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Species | David AllisonSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)David B Allison
Department of Biostatistics, School of Public Health and Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 20:330-42. 2012..75/23 patients, and 33.6% of 15/92 patients. PHEN/TPM CR demonstrated dose-dependent effects on weight and metabolic variables in the direction expected to be beneficial with no evidence of serious adverse events induced by treatment...- Overweight, obesity, and colorectal cancer screening: disparity between men and womenMoonseong Heo
Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
BMC Public Health 4:53. 2004..To estimate the association between body-mass index (BMI: kg/m2) and colorectal cancer (CRC) screening among US adults aged >or= 50 years... - Testing for differences in distribution tails to test for differences in 'maximum' lifespanGuimin Gao
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
BMC Med Res Methodol 8:49. 2008..However, a limitation of these tests is that they do not consider how much above the threshold any particular observation is... - Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rateGeorgina A Ankra-Badu
Department of Poultry Science Institute of Bioinformatics, University of Georgia, Athens, GA 30602, USA
BMC Genomics 11:107. 2010..We used Bayesian model selection to comprehensively map main, epistatic and sex-specific QTL in an F2 reciprocal intercross between two chicken lines divergently selected for high or low growth rate... - Comparing self-reported ethnicity to genetic background measures in the context of the Multi-Ethnic Study of Atherosclerosis (MESA)Jasmin Divers
Department of Biostatistical Sciences, Wake Forest University School of Medicine Winston Salem, North Carolina 27157, USA
BMC Genet 12:28. 2011..We compare the agreement between SRE and genetic based measures of ancestry (GBMA), and conduct simulation studies based on observed MESA data to evaluate the performance of each measure under various conditions... - Natural selection among Eurasians at genomic regions associated with HIV-1 controlYann C Klimentidis
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
BMC Evol Biol 11:173. 2011.... - Sources of variation in Affymetrix microarray experimentsStanislav O Zakharkin
University of Alabama, Birmingham, Alabama, USA
BMC Bioinformatics 6:214. 2005..The objectives of this study were: (1) to estimate relative magnitudes of different sources of variation and (2) to evaluate agreement between biological and technical replicates... - Reproducible clusters from microarray research: whither?Nikhil R Garge
Medical College of Georgia, 1120 15th Street, Ca4100, Augusta, GA 30912, USA, Email
BMC Bioinformatics 6:S10. 2005..We used this approach to determine the performance of commonly used clustering algorithms and the degree of replicability achieved using several microarray datasets... - The PowerAtlas: a power and sample size atlas for microarray experimental design and researchGrier P Page
Department of Biostatistics, University of Alabama, Birmingham, AL, USA
BMC Bioinformatics 7:84. 2006..In addition, investigators frequently do not have pilot data to estimate the sample sizes required for microarray studies... - HDBStat!: a platform-independent software suite for statistical analysis of high dimensional biology dataPrinal Trivedi
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
BMC Bioinformatics 6:86. 2005..HDBStat! provides statisticians and biologists a flexible and easy-to-use interface to analyze complex microarray data using a variety of methods for data preprocessing, quality control analysis and hypothesis testing... - A proposed metric for assessing the measurement quality of individual microarraysKyoungmi Kim
Department of Biostatistics, University of Alabama, Birmingham, Alabama, USA
BMC Bioinformatics 7:35. 2006..In some cases this may be manifested as systematic spatial variation on the surface of microarray in which expression measurements within an individual array may vary as a function of geographic position on the array surface... - Obesity as a disease: a white paper on evidence and arguments commissioned by the Council of the Obesity SocietyDavid B Allison
Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 16:1161-77. 2008 - Exactly which synephrine alkaloids does Citrus aurantium (bitter orange) contain?D B Allison
Department of Nutritional Sciences, Section on Statistical Genetics, Clinical Nutrition Research Center, Montreal, Quebec, Canada
Int J Obes (Lond) 29:443-6. 2005..We believe this justifies further investigation into which synephrine alkaloids are present in CA and products purportedly containing synephrine alkaloids from CA and the relative quantities of each of the different isomers... - Sample size in obesity trials: patient perspective versus current practiceDavid B Allison
Department of Nutrition Sciences and the Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Med Decis Making 30:68-75. 2010..To evaluate patient opinions on acceptable risks in exchange for a given degree of weight loss and their implications for sample size determination in obesity randomized clinical trials (RCTs)... - Treatment and prevention of obesity: what works, what doesn't work, and what might workDavid B Allison
Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Alabama 35294 0022, USA
