Bradley E Alger

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Endocannabinoids: getting the message across
    Bradley E Alger
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 101:8512-3. 2004
  2. ncbi request reprint The brain's own marijuana
    Roger A Nicoll
    University of California, San Francisco, USA
    Sci Am 291:68-75. 2004
  3. ncbi request reprint Regulation of IPSP theta rhythm by muscarinic receptors and endocannabinoids in hippocampus
    Christian G Reich
    Department of Physiology, Program in Neuronscience, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Neurophysiol 94:4290-9. 2005
  4. ncbi request reprint Endocannabinoid identification in the brain: studies of breakdown lead to breakthrough, and there may be NO hope
    Bradley E Alger
    Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Sci STKE 2005:pe51. 2005
  5. ncbi request reprint Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids
    Bradley E Alger
    Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Prog Neurobiol 68:247-86. 2002
  6. pmc Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses
    Jimok Kim
    Departments of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 13:592-600. 2010
  7. ncbi request reprint Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus
    Jimok Kim
    Program in Neuroscience and Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
    Nat Neurosci 7:697-8. 2004
  8. ncbi request reprint Ryanodine receptor regulates endogenous cannabinoid mobilization in the hippocampus
    Masako Isokawa
    Department of Physiology, University of Maryland, Baltimore, Maryland, USA
    J Neurophysiol 95:3001-11. 2006
  9. pmc Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation
    Meina Wang
    Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Psychopharmacol 26:56-70. 2012
  10. ncbi request reprint Novel form of LTD induced by transient, partial inhibition of the Na,K-pump in rat hippocampal CA1 cells
    Christian G Reich
    Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurophysiol 91:239-47. 2004

