H Allayee

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Biochemistry. An absorbing study of cholesterol
    H Allayee
    Department of Medicine, University of California, Los Angeles UCLA School of Medicine, Los Angeles, CA 90095, USA
    Science 290:1709-11. 2000
  2. ncbi request reprint Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia
    Hooman Allayee
    Department of Human Genetics, Gonda Genetics Research Center, University of California, Los Angeles 90095, USA
    Circ Res 90:926-31. 2002
  3. ncbi request reprint Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia
    Hooman Allayee
    Department of Human Genetics, Gonda Genetics Research Center, of California, Los Angeles, Calif 90095, USA
    Circ Res 92:1262-7. 2003
  4. pmc A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11
    B E Aouizerat
    Departments of 1Microbiology and Molecular Genetics, Medicine, Human Genetics, Molecular Biology Institute, University of California, UCLA School of Medicine Los Angeles, CA 90095 1679, USA
    Am J Hum Genet 65:397-412. 1999
  5. ncbi request reprint A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2
    A Mouzeyan
    Department of Microbiology, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 41:573-82. 2000
  6. ncbi request reprint Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p
    H Allayee
    Department of Microbiology, University of California, Los Angeles, CA, USA
    Hypertension 38:773-8. 2001
  7. doi request reprint A novel g.-1258G>A mutation in a conserved putative regulatory element of PAX9 is associated with autosomal dominant molar hypodontia
    G A Mendoza-Fandino
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Clin Genet 80:265-72. 2011
  8. pmc Identification of ALOX5 as a gene regulating adiposity and pancreatic function
    M Mehrabian
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Diabetologia 51:978-88. 2008
  9. pmc Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice
    F Liao
    Department of Medicine, University of California, Los Angeles, School of Medicine 90024
    J Clin Invest 94:877-84. 1994
  10. pmc Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q
    Paivi Pajukanta
    Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 72:903-17. 2003

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Biochemistry. An absorbing study of cholesterol
    H Allayee
    Department of Medicine, University of California, Los Angeles UCLA School of Medicine, Los Angeles, CA 90095, USA
    Science 290:1709-11. 2000
    ..In a Perspective, Allayee and colleagues discuss a new study (Berge et al.) that implicates two new ABC transporter proteins in the efflux of plant and animal sterols from gut epithelial cells into the gut lumen...
  2. ncbi request reprint Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia
    Hooman Allayee
    Department of Human Genetics, Gonda Genetics Research Center, University of California, Los Angeles 90095, USA
    Circ Res 90:926-31. 2002
    ..This is one of the first loci identified for apoB levels in humans and is the second major locus implicated in the genetic etiology of FCH...
  3. ncbi request reprint Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia
    Hooman Allayee
    Department of Human Genetics, Gonda Genetics Research Center, of California, Los Angeles, Calif 90095, USA
    Circ Res 92:1262-7. 2003
    ..Our results demonstrate that apoA-II is biochemically and genetically associated with FCH and may serve as a useful marker for understanding the mechanism by which FCH develops...
  4. pmc A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11
    B E Aouizerat
    Departments of 1Microbiology and Molecular Genetics, Medicine, Human Genetics, Molecular Biology Institute, University of California, UCLA School of Medicine Los Angeles, CA 90095 1679, USA
    Am J Hum Genet 65:397-412. 1999
    ..This region does not contain any strong candidate genes. These results provide evidence for a candidate chromosomal region for FCHL and support the concept that FCHL is complex and heterogeneous...
  5. ncbi request reprint A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2
    A Mouzeyan
    Department of Microbiology, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 41:573-82. 2000
    ..6) between B6By alleles and hypo-response to diet. Examination of known genes in this region suggested that this locus represents a novel gene affecting plasma lipids and atherogenesis in response to diet...
  6. ncbi request reprint Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p
    H Allayee
    Department of Microbiology, University of California, Los Angeles, CA, USA
    Hypertension 38:773-8. 2001
    ..4) and plasma apolipoprotein B levels (lod=2.0) to a locus on proximal chromosome 19p. In conclusion, our genome scan results support the existence of multiple genetic factors that can influence both BP and plasma lipid parameters...