Lipids 38:147-55. 2003..Perhaps, with continued efforts at enhancing treatments, we will see incremental advances in the treatment and prevention of obesity... - Microarray data analysis: from disarray to consolidation and consensusDavid B Allison
Section on Statistical Genetics, Department of Biostatistics, Ryals Public Health Building, 1665 University Avenue, University of Alabama at Birmingham, Alabama 35294 0022, USA
Nat Rev Genet 7:55-65. 2006..Many are special cases of more general models, and points of consensus are emerging about the general approaches that warrant use and elaboration... - The impact of weight gain on quality of life among persons with schizophreniaDavid B Allison
Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, Suite 327 Ryals Public Health Building, University of Alabama at Birmingham, 1665 University Avenue, Birmingham, AL 35294, USA
Psychiatr Serv 54:565-7. 2003..Clinicians should consider the effect of weight gain on quality of life when prescribing antipsychotics and should help patients adopt weight maintenance behaviors... - Differential associations of body mass index and adiposity with all-cause mortality among men in the first and second National Health and Nutrition Examination Surveys (NHANES I and NHANES II) follow-up studiesD B Allison
Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Int J Obes Relat Metab Disord 26:410-6. 2002..The purpose is to test the hypothesis stated above... - Characterization of epistasis influencing complex spontaneous obesity in the BSB modelNengjun Yi
Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, Alabama 35294, USA
Genetics 167:399-409. 2004..Chromosomes 6 and 12 have not only main effects but also strong epistatic effects on plasma total cholesterol. Our results emphasize the importance of modeling epistasis for discovery of obesity genes... - Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB miceNengjun Yi
Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294, USA
J Lipid Res 45:2063-70. 2004..SPRET/Pt alleles of the QTL on each chromosome promote hepatic lipase activity. The proportion of phenotypic variance explained by the epistatic effect is higher than that explained by the main effect of the QTL on chromosome 7... - Bayesian analyses of multiple epistatic QTL models for body weight and body composition in miceNengjun Yi
Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294, USA
Genet Res 87:45-60. 2006..Several main and epistatic effects were shared by the body composition and body weight traits, suggesting that pleiotropy plays an important role in growth and obesity... - The effects of intentional weight loss as a latent variable problemChristopher S Coffey
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Stat Med 24:941-54. 2005.... - Endocrine disruptors and obesity: an examination of selected persistent organic pollutants in the NHANES 1999-2002 dataMai A Elobeid
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Int J Environ Res Public Health 7:2988-3005. 2010..Hence, BMI and WC are associated with POPs levels, making the chemicals plausible contributors to the obesity epidemic... - No evidence for a major role of polymorphisms during bupropion treatmentJianfang Hu
Department of Biostatistics, Section on Statistical Genetics, Ryals Public Health Building, Suite 327, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA
Obesity (Silver Spring) 14:1863-7. 2006..Overall, our results do not support a major role for these five candidate genes in weight gain after smoking cessation... - Metformin supplementation and life span in Fischer-344 ratsDaniel L Smith
Department of Biostatistics, Ryals Public Health Building, Suite 414, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, USA
J Gerontol A Biol Sci Med Sci 65:468-74. 2010..05) compared with control... - Optimal allocation of replicates for measurement evaluation studiesStanislav O Zakharkin
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA
Genomics Proteomics Bioinformatics 4:196-202. 2006..Therefore, it is recommended to use two technical replicates for each biological replicate if the goal is to evaluate the reproducibility of measurements... - Haplotyping methods for pedigreesGuimin Gao
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Ala, USA
Hum Hered 67:248-66. 2009..We explore the connections among these methods, and describe the challenges that remain to be addressed... - Comparison of linear weighting schemes for perfect match and mismatch gene expression levels from microarray dataT Mark Beasley
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Am J Pharmacogenomics 5:197-205. 2005..However, the PM-only model demonstrates superior power in an overwhelming majority of realistic situations, which provides theoretical support for the current trend to employ PM-only models in microarray data analyzes... - Obesity among those with mental disorders: a National Institute of Mental Health meeting reportDavid B Allison
University of Alabama at Birmingham, Birmingham, Alabama, USA
Am J Prev Med 36:341-50. 2009.... - Detection of gene x gene interactions in genome-wide association studies of human population dataSolomon K Musani
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Hum Hered 63:67-84. 2007..Instead, a combination of approaches with the aim of balancing their specific strengths may be the optimal approach to investigate gene x gene interactions in human data... - Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear modelDavid T Redden