Research Grants

Collaborators

Detail Information

Publications34

  1. pmc Endocannabinoids: getting the message across
    Bradley E Alger
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 101:8512-3. 2004
  2. ncbi request reprint The brain's own marijuana
    Roger A Nicoll
    University of California, San Francisco, USA
    Sci Am 291:68-75. 2004
  3. ncbi request reprint Regulation of IPSP theta rhythm by muscarinic receptors and endocannabinoids in hippocampus
    Christian G Reich
    Department of Physiology, Program in Neuronscience, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Neurophysiol 94:4290-9. 2005
    ..Simultaneous recordings from pyramidal cell pairs reveal synchronous theta-frequency IPSPs in neighboring pyramidal cells, suggesting that these IPSPs may help entrain or modulate small groups of pyramidal cells...
  4. ncbi request reprint Endocannabinoid identification in the brain: studies of breakdown lead to breakthrough, and there may be NO hope
    Bradley E Alger
    Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Sci STKE 2005:pe51. 2005
    ....
  5. ncbi request reprint Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids
    Bradley E Alger
    Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Prog Neurobiol 68:247-86. 2002
    ..The study of the endocannabinoids can therefore serve as a model for the investigation of other putative messengers, and most attention is devoted to a discussion of systems that use these new messenger molecules...
  6. pmc Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses
    Jimok Kim
    Departments of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 13:592-600. 2010
    ..This regulatory mechanism, mediated by activity-dependent changes in tonic endocannabinoid level, permits selective local tuning of inhibitory synapses in hippocampal networks...
  7. ncbi request reprint Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus
    Jimok Kim
    Program in Neuroscience and Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
    Nat Neurosci 7:697-8. 2004
    ..Here we show that inhibition of cyclooxygenase-2 (COX-2), not fatty acid amide hydrolase (FAAH), prolongs DSI, suggesting that COX-2 limits endocannabinoid action...
  8. ncbi request reprint Ryanodine receptor regulates endogenous cannabinoid mobilization in the hippocampus
    Masako Isokawa
    Department of Physiology, University of Maryland, Baltimore, Maryland, USA
    J Neurophysiol 95:3001-11. 2006
    ..RyR may be a key molecule for the depolarization-induced production of eCBs that inhibit GABA release in the hippocampus...
  9. pmc Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation
    Meina Wang
    Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Psychopharmacol 26:56-70. 2012
    ..These results support the hypothesis that the ECS is a biochemical effector of glucocorticoids in the brain, linking stress with changes in synaptic strength...
  10. ncbi request reprint Novel form of LTD induced by transient, partial inhibition of the Na,K-pump in rat hippocampal CA1 cells
    Christian G Reich
    Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurophysiol 91:239-47. 2004
    ..Certain pathological conditions, including hypoxia and ischemia, are associated with a decrease in Na,K-pump activity and hence DHO-LTD may serve as a model for the effects on neuronal function in these conditions...
  11. pmc Retrograde endocannabinoid regulation of GABAergic inhibition in the rat dentate gyrus granule cell
    Masako Isokawa
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Physiol 567:1001-10. 2005
    ..Our findings suggest eCBs probably have physiological functions in the regulation of GABAergic plasticity in the dentate gyrus...
  12. pmc Synaptic cross talk between perisomatic-targeting interneuron classes expressing cholecystokinin and parvalbumin in hippocampus
    Miranda A Karson
    Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21210, USA
    J Neurosci 29:4140-54. 2009
    ..The prevalence of CCK and PV networks in other brain regions suggests that internetwork interactions could be generally important...
  13. pmc Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others
    Miranda A Karson
    Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201, USA
    Neuropharmacology 54:117-28. 2008
    ..In summary, our data are compatible with the hypothesis that CCK has opposite actions on sIPSPs that originate from functionally distinct interneurons...
  14. pmc Nerve terminal nicotinic acetylcholine receptors initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca²⁺ channels and Ca²⁺ release from stores
    Ai Hui Tang
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 31:13546-61. 2011
    ..It may therefore operate in parallel with the normal HVA-dependent processes. The results reveal new aspects of the regulation of GABA transmission and contribute to a deeper understanding of ACh and nicotine actions in CNS...
  15. pmc Novel mGluR- and CB1R-independent suppression of GABA release caused by a contaminant of the group I metabotropic glutamate receptor agonist, DHPG
    Carlos A Lafourcade
    Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 4:e6122. 2009
    ..We now report that a particular commercial preparation of DHPG can produce mGluR-independent effects. These findings may help reconcile some discrepant reports...
  16. pmc Distinctions among GABAA and GABAB responses revealed by calcium channel antagonists, cannabinoids, opioids, and synaptic plasticity in rat hippocampus
    Carlos A Lafourcade
    Departments of Physiology and Psychiatry, University of Maryland School of Medicine, 655 West Baltimore Street, BRB 5 025, Baltimore, MD 21201, USA
    Psychopharmacology (Berl) 198:539-49. 2008
    ..In addition, while both micro-opioid receptors (microORs) and cannabinoid CB1R receptors (CB1Rs) are present on hippocampal interneurons, it is not clear how these two systems interact...
  17. ncbi request reprint Multiple mechanisms of endocannabinoid response initiation in hippocampus
    David A Edwards
    Department of Physiology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    J Neurophysiol 95:67-75. 2006
