David Allison

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)
    David B Allison
    Department of Biostatistics, School of Public Health and Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obesity (Silver Spring) 20:330-42. 2012
  2. pmc No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight
    D L Smith
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Int J Obes (Lond) 35:652-7. 2011
  3. pmc Missing data in randomized clinical trials for weight loss: scope of the problem, state of the field, and performance of statistical methods
    Mai A Elobeid
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 4:e6624. 2009
  4. pmc Drugs associated with more suicidal ideations are also associated with more suicide attempts
    Henry T Robertson
    Department of Biostatistics, University of Alabama at Birmingham, Ryals School of Public Health, Birmingham, Alabama, United States of America
    PLoS ONE 4:e7312. 2009
  5. pmc Conjectures on some curious connections among social status, calorie restriction, hunger, fatness, and longevity
    Kathryn A Kaiser
    Office of Energetics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Ann N Y Acad Sci 1264:1-12. 2012
  6. pmc The 'obesity paradox': a parsimonious explanation for relations among obesity, mortality rate and aging?
    D K Childers
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    Int J Obes (Lond) 34:1231-8. 2010
  7. pmc Is socioeconomic status of the rearing environment causally related to obesity in the offspring?
    Kevin R Fontaine
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e27692. 2011
  8. pmc Recent advances in understanding and mitigating adipogenic and metabolic effects of antipsychotic drugs
    Julia M Gohlke
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham Birmingham, AL, USA
    Front Psychiatry 3:62. 2012
  9. pmc Overweight, obesity, and colorectal cancer screening: disparity between men and women
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    BMC Public Health 4:53. 2004
  10. pmc Testing for differences in distribution tails to test for differences in 'maximum' lifespan
    Guimin Gao
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    BMC Med Res Methodol 8:49. 2008

Research Grants

Detail Information

Publications104 found, 100 shown here

  1. pmc Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)
    David B Allison
    Department of Biostatistics, School of Public Health and Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obesity (Silver Spring) 20:330-42. 2012
    ..75/23 patients, and 33.6% of 15/92 patients. PHEN/TPM CR demonstrated dose-dependent effects on weight and metabolic variables in the direction expected to be beneficial with no evidence of serious adverse events induced by treatment...
  2. pmc No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight
    D L Smith
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Int J Obes (Lond) 35:652-7. 2011
    ....
  3. pmc Missing data in randomized clinical trials for weight loss: scope of the problem, state of the field, and performance of statistical methods
    Mai A Elobeid
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 4:e6624. 2009
    ..Herein, we meta-analytically evaluate the extent of missing data, the frequency with which various analytic methods are employed to accommodate dropouts, and the performance of multiple statistical methods...
  4. pmc Drugs associated with more suicidal ideations are also associated with more suicide attempts
    Henry T Robertson
    Department of Biostatistics, University of Alabama at Birmingham, Ryals School of Public Health, Birmingham, Alabama, United States of America
    PLoS ONE 4:e7312. 2009
    ..This is difficult to determine in RCTs because of the rarity of suicidal attempts and completions...
  5. pmc Conjectures on some curious connections among social status, calorie restriction, hunger, fatness, and longevity
    Kathryn A Kaiser
    Office of Energetics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Ann N Y Acad Sci 1264:1-12. 2012
    ..Second, we examine models of the interactions between caloric restriction, body composition, and longevity. Finally, we put forth a relational model of the influences of differing environmental cues on body composition and longevity...
  6. pmc The 'obesity paradox': a parsimonious explanation for relations among obesity, mortality rate and aging?
    D K Childers
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    Int J Obes (Lond) 34:1231-8. 2010
    ....
  7. pmc Is socioeconomic status of the rearing environment causally related to obesity in the offspring?
    Kevin R Fontaine
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e27692. 2011
    ..09). Thus, despite the differing structures of the two adoption studies, both suggest that shared genetic diathesis and direct environmental transmission contribute about equally to the association between rearing SES and offspring BMI...
  8. pmc Recent advances in understanding and mitigating adipogenic and metabolic effects of antipsychotic drugs
    Julia M Gohlke
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham Birmingham, AL, USA
    Front Psychiatry 3:62. 2012
    ..This paper summarizes the major conclusions and important supporting data from the meeting...
  9. pmc Overweight, obesity, and colorectal cancer screening: disparity between men and women
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    BMC Public Health 4:53. 2004
    ..To estimate the association between body-mass index (BMI: kg/m2) and colorectal cancer (CRC) screening among US adults aged >or= 50 years...
