Richard B Alexander

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint CD8-based T cell vaccination and CD4 T cell responses in prostate cancer
    Richard B Alexander
    Division of Urology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Immunother 28:295-6. 2005
  2. ncbi request reprint Treatment of chronic prostatitis
    Richard B Alexander
    Veterans Affairs Maryland Health Care System and University of Maryland School of Medicine, Baltimore 21201, USA
    Nat Clin Pract Urol 1:2-3. 2004
  3. ncbi request reprint Ciprofloxacin or tamsulosin in men with chronic prostatitis/chronic pelvic pain syndrome: a randomized, double-blind trial
    Richard B Alexander
    Veterans Affairs Maryland Health Care System and University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Ann Intern Med 141:581-9. 2004
  4. pmc Cutting edge: permissive MHC class II allele changes the pattern of antitumor immune response resulting in failure of tumor rejection
    Elena N Klyushnenkova
    Division of Urology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 182:1242-6. 2009
  5. ncbi request reprint Identification of HLA-DRB1*1501-restricted T-cell epitopes from human prostatic acid phosphatase
    Elena N Klyushnenkova
    Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Prostate 67:1019-28. 2007
  6. pmc A cytomegalovirus-based vaccine expressing a single tumor-specific CD8+ T-cell epitope delays tumor growth in a murine model of prostate cancer
    Elena N Klyushnenkova
    Department of Surgery, Division of Urology, University of Maryland, Baltimore, MD 21201, USA
    J Immunother 35:390-9. 2012
  7. ncbi request reprint Granulomatous prostatitis linked to HLA-DRB1*1501
    Richard B Alexander
    Urology Section, Veterans Affairs Health Care System, University of Maryland School of Medicine, Baltimore 21201, USA
    J Urol 171:2326-9. 2004
  8. ncbi request reprint Identification of HLA-DRB1*1501-restricted T-cell epitopes from prostate-specific antigen
    Elena N Klyushnenkova
    Urology Section, VA Maryland Health Care System, and Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland 21202, USA
    Clin Cancer Res 11:2853-61. 2005
  9. ncbi request reprint Activation of innate immunity by prostate specific antigen (PSA)
    James A Kodak
    Division of Urology, University of Maryland School of Medicine and VA Maryland Health Care System, Baltimore, Maryland 21201, USA
    Prostate 66:1592-9. 2006
  10. pmc T-cell recognition of prostatic peptides in men with chronic prostatitis/chronic pelvic pain syndrome
    Diana V Kouiavskaia
    Division of Urology, Department of Surgery, University of Maryland School of Medicine and Urology Section, Veterans Affairs Maryland Health Care System, Baltimore, Maryland 21201, USA
    J Urol 182:2483-9. 2009

Research Grants

  1. CHRONIC PROSTATITIS COLLABORATIVE CLINICAL STUDIES
    Richard Alexander; Fiscal Year: 2007
  2. CHRONIC PROSTATITIS COLLABORATIVE CLINICAL STUDIES
    Richard Alexander; Fiscal Year: 2007

