Christopher D C Allen

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Germinal center quality control: death by Fas
    Christopher D C Allen
    Department of Anatomy, Cardiovascular Research Institute, and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA, USA Electronic address
    Immunity 42:783-5. 2015
  2. pmc Germinal-center organization and cellular dynamics
    Christopher D C Allen
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Immunity 27:190-202. 2007
  3. pmc Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, 513 Parnassus Avenue, Box 0414, University of California, San Francisco, CA 94143 0414, USA
    Semin Immunol 20:14-25. 2008
  4. ncbi request reprint Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    Nicole M Haynes
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:5099-108. 2007
  5. pmc Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection
    Oliver Bannard
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunity 39:912-24. 2013
  6. pmc IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function
    Laurence E Cheng
    Department of Pediatrics, Department of Medicine, Department of Anatomy, Sandler Asthma Basic Research Center, Cardiovascular Research Institute, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 Department of Pediatrics, Department of Medicine, Department of Anatomy, Sandler Asthma Basic Research Center, Cardiovascular Research Institute, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143
    J Exp Med 212:513-24. 2015
  7. doi request reprint Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition
    Zhiyong Yang
    Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunity 36:857-72. 2012
  8. ncbi request reprint Imaging of germinal center selection events during affinity maturation
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Science 315:528-31. 2007
  9. pmc Genetic analysis of basophil function in vivo
    Brandon M Sullivan
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, USA
    Nat Immunol 12:527-35. 2011
  10. pmc MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells
    David F Steiner
    Sandler Asthma Basic Research Center and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunity 35:169-81. 2011

Collaborators

Detail Information

Publications14

  1. doi request reprint Germinal center quality control: death by Fas
    Christopher D C Allen
    Department of Anatomy, Cardiovascular Research Institute, and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA, USA Electronic address
    Immunity 42:783-5. 2015
    ..Fas is a cell surface death receptor critical for immune regulation. In this issue of Immunity, Butt et al. (2015) show that Fas eliminates B cells that have become uncoupled from positive and negative selection in the germinal center...
  2. pmc Germinal-center organization and cellular dynamics
    Christopher D C Allen
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Immunity 27:190-202. 2007
    ....
  3. pmc Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, 513 Parnassus Avenue, Box 0414, University of California, San Francisco, CA 94143 0414, USA
    Semin Immunol 20:14-25. 2008
    ..We will then discuss current understanding of how they help support the B cell immune response...
  4. ncbi request reprint Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    Nicole M Haynes
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:5099-108. 2007
    ....
  5. pmc Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection
    Oliver Bannard
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunity 39:912-24. 2013
    ..Finally, we identify a network of DZ CXCL12-expressing reticular cells that likely support DZ functions. ..
  6. pmc IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function
    Laurence E Cheng
    Department of Pediatrics, Department of Medicine, Department of Anatomy, Sandler Asthma Basic Research Center, Cardiovascular Research Institute, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 Department of Pediatrics, Department of Medicine, Department of Anatomy, Sandler Asthma Basic Research Center, Cardiovascular Research Institute, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143
    J Exp Med 212:513-24. 2015
    ..Thus, basophils are gatekeepers that link adaptive immunity with innate effector programs by altering access to tissue sites by activation-induced interactions with the endothelium. ..
  7. doi request reprint Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition
    Zhiyong Yang
    Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunity 36:857-72. 2012
    ..Most IgE(+) PCs were short lived and showed reduced affinity maturation, revealing intrinsic mechanisms that restrict the IgE antibody response...
  8. ncbi request reprint Imaging of germinal center selection events during affinity maturation
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Science 315:528-31. 2007
    ..On the basis of these observations, we propose a model in which competition for T cell help plays a more dominant role in the selection of GC B cells than previously appreciated...
  9. pmc Genetic analysis of basophil function in vivo
    Brandon M Sullivan
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, USA
    Nat Immunol 12:527-35. 2011
    ..Although targeted deletion of IL-4 and IL-13 in either CD4(+) T cells or basophils had a minimal effect on worm clearance, deletion from both lineages demonstrated a nonredundant role for basophil cytokines in primary helminth immunity...
  10. pmc MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells
    David F Steiner
    Sandler Asthma Basic Research Center and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunity 35:169-81. 2011
    ..These results demonstrate that miR-29 regulates helper T cell differentiation by repressing multiple target genes, including at least two that are independently capable of inducing the T helper 1 (Th1) cell gene expression program...
  11. pmc The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement
    Jesse A Green
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, San Francisco, California, USA
    Nat Immunol 12:672-80. 2011
    ..We suggest that by inhibiting Akt activation and migration, S1P(2) helps restrict GC B cell survival and localization to an S1P-low niche at the follicle center...
  12. pmc TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis
    Thomas T Chen
    Veterans Administration Medical Center, San Francisco, CA 94121, USA
    J Exp Med 202:955-65. 2005
    ..This is the first identification of a receptor for ferritin and reveals a new role for TIM-2...
  13. ncbi request reprint Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Immunol 5:943-52. 2004
    ..In contrast, CXCR5 helped direct cells to the light zone and deficiency in CXCL13 was associated with aberrant light zone localization...
  14. pmc Regulatory constraints in the generation and differentiation of IgE-expressing B cells
    Zhiyong Yang
    Cardiovascular Research Institute and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Curr Opin Immunol 28:64-70. 2014
    ....