  10. pmc Testing for differences in distribution tails to test for differences in 'maximum' lifespan
    Guimin Gao
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    BMC Med Res Methodol 8:49. 2008
    ..However, a limitation of these tests is that they do not consider how much above the threshold any particular observation is...
  11. pmc Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate
    Georgina A Ankra-Badu
    Department of Poultry Science Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA
    BMC Genomics 11:107. 2010
    ..We used Bayesian model selection to comprehensively map main, epistatic and sex-specific QTL in an F2 reciprocal intercross between two chicken lines divergently selected for high or low growth rate...
  12. pmc Comparing self-reported ethnicity to genetic background measures in the context of the Multi-Ethnic Study of Atherosclerosis (MESA)
    Jasmin Divers
    Department of Biostatistical Sciences, Wake Forest University School of Medicine Winston Salem, North Carolina 27157, USA
    BMC Genet 12:28. 2011
    ..We compare the agreement between SRE and genetic based measures of ancestry (GBMA), and conduct simulation studies based on observed MESA data to evaluate the performance of each measure under various conditions...
  13. pmc Natural selection among Eurasians at genomic regions associated with HIV-1 control
    Yann C Klimentidis
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Evol Biol 11:173. 2011
    ....
  14. pmc Sources of variation in Affymetrix microarray experiments
    Stanislav O Zakharkin
    University of Alabama, Birmingham, Alabama, USA
    BMC Bioinformatics 6:214. 2005
    ..The objectives of this study were: (1) to estimate relative magnitudes of different sources of variation and (2) to evaluate agreement between biological and technical replicates...
  15. pmc Reproducible clusters from microarray research: whither?
    Nikhil R Garge
    Medical College of Georgia, 1120 15th Street, Ca4100, Augusta, GA 30912, USA, Email
    BMC Bioinformatics 6:S10. 2005
    ..We used this approach to determine the performance of commonly used clustering algorithms and the degree of replicability achieved using several microarray datasets...
  16. pmc The PowerAtlas: a power and sample size atlas for microarray experimental design and research
    Grier P Page
    Department of Biostatistics, University of Alabama, Birmingham, AL, USA
    BMC Bioinformatics 7:84. 2006
    ..In addition, investigators frequently do not have pilot data to estimate the sample sizes required for microarray studies...
  17. pmc HDBStat!: a platform-independent software suite for statistical analysis of high dimensional biology data
    Prinal Trivedi
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Bioinformatics 6:86. 2005
    ..HDBStat! provides statisticians and biologists a flexible and easy-to-use interface to analyze complex microarray data using a variety of methods for data preprocessing, quality control analysis and hypothesis testing...
  18. pmc A proposed metric for assessing the measurement quality of individual microarrays
    Kyoungmi Kim
    Department of Biostatistics, University of Alabama, Birmingham, Alabama, USA
    BMC Bioinformatics 7:35. 2006
    ..In some cases this may be manifested as systematic spatial variation on the surface of microarray in which expression measurements within an individual array may vary as a function of geographic position on the array surface...
  19. ncbi request reprint Treatment and prevention of obesity: what works, what doesn't work, and what might work
    David B Allison
    Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Alabama 35294 0022, USA
    Lipids 38:147-55. 2003
    ..Perhaps, with continued efforts at enhancing treatments, we will see incremental advances in the treatment and prevention of obesity...
  20. ncbi request reprint Exactly which synephrine alkaloids does Citrus aurantium (bitter orange) contain?
    D B Allison
    Department of Nutritional Sciences, Section on Statistical Genetics, Clinical Nutrition Research Center, Montreal, Quebec, Canada
    Int J Obes (Lond) 29:443-6. 2005
    ..We believe this justifies further investigation into which synephrine alkaloids are present in CA and products purportedly containing synephrine alkaloids from CA and the relative quantities of each of the different isomers...
  21. ncbi request reprint The impact of weight gain on quality of life among persons with schizophrenia
    David B Allison
    Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, Suite 327 Ryals Public Health Building, University of Alabama at Birmingham, 1665 University Avenue, Birmingham, AL 35294, USA
    Psychiatr Serv 54:565-7. 2003
    ..Clinicians should consider the effect of weight gain on quality of life when prescribing antipsychotics and should help patients adopt weight maintenance behaviors...
  22. ncbi request reprint Differential associations of body mass index and adiposity with all-cause mortality among men in the first and second National Health and Nutrition Examination Surveys (NHANES I and NHANES II) follow-up studies
    D B Allison
    Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Int J Obes Relat Metab Disord 26:410-6. 2002
    ..The purpose is to test the hypothesis stated above...