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS Genet 2:e137. 2006.... - Principal component analysis of quantitative trait loci for immune response to adenovirus in miceSolomon K Musani
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, AL 35294 0007, USA
Hereditas 143:189-97. 2006..01 and 31.01 cM) and 15 (29.21, 36.01, and 56.31 cM). These results illustrate the use of principal component analysis in mapping QTLs using multiple correlated traits... - The impact of cost on the availability of fruits and vegetables in the homes of schoolchildren in Birmingham, AlabamaJamy D Ard
Department of Nutrition Sciences, University of Alabama, Birmingham, USA
Am J Public Health 97:367-72. 2007..We sought to determine whether fruit and vegetable cost and consumers' race and income would predict availability of fruits and vegetables in homes of schoolchildren in the Birmingham, Ala, area... - Use of causal language in observational studies of obesity and nutritionStacey S Cofield
Department of Biostatistics, University of Alabama, Birmingham, AL, USA
Obes Facts 3:353-6. 2010..To assess the inappropriate use of causal language in studies on obesity and nutrition... - An empirical Bayes method for updating inferences in analysis of quantitative trait loci using information from related genome scansKui Zhang
Department of Biostatistics, Section of Statistical Genetics, University of Alabama, Birmingham 35294, USA
Genetics 173:2283-96. 2006..In the face of marked heterogeneity among studies, the empirical Bayes method outperforms the comparator... - Divergence in popular diets relative to diets consumed by Americans, and implications for diet selectionJames M Shikany
Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, USA
MedGenMed 9:8. 2007..We hypothesized that because most of these diets differ greatly from the way most Americans spontaneously eat, the choice of a WLD may be less critical than the decision to adopt any WLD... - Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of childrenYann C Klimentidis
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
Hum Genomics 5:79-89. 2011..Importantly, we have implicated this region in the early development of diabetes-related phenotypes, and in the genetic aetiology of population differences in these phenotypes... - Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regionsYann C Klimentidis
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, 1665 University Blvd, RPHB 327, Birmingham, AL 35294, USA
Hum Genet 129:407-18. 2011..Our findings suggest that there is an evolutionary genetic basis for population differences in these traits, and we have identified potential group-specific genetic risk factors... - Predicting genetic predisposition in humans: the promise of whole-genome markersGustavo de Los Campos
University of Alabama at Birmingham, 35294, USA
Nat Rev Genet 11:880-6. 2010..We propose that alternative approaches, which are largely borrowed from animal breeding, provide potential for advances. We review selected methods and discuss the challenges and opportunities ahead... - Fruit and vegetable pricing by demographic factors in the Birmingham, Alabama, metropolitan area, 2004-2005Jamy D Ard
University of Alabama at Birmingham, 1675 University Blvd, Webb 441, Birmingham, AL 35294, USA
Prev Chronic Dis 7:A78. 2010..Because the contextual environment influences food outlet type and availability, we wanted to determine whether neighborhood demographics were associated with prices of fruits and vegetables... - Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network studyYongjun Liu
Departments of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pharmacogenet Genomics 19:161-9. 2009..The apolipoproteins (APOA1/C3/A4/A5) are key components in modulating lipoprotein metabolism. It is unknown whether variants at the APOA1/C3/A4/A5 gene cluster are associated with lipid response to pharmacologic intervention... - Understanding the relationship between baseline BMI and subsequent weight change in antipsychotic trials: effect modification or regression to the mean?David B Allison
Department of Biostatistics, University of Alabama, Birmingham, AL, USA
Psychiatry Res 170:172-6. 2009..This class of drugs appears to cause similar weight gain in both high and low baseline BMI groups... - The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J miceDaniel L Smith
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
Obesity (Silver Spring) 18:995-9. 2010..247 g; P = 0.57). Contrary to previous research, MOS supplementation had no discernable effect on body weight gain or composition during this 12-week study, challenging the potential use of MOS as a CRM or body composition enhancer... - Weighted multiple hypothesis testing proceduresGuolian Kang
University of Alabama at Birmingham, Birmingham, AL 35294, USA
Stat Appl Genet Mol Biol 8:Article23. 2009..All proposed procedures control the FWER well and are useful when prior information is available to estimate the weights... - An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African AmericansJames M Kelley
University of Alabama at Birmingham, Birmingham, AL, USA
PLoS Genet 5:e1000424. 2009..An African ancestry-specific genetic variant of CTLA4 appears to be associated with protection from RA in African Americans. This finding may explain, in part, the relatively low prevalence of RA in black African populations... - Rank-based inverse normal transformations are increasingly used, but are they merited?T Mark Beasley