  7. doi request reprint A novel g.-1258G>A mutation in a conserved putative regulatory element of PAX9 is associated with autosomal dominant molar hypodontia
    G A Mendoza-Fandino
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Clin Genet 80:265-72. 2011
    ..Based on our previous findings that haploinsufficiency for PAX9 leads to hypodontia, we postulate that the g.-1258G>A variant reduces the expression of PAX9 which underlies the hypodontia phenotype in this family...
  8. pmc Identification of ALOX5 as a gene regulating adiposity and pancreatic function
    M Mehrabian
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Diabetologia 51:978-88. 2008
    ..In the present study, we sought to further examine the role of 5-LO in adiposity and pancreatic function...
  9. pmc Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice
    F Liao
    Department of Medicine, University of California, Los Angeles, School of Medicine 90024
    J Clin Invest 94:877-84. 1994
    ..They also suggest that a major gene contributing to aortic lesion development in this mouse model, designated Ath-1, may control either the accumulation of lipid peroxides in tissues or the cellular responses to such lipid peroxides...
  10. pmc Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q
    Paivi Pajukanta
    Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 72:903-17. 2003
    ..1 region, we investigated a novel functional and positional candidate gene, helix/forkhead transcription factor (FOXC2), by sequencing and by genotyping of two single-nucleotide polymorphisms in the families...
  11. pmc Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction
    Hooman Allayee
    Department of Preventive Medicine and the Institute for Genetic Medicine, The University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9075, USA
    Am J Clin Nutr 88:934-40. 2008
    ..We previously reported that variants of a 5-LO promoter repeat polymorphism were associated with carotid atherosclerosis in humans, an effect that was exacerbated by high dietary AA but mitigated by high dietary n-3 fatty acids...
  12. doi request reprint Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease
    Themistocles L Assimes
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Hum Genet 123:399-408. 2008
    ..However, additional studies are needed to exclude modest effects of promoter variation in ALOX5 on the risk of CAD assuming a recessive mode of inheritance...
  13. pmc Prevalence of common disease-associated variants in Asian Indians
    Trevor J Pemberton
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    BMC Genet 9:13. 2008
    ....
  14. ncbi request reprint Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans
    Mary Helen Black
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar St, CHP 220, Los Angeles, CA 90089 9011, USA
    Diabetes 57:1048-56. 2008
    ....
  15. ncbi request reprint FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice
    Lisa Joy Martin
    Interdepartmental Program in Molecular Toxicology, University of California, Los Angeles School of Public Health, Los Angeles, CA 90095, USA
    Toxicol Sci 100:474-85. 2007
    ..The protection afforded by FK506, found by the current study, indicated that CN is likely to be important in the mechanism of cadmium toxicity in the testis and possibly other organs...
  16. ncbi request reprint A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q24.3
    Gustavo Mendoza
    Institute for Genetic Medicine, University of Southern California, 2250 Alcazar Street, CSC 240, Los Angeles, CA 90033, USA
    Hum Genet 120:653-62. 2007
    ..However, no causative mutation was identified...
  17. ncbi request reprint Using inbred mouse strains to identify genes for complex diseases
    Hooman Allayee
    Department of Preventive Medicine, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 907, USA
    Front Biosci 11:1216-26. 2006
    ..This review focuses on the utility of mouse genetics for identification of complex disease genes. Atherosclerosis is used as a representative example, followed by an overview for the prospects of successful gene discovery in the future...
  18. pmc Influence of leukotriene pathway polymorphisms on response to montelukast in asthma
    John J Lima
    The American Lung Association Asthma Clinical Research Centers, Center for Pharmacogenetics, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Am J Respir Crit Care Med 173:379-85. 2006
    ..Interpatient variability in montelukast response may be related to variation in leukotriene pathway candidate genes...
  19. ncbi request reprint Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
    Margarete Mehrabian
    Department of Medicine, UCLA School of Medicine, Los Angeles, Calif 90095 1679, USA
    Circ Res 91:120-6. 2002
    ..These results indicate that 5-LO contributes importantly to the atherogenic process and they provide strong presumptive evidence that reduced 5-LO expression is partly responsible for the resistance to atherosclerosis in CON6 mice...
