Kristina Allen-Brady

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Impact of renal failure on the risk of myocardial infarction and death
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA
    Kidney Int 62:1776-83. 2002
  2. pmc Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis
    Kristina Allen-Brady
    Department of Medicine and Obstetrics, University of Utah, Salt Lake City, Utah, USA
    Obstet Gynecol 118:1345-53. 2011
  3. pmc Analysis of high-density single-nucleotide polymorphism data: three novel methods that control for linkage disequilibrium between markers in a linkage analysis
    Kristina Allen Brady
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, Utah 84108, USA
    BMC Proc 1:S160. 2007
  4. pmc Significant linkage evidence for a predisposition gene for pelvic floor disorders on chromosome 9q21
    Kristina Allen-Brady
    Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84105, USA
    Am J Hum Genet 84:678-82. 2009
  5. pmc No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees
    Kristina Allen Brady
    Genetic Epidemiology Group, Department of Biomedical Informatics, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 USA
    BMC Res Notes 2:94. 2009
  6. doi request reprint A high-density SNP genome-wide linkage scan in a large autism extended pedigree
    K Allen-Brady
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Mol Psychiatry 14:590-600. 2009
  7. pmc PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size
    Kristina Allen-Brady
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah Salt Lake City, Utah, USA
    BMC Bioinformatics 7:209. 2006
  8. doi request reprint No evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data set
    Kristina Allen-Brady
    Utah ASD Research Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
    Autism Res 4:293-6. 2011
  9. doi request reprint A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families
    Kristina Allen-Brady
    Department of Psychiatry, Utah Autism Research Project, University of Utah, Salt Lake City, Utah, 84108, USA
    Autism Res 3:47-52. 2010
  10. pmc Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes
    Kristina Allen-Brady
    Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    BMC Cancer 5:99. 2005

