Benjamin L Allen
Affiliation: University of Michigan
Camp D, Haitian He B, Li S, Althaus I, Holtz A, Allen B, et al
. Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand. Development. 2014;141:3879-88 pubmed publisher
Allen B. Spinal Cords Built to Scale. Dev Cell. 2016;37:108-9 pubmed publisher
..In this issue of Developmental Cell, Uygur et al. (2016) tackle this issue in the context of neural tube patterning, discovering that differential sensitivity to the Hedgehog pathway may provide one answer to this fundamental issue. ..
Mathew E, Zhang Y, Holtz A, Kane K, Song J, Allen B, et al
. Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. Cell Rep. 2014;9:484-94 pubmed publisher
..Collectively, these data identify a role for HH dosage in pancreatic cancer promotion and may explain the clinical failure of HH pathway blockade as a therapeutic approach in pancreatic cancer. ..
Song J, Holtz A, Pinskey J, Allen B. Distinct structural requirements for CDON and BOC in the promotion of Hedgehog signaling. Dev Biol. 2015;402:239-52 pubmed publisher
..Further, we identify novel and separate extracellular motifs in CDON and BOC that are required to promote HH signaling. Together, these data suggest that HH co-receptors employ distinct mechanisms to mediate HH pathway activity. ..
Allen B, Song J, Izzi L, Althaus I, Kang J, Charron F, et al
. Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev Cell. 2011;20:775-87 pubmed publisher
..Most strikingly, genetic loss-of-function experiments indicate an obligatory requirement for GAS1, CDO, and BOC in HH pathway activity in multiple tissues. ..
Carpenter B, Barry R, Verhey K, Allen B. The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function. J Cell Sci. 2015;128:1034-50 pubmed publisher
..These data suggest that GLI interactions with KIF3A-KIF3B-KAP3 complexes are essential for proper GLI transcriptional activity. ..
Holtz A, Griffiths S, Davis S, Bishop B, Siebold C, Allen B. Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Cell Biol. 2015;209:739-57 pubmed publisher
..Overall, the secreted activity of HHIP1 represents a novel mechanism to regulate HH ligand localization and function during embryogenesis. ..
Pinskey J, Franks N, McMellen A, Giger R, Allen B. Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif. J Biol Chem. 2017;292:15192-15204 pubmed publisher
..These insights have implications for the development of novel modulators of HH-driven developmental disorders and diseases. ..