Robert H Allen

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells
    Mihalis I Panayiotidis
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Chem Biol Interact 147:87-97. 2004
  2. ncbi request reprint High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Hum Mutat 19:641-55. 2002
  3. pmc Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle
    Randy J Chandler
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:64. 2007
  4. pmc Identification and quantitation of cobalamin and cobalamin analogues in human feces
    Robert H Allen
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 87:1324-35. 2008
  5. ncbi request reprint Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment
    Sally P Stabler
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 84:1422-9. 2006
  6. ncbi request reprint Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia
    Mihalis I Panayiotidis
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Free Radic Biol Med 40:348-58. 2006
  7. ncbi request reprint Vitamin B12 deficiency as a worldwide problem
    Sally P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Annu Rev Nutr 24:299-326. 2004
  8. pmc Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice
    Anna E Beaudin
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    Am J Clin Nutr 95:882-91. 2012
  9. ncbi request reprint Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry
    Sally P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Chem 50:365-72. 2004
  10. ncbi request reprint Cystathionine beta-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiae
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Cell Physiol 192:81-92. 2002

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells
    Mihalis I Panayiotidis
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Chem Biol Interact 147:87-97. 2004
    ..The transsulfuration pathway was likely activated by CSE since cystathionine increased, potentially contributing to the increased total intracellular GSH content...
  2. ncbi request reprint High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Hum Mutat 19:641-55. 2002
    ....
  3. pmc Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle
    Randy J Chandler
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:64. 2007
    ..Current treatment regimens rely on dietary management and, in severely affected patients, liver or combined liver-kidney transplantation. For undetermined reasons, transplantation does not correct the biochemical phenotype...
  4. pmc Identification and quantitation of cobalamin and cobalamin analogues in human feces
    Robert H Allen
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 87:1324-35. 2008
    ..Cobalamin (vitamin B-12) and cobalamin analogues are present in human feces, but a complete identification has not been established, and the amounts present have not been determined...
  5. ncbi request reprint Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment
    Sally P Stabler
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 84:1422-9. 2006
    ..S-Adenosylmethionine (SAM)-dependent methylation reactions produce S-adenosylhomocysteine (SAH), the precursor of homocysteine, which has been associated with adverse events when it is elevated...
  6. ncbi request reprint Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia
    Mihalis I Panayiotidis
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Free Radic Biol Med 40:348-58. 2006
    ..These results indicate activation of MAT 2A and the transmethylation pathway in the metabolic response to hyperoxia in lung epithelium...
  7. ncbi request reprint Vitamin B12 deficiency as a worldwide problem
    Sally P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Annu Rev Nutr 24:299-326. 2004
    ..Areas for research include intermittent vitamin B12 supplement dosing and better measurements of the bioavailability of B12 in fermented vegetarian foods and algae...
  8. pmc Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice
    Anna E Beaudin
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    Am J Clin Nutr 95:882-91. 2012
    ..A polymorphism in MTHFD1 (1958G→A) impairs enzymatic activity and is associated with increased risk of adverse pregnancy outcomes, but the mechanisms are unknown...
  9. ncbi request reprint Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry
    Sally P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Chem 50:365-72. 2004
    ....
  10. ncbi request reprint Cystathionine beta-synthase is coordinately regulated with proliferation through a redox-sensitive mechanism in cultured human cells and Saccharomyces cerevisiae
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Cell Physiol 192:81-92. 2002
    ..Our data indicates that screening compounds for the ability to affect transsulfuration in cultured cell models must take proliferation status into account to avoid masking regulatory interactions that may be of significance in vivo...
  11. ncbi request reprint Methyl balance and transmethylation fluxes in humans
    S Harvey Mudd
    Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Am J Clin Nutr 85:19-25. 2007
    ....
  12. ncbi request reprint Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women
    Patricia R Barbosa
    Department of Clinical Chemistry and Toxicology, School of Pharmaceutical Sciences, University of Sao Paulo, Brazil
    Clin Chim Acta 388:139-47. 2008
    ..We investigated the nutritional and genetic determinants for total homocysteine (tHcy), methylmalonic acid (MMA) and SAM/SAH in healthy Brazilian childbearing-age women...
  13. ncbi request reprint Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adults
    Sohyun Park
    Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA
    J Nutr Elder 25:105-20. 2006
    ..Thus, elevated MMA concentration may be associated with hearing loss in older adults. However, short-term B12 supplementation was unrelated to improvements in hearing status in B12-deficient individuals...