  23. doi request reprint Obesity as a disease: a white paper on evidence and arguments commissioned by the Council of the Obesity Society
    David B Allison
    Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obesity (Silver Spring) 16:1161-77. 2008
  24. ncbi request reprint Microarray data analysis: from disarray to consolidation and consensus
    David B Allison
    Section on Statistical Genetics, Department of Biostatistics, Ryals Public Health Building, 1665 University Avenue, University of Alabama at Birmingham, Alabama 35294 0022, USA
    Nat Rev Genet 7:55-65. 2006
    ..Many are special cases of more general models, and points of consensus are emerging about the general approaches that warrant use and elaboration...
  25. pmc Sample size in obesity trials: patient perspective versus current practice
    David B Allison
    Department of Nutrition Sciences and the Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Med Decis Making 30:68-75. 2010
    ..To evaluate patient opinions on acceptable risks in exchange for a given degree of weight loss and their implications for sample size determination in obesity randomized clinical trials (RCTs)...
  26. pmc Characterization of epistasis influencing complex spontaneous obesity in the BSB model
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, Alabama 35294, USA
    Genetics 167:399-409. 2004
    ..Chromosomes 6 and 12 have not only main effects but also strong epistatic effects on plasma total cholesterol. Our results emphasize the importance of modeling epistasis for discovery of obesity genes...
  27. ncbi request reprint Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294, USA
    J Lipid Res 45:2063-70. 2004
    ..SPRET/Pt alleles of the QTL on each chromosome promote hepatic lipase activity. The proportion of phenotypic variance explained by the epistatic effect is higher than that explained by the main effect of the QTL on chromosome 7...
  28. pmc Metformin supplementation and life span in Fischer-344 rats
    Daniel L Smith
    Department of Biostatistics, Ryals Public Health Building, Suite 414, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, USA
    J Gerontol A Biol Sci Med Sci 65:468-74. 2010
    ..05) compared with control...
  29. ncbi request reprint Optimal allocation of replicates for measurement evaluation studies
    Stanislav O Zakharkin
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Genomics Proteomics Bioinformatics 4:196-202. 2006
    ..Therefore, it is recommended to use two technical replicates for each biological replicate if the goal is to evaluate the reproducibility of measurements...
  30. ncbi request reprint Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294, USA
    Genet Res 87:45-60. 2006
    ..Several main and epistatic effects were shared by the body composition and body weight traits, suggesting that pleiotropy plays an important role in growth and obesity...
  31. pmc Endocrine disruptors and obesity: an examination of selected persistent organic pollutants in the NHANES 1999-2002 data
    Mai A Elobeid
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Environ Res Public Health 7:2988-3005. 2010
    ..Hence, BMI and WC are associated with POPs levels, making the chemicals plausible contributors to the obesity epidemic...
  32. ncbi request reprint No evidence for a major role of polymorphisms during bupropion treatment
    Jianfang Hu
    Department of Biostatistics, Section on Statistical Genetics, Ryals Public Health Building, Suite 327, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA
    Obesity (Silver Spring) 14:1863-7. 2006
    ..Overall, our results do not support a major role for these five candidate genes in weight gain after smoking cessation...
  33. ncbi request reprint The effects of intentional weight loss as a latent variable problem
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Stat Med 24:941-54. 2005
    ....
  34. pmc Haplotyping methods for pedigrees
    Guimin Gao
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Ala, USA
    Hum Hered 67:248-66. 2009
    ..We explore the connections among these methods, and describe the challenges that remain to be addressed...
  35. ncbi request reprint Comparison of linear weighting schemes for perfect match and mismatch gene expression levels from microarray data
    T Mark Beasley
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Pharmacogenomics 5:197-205. 2005
    ....
  36. doi request reprint Obesity among those with mental disorders: a National Institute of Mental Health meeting report
    David B Allison
    University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Prev Med 36:341-50. 2009
    ....
  37. pmc An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans
    James M Kelley
    University of Alabama at Birmingham, Birmingham, AL, USA
    PLoS Genet 5:e1000424. 2009
    ..An African ancestry-specific genetic variant of CTLA4 appears to be associated with protection from RA in African Americans. This finding may explain, in part, the relatively low prevalence of RA in black African populations...