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Ryals Public Health Building, Suite 327, Birmingham, AL, 35294, USA
Behav Genet 39:580-95. 2009..Rigorous research evaluating the utility of INTs seems warranted... - Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principlesHemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Hum Hered 66:67-86. 2008.... - Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profilesCarl E G Bruder
Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294 0024, USA
Am J Hum Genet 82:763-71. 2008..Our results also imply that caution should be exercised when interpreting disease causality of de novo CNVs found in patients based on analysis of a single tissue in routine disease-related DNA diagnostics... - Attitudes and beliefs associated with leisure-time physical activity among African American adultsOlivia Affuso
Department of Epidemiology, University of Alabama at Birmingham 35294 0013, USA
Ethn Dis 21:63-7. 2011..We sought to discover the extent to which health attitudes and beliefs are associated with leisure-time physical activity in this population... - Two-stage testing in microarray analysis: what is gained?David B Allison
Department of Biostatistics, University of Alabama at Birmingham, USA
J Gerontol A Biol Sci Med Sci 57:B189-92. 2002..Therefore, investigators are encouraged to consider alternative analytic approaches... - Joint tests for quantitative trait loci in experimental crossesT Mark Beasley
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
Genet Sel Evol 36:601-19. 2004..Joint tests were generally more powerful for one-tailed selection under both backcross and F2 intercross situations. However, joint tests cannot be recommended for one-tailed selective genotyping if segregation distortion is suspected... - Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescentsJose R Fernandez
Section on Statistical Genetics, Department of Biostatistics, Clinical Nutrition Research Center, University of Alabama at Birmingham, 35294 3360, USA
J Pediatr 145:439-44. 2004..To describe and provide estimates of the distribution of waist circumference (WC) according to percentiles in African-, European-, and Mexican-American children, and to test for group differences at different percentiles... - A simple significance test for quantile regressionDavid T Redden
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Stat Med 23:2587-97. 2004.... - A design and statistical perspective on microarray gene expression studies in nutrition: the need for playful creativity and scientific hard-mindednessGrier P Page
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Nutrition 19:997-1000. 2003.... - Mapping multiple quantitative trait Loci for ordinal traitsNengjun Yi
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Behav Genet 34:3-15. 2004..To this end, we provide a unified approach to mapping multiple QTL for continuous, binary, and ordinal traits. Utility and flexibility of the method are demonstrated using simulated data... - Nonreplication in genetic association studies of obesity and diabetes researchDavid T Redden
Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Nutr 133:3323-6. 2003..Recommendations to improve future association studies are presented... - Stochastic search variable selection for identifying multiple quantitative trait lociNengjun Yi
Department of Biostatistics, University of Alabama, Birmingham 35294 0022, USA
Genetics 164:1129-38. 2003..The results demonstrate that the proposed method works well under typical situations of most QTL studies in terms of number of markers and marker density... - Association of African genetic admixture with resting metabolic rate and obesity among womenJose R Fernandez
Department of Nutrition Sciences and the Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Obes Res 11:904-11. 2003.... - Calorie restriction: what recent results suggest for the future of ageing researchDaniel L Smith
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Eur J Clin Invest 40:440-50. 2010..Thus, the search for substances that can reproduce the beneficial physiologic responses of CR without a requisite calorie intake reduction, termed CR mimetics (CRMs), has gained momentum... - Is percentage body fat differentially related to body mass index in Hispanic Americans, African Americans, and European Americans?Jose R Fernandez
Obesity Research Center, St Luke s Roosevelt Hospital and the Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, USA
Am J Clin Nutr 77:71-5. 2003.... - Bias in estimates of quantitative-trait-locus effect in genome scans: demonstration of the phenomenon and a method-of-moments procedure for reducing biasDavid B Allison
Department of Biostatistics and Center for Research on Clinical Nutrition, University of Alabama at Birmingham, 35294 0022, USA
Am J Hum Genet 70:575-85. 2002..Finally, limitations of the MOM approach are noted, and we discuss some alternative procedures that may also reduce bias... - Beneficial influences of systemic cooperation and sociological behavior on longevityJohn D Mountz
Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
Mech Ageing Dev 123:963-73. 2002.... - Improving the power of sib pair quantitative trait loci detection by phenotype winsorizationJose R Fernandez
Department of Nutrition Sciences, Division of Physiology and Metabolism, The University of Alabama at Birmingham, 35294 3360, USA
