O Aley

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat
    E K Joseph
    Department of Medicine, Division of Neuroscience and Biomedical Sciences Program and UCSF NIH Pain Center, Box 0440 Room C522, 521 Parnassus Avenue, University of California, San Francisco, CA 94143 0440, USA
    Neuroscience 120:907-13. 2003
  2. ncbi request reprint Hyperalgesic priming in the rat demonstrates marked sexual dimorphism
    Elizabeth K Joseph
    Department of Medicine, UCSF NIH Pain Center, University of California, San Francisco, CA 94143 0440, USA
    Pain 105:143-50. 2003
  3. ncbi request reprint Rapid onset pain induced by intravenous streptozotocin in the rat
    K O Aley
    NIH Pain Center, University of California, San Francisco, 94143 0440, USA
    J Pain 2:146-50. 2001
  4. ncbi request reprint Caspase signalling in neuropathic and inflammatory pain in the rat
    Elizabeth K Joseph
    Department of Medicine, Division of Neuroscience and Biomedical Sciences Programme, NIH Pain Centre, Box 0440 C522, University of California, San Francisco, San Francisco, CA 94143, USA
    Eur J Neurosci 20:2896-902. 2004
  5. ncbi request reprint Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat
    Elizabeth K Joseph
    Department of Medicine, Division of Neuroscience and Biomedical Sciences Program, and UCSF NIH Pain Center, University of California, San Francisco, CA 94143 0440, USA
    Pain 107:147-58. 2004
  6. ncbi request reprint Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy
    E K Joseph
    Department of Oral and Maxillofacial Surgery, University of California, 521 Parnassus Avenue, San Francisco, CA, 94143 0440, USA
    Neuroscience 119:831-8. 2003
  7. ncbi request reprint Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat
    O Aley
    NIH Pain Center, University of California, Box 0440, Room C522, 521 Parnassus Ave, San Francisco, CA 94143 0440, USA
    Exp Brain Res 148:482-7. 2003
  8. ncbi request reprint Different peripheral mechanisms mediate enhanced nociception in metabolic/toxic and traumatic painful peripheral neuropathies in the rat
    K O Aley
    NIH Pain Center UCSF, Box 0440, University of California San Francisco, 521 Parnassus Avenue, 94143 0440, USA
    Neuroscience 111:389-97. 2002
  9. ncbi request reprint Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C
    K O Aley
    National Institutes of Health Pain Center, University of California, San Francisco, San Francisco, California 94143 0440, USA
    J Neurosci 20:4680-5. 2000
  10. ncbi request reprint Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat
    O A Dina
    Departments of Medicine and Oral and Maxillofacial Surgery, Division of Neuroscience and Biomedical Sciences Program, NIH Pain Center, University of California at San, Francisco, San Francisco, CA 94143-0440, USA
    Eur J Neurosci 13:2227-33. 2001

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat
    E K Joseph
    Department of Medicine, Division of Neuroscience and Biomedical Sciences Program and UCSF NIH Pain Center, Box 0440 Room C522, 521 Parnassus Avenue, University of California, San Francisco, CA 94143 0440, USA
    Neuroscience 120:907-13. 2003
    ....
  2. ncbi request reprint Hyperalgesic priming in the rat demonstrates marked sexual dimorphism
    Elizabeth K Joseph
    Department of Medicine, UCSF NIH Pain Center, University of California, San Francisco, CA 94143 0440, USA
    Pain 105:143-50. 2003
    ..Thus, mechanisms mediating the development of hyperalgesic priming produced by inflammation are suppressed by estrogen. This regulation of priming by estrogen appears to occur at or downstream of the activation of PKC epsilon...
  3. ncbi request reprint Rapid onset pain induced by intravenous streptozotocin in the rat
    K O Aley
    NIH Pain Center, University of California, San Francisco, 94143 0440, USA
    J Pain 2:146-50. 2001
    ..We conclude that streptozotocin can induce pain independent of a general debility or direct toxic effect of streptozotocin on peripheral nerve and that elevated blood glucose may contribute to the enhanced nociception...
  4. ncbi request reprint Caspase signalling in neuropathic and inflammatory pain in the rat
    Elizabeth K Joseph
    Department of Medicine, Division of Neuroscience and Biomedical Sciences Programme, NIH Pain Centre, Box 0440 C522, University of California, San Francisco, San Francisco, CA 94143, USA
    Eur J Neurosci 20:2896-902. 2004
    ..This suggests that these pathways are potential targets for novel pharmacological agents for the treatment of inflammatory as well as neuropathic pain...
  5. ncbi request reprint Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat
    Elizabeth K Joseph
    Department of Medicine, Division of Neuroscience and Biomedical Sciences Program, and UCSF NIH Pain Center, University of California, San Francisco, CA 94143 0440, USA
    Pain 107:147-58. 2004
    ..This study provides evidence for a novel, calcium-dependent, mechanism for neuropathic pain in a model of AIDS therapy-induced painful peripheral neuropathy...
  6. ncbi request reprint Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy
    E K Joseph
    Department of Oral and Maxillofacial Surgery, University of California, 521 Parnassus Avenue, San Francisco, CA, 94143 0440, USA
    Neuroscience 119:831-8. 2003
    ....
  7. ncbi request reprint Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat
    O Aley
    NIH Pain Center, University of California, Box 0440, Room C522, 521 Parnassus Ave, San Francisco, CA 94143 0440, USA
    Exp Brain Res 148:482-7. 2003
    ..products of the 5-lipoxygenase and 12-lipoxygenase pathway are involved in this function, and (3). these lipoxygenase products contribute to hyperalgesia at or downstream of protein kinase A and PKCepsilon...
  8. ncbi request reprint Different peripheral mechanisms mediate enhanced nociception in metabolic/toxic and traumatic painful peripheral neuropathies in the rat
    K O Aley
    NIH Pain Center UCSF, Box 0440, University of California San Francisco, 521 Parnassus Avenue, 94143 0440, USA
    Neuroscience 111:389-97. 2002
    ....
  9. ncbi request reprint Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C
    K O Aley
    National Institutes of Health Pain Center, University of California, San Francisco, San Francisco, California 94143 0440, USA
    J Neurosci 20:4680-5. 2000
    ..However, these antagonists did not inhibit development of the hypersensitivity to inflammatory mediators. Our findings indicate that different second messenger pathways underlie acute and prolonged inflammatory pain...
  10. ncbi request reprint Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat
    O A Dina
    Departments of Medicine and Oral and Maxillofacial Surgery, Division of Neuroscience and Biomedical Sciences Program, NIH Pain Center, University of California at San, Francisco, San Francisco, CA 94143-0440, USA
    Eur J Neurosci 13:2227-33. 2001
    ....
  11. ncbi request reprint Nociceptor sensitization by extracellular signal-regulated kinases
    K O Aley
    Departments of Medicine and Oral Surgery, National Institutes of Health Pain Center at the University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 21:6933-9. 2001
    ..We conclude that a Ras-MEK-ERK1/2 cascade acts independent of PKA or PKCepsilon as a novel signaling pathway for the production of inflammatory pain. This pathway may present a target for a new class of analgesic agents...
  12. ncbi request reprint A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice
    S G Khasar
    Department of Internal Medicine and Oral Surgery, National Institutes of Health University of California, USA
    Neuron 24:253-60. 1999
    ..Our findings indicate that PKCepsilon regulates nociceptor function and suggest that PKCepsilon inhibitors could prove useful in the treatment of pain...