  38. pmc Fruit and vegetable pricing by demographic factors in the Birmingham, Alabama, metropolitan area, 2004-2005
    Jamy D Ard
    University of Alabama at Birmingham, 1675 University Blvd, Webb 441, Birmingham, AL 35294, USA
    Prev Chronic Dis 7:A78. 2010
    ..Because the contextual environment influences food outlet type and availability, we wanted to determine whether neighborhood demographics were associated with prices of fruits and vegetables...
  39. pmc The impact of cost on the availability of fruits and vegetables in the homes of schoolchildren in Birmingham, Alabama
    Jamy D Ard
    Department of Nutrition Sciences, University of Alabama, Birmingham, USA
    Am J Public Health 97:367-72. 2007
    ..We sought to determine whether fruit and vegetable cost and consumers' race and income would predict availability of fruits and vegetables in homes of schoolchildren in the Birmingham, Ala, area...
  40. ncbi request reprint Detection of gene x gene interactions in genome-wide association studies of human population data
    Solomon K Musani
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Hered 63:67-84. 2007
    ..Instead, a combination of approaches with the aim of balancing their specific strengths may be the optimal approach to investigate gene x gene interactions in human data...
  41. ncbi request reprint Principal component analysis of quantitative trait loci for immune response to adenovirus in mice
    Solomon K Musani
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, AL 35294 0007, USA
    Hereditas 143:189-97. 2006
    ..01 and 31.01 cM) and 15 (29.21, 36.01, and 56.31 cM). These results illustrate the use of principal component analysis in mapping QTLs using multiple correlated traits...
  42. doi request reprint Predicting genetic predisposition in humans: the promise of whole-genome markers
    Gustavo de Los Campos
    University of Alabama at Birmingham, 35294, USA
    Nat Rev Genet 11:880-6. 2010
    ..We propose that alternative approaches, which are largely borrowed from animal breeding, provide potential for advances. We review selected methods and discuss the challenges and opportunities ahead...
  43. pmc Divergence in popular diets relative to diets consumed by Americans, and implications for diet selection
    James M Shikany
    Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, USA
    MedGenMed 9:8. 2007
    ..We hypothesized that because most of these diets differ greatly from the way most Americans spontaneously eat, the choice of a WLD may be less critical than the decision to adopt any WLD...
  44. doi request reprint Understanding the relationship between baseline BMI and subsequent weight change in antipsychotic trials: effect modification or regression to the mean?
    David B Allison
    Department of Biostatistics, University of Alabama, Birmingham, AL, USA
    Psychiatry Res 170:172-6. 2009
    ..This class of drugs appears to cause similar weight gain in both high and low baseline BMI groups...
  45. pmc Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Hered 66:67-86. 2008
    ....
  46. pmc Rank-based inverse normal transformations are increasingly used, but are they merited?
    T Mark Beasley
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Ryals Public Health Building, Suite 327, Birmingham, AL, 35294, USA
    Behav Genet 39:580-95. 2009
    ..Rigorous research evaluating the utility of INTs seems warranted...
  47. pmc The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J mice
    Daniel L Smith
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
    Obesity (Silver Spring) 18:995-9. 2010
    ..247 g; P = 0.57). Contrary to previous research, MOS supplementation had no discernable effect on body weight gain or composition during this 12-week study, challenging the potential use of MOS as a CRM or body composition enhancer...
  48. pmc Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions
    Yann C Klimentidis
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, 1665 University Blvd, RPHB 327, Birmingham, AL 35294, USA
    Hum Genet 129:407-18. 2011
    ..Our findings suggest that there is an evolutionary genetic basis for population differences in these traits, and we have identified potential group-specific genetic risk factors...
  49. pmc Use of causal language in observational studies of obesity and nutrition
    Stacey S Cofield
    Department of Biostatistics, University of Alabama, Birmingham, AL, USA
    Obes Facts 3:353-6. 2010
    ..To assess the inappropriate use of causal language in studies on obesity and nutrition...
  50. pmc Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study
    Yongjun Liu
    Departments of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pharmacogenet Genomics 19:161-9. 2009
    ..The apolipoproteins (APOA1/C3/A4/A5) are key components in modulating lipoprotein metabolism. It is unknown whether variants at the APOA1/C3/A4/A5 gene cluster are associated with lipid response to pharmacologic intervention...
  51. pmc Attitudes and beliefs associated with leisure-time physical activity among African American adults
    Olivia Affuso
    Department of Epidemiology, University of Alabama at Birmingham 35294 0013, USA
    Ethn Dis 21:63-7. 2011
    ..We sought to discover the extent to which health attitudes and beliefs are associated with leisure-time physical activity in this population...
