Oleg M Alekseev

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP
    Oleg M Alekseev
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 7090, USA
    Reprod Biol Endocrinol 7:45. 2009
  2. pmc Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells
    Oleg M Alekseev
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Reprod Biol Endocrinol 9:50. 2011
  3. ncbi request reprint Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation
    Richard T Richardson
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, 27599, USA
    J Biol Chem 281:21526-34. 2006
  4. ncbi request reprint Mass spectrometry identification of NASP binding partners in HeLa cells
    Oleg M Alekseev
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, 27599 7090, USA
    Proteins 61:1-5. 2005
  5. ncbi request reprint Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei
    Oleg M Alekseev
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090
    J Biol Chem 280:2904-11. 2005
  6. ncbi request reprint Characterization of the NASP promoter in 3T3 fibroblasts and mouse spermatogenic cells
    Richard T Richardson
    Department of Cell and Developmental Biology and Laboratories for Reproductive Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Gene 371:52-8. 2006
  7. pmc Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/Cyclin B1 complex formation during meiosis in the mouse
    Oleg M Alekseev
    Department of Cell and Developmental Biology and the Laboratories for Reproductive Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Biol Reprod 81:739-48. 2009
  8. ncbi request reprint Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle
    Oleg M Alekseev
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill 27599 7090, USA
    J Biol Chem 278:8846-52. 2003

Collaborators

Detail Information

Publications8

  1. pmc Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP
    Oleg M Alekseev
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 7090, USA
    Reprod Biol Endocrinol 7:45. 2009
    ..To understand the pathways and networks that may involve NASP function, we evaluated gene expression in HeLa cells in which NASP was either overexpressed or depleted by siRNA...
  2. pmc Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells
    Oleg M Alekseev
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Reprod Biol Endocrinol 9:50. 2011
    ..Only cancer, germ, transformed, and embryonic cells have a high level of expression of the tNASP splice variant. We examined the consequences of tNASP depletion for prostate cancer PC-3 cells...
  3. ncbi request reprint Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation
    Richard T Richardson
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, 27599, USA
    J Biol Chem 281:21526-34. 2006
    ..We conclude from this study that NASP and therefore the linker histones are key players in the assembly of chromatin after DNA replication...
  4. ncbi request reprint Mass spectrometry identification of NASP binding partners in HeLa cells
    Oleg M Alekseev
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, 27599 7090, USA
    Proteins 61:1-5. 2005
    ..This new method can be used for expedited identification of binding partners of different proteins in enriched fractions and as a complementary or alternative strategy to the yeast two-hybrid system and immunoprecipitation methods...
  5. ncbi request reprint Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei
    Oleg M Alekseev
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090
    J Biol Chem 280:2904-11. 2005
    ..NASP-H1 is subsequently released from the complex and translocates to the nucleus where the H1 is released for binding to the DNA...
  6. ncbi request reprint Characterization of the NASP promoter in 3T3 fibroblasts and mouse spermatogenic cells
    Richard T Richardson
    Department of Cell and Developmental Biology and Laboratories for Reproductive Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Gene 371:52-8. 2006
    ..Supershift assays further confirmed the presence of Sp1 bound to their respective sites suggesting that Sp1 and Ets are the primary activators of the NASP promoter...
  7. pmc Linker histones stimulate HSPA2 ATPase activity through NASP binding and inhibit CDC2/Cyclin B1 complex formation during meiosis in the mouse
    Oleg M Alekseev
    Department of Cell and Developmental Biology and the Laboratories for Reproductive Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Biol Reprod 81:739-48. 2009
    ....
  8. ncbi request reprint Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle
    Oleg M Alekseev
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill 27599 7090, USA
    J Biol Chem 278:8846-52. 2003
    ..These data suggest that NASP-H1 complexes exist in the nucleus and that tNASP can influence cell cycle progression through the G(1)/S border through mediation of DNA-H1 histone binding...