Detail Information

Publications22

  1. ncbi request reprint CD8-based T cell vaccination and CD4 T cell responses in prostate cancer
    Richard B Alexander
    Division of Urology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Immunother 28:295-6. 2005
  2. ncbi request reprint Treatment of chronic prostatitis
    Richard B Alexander
    Veterans Affairs Maryland Health Care System and University of Maryland School of Medicine, Baltimore 21201, USA
    Nat Clin Pract Urol 1:2-3. 2004
  3. ncbi request reprint Ciprofloxacin or tamsulosin in men with chronic prostatitis/chronic pelvic pain syndrome: a randomized, double-blind trial
    Richard B Alexander
    Veterans Affairs Maryland Health Care System and University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Ann Intern Med 141:581-9. 2004
    ..No cause of the disease has been established, and therapies are empirical and mostly untested. Antimicrobial agents and alpha-adrenergic receptor blockers are frequently used...
  4. pmc Cutting edge: permissive MHC class II allele changes the pattern of antitumor immune response resulting in failure of tumor rejection
    Elena N Klyushnenkova
    Division of Urology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 182:1242-6. 2009
    ..Our data demonstrate that the expression of a permissive HLA class II allele can change the pattern of the immune response to a tumor Ag, resulting in the failure of tumor rejection...
  5. ncbi request reprint Identification of HLA-DRB1*1501-restricted T-cell epitopes from human prostatic acid phosphatase
    Elena N Klyushnenkova
    Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Prostate 67:1019-28. 2007
    ..One of the antigens implicated in the development of autoimmunity in the prostate is prostatic acid phosphatase (PAP), which is also considered a promising target for prostate cancer immunotherapy...
  6. pmc A cytomegalovirus-based vaccine expressing a single tumor-specific CD8+ T-cell epitope delays tumor growth in a murine model of prostate cancer
    Elena N Klyushnenkova
    Department of Surgery, Division of Urology, University of Maryland, Baltimore, MD 21201, USA
    J Immunother 35:390-9. 2012
    ....
  7. ncbi request reprint Granulomatous prostatitis linked to HLA-DRB1*1501
    Richard B Alexander
    Urology Section, Veterans Affairs Health Care System, University of Maryland School of Medicine, Baltimore 21201, USA
    J Urol 171:2326-9. 2004
    ....
  8. ncbi request reprint Identification of HLA-DRB1*1501-restricted T-cell epitopes from prostate-specific antigen
    Elena N Klyushnenkova
    Urology Section, VA Maryland Health Care System, and Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland 21202, USA
    Clin Cancer Res 11:2853-61. 2005
    ..The use of these peptides for the immunotherapy of prostate cancer is under investigation...
  9. ncbi request reprint Activation of innate immunity by prostate specific antigen (PSA)
    James A Kodak
    Division of Urology, University of Maryland School of Medicine and VA Maryland Health Care System, Baltimore, Maryland 21201, USA
    Prostate 66:1592-9. 2006
    ..Prostate specific antigen (PSA) is a serine protease secreted by the prostatic epithelium. The only known function of the protein is to cleave seminogelin. We wished to determine if PSA activated peripheral blood mononuclear cells (PBMC)...
  10. pmc T-cell recognition of prostatic peptides in men with chronic prostatitis/chronic pelvic pain syndrome
    Diana V Kouiavskaia
    Division of Urology, Department of Surgery, University of Maryland School of Medicine and Urology Section, Veterans Affairs Maryland Health Care System, Baltimore, Maryland 21201, USA
    J Urol 182:2483-9. 2009
    ..We determined whether T cells from men with chronic prostatitis/chronic pelvic pain syndrome would recognize peptides derived from the normal self-prostatic proteins prostate specific antigen and prostatic acid phosphatase...
  11. pmc Vaccination with agonist peptide PSA: 154-163 (155L) derived from prostate specific antigen induced CD8 T-cell response to the native peptide PSA: 154-163 but failed to induce the reactivity against tumor targets expressing PSA: a phase 2 study in patient
    Diana V Kouiavskaia
    Division of Urology, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunother 32:655-66. 2009
    ..PSA: 154-163 (155L) is not an effective immunogen when given with Montanide ISA-51. The PSA: 154-163 peptide is poorly processed from endogenous PSA and therefore represents a cryptic epitope of PSA in HLA-A2 antigen-presenting cells...
  12. ncbi request reprint Magnetic resonance spectroscopic imaging-guided brachytherapy for localized prostate cancer
    Steven J DiBiase
    Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, MD 21201, USA
    Int J Radiat Oncol Biol Phys 52:429-38. 2002
    ..This report reveals our initial experience of MRSI-guided PB...
  13. ncbi request reprint CD4 and CD8 T-lymphocyte recognition of prostate specific antigen in granulomatous prostatitis
    Elena N Klyushnenkova
    Division of Urology, VA Maryland Health Care System, Baltimore, Maryland, USA
    J Immunother 27:136-46. 2004
    ....
  14. doi request reprint CD4 T-Cell-mediated immune response to prostatic proteins in HLA-DRB1*1503 transgenic mice and identification of a novel HLA-DRB1*1503-restricted T-cell epitope from human prostatic acid phosphatase
    Elena N Klyushnenkova
    VA Maryland Health Care System, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Prostate 71:561-6. 2011
    ..Hence characterization of peptide immunogenicity for these alleles is important for the development of prostate cancer immunotherapy in white and black patients...
  15. ncbi request reprint Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis: the National Institutes of Health Chronic Prostatitis Cohort Study
    Anthony J Schaeffer
    Department of Urology, Northwestern University, Chicago, IL 60611, USA
    J Urol 168:1048-53. 2002
    ..We examine whether leukocytes and bacteria correlate with symptom severity in men with chronic prostatitis/chronic pelvic pain syndrome...
  16. ncbi request reprint Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada
    J Urol 170:818-22. 2003
    ....
  17. ncbi request reprint Design of a multicenter randomized clinical trial for chronic prostatitis/chronic pelvic pain syndrome
    Kathleen J Propert
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Urology 59:870-6. 2002
    ..To describe the study design and rationale for the first placebo-controlled, randomized clinical trial to be conducted by the Chronic Prostatitis Collaborative Research Network sponsored by the National Institutes of Health...
  18. ncbi request reprint Psychosocial variables affect the quality of life of men diagnosed with chronic prostatitis/chronic pelvic pain syndrome
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    BJU Int 101:59-64. 2008
    ..To examine interactions between demographic, pain, urinary, psychological and environmental predictors of quality of life (QOL) in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)...
  19. ncbi request reprint Demographic and clinical characteristics of men with chronic prostatitis: the national institutes of health chronic prostatitis cohort study
    Anthony J Schaeffer
    Department of Urology, Northwestern University, Chicago, Illinois 60611, USA
    J Urol 168:593-8. 2002
    ..We describe the study design of the National Institutes of Health Chronic Prostatitis Cohort (CPC) study characterizing men with chronic prostatitis/the chronic pelvic pain syndrome...
  20. ncbi request reprint Prostate-specific antigen test in diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome
    Robert B Nadler
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 67:337-42. 2006
    ....
  21. ncbi request reprint How does the pre-massage and post-massage 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome?
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    J Urol 176:119-24. 2006
    ..We evaluated a simpler test, the 2-glass pre-massage and post-massage test, and compared it with the Meares-Stamey 4-glass test to detect inflammation and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome...
  22. ncbi request reprint Catastrophizing and pain-contingent rest predict patient adjustment in men with chronic prostatitis/chronic pelvic pain syndrome
    Dean A Tripp
    Department of Psychology, Anesthesiology and Urology, Queen s University, Kingston, Ontario, Canada
    J Pain 7:697-708. 2006
    ..Findings support the need for greater research of such pain-related variables in CP/CPPS...

Research Grants3

  1. CHRONIC PROSTATITIS COLLABORATIVE CLINICAL STUDIES
    Richard Alexander; Fiscal Year: 2007
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  2. CHRONIC PROSTATITIS COLLABORATIVE CLINICAL STUDIES
    Richard Alexander; Fiscal Year: 2007
    ..abstract_text> ..