  14. ncbi request reprint Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition services
    Mary Ann Johnson
    Department of Foods and Nutrition, University of Georgia, Athens, USA
    Am J Clin Nutr 77:211-20. 2003
    ..The effect of the folate food fortification program on the prevalence of hyperhomocysteinemia in the older population with coexisting vitamin B-12 deficiency is not known...
  15. ncbi request reprint Low ratio of S-adenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newborns
    Elvira M Guerra-Shinohara
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciências Farmacêuticas da Universidade de São Paulo, Sao Paulo, Brazil
    Am J Clin Nutr 80:1312-21. 2004
    ..The effect of low maternal cobalamin concentrations on transmethylation metabolism in pregnant women and their newborns is unknown...
  16. pmc Elevated serum S-adenosylhomocysteine in cobalamin-deficient megaloblastic anemia
    Elvira M Guerra-Shinohara
    Department of Clinical and Toxicological Analysis, Pharmaceutical School, University of Sao Paulo, Sao Paulo 05508 900, Brazil
    Metabolism 56:339-47. 2007
    ..In conclusion, serum SAH is elevated in cobalamin-deficient subjects with megaloblastic anemia and corrects with parenteral cobalamin therapy...
  17. pmc Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern Ethiopia
    Rosalind S Gibson
    Department of Human Nutrition, University of Otago, Dunedin, New Zealand 9015
    J Nutr 138:581-6. 2008
    ..Despite some early functional vitamin B-12 deficiency, there was no macrocytic anemia. Consumption of fermented enset may have increased vitamin B-12 levels in diet and plasma...
  18. ncbi request reprint Adverse event associated with methionine loading test: a case report
    E M Cottington
    Case Western Reserve University, Cleveland, Ohio, USA
    Arterioscler Thromb Vasc Biol 22:1046-50. 2002
    ....
  19. ncbi request reprint Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency
    Kevin A Strauss
    Clinic for Special Children, Strasburg, PA 17579, USA
    Mol Genet Metab 91:165-75. 2007
    ..To effectively support the metabolic requirements of rapid brain growth, a large dose of betaine should be started early in life...
  20. ncbi request reprint The descent curve of the grand multiparous woman
    Edith D Gurewitsch
    Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 189:1036-41. 2003
    ..The purpose of this study was to compare the descent curves and second-stage length among grand multiparous, nulliparous, and lower parity multiparous women...
  21. ncbi request reprint Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults
    Suparna Rajan
    Seattle Veteran Affairs Puget Sound Health Care System, Seattle, Washington, USA
    J Am Geriatr Soc 50:1789-95. 2002
    ....
  22. ncbi request reprint Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy
    Clet Niyikiza
    Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Mol Cancer Ther 1:545-52. 2002
    ..Most importantly, decreasing homocysteine levels via vitamin supplementation leads to a better safety profile of pemetrexed and possibly to an improved efficacy...
  23. pmc Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products
    Julie Robertson
    Department of Family Medicine, McMaster University, Hamilton, Ont
    CMAJ 172:1569-73. 2005
    ....
  24. ncbi request reprint Elevated methylmalonic acid is related to cognitive impairement in older adults enrolled in an elderly nutrition program
    Monica S Lewis
    Department of Psychology, The University of Georgia, Athens, GA 30602, USA
    J Nutr Elder 24:47-65. 2005
    ..Monitoring and reducing serum MMA concentrations by increasing the intake of vitamin B12 may provide protection against cognitive decline in this and other older populations...
  25. ncbi request reprint Infantile hypermethioninemia and hyperhomocysteinemia due to high methionine intake: a diagnostic trap
    S Harvey Mudd
    NIMH DIRP LMB, Laboratory of Molecular Biology, National Institute of Mental Health, Building 36, Room 1B 08, 36 Convent Drive, MSC 4034, Bethesda, MD 20892 4034, USA
    Mol Genet Metab 79:6-16. 2003
    ....
  26. pmc S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism
    Ivo Baric
    Department of Pediatrics, University Hospital Center, Kispaticeva 12, 10000 Zagreb, Croatia
    Proc Natl Acad Sci U S A 101:4234-9. 2004
    ..Gene analysis revealed two mutations in exon 4: a maternally derived stop codon, and a paternally derived missense mutation. We discuss reasons for biochemical abnormalities and pathophysiological aspects of AdoHcy hydrolase deficiency...
  27. pmc Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study
    Clinton B Wright
    Department of Neurology, Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY, USA
    Stroke 36:1207-11. 2005
    ..White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations...