Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
Mech Ageing Dev 123:963-73. 2002.... - The impact of cost on the availability of fruits and vegetables in the homes of schoolchildren in Birmingham, AlabamaJamy D Ard
Department of Nutrition Sciences, University of Alabama, Birmingham, USA
Am J Public Health 97:367-72. 2007..We sought to determine whether fruit and vegetable cost and consumers' race and income would predict availability of fruits and vegetables in homes of schoolchildren in the Birmingham, Ala, area... - Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profilesCarl E G Bruder
Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294 0024, USA
Am J Hum Genet 82:763-71. 2008..Our results also imply that caution should be exercised when interpreting disease causality of de novo CNVs found in patients based on analysis of a single tissue in routine disease-related DNA diagnostics... - Use of causal language in observational studies of obesity and nutritionStacey S Cofield
Department of Biostatistics, University of Alabama, Birmingham, AL, USA
Obes Facts 3:353-6. 2010..To assess the inappropriate use of causal language in studies on obesity and nutrition... - Project Grow-2-Gether: a study of the genetic and environmental influences on child eating and obesityMyles S Faith
Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Twin Res 5:472-5. 2002..Future directions may involve longitudinal assessment of child growth and molecular analyses for specific genes that influence child eating behavior... - Years of life lost due to obesityKevin R Fontaine
Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
JAMA 289:187-93. 2003..However, blacks at younger ages with severe levels of obesity had a maximum YLL of 20 for men and 5 for women. CONCLUSION: Obesity appears to lessen life expectancy markedly, especially among younger adults... - Changes in body mass index for individuals with and without schizophrenia, 1987-1996Peter Homel
Office of Research Support, Beth Israel Medical Center, New York, NY, USA
Schizophr Res 55:277-84. 2002..The mechanism that underlies this weight age and sex specific time trend is unclear... - Power and sample sizes for linkage with extreme sampling under an oligogenic model for quantitative traitsMoonseong Heo
New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
Behav Genet 32:23-36. 2002..However, power to detect a locus with the lesser (in magnitude) displacement effect does not necessarily increase with extremity of sampling. Combinations of extreme discordant and extreme concordant sibling pairs are briefly discussed... - Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticismJan Fullerton
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Am J Hum Genet 72:879-90. 2003..One locus, on chromosome 1, is syntenic with that reported from QTL mapping of rodent emotionality, an animal model of neuroticism, suggesting that some animal and human QTLs influencing emotional stability may be homologous... - Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restrictionYoshikazu Higami
Wisconsin Primate Research Center, Madison, Wisconsin, USA
FASEB J 18:415-7. 2004..Our data provide new insights on the metabolic state associated with aging retardation by LCR... - Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention programAllan F Moore
Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Diabetes 57:2503-10. 2008.... - alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of miceSang Kyu Park
Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
J Nutr 138:1010-8. 2008..These results demonstrate that middle age-onset dietary supplementation with alphaT and gammaT can partially prevent age-associated transcriptional changes and that these effects are tissue and tocopherol specific... - Obesity--still highly heritable after all these yearsSolomon K Musani
Am J Clin Nutr 87:275-6. 2008 - The effect of insulin on expression of genes and biochemical pathways in human skeletal muscleXuxia Wu
Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
Endocrine 31:5-17. 2007..The role of NGFI-B (NR4A1) as a new potential mediator of insulin action highlights the need for greater understanding of nuclear transcription factors in insulin action... - Murine weight loss exhibits significant genetic variation during dietary restrictionBrad A Rikke
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
Physiol Genomics 27:122-30. 2006..The genetic variation also implies the existence of genes that would be novel therapeutic targets, distinct from genes affecting AL body weight or body fat, for enhancing (or mitigating) weight loss during food restriction...