Hum Hered 53:59-67. 2002..We evaluated the robustness and power of reducing the influence of subjects with extreme phenotypic values by Winsorizing non-normal distributions in three versions of Haseman-Elston regression-based methods of QTL linkage analysis... - New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random samplingHemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Genet Epidemiol 28:48-57. 2005..Both random sampling and extreme sampling schemes were investigated. A multinomial logistic joint test provides the highest overall power irrespective of sample size, allele frequency, heritability, and modes of inheritance... - Mapping quantitative trait loci affecting variation in Drosophila triacylglycerol storageMaria De Luca
Department of Environmental Health Sciences, University of Alabama, Birmingham, AL 35294, USA
Obes Res 13:1596-605. 2005..The objective of our study was to identify quantitative trait loci (QTLs) that contribute to variation in triacylglycerol (TAG) storage in two D. melanogaster laboratory strains... - Is GAD2 on chromosome 10p12 a potential candidate gene for morbid obesity?Hemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham 35294, USA
Nutr Rev 63:315-9. 2005..Also discussed are additional research questions that merit inquiry when further evaluating this genetic variant as a putative contributor to human obesity... - Bayesian model selection for genome-wide epistatic quantitative trait loci analysisNengjun Yi
Department of Biostatistics, University of Alabama, Birmingham 35294, USA
Genetics 170:1333-44. 2005..We illustrate the proposed method by detecting new epistatic QTL for obesity in a backcross of CAST/Ei mice onto M16i... - Dietary restraint and disinhibition do not affect accuracy of 24-hour recall in a multiethnic populationJamy D Ard
Nutrition Sciences and Medicine, Department of Medicine, University of Alabama, Birmingham, USA
J Am Diet Assoc 106:434-7. 2006..Disinhibition was not related to intake or accuracy. Dietetics professionals should consider dietary restraint a possible reason for a lower than expected estimate of energy intake when using 24-hour recalls... - Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated resultsDavid T Redden
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Alabama 35294 0022, USA
Cancer Epidemiol Biomarkers Prev 14:1384-9. 2005.... - The effect of assortative mating upon genetic association studies: spurious associations and population substructure in the absence of admixtureDavid T Redden
Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, USA
Behav Genet 36:678-86. 2006.... - Effect of dairy supplementation on body composition and insulin resistance in miceMaria S Johnson
Department of Nutrition Sciences, University of Alabama at Birmingham, Alabama, USA
Nutrition 23:836-43. 2007..This study examined whether yogurt supplementation attenuated the weight gain and insulin resistance in mice fed a moderate-fat diet... - The effect of insulin on expression of genes and biochemical pathways in human skeletal muscleXuxia Wu
Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
Endocrine 31:5-17. 2007..The role of NGFI-B (NR4A1) as a new potential mediator of insulin action highlights the need for greater understanding of nuclear transcription factors in insulin action... - BMI and headache among women: results from 11 epidemiologic datasetsScott W Keith
Section on Statistical Genetics and Clinical Nutrition Research Center, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
Obesity (Silver Spring) 16:377-83. 2008..To evaluate the association between BMI (kg/m(2)) and headaches among women... - Bayesian model choice and search strategies for mapping interacting quantitative trait LociNengjun Yi
Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294, USA
Genetics 165:867-83. 2003..Utility and flexibility of the method are demonstrated using both simulated data and a real data set. Sensitivity of posterior inference to prior specifications of the number and genetic effects of QTL is investigated... - Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM)Jessica M Grunda
Departments of Pharmacology and Toxicology, Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA
J Neurooncol 80:261-74. 2006.... - Empirical bayes method for incorporating data from multiple genome scansT Mark Beasley
Department of Biostatistics, Section of Statistical Genetics, The University of Alabama at Birmingham, 35294, USA
Hum Hered 60:36-42. 2005..This EB method for incorporating data from multiple studies into genome scan analyses seems promising... - Can rodent longevity studies be both short and powerful?Henry T Robertson
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
J Gerontol A Biol Sci Med Sci 66:279-86. 2011..4 times as many rodents will often have equivalent or greater power. Cost calculations suggest that shorter studies will be more expensive but perhaps not so much to not be worth the reduced time... - Years of life lost due to obesityKevin R Fontaine
Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
JAMA 289:187-93. 2003..However, blacks at younger ages with severe levels of obesity had a maximum YLL of 20 for men and 5 for women. CONCLUSION: Obesity appears to lessen life expectancy markedly, especially among younger adults... - Power and sample sizes for linkage with extreme sampling under an oligogenic model for quantitative traitsMoonseong Heo
New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
