CAROLINE MARGARET ALEXANDER

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. doi request reprint Fully interlocking: a story of teamwork among breast epithelial cells
    Caroline M Alexander
    McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53706, USA Electronic address
    Dev Cell 28:114-5. 2014
  2. pmc Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures
    Marni A Slavik
    McArdle Lab for Cancer Research, University of Wisconsin Medical School Madison, Madison, Wisconsin, USA
    BMC Dev Biol 7:9. 2007
  3. pmc Wnt4 is not sufficient to induce lobuloalveolar mammary development
    Young Chul Kim
    McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin Madison, Wisconsin, USA
    BMC Dev Biol 9:55. 2009
  4. pmc Separating stem cells by flow cytometry: reducing variability for solid tissues
    Caroline M Alexander
    McArdle Laboratory for Cancer Research, Madison, WI 53706, USA
    Cell Stem Cell 5:579-83. 2009
  5. doi request reprint Base behavior behind budding breasts: integrins and mammary stem cell activity
    Caroline M Alexander
    McArdle Lab for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison WI 53706, USA
    Cell Stem Cell 3:5-6. 2008
  6. ncbi request reprint Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice
    C M Alexander
    Division of Newborn Medicine, Childrens Hospital, Enders 950, Boston, Massachusetts, USA
    Nat Genet 25:329-32. 2000
  7. pmc Stromelysin-1 regulates adipogenesis during mammary gland involution
    C M Alexander
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin 53706 1599, USA
    J Cell Biol 152:693-703. 2001
  8. ncbi request reprint Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development
    S P McDermott
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
    Oncogene 26:1407-16. 2007
  9. ncbi request reprint Simulating mouse mammary gland development: cell ageing and its relation to stem and progenitor activity
    A Paguirigan
    Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706, USA
    Cell Prolif 40:106-24. 2007
  10. pmc The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    Bob Y Liu
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 1400 University Avenue, Madison, WI 53706 1599, USA
    Proc Natl Acad Sci U S A 101:4158-63. 2004

Research Grants

  1. The Role of Syndecan-1 in Mouse Mammary Neoplasia
    CAROLINE MARGARET ALEXANDER; Fiscal Year: 2010
  2. The Role of Syndecan-1 in Mouse Mammary Neoplasia
    Caroline Alexander; Fiscal Year: 2006
  3. The Role of Syndecan-1 in Mouse Mammary Neoplasia
    Caroline Alexander; Fiscal Year: 2007

Collaborators

  • Peter Dirks
  • M J Bissell
  • M D Sternlicht
  • Leif R Lund
  • Marni A Slavik
  • Matthew J Smalley
  • Bob Y Liu
  • Young Chul Kim
  • S P McDermott
  • A Paguirigan
  • Charlotta Lindvall
  • Takashi Maeda
  • Bryony S Wiseman
  • Rod J Clark
  • Francisco Pelegri
  • K S Klos
  • S S Khwaja
  • V S Leatherberry
  • E A Ranheim
  • D J Beebe
  • Cassandra R Zylstra
  • Nicole C Evans
  • Yi Li
  • Bart O Williams
  • Shariq S Khwaja
  • Sean P McDermott
  • Andreas Friedl
  • Pam Cowin
  • Zena Werb
  • Paul Soloway
  • Shigeyoshi Itohara
  • Vicki Leatherberry
  • Joni Mott