    ..The results show that the biochemical pathways for the various eCB-dependent responses differ and might therefore be independently manipulated...
  18. pmc Prostaglandin E2 stimulates estradiol synthesis in the cerebellum postnatally with associated effects on Purkinje neuron dendritic arbor and electrophysiological properties
    Shannon L Dean
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, 21201, USA
    Endocrinology 153:5415-27. 2012
    ..These findings reveal a previously unappreciated role for PG-stimulated steroidogenesis in the developing brain and a new potential route for inflammation-mediated disruption of neuronal maturation...
  19. pmc Optogenetic release of ACh induces rhythmic bursts of perisomatic IPSCs in hippocampus
    Daniel A Nagode
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e27691. 2011
    ..pyramidale confirmed that the LFPs were driven by perisomatic inhibition. This optogenetic approach may be a useful complementary technique in future investigations of endogenous ACh effects...
  20. pmc Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus
    David A Edwards
    Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 105:8142-7. 2008
    ..Conversely, short-term, [Ca2+]i-dependent eCB release can be persistently enhanced by mGluR activation. Hence, eCBs are also objects of metaplasticity, subject to higher levels of physiological control...
  21. ncbi request reprint Regulation of exocytosis from single visualized GABAergic boutons in hippocampal slices
    Darrin H Brager
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 23:10475-86. 2003
    ..These features advance the understanding of the regulation of synapses and networks by presynaptic inhibition...
  22. ncbi request reprint Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus
    Jimok Kim
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 22:10182-91. 2002
    ..This study reveals a new role of the muscarinic cholinergic system in mammalian brain...
  23. pmc Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase
    Longhua Zhang
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e16305. 2011
    ....
  24. ncbi request reprint Mechanisms of neuronal hyperexcitability caused by partial inhibition of Na+-K+-ATPases in the rat CA1 hippocampal region
    Cyrille Vaillend
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurophysiol 88:2963-78. 2002
    ..We conclude that reduced GABAergic potentials and enhanced E-S coupling are the primary mechanisms underlying the hyperexcitability associated with impaired Na(+)-K(+) pump activity...
  25. pmc Dendritic hold and read: a gated mechanism for short term information storage and retrieval
    Mariton D Santos
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e37542. 2012
    ..Because the read-out of the input is not dependent on repetition of the input and information flows in a single-pass manner, DHR can potentially support a feedforward memory architecture...
  26. ncbi request reprint Endocannabinoid signaling dynamics probed with optical tools
    Thomas Heinbockel
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 25:9449-59. 2005
    ..Our findings imply that lipid messenger dynamics are comparable with those of metabotropic neurotransmitters and can modulate neuronal interactions on a similarly fast time scale...
  27. pmc The depolarizing action of GABA in cultured hippocampal neurons is not due to the absence of ketone bodies
    Jaylyn Waddell
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e23020. 2011
    ..Our data are consistent with the existence of a genuine "developmental switch" mechanism in which GABA goes from having a predominantly excitatory role in immature cells to a predominantly inhibitory one in adults...
  28. pmc Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know
    Bradley E Alger
    Department of Physiology, University of Maryland School of Medicine, 655 W Baltimore Street, Rm 5 025, Baltimore, MD 21201, USA
    J Physiol 590:2203-12. 2012
    ..Long-standing fundamental issues such as the synthesis pathway for AEA and the molecular mechanism(s) underlying cellular uptake and release of eCBs remain problematical...
  29. pmc Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome
    Longhua Zhang
    Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 30:5724-9. 2010
    ..Alterations in eCB signaling could contribute to the cognitive dysfunction associated with FXS...
  30. ncbi request reprint Not too excited? Thank your endocannabinoids
    Bradley E Alger
    Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, 21201, USA
    Neuron 51:393-5. 2006
    ..They show that protection against kainic acid-induced seizures and cell death is conferred by CB1Rs on hippocampal glutamatergic nerve terminals...
  31. pmc Supply and demand for endocannabinoids
    Bradley E Alger
    Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Trends Neurosci 34:304-15. 2011
    ..This review focuses on recent investigations that illuminate fundamental issues of eCB storage, release, and functional roles...
  32. doi request reprint Endocannabinoid signaling in neural plasticity
    Bradley E Alger
    Departments of Physiology and Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Curr Top Behav Neurosci 1:141-72. 2009
    ..This chapter concentrates on developments in the roles of ECBs in synaptic plasticity that have come to light since the major review by Chevaleyre et al. (Annu Rev Neurosci 29:37-76, 2006)...
  33. pmc Optogenetic identification of an intrinsic cholinergically driven inhibitory oscillator sensitive to cannabinoids and opioids in hippocampal CA1
    Daniel A Nagode
    B E Alger, Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Rm 5 025, Baltimore, MD 21201, USA
    J Physiol 592:103-23. 2014
    ..The oscillations could contribute to behaviourally relevant, atropine-sensitive, theta rhythms and link cannabinoid and opioid actions functionally...
  34. ncbi request reprint Endocannabinoids facilitate the induction of LTP in the hippocampus
    Gregory Carlson
    Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
    Nat Neurosci 5:723-4. 2002
    ....

Research Grants2

  1. Training Program in Cellular & Integrative Neuroscience
    Bradley Alger; Fiscal Year: 2007
    ..abstract_text> ..