  52. pmc Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children
    Yann C Klimentidis
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    Hum Genomics 5:79-89. 2011
    ..Importantly, we have implicated this region in the early development of diabetes-related phenotypes, and in the genetic aetiology of population differences in these phenotypes...
  53. pmc Weighted multiple hypothesis testing procedures
    Guolian Kang
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Stat Appl Genet Mol Biol 8:Article23. 2009
    ..All proposed procedures control the FWER well and are useful when prior information is available to estimate the weights...
  54. pmc Calorie restriction: what recent results suggest for the future of ageing research
    Daniel L Smith
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Eur J Clin Invest 40:440-50. 2010
    ..Thus, the search for substances that can reproduce the beneficial physiologic responses of CR without a requisite calorie intake reduction, termed CR mimetics (CRMs), has gained momentum...
  55. ncbi request reprint Two-stage testing in microarray analysis: what is gained?
    David B Allison
    Department of Biostatistics, University of Alabama at Birmingham, USA
    J Gerontol A Biol Sci Med Sci 57:B189-92. 2002
    ..Therefore, investigators are encouraged to consider alternative analytic approaches...
  56. pmc Bayesian model selection for genome-wide epistatic quantitative trait loci analysis
    Nengjun Yi
    Department of Biostatistics, University of Alabama, Birmingham 35294, USA
    Genetics 170:1333-44. 2005
    ..We illustrate the proposed method by detecting new epistatic QTL for obesity in a backcross of CAST/Ei mice onto M16i...
  57. ncbi request reprint New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random sampling
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Genet Epidemiol 28:48-57. 2005
    ..Both random sampling and extreme sampling schemes were investigated. A multinomial logistic joint test provides the highest overall power irrespective of sample size, allele frequency, heritability, and modes of inheritance...
  58. pmc Joint tests for quantitative trait loci in experimental crosses
    T Mark Beasley
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
    Genet Sel Evol 36:601-19. 2004
    ..Joint tests were generally more powerful for one-tailed selection under both backcross and F2 intercross situations. However, joint tests cannot be recommended for one-tailed selective genotyping if segregation distortion is suspected...
  59. ncbi request reprint Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents
    Jose R Fernandez
    Section on Statistical Genetics, Department of Biostatistics, Clinical Nutrition Research Center, University of Alabama at Birmingham, 35294 3360, USA
    J Pediatr 145:439-44. 2004
    ..To describe and provide estimates of the distribution of waist circumference (WC) according to percentiles in African-, European-, and Mexican-American children, and to test for group differences at different percentiles...
  60. ncbi request reprint A simple significance test for quantile regression
    David T Redden
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Stat Med 23:2587-97. 2004
    ....
  61. ncbi request reprint Mapping multiple quantitative trait Loci for ordinal traits
    Nengjun Yi
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Behav Genet 34:3-15. 2004
    ..To this end, we provide a unified approach to mapping multiple QTL for continuous, binary, and ordinal traits. Utility and flexibility of the method are demonstrated using simulated data...
  62. ncbi request reprint A design and statistical perspective on microarray gene expression studies in nutrition: the need for playful creativity and scientific hard-mindedness
    Grier P Page
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Nutrition 19:997-1000. 2003
    ....
  63. ncbi request reprint Nonreplication in genetic association studies of obesity and diabetes research
    David T Redden
    Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Nutr 133:3323-6. 2003
    ..Recommendations to improve future association studies are presented...
  64. pmc Stochastic search variable selection for identifying multiple quantitative trait loci
    Nengjun Yi
    Department of Biostatistics, University of Alabama, Birmingham 35294 0022, USA
    Genetics 164:1129-38. 2003
    ..The results demonstrate that the proposed method works well under typical situations of most QTL studies in terms of number of markers and marker density...
  65. ncbi request reprint Association of African genetic admixture with resting metabolic rate and obesity among women
    Jose R Fernandez
    Department of Nutrition Sciences and the Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Obes Res 11:904-11. 2003
    ....
  66. pmc Bias in estimates of quantitative-trait-locus effect in genome scans: demonstration of the phenomenon and a method-of-moments procedure for reducing bias
    David B Allison
    Department of Biostatistics and Center for Research on Clinical Nutrition, University of Alabama at Birmingham, 35294 0022, USA
    Am J Hum Genet 70:575-85. 2002
    ..Finally, limitations of the MOM approach are noted, and we discuss some alternative procedures that may also reduce bias...