Behav Genet 32:23-36. 2002..However, power to detect a locus with the lesser (in magnitude) displacement effect does not necessarily increase with extremity of sampling. Combinations of extreme discordant and extreme concordant sibling pairs are briefly discussed... - Project Grow-2-Gether: a study of the genetic and environmental influences on child eating and obesityMyles S Faith
Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Twin Res 5:472-5. 2002..Future directions may involve longitudinal assessment of child growth and molecular analyses for specific genes that influence child eating behavior... - Murine weight loss exhibits significant genetic variation during dietary restrictionBrad A Rikke
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
Physiol Genomics 27:122-30. 2006..The genetic variation also implies the existence of genes that would be novel therapeutic targets, distinct from genes affecting AL body weight or body fat, for enhancing (or mitigating) weight loss during food restriction... - Obesity--still highly heritable after all these yearsSolomon K Musani
Am J Clin Nutr 87:275-6. 2008 - Associations of body mass index and anthropometric indicators of fat mass and fat free mass with all-cause mortality among women in the first and second National Health and Nutrition Examination Surveys follow-up studiesShankuan Zhu
New York Obesity Research Center, St. Luke's/Roosevelt Hospital, Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY, USA
Ann Epidemiol 13:286-93. 2003..These results differ from patterns previously observed in males and may reflect sex differences in fat distribution. Research using superior measures of body fat amount and distribution may resolve these discrepancies... - Insulin sensitivity and glucose effectiveness from three minimal models: effects of energy restriction and body fat in adult male rhesus monkeysTheresa A Gresl
Wisconsin Primate Research Center, 1220 Capitol Court, Madison, WI 53715, USA
Am J Physiol Regul Integr Comp Physiol 285:R1340-54. 2003..The observed insulin sensitivity indexes from all models, elevated among R vs. C monkeys, may be explained, at least in part, by the difference in body fat content between these groups after chronic DR... - Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: a frequently sampled intravenous glucose tolerance test and minimal model analysisDavid C Henderson
Schizophrenia Program, Massachusetts General Hospital, Boston, MA, USA
Arch Gen Psychiatry 62:19-28. 2005.... - alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of miceSang Kyu Park
Department of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
J Nutr 138:1010-8. 2008..These results demonstrate that middle age-onset dietary supplementation with alphaT and gammaT can partially prevent age-associated transcriptional changes and that these effects are tissue and tocopherol specific... - Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention programAllan F Moore
Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Diabetes 57:2503-10. 2008.... - Evaluating statistical methods using plasmode data sets in the age of massive public databases: an illustration using false discovery ratesGary L Gadbury
Department of Statistics, Kansas State University, Manhattan, Kansas, United States of America
PLoS Genet 4:e1000098. 2008..We use the procedure to compare estimates for the proportion of true null hypotheses, the false discovery rate (FDR), and a local version of FDR obtained from 15 different statistical methods... - Quantitative trait Loci specifying the response of body temperature to dietary restrictionBrad A Rikke
Institute for Behavioral Genetics, University of Colorado at Boulder, USA
J Gerontol A Biol Sci Med Sci 59:118-25. 2004..Importantly, the genes underlying such QTLs would be causal factors affecting these responses and could be identified by positional cloning... - Effect of winsorization on power and type 1 error of variance components and related methods of QTL detectionSanjay Shete
Department of Epidemiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Behav Genet 34:153-9. 2004..A robust version of the LRT that adjusts for sample kurtosis showed the best power for nonnormal data. Finally, phenotype winsorization of nonnormal data reduces the bias in estimation of the major gene variance component... - Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restrictionYoshikazu Higami
Wisconsin Primate Research Center, Madison, Wisconsin, USA
FASEB J 18:415-7. 2004..Our data provide new insights on the metabolic state associated with aging retardation by LCR... - The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in miceCheol-Koo Lee
Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI 53706, USA
Free Radic Biol Med 36:1043-57. 2004.... - Habitual physical activity in children: the role of genes and the environmentPaul W Franks
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014, USA
Am J Clin Nutr 82:901-8. 2005..Understanding the factors that contribute to physical inactivity in children is important because sedentary behavior strongly relates to metabolic disorders such as obesity and diabetes... - Changes in body mass index for individuals with and without schizophrenia, 1987-1996Peter Homel
Office of Research Support, Beth Israel Medical Center, New York, NY, USA
Schizophr Res 55:277-84. 2002..The mechanism that underlies this weight age and sex specific time trend is unclear...
