Paul D Allen

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Kcna1 gene deletion lowers the behavioral sensitivity of mice to small changes in sound location and increases asynchronous brainstem auditory evoked potentials but does not affect hearing thresholds
    Paul D Allen
    Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 32:2538-43. 2012
  2. pmc Sensitivity of the mouse to changes in azimuthal sound location: angular separation, spectral composition, and sound level
    Paul D Allen
    Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, NY 14642, USA
    Behav Neurosci 124:265-77. 2010
  3. pmc Presbycusis phenotypes form a heterogeneous continuum when ordered by degree and configuration of hearing loss
    Paul D Allen
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 603, Rochester, NY 14642, USA
    Hear Res 264:10-20. 2010
  4. pmc Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
    Marie Eve Tremblay
    Department of Neurobiology and Anatomy and Center for Visual Science, University of Rochester, Rochester, New York 14642, USA
    Glia 60:541-58. 2012
  5. pmc Kv1.1 channel subunits are not necessary for high temporal acuity in behavioral and electrophysiological gap detection
    Paul D Allen
    Department of Otolaryngology, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Hear Res 246:52-8. 2008
  6. ncbi request reprint Pre- but not post-menopausal female CBA/CaJ mice show less prepulse inhibition than male mice of the same age
    James R Ison
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    Behav Brain Res 185:76-81. 2007
  7. ncbi request reprint The behavioral response of mice to gaps in noise depends on its spectral components and its bandwidth
    James R Ison
    Department of Brain and Cognitive Sciences, Meliora Hall, University of Rochester, Rochester, New York 14627, USA
    J Acoust Soc Am 117:3944-51. 2005
  8. doi request reprint Neural correlates of age-related declines in frequency selectivity in the auditory midbrain
    U Cheng Leong
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA U Cheng
    Neurobiol Aging 32:168-78. 2011
  9. ncbi request reprint Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levels
    Paul D Allen
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    Hear Res 186:17-29. 2003
  10. pmc Low-frequency tone pips elicit exaggerated startle reflexes in C57BL/6J mice with hearing loss
    James R Ison
    Department of Brain and Cognitive Sciences, Meliora Hall, University of Rochester, Rochester, NY 14627, USA
    J Assoc Res Otolaryngol 4:495-504. 2003

Collaborators

Detail Information

Publications15

  1. pmc Kcna1 gene deletion lowers the behavioral sensitivity of mice to small changes in sound location and increases asynchronous brainstem auditory evoked potentials but does not affect hearing thresholds
    Paul D Allen
    Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 32:2538-43. 2012
    ....
  2. pmc Sensitivity of the mouse to changes in azimuthal sound location: angular separation, spectral composition, and sound level
    Paul D Allen
    Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, NY 14642, USA
    Behav Neurosci 124:265-77. 2010
    ..These experiments extend the prior findings on sound localization in mice, and the dependence of PPI on ISI adds a reaction time-like dimension to this behavioral analysis...
  3. pmc Presbycusis phenotypes form a heterogeneous continuum when ordered by degree and configuration of hearing loss
    Paul D Allen
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 603, Rochester, NY 14642, USA
    Hear Res 264:10-20. 2010
    ..Further, most phenotypes lie intermediate to the extremes of either Flat or Sloping loss, indicating that if audiometric configuration does predict presbycusis etiology, then a mixed origin is the most prevalent...
  4. pmc Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
    Marie Eve Tremblay
    Department of Neurobiology and Anatomy and Center for Visual Science, University of Rochester, Rochester, New York 14642, USA
    Glia 60:541-58. 2012
    ....
  5. pmc Kv1.1 channel subunits are not necessary for high temporal acuity in behavioral and electrophysiological gap detection
    Paul D Allen
    Department of Otolaryngology, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Hear Res 246:52-8. 2008
    ..These data suggest that the neural pathways encoding behaviorally relevant, rapid auditory temporal fluctuations are not limited by the absence of Kv1.1 expression...
  6. ncbi request reprint Pre- but not post-menopausal female CBA/CaJ mice show less prepulse inhibition than male mice of the same age
    James R Ison
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    Behav Brain Res 185:76-81. 2007
    ..The negative findings previously reported in the mouse can be attributed to the small effect size and to procedural differences, including stimulus conditions, and the different strains and ages of mice...
  7. ncbi request reprint The behavioral response of mice to gaps in noise depends on its spectral components and its bandwidth
    James R Ison
    Department of Brain and Cognitive Sciences, Meliora Hall, University of Rochester, Rochester, New York 14627, USA
    J Acoust Soc Am 117:3944-51. 2005
    ..These effects are similar to those obtained in humans, and reveal a special contribution of wide band, high-frequency stimulation to temporal acuity...
  8. doi request reprint Neural correlates of age-related declines in frequency selectivity in the auditory midbrain
    U Cheng Leong
    Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA U Cheng
    Neurobiol Aging 32:168-78. 2011
    ..Collectively, these results support the view that aging alters frequency selectivity by widening excitatory FRAs and that these changes begin to appear in middle age...
  9. ncbi request reprint Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levels
    Paul D Allen
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    Hear Res 186:17-29. 2003
    ..These results demonstrate that age-related changes in temporal acuity may interact with stimulus level, and suggest that adequate amplification may be critically important for maintaining temporal acuity with advancing age...
  10. pmc Low-frequency tone pips elicit exaggerated startle reflexes in C57BL/6J mice with hearing loss
    James R Ison
    Department of Brain and Cognitive Sciences, Meliora Hall, University of Rochester, Rochester, NY 14627, USA
    J Assoc Res Otolaryngol 4:495-504. 2003
    ....
  11. pmc Deficits in responding to brief noise offsets in Kcna1 -/- mice reveal a contribution of this gene to precise temporal processing seen previously only for stimulus onsets
    James R Ison
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    J Assoc Res Otolaryngol 13:351-8. 2012
    ..1 contributes to the perception of animal vocalizations and human speech...
  12. pmc Age-related hearing loss in C57BL/6J mice has both frequency-specific and non-frequency-specific components that produce a hyperacusis-like exaggeration of the acoustic startle reflex
    James R Ison
    Department of Brain and Cognitive Sciences, University of Rochester, Meliora Hall, Rochester, NY 14627, USA
    J Assoc Res Otolaryngol 8:539-50. 2007
    ....
  13. ncbi request reprint The attention filter for tones in noise has the same shape and effective bandwidth in the elderly as it has in young listeners
    James R Ison
    J Acoust Soc Am 112:238-46. 2002
    ..Confidence intervals (95%) showed that the elderly ERB could be at most only about 20% larger than that of younger listeners...
  14. ncbi request reprint Humans detect gaps in broadband noise according to effective gap duration without additional cues from abrupt envelope changes
    Paul D Allen
    Department of Brain and Cognitive Sciences, Meliora Hall, University of Rochester, Rochester, New York 14627, USA
    J Acoust Soc Am 112:2967-74. 2002
    ..These findings suggest that human listeners do not make use of abrupt onset or offset information to enhance gap detection, but seem to rely on the effective sound level reduction associated with the gap for detection...
  15. pmc Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body
    Walid Jalabi
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106, Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom, Department of Neurobiology and Anatomy, University of Rochester, Rochester, New York 14642, and Richard King Mellon Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania 15224
    J Neurosci 33:15044-9. 2013
    ..These findings redefine the role of MNTB in sound localization and suggest that the inhibitory network is more complex than previously thought. ..