  20. ncbi request reprint 5-lipoxygenase and atherosclerosis
    Margarete Mehrabian
    Departments of Medicine and Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1679, USA
    Curr Opin Lipidol 14:447-57. 2003
    ..5-Lipoxygenase (5LO) was recently identified as a gene that makes an important contribution to atherosclerosis in mice and humans, but the underlying mechanism(s) remains unknown...
  21. ncbi request reprint Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis
    James H Dwyer
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA 91803 8000, USA
    N Engl J Med 350:29-37. 2004
    ....
  22. ncbi request reprint Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia
    Rebecca Mar
    Department of Human Genetics, University of California, Los Angeles, USA
    Circ Res 94:993-9. 2004
    ....
  23. ncbi request reprint Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigrees
    Rita M Cantor
    Department of Human Genetics, David Geffen School of Medicine at UCLA, 695 Charles E Young Dr South, Los Angeles, CA 90095 7088, USA
    Arterioscler Thromb Vasc Biol 24:1935-41. 2004
    ..This is a report of a quantitative trait loci (QTL) analysis of FCHL...
  24. ncbi request reprint Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits
    Margarete Mehrabian
    Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1679, USA
    Nat Genet 37:1224-33. 2005
    ....
  25. ncbi request reprint A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background
    Richard C Davis
    Department of Microbiology, Immunology and Molecular Genetics, Department of Medicine, and Department of Human Genetics, University of California, Los Angeles, CA 90095 1679, USA
    Genomics 86:259-70. 2005
    ..These 65 strains cover more than 95% of the autosomal genome and should facilitate the analysis of the many genetic trait differences that have been reported between these parental strains...
  26. ncbi request reprint Using mice to dissect genetic factors in atherosclerosis
    Hooman Allayee
    Department of Human Genetics, David Geffen School of Medicine at UCLA, USA
    Arterioscler Thromb Vasc Biol 23:1501-9. 2003
    ....
  27. doi request reprint Non-conventional genetic risk factors for cardiovascular disease
    Hooman Allayee
    Department of Preventive Medicine and Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Calif 90089 9075, USA
    World Rev Nutr Diet 98:62-76. 2008
  28. ncbi request reprint Understanding atherosclerosis through mouse genetics
    Sonal S Sheth
    Department of Human Genetics, UCLA School of Medicine, Los Angeles, California 90095, USA
    Curr Opin Lipidol 13:181-9. 2002
    ....
  29. pmc Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk
    Tamali Bhattacharyya
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 299:1265-76. 2008
    ..The relationship between PON1 genotypes and functional activity with systemic measures of oxidative stress and cardiovascular disease (CVD) risk in humans has not been systematically investigated...
  30. ncbi request reprint Nonconventional genetic risk factors for cardiovascular disease
    Christopher N Tymchuk
    Institute for Genetic Medicine, USC Keck School of Medicine, University of Southern California, 2250 Alcazar Street, IGM 240, Los Angeles, CA 90089 9075, USA
    Curr Atheroscler Rep 8:184-92. 2006
    ..We conclude with a discussion of the prospects for identifying CVD genes in the future and for potentially developing more effective therapeutic strategies...
  31. ncbi request reprint Vascular cross-talk: a conversation
    Margarete Mehrabian
    Arterioscler Thromb Vasc Biol 24:1748-9. 2004
  32. pmc Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans
    Richard M Watanabe
    Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine, The University of Southern California, Los Angeles, California 90089 9011, USA
    Diabetes 56:1481-5. 2007
    ..We examined variation in a 0.1-Mb region surrounding marker DG10S478 for association with diabetes-related quantitative traits in 132 Mexican-American families of a proband with previous gestational diabetes mellitus (GDM)...
  33. ncbi request reprint The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics
    Hooman Allayee
    Department of Preventive Medicine, USC Keck School of Medicine, 2250 Alcazar St, IGM 206, Los Angeles, CA 90033, USA
    Chest 132:868-74. 2007
    ..We sought to determine whether montelukast, a cysteinyl LT antagonist, and low-dose theophylline affected serum inflammatory and lipid CVD risk factors in a recently completed clinical trial in asthmatic patients...
  34. pmc Genetics of gestational diabetes mellitus and type 2 diabetes
    Richard M Watanabe
    Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089 9011, USA
    Diabetes Care 30:S134-40. 2007