Detail Information

Publications14

  1. doi request reprint Fully interlocking: a story of teamwork among breast epithelial cells
    Caroline M Alexander
    McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53706, USA Electronic address
    Dev Cell 28:114-5. 2014
    ..Do all mammary epithelial cells both give and take instructions from others to create the milk production machinery? ..
  2. pmc Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures
    Marni A Slavik
    McArdle Lab for Cancer Research, University of Wisconsin Medical School Madison, Madison, Wisconsin, USA
    BMC Dev Biol 7:9. 2007
    ..Wnt signaling has been shown to be an important growth-inducer of stem cell compartments in skin and many other tissues...
  3. pmc Wnt4 is not sufficient to induce lobuloalveolar mammary development
    Young Chul Kim
    McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin Madison, Wisconsin, USA
    BMC Dev Biol 9:55. 2009
    ..Therefore, we generated conditional transgenic mice to test whether Wnt4 can stimulate mammary epithelial cell growth...
  4. pmc Separating stem cells by flow cytometry: reducing variability for solid tissues
    Caroline M Alexander
    McArdle Laboratory for Cancer Research, Madison, WI 53706, USA
    Cell Stem Cell 5:579-83. 2009
    ..In our view, clear reporting guidelines could improve reproducibility of stem cell analyses in solid tissues...
  5. doi request reprint Base behavior behind budding breasts: integrins and mammary stem cell activity
    Caroline M Alexander
    McArdle Lab for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison WI 53706, USA
    Cell Stem Cell 3:5-6. 2008
    ..2008) reveal that deletion of beta1 integrin from K5-expressing mammary epithelial basal cells specifically attenuates ductal stem cell activity, without dramatically altering the basal cell layer, or morphogenesis overall...
  6. ncbi request reprint Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice
    C M Alexander
    Division of Newborn Medicine, Childrens Hospital, Enders 950, Boston, Massachusetts, USA
    Nat Genet 25:329-32. 2000
    ..Our results provide both genetic and biochemical evidence that syndecan-1 can modulate Wnt signalling, and is critical for Wnt-1-induced tumorigenesis of the mouse mammary gland...
  7. pmc Stromelysin-1 regulates adipogenesis during mammary gland involution
    C M Alexander
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin 53706 1599, USA
    J Cell Biol 152:693-703. 2001
    ..We conclude that MMPs, especially Str1, determine the rate of adipocyte differentiation during involutive mammary gland remodeling...
  8. ncbi request reprint Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development
    S P McDermott
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
    Oncogene 26:1407-16. 2007
    ..Both observations imply that the DMBA-induced tumor precursor cells are drawn from the stem/progenitor fraction, and we suggest that pathogenic activation of these cells could be abnormal in Sdc1-/- mice...
  9. ncbi request reprint Simulating mouse mammary gland development: cell ageing and its relation to stem and progenitor activity
    A Paguirigan
    Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706, USA
    Cell Prolif 40:106-24. 2007
    ..Each division is accompanied by a risk of fixing genetic mutations, and/or generating innately immortal cells that escape normal physiological controls...
  10. pmc The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    Bob Y Liu
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 1400 University Avenue, Madison, WI 53706 1599, USA
    Proc Natl Acad Sci U S A 101:4158-63. 2004
    ..We propose that the growth dynamic of the stem cell fraction is a major determinant of tumor susceptibility...
  11. ncbi request reprint Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells
    Takashi Maeda
    Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, Madison, Wisconsin, USA
    Cancer Res 64:612-21. 2004
    ..In conclusion, we have demonstrated that a growth-promoting loop exists between breast cancer cells and their stroma that depends on the activity of glycanated Sdc1...
  12. ncbi request reprint Mammary gland development requires syndecan-1 to create a beta-catenin/TCF-responsive mammary epithelial subpopulation
    Bob Y Liu
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 1400 University Ave, Madison, WI, USA
    Oncogene 22:9243-53. 2003
    ....
  13. pmc Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis
    Bryony S Wiseman
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    J Cell Biol 162:1123-33. 2003
    ..Nevertheless, the mammary gland is able to develop lactational competence in MMP mutant mice. Thus, specific MMPs refine the mammary branching pattern by distinct mechanisms during mammary gland branching morphogenesis...
  14. ncbi request reprint The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis
    Charlotta Lindvall
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 281:35081-7. 2006
    ..These findings suggest that Lrp5-mediated canonical signaling is required for mammary ductal stem cell activity and for tumor development in response to oncogenic Wnt effectors...

Research Grants9

  1. The Role of Syndecan-1 in Mouse Mammary Neoplasia
    CAROLINE MARGARET ALEXANDER; Fiscal Year: 2010
    ....
  2. The Role of Syndecan-1 in Mouse Mammary Neoplasia
    Caroline Alexander; Fiscal Year: 2006
    ..In summary, this proposal aims to establish the molecular mechanism underlying the collaboration between Sdc1 and the Wnt signaling pathway that has been demonstrated in mice and may be important to man. ..
  3. The Role of Syndecan-1 in Mouse Mammary Neoplasia
    Caroline Alexander; Fiscal Year: 2007
    ..By understanding the defects in these mice we aim to find out when somatic stem cell compartments are prone to transformation, and what factors regulate this process. ..