  67. ncbi request reprint Is percentage body fat differentially related to body mass index in Hispanic Americans, African Americans, and European Americans?
    Jose R Fernandez
    Obesity Research Center, St Luke s Roosevelt Hospital and the Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Clin Nutr 77:71-5. 2003
    ....
  68. ncbi request reprint Beneficial influences of systemic cooperation and sociological behavior on longevity
    John D Mountz
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 123:963-73. 2002
    ....
  69. ncbi request reprint Improving the power of sib pair quantitative trait loci detection by phenotype winsorization
    Jose R Fernandez
    Department of Nutrition Sciences, Division of Physiology and Metabolism, The University of Alabama at Birmingham, 35294 3360, USA
    Hum Hered 53:59-67. 2002
    ..We evaluated the robustness and power of reducing the influence of subjects with extreme phenotypic values by Winsorizing non-normal distributions in three versions of Haseman-Elston regression-based methods of QTL linkage analysis...
  70. ncbi request reprint Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results
    David T Redden
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Alabama 35294 0022, USA
    Cancer Epidemiol Biomarkers Prev 14:1384-9. 2005
    ....
  71. pmc Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles
    Carl E G Bruder
    Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294 0024, USA
    Am J Hum Genet 82:763-71. 2008
    ..Our results also imply that caution should be exercised when interpreting disease causality of de novo CNVs found in patients based on analysis of a single tissue in routine disease-related DNA diagnostics...
  72. ncbi request reprint Dietary restraint and disinhibition do not affect accuracy of 24-hour recall in a multiethnic population
    Jamy D Ard
    Nutrition Sciences and Medicine, Department of Medicine, University of Alabama, Birmingham, USA
    J Am Diet Assoc 106:434-7. 2006
    ..Disinhibition was not related to intake or accuracy. Dietetics professionals should consider dietary restraint a possible reason for a lower than expected estimate of energy intake when using 24-hour recalls...
  73. ncbi request reprint Mapping quantitative trait loci affecting variation in Drosophila triacylglycerol storage
    Maria De Luca
    Department of Environmental Health Sciences, University of Alabama, Birmingham, AL 35294, USA
    Obes Res 13:1596-605. 2005
    ..The objective of our study was to identify quantitative trait loci (QTLs) that contribute to variation in triacylglycerol (TAG) storage in two D. melanogaster laboratory strains...
  74. pmc An empirical Bayes method for updating inferences in analysis of quantitative trait loci using information from related genome scans
    Kui Zhang
    Department of Biostatistics, Section of Statistical Genetics, University of Alabama, Birmingham 35294, USA
    Genetics 173:2283-96. 2006
    ..In the face of marked heterogeneity among studies, the empirical Bayes method outperforms the comparator...
  75. pmc Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model
    David T Redden
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Genet 2:e137. 2006
    ....
  76. ncbi request reprint The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixture
    David T Redden
    Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, USA
    Behav Genet 36:678-86. 2006
    ....
  77. ncbi request reprint Is GAD2 on chromosome 10p12 a potential candidate gene for morbid obesity?
    Hemant K Tiwari
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham 35294, USA
    Nutr Rev 63:315-9. 2005
    ..Also discussed are additional research questions that merit inquiry when further evaluating this genetic variant as a putative contributor to human obesity...
  78. pmc BMI and headache among women: results from 11 epidemiologic datasets
    Scott W Keith
    Section on Statistical Genetics and Clinical Nutrition Research Center, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    Obesity (Silver Spring) 16:377-83. 2008
    ..To evaluate the association between BMI (kg/m(2)) and headaches among women...
  79. ncbi request reprint Effect of dairy supplementation on body composition and insulin resistance in mice
    Maria S Johnson
    Department of Nutrition Sciences, University of Alabama at Birmingham, Alabama, USA
    Nutrition 23:836-43. 2007
    ..This study examined whether yogurt supplementation attenuated the weight gain and insulin resistance in mice fed a moderate-fat diet...
  80. pmc Bayesian model choice and search strategies for mapping interacting quantitative trait Loci
    Nengjun Yi
    Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294, USA
    Genetics 165:867-83. 2003
    ..Utility and flexibility of the method are demonstrated using both simulated data and a real data set. Sensitivity of posterior inference to prior specifications of the number and genetic effects of QTL is investigated...
  81. ncbi request reprint The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle
    Xuxia Wu
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
    Endocrine 31:5-17. 2007
    ..The role of NGFI-B (NR4A1) as a new potential mediator of insulin action highlights the need for greater understanding of nuclear transcription factors in insulin action...