Detail Information

Publications26

  1. ncbi request reprint Impact of renal failure on the risk of myocardial infarction and death
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA
    Kidney Int 62:1776-83. 2002
    ..We examined whether renal failure independently increases the risk of myocardial infarction and death...
  2. pmc Identification of six loci associated with pelvic organ prolapse using genome-wide association analysis
    Kristina Allen-Brady
    Department of Medicine and Obstetrics, University of Utah, Salt Lake City, Utah, USA
    Obstet Gynecol 118:1345-53. 2011
    ..There is evidence that both environmental and genetic factors contribute to pelvic organ prolapse. We conducted a genome-wide association study to investigate whether common genetic variants modify the risk of pelvic organ prolapse...
  3. pmc Analysis of high-density single-nucleotide polymorphism data: three novel methods that control for linkage disequilibrium between markers in a linkage analysis
    Kristina Allen Brady
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, Utah 84108, USA
    BMC Proc 1:S160. 2007
    ..Additional work is required to further understand the effects of LD on linkage results and explore LD control methodology...
  4. pmc Significant linkage evidence for a predisposition gene for pelvic floor disorders on chromosome 9q21
    Kristina Allen-Brady
    Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84105, USA
    Am J Hum Genet 84:678-82. 2009
    ..41 under a recessive model. Seventeen pedigrees (53%) had at least nominal evidence for linkage on a by-pedigree basis at this region. These results provide evidence for a predisposition gene for PFDs on chromosome 9q...
  5. pmc No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees
    Kristina Allen Brady
    Genetic Epidemiology Group, Department of Biomedical Informatics, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 USA
    BMC Res Notes 2:94. 2009
    ..CONCLUSION: In this set of high-risk prostate cancer pedigrees with at least nominal linkage evidence to BRCA2, we saw no evidence for segregating BRCA2 protein truncating mutations in heritable prostate cancer...
  6. doi request reprint A high-density SNP genome-wide linkage scan in a large autism extended pedigree
    K Allen-Brady
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Mol Psychiatry 14:590-600. 2009
    ....
  7. pmc PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size
    Kristina Allen-Brady
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah Salt Lake City, Utah, USA
    BMC Bioinformatics 7:209. 2006
    ....
  8. doi request reprint No evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data set
    Kristina Allen-Brady
    Utah ASD Research Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
    Autism Res 4:293-6. 2011
    ..In conclusion, coding changes of the IL1RAPL1 gene do not appear to be associated with ASD in selected AGRE families with linkage evidence to the chromosome Xp22.11-p21.2 region...
  9. doi request reprint A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families
    Kristina Allen-Brady
    Department of Psychiatry, Utah Autism Research Project, University of Utah, Salt Lake City, Utah, 84108, USA
    Autism Res 3:47-52. 2010
    ..These results demonstrate that identification of a more homogeneous subset of autism cases, which was based on family structure in this study, may help to identify, localize and further our understanding of autism predisposition genes...
  10. pmc Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes
    Kristina Allen-Brady
    Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    BMC Cancer 5:99. 2005
    ..In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, MRE11A, XRCC4, NBS1 and RAD50...
  11. ncbi request reprint A role for XRCC4 in age at diagnosis and breast cancer risk
    Kristina Allen-Brady
    Genetic Epidemiology, Department of Medical Informatics, University of Utah, Salt Lake City, 84108, USA
    Cancer Epidemiol Biomarkers Prev 15:1306-10. 2006
    ..Our results suggest that XRCC4 may play a role in the age at diagnosis and risk of breast cancer in non-BRCA1/2, heritable breast cancer cases...
  12. doi request reprint A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q
    Craig Teerlink
    Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Hum Genet 131:77-85. 2012
    ..Our approach illustrates an example of using high-risk pedigrees for the identification of new melanoma predisposition variants...
  13. ncbi request reprint Statistical recombinant mapping in extended high-risk Utah pedigrees narrows the 8q24 prostate cancer locus to 2.0 Mb
    Nicola J Camp
    Division of Genetic Epidemiology, Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Prostate 67:1456-64. 2007
    ..In addition to potential allelic heterogeneity, 8q24 exhibits strong linkage disequilibrium over vast distances and is prone to chromosomal aberrations...
  14. pmc PedGenie: meta genetic association testing in mixed family and case-control designs
    Karen Curtin
    Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, USA
    BMC Bioinformatics 8:448. 2007
    ..4 software, is significantly enhanced by incorporating meta statistics for detecting genetic association with disease using data across multiple study groups...
  15. pmc Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees
    Hilary Coon
    Utah Autism Research Project, Department of Psychiatry and Division of Genetic Epidemiology, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT 84108, USA
    Mol Autism 1:8. 2010
    ..Such data are available from the Social Responsiveness Scale (SRS) which is a continuous, quantitative measure of social ability giving scores that range from significant impairment to above average ability...
  16. pmc A cautionary note on the appropriateness of using a linkage resource for an association study
    Kristina Allen-Brady
    Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    BMC Genet 4:S89. 2003
    ....
  17. ncbi request reprint Heterogeneous association between engrailed-2 and autism in the CPEA network
    Camille W Brune
    Department of Psychiatry, Institute for Juvenile Research, University of Illinois Chicago, Chicago, Illinois, USA
    Am J Med Genet B Neuropsychiatr Genet 147:187-93. 2008
    ..Future studies investigating EN2 should consider how the association of variants in this gene with autism could be influenced by differences in phenotype and possible interactions with genotypes at other autism candidate genes...
  18. ncbi request reprint Lobular breast cancer: excess familiality observed in the Utah Population Database
    Kristina Allen-Brady
    Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, 84108, USA
    Int J Cancer 117:655-61. 2005
    ..Relatives of women with LOB are at higher risk for BC than relatives of other BC subtypes; a more rigorous BC screening regime may be warranted for these individuals...
  19. doi request reprint Genetic distance and markers used in linkage mapping
    Kristina Allen-Brady
    Genetic Epidemiology Division, Department of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA
    Methods Mol Biol 713:43-53. 2011
    ....
  20. pmc A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes
    Douglas F Easton
    Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, Cambridge, UK
    Am J Hum Genet 81:873-83. 2007
    ..In addition to their utility for improved genetics counseling of patients and their families, the global assessment reported here will be invaluable for validation of functional assays, structural models, and in silico analyses...
  21. pmc Meta-genetic association of rheumatoid arthritis and PTPN22 using PedGenie 2.1
    Karen Curtin
    Division of Genetic Epidemiology, Department of Biomedical Informatics, University of Utah School of Medicine, 391 South Chipeta Way, Suite D, Salt Lake City, Utah 84108 1206, USA
    BMC Proc 1:S12. 2007
    ..More power to detect associations was achieved in certain analyses by using extra family-based samples, rather than restricting analyses to single cases randomly selected from each pedigree...
  22. pmc Shared genomic segment analysis. Mapping disease predisposition genes in extended pedigrees using SNP genotype assays
    A Thomas
    Department of Biomedical Informatics, University of Utah, 391 Chipeta Way, Salt Lake City, UT 84108, USA
    Ann Hum Genet 72:279-87. 2008
    ....
  23. doi request reprint The familiality of pelvic organ prolapse in the Utah Population Database
    Peggy A Norton
    Department of Obstetrics and Gynecology, Division of Urogynecology and Reconstructive Pelvic Surgery, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Int Urogynecol J 24:413-8. 2013
    ..Pelvic organ prolapse (POP) in women is a common condition whose etiology is poorly understood. There is increasing evidence that POP is heritable. The aim of our study was to define and evaluate familial clustering of POP...
  24. pmc Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study
    Stephen R Piccolo
    Department of Biomedical Informatics, School of Medicine, University of Utah, 26 South 2000 East, Salt Lake City, Utah 84112, USA
    BMC Proc 3:S46. 2009
    ..In this paper, we evaluate a weighted and an unweighted approach for estimating the combined effect of multiple markers (using genotypes and haplotypes) on lipid levels for a given individual...
  25. pmc Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders
    Dale S Cannon
    Utah Autism Research Project, Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT, 84108 3528, USA
    Mol Autism 1:3. 2010
    ..Secondary aims were to examine the correlates of IS and RSMA and to assess the heritability of both scales...
  26. ncbi request reprint Effect of linkage disequilibrium between markers in linkage and association analyses
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Genet Epidemiol 31:S139-48. 2007
    ....