MICHAEL ALKIRE

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Positron emission tomography study of regional cerebral metabolism in humans during isoflurane anesthesia
    M T Alkire
    Department of Anesthesiology, University of California Irvine Medical Center, Orange 92668, USA
    Anesthesiology 86:549-57. 1997
  2. ncbi request reprint Relative amnesic potency of five inhalational anesthetics follows the Meyer-Overton rule
    Michael T Alkire
    Department of Anesthesiology, Center for the Nuerobiology of Learning and Memory, University of California Irvine, Irvine, California, USA
    Anesthesiology 101:417-29. 2004
  3. ncbi request reprint Thalamic microinfusion of antibody to a voltage-gated potassium channel restores consciousness during anesthesia
    Michael T Alkire
    Department of Anesthesiology and Perioperative Care, Center for Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, USA
    Anesthesiology 110:766-73. 2009
  4. ncbi request reprint Does the amygdala mediate anesthetic-induced amnesia? Basolateral amygdala lesions block sevoflurane-induced amnesia
    Michael T Alkire
    Department of Anesthesiology, Medical Center, Universitry of California Irvine, 101 City Drive South, Irvine, CA 92868, USA
    Anesthesiology 102:754-60. 2005
  5. ncbi request reprint General anesthesia and the neural correlates of consciousness
    Michael T Alkire
    Department of Anesthesiology and The Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA, USA
    Prog Brain Res 150:229-44. 2005
  6. ncbi request reprint Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats
    Michael T Alkire
    Department of Anesthesiology, and Center for the Neurobiology of Learning and Memory, University of California Irvine, 101 The City Drive South, Bldg 53, Route 81 A, Orange, CA 92868, USA
    Anesthesiology 103:1167-73. 2005
  7. pmc Neuroimaging analysis of an anesthetic gas that blocks human emotional memory
    Michael T Alkire
    Department of Anesthesiology, University of California at Irvine, Orange, CA 92868, USA
    Proc Natl Acad Sci U S A 105:1722-7. 2008
  8. doi request reprint Loss of effective connectivity during general anesthesia
    Michael T Alkire
    University of California, Irvine, California, USA
    Int Anesthesiol Clin 46:55-73. 2008
  9. pmc Hypothesis: suppression of memory protein formation underlies anesthetic-induced amnesia
    Michael T Alkire
    Department of Anesthesiology and Perioperative Care, and Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA
    Anesthesiology 109:768-70. 2008
  10. ncbi request reprint Dissociable brain activation responses to 5-Hz electrical pain stimulation: a high-field functional magnetic resonance imaging study
    Michael T Alkire
    Department of Anesthesiology, University of California, Irvine, Orange, 92868, USA
    Anesthesiology 100:939-46. 2004