  82. ncbi request reprint Empirical bayes method for incorporating data from multiple genome scans
    T Mark Beasley
    Department of Biostatistics, Section of Statistical Genetics, The University of Alabama at Birmingham, 35294, USA
    Hum Hered 60:36-42. 2005
    ..This EB method for incorporating data from multiple studies into genome scan analyses seems promising...
  83. ncbi request reprint Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM)
    Jessica M Grunda
    Departments of Pharmacology and Toxicology, Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA
    J Neurooncol 80:261-74. 2006
    ....
  84. ncbi request reprint Quantitative prediction of body diameter in severely obese individuals
    Kevin R Fontaine
    Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Ergonomics 45:49-60. 2002
    ..9-1.1 cm. These analyses provide body size-to-weight estimates that may help manufacturers develop products and services that are more appropriate for increasing numbers of severely obese individuals...
  85. pmc Can rodent longevity studies be both short and powerful?
    Henry T Robertson
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    J Gerontol A Biol Sci Med Sci 66:279-86. 2011
    ..4 times as many rodents will often have equivalent or greater power. Cost calculations suggest that shorter studies will be more expensive but perhaps not so much to not be worth the reduced time...
  86. ncbi request reprint Murine weight loss exhibits significant genetic variation during dietary restriction
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
    Physiol Genomics 27:122-30. 2006
    ..The genetic variation also implies the existence of genes that would be novel therapeutic targets, distinct from genes affecting AL body weight or body fat, for enhancing (or mitigating) weight loss during food restriction...
  87. ncbi request reprint Power and sample sizes for linkage with extreme sampling under an oligogenic model for quantitative traits
    Moonseong Heo
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Behav Genet 32:23-36. 2002
    ..However, power to detect a locus with the lesser (in magnitude) displacement effect does not necessarily increase with extremity of sampling. Combinations of extreme discordant and extreme concordant sibling pairs are briefly discussed...
  88. ncbi request reprint Associations of body mass index and anthropometric indicators of fat mass and fat free mass with all-cause mortality among women in the first and second National Health and Nutrition Examination Surveys follow-up studies
    Shankuan Zhu
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Ann Epidemiol 13:286-93. 2003
    ..This study tests whether fat mass (FM) and fat free mass (FFM) have opposite associations with mortality in a nationally representative sample of females...
  89. ncbi request reprint Project Grow-2-Gether: a study of the genetic and environmental influences on child eating and obesity
    Myles S Faith
    Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Twin Res 5:472-5. 2002
    ..Future directions may involve longitudinal assessment of child growth and molecular analyses for specific genes that influence child eating behavior...
  90. ncbi request reprint Years of life lost due to obesity
    Kevin R Fontaine
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    JAMA 289:187-93. 2003
    ..Public health officials and organizations have disseminated health messages regarding the dangers of obesity, but these have not produced the desired effect...
  91. ncbi request reprint Changes in body mass index for individuals with and without schizophrenia, 1987-1996
    Peter Homel
    Office of Research Support, Beth Israel Medical Center, New York, NY, USA
    Schizophr Res 55:277-84. 2002
    ..The mechanism that underlies this weight age and sex specific time trend is unclear...
  92. ncbi request reprint Habitual physical activity in children: the role of genes and the environment
    Paul W Franks
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014, USA
    Am J Clin Nutr 82:901-8. 2005
    ..Understanding the factors that contribute to physical inactivity in children is important because sedentary behavior strongly relates to metabolic disorders such as obesity and diabetes...
  93. pmc Evaluating statistical methods using plasmode data sets in the age of massive public databases: an illustration using false discovery rates
    Gary L Gadbury
    Department of Statistics, Kansas State University, Manhattan, Kansas, United States of America
    PLoS Genet 4:e1000098. 2008
    ..We use the procedure to compare estimates for the proportion of true null hypotheses, the false discovery rate (FDR), and a local version of FDR obtained from 15 different statistical methods...
  94. ncbi request reprint Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: a frequently sampled intravenous glucose tolerance test and minimal model analysis
    David C Henderson
    Schizophrenia Program, Massachusetts General Hospital, Boston, MA, USA
    Arch Gen Psychiatry 62:19-28. 2005
    ....
  95. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  96. pmc alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice
    Sang Kyu Park
    Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
    J Nutr 138:1010-8. 2008
    ..These results demonstrate that middle age-onset dietary supplementation with alphaT and gammaT can partially prevent age-associated transcriptional changes and that these effects are tissue and tocopherol specific...