Research Grants
- STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERSDavid Allison; Fiscal Year: 2004..At each course, lectures will be supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
- Body Composition, Energetics, and LongevityDavid B Allison; Fiscal Year: 2010..The proposed research will help provide information to inform that dialogue. ..
- Effects of Intentional Weight Loss on Mortality RateDavid Allison; Fiscal Year: 2007..i ..
- Design Issues in Obesity RCTs: Building an Evidence BaseDavid Allison; Fiscal Year: 2009..This research should give valuable answers and critical information for more evidence-based decisions about the design, analysis, and interpretation of obesity RCTs. ..
- Obesity and MortalityDavid Allison; Fiscal Year: 2009..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
- Genome-wide Structured Association Testing & Regional Admixture MappingDavid Allison; Fiscal Year: 2009..abstract_text> ..
- Design Issues in Obesity RCTs: Building an Evidence BaseDavid B Allison; Fiscal Year: 2010..This research should give valuable answers and critical information for more evidence-based decisions about the design, analysis, and interpretation of obesity RCTs. ..
- Obesity and MortalityDavid Allison; Fiscal Year: 2009..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
- Obesity and MortalityDavid Allison; Fiscal Year: 2007..Measuring obesity as body fatness and fat distribution instead of just using BMI should provide a more solid basis for public health and clinical recommendations by focusing on the more relevant variables of body fatness. ..
- Genome-wide Structured Association Testing & Regional Admixture MappingDavid Allison; Fiscal Year: 2007....
- DOES WEIGHT LOSS REDUCE MORTALITY RATE AMONG OBESE RATS?David Allison; Fiscal Year: 2002..This study will, for the first time, allow a rigorous experimental test of the hypothesis that among obese organisms, WL promotes longevity. ..
- STATISTICAL GENETICS FOR OBESITY & NUTRITION RESEARCHERSDavid Allison; Fiscal Year: 2005..Lectures are supplemented with extensive discussion sessions, handouts, presentation of worked examples, and interactive demonstrations of statistical genetic data analyses. ..
- Effects of Intentional Weight Loss on Mortality RateDavid Allison; Fiscal Year: 2007..abstract_text> ..
- UAB Statistical Genetics Post-doctoral Training ProgramDavid Allison; Fiscal Year: 2007..Regular reviews of trainees will be completed to insure adequate progress toward an independent research career. ..
- Design, Analysis, & Interpretation of RCTs in ObesityDavid Allison; Fiscal Year: 2006..The meeting will take place in December of 2006 and be attended by scientists from academia, government, and industry. ..
- UAB Obesity Training ProgramDavid Allison; Fiscal Year: 2007..Funding is requested for four post-doctoral trainee slots. ..
- UAB Biostatistics Pre-doctoral Training ProgramDavid Allison; Fiscal Year: 2007..Applied experience is provided via co-mentorship by UAB's well established NHLBI-funded investigators. (END OF ABSTRACT) ..
- Body Weight, Adiposity, Energetics and LongevityDavid Allison; Fiscal Year: 2007..This 2-day meeting will bring together expert scientists from diverse disciplines to explore unanswered questions about these interactions and to introduce novel thoughts for future research. ..
- Genome-wide Structured Association Testing & Regional Admixture MappingDavid B Allison; Fiscal Year: 2010..abstract_text> ..