Research Grants

Detail Information

Publications25

  1. ncbi request reprint Positron emission tomography study of regional cerebral metabolism in humans during isoflurane anesthesia
    M T Alkire
    Department of Anesthesiology, University of California Irvine Medical Center, Orange 92668, USA
    Anesthesiology 86:549-57. 1997
    ..To examine this issue, the authors studied the effects of isoflurane anesthesia on human cerebral glucose metabolism using positron emission tomography (PET)...
  2. ncbi request reprint Relative amnesic potency of five inhalational anesthetics follows the Meyer-Overton rule
    Michael T Alkire
    Department of Anesthesiology, Center for the Nuerobiology of Learning and Memory, University of California Irvine, Irvine, California, USA
    Anesthesiology 101:417-29. 2004
    ..However, threshold amnesic doses and relative potencies between agents are not well established. The authors determined amnesic potency in rats for four common volatiles and nitrous oxide...
  3. ncbi request reprint Thalamic microinfusion of antibody to a voltage-gated potassium channel restores consciousness during anesthesia
    Michael T Alkire
    Department of Anesthesiology and Perioperative Care, Center for Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, USA
    Anesthesiology 110:766-73. 2009
    ..2 channel might awaken anesthetized rats...
  4. ncbi request reprint Does the amygdala mediate anesthetic-induced amnesia? Basolateral amygdala lesions block sevoflurane-induced amnesia
    Michael T Alkire
    Department of Anesthesiology, Medical Center, Universitry of California Irvine, 101 City Drive South, Irvine, CA 92868, USA
    Anesthesiology 102:754-60. 2005
    ..If so, a general principle of anesthetic-induced amnesia may be emerging. Here, using an inhibitory avoidance paradigm, the authors determine whether BLA lesions prevent sevoflurane-induced amnesia...
  5. ncbi request reprint General anesthesia and the neural correlates of consciousness
    Michael T Alkire
    Department of Anesthesiology and The Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA, USA
    Prog Brain Res 150:229-44. 2005
    ..Taken together these intriguing observations offer strong empirical support that the thalamus and thalamocortical reverberant network loop interactions are at the heart of the neurobiology of consciousness...
  6. ncbi request reprint Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats
    Michael T Alkire
    Department of Anesthesiology, and Center for the Neurobiology of Learning and Memory, University of California Irvine, 101 The City Drive South, Bldg 53, Route 81 A, Orange, CA 92868, USA
    Anesthesiology 103:1167-73. 2005
    ..1 minimum alveolar concentration. This issue was investigated in a rat model of learning and memory. In addition, evidence for basolateral amygdala (BLA) involvement in mediating memory enhancement was sought...
  7. pmc Neuroimaging analysis of an anesthetic gas that blocks human emotional memory
    Michael T Alkire
    Department of Anesthesiology, University of California at Irvine, Orange, CA 92868, USA
    Proc Natl Acad Sci U S A 105:1722-7. 2008
    ..Collectively, the findings support the hypothesis that the amygdala mediates memory modulation by demonstrating that suppressed amygdala effectiveness equates with a loss of emotional memory...
  8. doi request reprint Loss of effective connectivity during general anesthesia
    Michael T Alkire
    University of California, Irvine, California, USA
    Int Anesthesiol Clin 46:55-73. 2008
  9. pmc Hypothesis: suppression of memory protein formation underlies anesthetic-induced amnesia
    Michael T Alkire
    Department of Anesthesiology and Perioperative Care, and Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA
    Anesthesiology 109:768-70. 2008
  10. ncbi request reprint Dissociable brain activation responses to 5-Hz electrical pain stimulation: a high-field functional magnetic resonance imaging study
    Michael T Alkire
    Department of Anesthesiology, University of California, Irvine, Orange, 92868, USA
    Anesthesiology 100:939-46. 2004
    ....
  11. ncbi request reprint Lesions of the basolateral amygdala complex block propofol-induced amnesia for inhibitory avoidance learning in rats
    M T Alkire
    Department of Anesthesiology, Center for the Neurobiology of Learning and Memory, University of California, Irvine 92868, USA
    Anesthesiology 95:708-15. 2001
    ..In the current study, we test the hypothesis that the basolateral amygdala complex (BLAC) is a brain site involved with mediating propofol-induced amnesia...
  12. ncbi request reprint Quantitative EEG correlations with brain glucose metabolic rate during anesthesia in volunteers
    M T Alkire
    University of California Irvine Medical Center, Department of Anesthesiology, Orange 92668, USA
    Anesthesiology 89:323-33. 1998
    ....
  13. pmc Hippocampal, but not amygdala, activity at encoding correlates with long-term, free recall of nonemotional information
    M T Alkire
    Department of Anesthesiology, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 95:14506-10. 1998
    ..The findings provide evidence for hippocampal involvement in long-term declarative memory encoding and for the view that the amygdala is not involved with declarative memory formation for nonemotional material...
  14. ncbi request reprint Functional brain imaging during anesthesia in humans: effects of halothane on global and regional cerebral glucose metabolism
    M T Alkire
    Department of Anesthesiology, University of California Irvine Medical Center, Orange 92668, USA
    Anesthesiology 90:701-9. 1999
    ..The authors describe an additional positron emission tomography study of halothane's in vivo cerebral metabolic effects...
  15. ncbi request reprint Toward a unified theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness
    M T Alkire
    Department of Anesthesiology, University of California at Irvine, Irvine, California 92697, USA
    Conscious Cogn 9:370-86. 2000
    ....
  16. ncbi request reprint Impaired thalamocortical connectivity in humans during general-anesthetic-induced unconsciousness
    Nathan S White
    Department of Anesthesiology, University of California at Irvine, Irvine, CA 92868, USA
    Neuroimage 19:402-11. 2003
    ..These findings support the hypothesis that a mechanistic component underlying general-anesthetic-induced unconsciousness involves disruption of functional interactions within thalamocortical neural networks...
  17. pmc Consciousness and anesthesia
    Michael T Alkire
    Department of Anesthesiology and The Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92868, USA
    Science 322:876-80. 2008
    ..Thus, anesthetics seem to cause unconsciousness when they block the brain's ability to integrate information...
  18. ncbi request reprint Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat
    Michael T Alkire
    Department of Anesthesiology, Center for the Neurobiology of Learning and Memory, University of California, Irvine, California, USA
    Anesthesiology 107:264-72. 2007
    ..The authors test this by separately attempting to block or enhance anesthetic-induced loss of righting in rats using intrathalamic microinjections of nicotine or its antagonist...
  19. ncbi request reprint Structural brain variation and general intelligence
    Richard J Haier
    Department of Pediatrics, University of California, Irvine, CA 92697 5000, USA
    Neuroimage 23:425-33. 2004
    ..These results underscore the distributed neural basis of intelligence and suggest a developmental course for volume--IQ relationships in adulthood...
  20. ncbi request reprint Structural brain variation, age, and response time
    Richard J Haier
    University of California, Irvine 92697, USA
    Cogn Affect Behav Neurosci 5:246-51. 2005
    ..The results suggest that individual differences in specific brain structure volumes should be considered as potential moderating factors in cognitive brain imaging studies...
  21. ncbi request reprint The neuroanatomy of general intelligence: sex matters
    Richard J Haier
    Department of Pediatrics, University of California, Med Sci I, B140, Irvine, CA 92697 5000, USA
    Neuroimage 25:320-7. 2005
    ....
  22. ncbi request reprint Epinephrine enhancement of human memory consolidation: interaction with arousal at encoding
    Larry Cahill
    Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 79:194-8. 2003
    ..Additionally, they suggest that in humans these hormones may interact with the degree of arousal at initial encoding of information to modulate memory consolidation processes for that information...
  23. ncbi request reprint A voxel-based morphometric study of nondemented adults with Down Syndrome
    Nathan S White
    Department of Anesthesiology, University of California at Irvine, Irvine, CA 92697, USA
    Neuroimage 20:393-403. 2003
    ..The consistency of these findings with prior imaging reports demonstrates the utility of the VBM technique for investigating the neuroanatomy of DS...
  24. ncbi request reprint Anesthesia-induced alterations in plasma tracer concentrations may have relevance for brain imaging studies
    Michael T Alkire
    Anesthesiology 97:281-2; author reply 282. 2002
  25. ncbi request reprint Functional brain imaging: some parameters for success
    Michael T Alkire
    Anesthesiology 101:817-9. 2004

Research Grants4

  1. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2003
    ..abstract_text> ..
  2. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..abstract_text> ..