  97. ncbi request reprint The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice
    Cheol Koo Lee
    Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI 53706, USA
    Free Radic Biol Med 36:1043-57. 2004
    ....
  98. ncbi request reprint Quantitative trait Loci specifying the response of body temperature to dietary restriction
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado at Boulder, USA
    J Gerontol A Biol Sci Med Sci 59:118-25. 2004
    ..Importantly, the genes underlying such QTLs would be causal factors affecting these responses and could be identified by positional cloning...
  99. ncbi request reprint Effect of winsorization on power and type 1 error of variance components and related methods of QTL detection
    Sanjay Shete
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Behav Genet 34:153-9. 2004
    ..A robust version of the LRT that adjusts for sample kurtosis showed the best power for nonnormal data. Finally, phenotype winsorization of nonnormal data reduces the bias in estimation of the major gene variance component...

Research Grants34

  1. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2004
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  2. Body Composition, Energetics, and Longevity
    David B Allison; Fiscal Year: 2010
    ..The proposed research will help provide information to inform that dialogue. ..
  3. Effects of Intentional Weight Loss on Mortality Rate
    David Allison; Fiscal Year: 2007
    ..abstract_text> ..
  4. Genome-wide Structured Association Testing & Regional Admixture Mapping
    David B Allison; Fiscal Year: 2010
    ..abstract_text> ..
  5. Obesity and Mortality
    David Allison; Fiscal Year: 2007
    ..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
  6. Effects of Intentional Weight Loss on Mortality Rate
    David Allison; Fiscal Year: 2007
    ..i ..
  7. Design Issues in Obesity RCTs: Building an Evidence Base
    David Allison; Fiscal Year: 2009
    ..This research should give valuable answers and critical information for more evidence-based decisions about the design, analysis, and interpretation of obesity RCTs. ..
  8. Obesity and Mortality
    David Allison; Fiscal Year: 2009
    ..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
  9. Genome-wide Structured Association Testing & Regional Admixture Mapping
    David Allison; Fiscal Year: 2009
    ..abstract_text> ..
  10. Design Issues in Obesity RCTs: Building an Evidence Base
    David B Allison; Fiscal Year: 2010
    ..This research should give valuable answers and critical information for more evidence-based decisions about the design, analysis, and interpretation of obesity RCTs. ..
  11. Obesity and Mortality
    David Allison; Fiscal Year: 2009
    ..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
  12. Genome-wide Structured Association Testing & Regional Admixture Mapping
    David Allison; Fiscal Year: 2007
    ....
  13. Body Weight, Adiposity, Energetics and Longevity
    David Allison; Fiscal Year: 2007
    ..This 2-day meeting will bring together expert scientists from diverse disciplines to explore unanswered questions about these interactions and to introduce novel thoughts for future research. ..
  14. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2002
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  15. Effects of Intentional Weight Loss on Mortality Rate
    David Allison; Fiscal Year: 2006
    ..abstract_text> ..
  16. UAB Statistical Genetics Post-doctoral Training Program
    David Allison; Fiscal Year: 2007
    ..Regular reviews of trainees will be completed to insure adequate progress toward an independent research career. ..
  17. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2001
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  18. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2000
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  19. UAB Obesity Training Program
    David Allison; Fiscal Year: 2007
    ..Funding is requested for four post-doctoral trainee slots. ..
  20. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2001
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  21. UAB Biostatistics Pre-doctoral Training Program
    David Allison; Fiscal Year: 2007
    ..Applied experience is provided via co-mentorship by UAB's well established NHLBI-funded investigators. (END OF ABSTRACT) ..
  22. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2003
    ..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  23. DOES WEIGHT LOSS REDUCE MORTALITY RATE AMONG OBESE RATS?
    David Allison; Fiscal Year: 2002
    ..This study will, for the first time, allow a rigorous experimental test of the hypothesis that among obese organisms, WL promotes longevity. ..
  24. STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERS
    David Allison; Fiscal Year: 2005
    ..Lectures are supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
  25. Design, Analysis, & Interpretation of RCTs in Obesity
    David Allison; Fiscal Year: 2006
    ..The meeting will take place in December of 2006 and be attended by scientists from academia, government, and industry. ..
  26. DOES WEIGHT LOSS REDUCE MORTALITY RATE AMONG OBESE RATS?
    David Allison; Fiscal Year: 2001
    ..This study will, for the first time, allow a rigorous experimental test of the hypothesis that among obese organisms, WL promotes longevity. ..