Maria Luisa Alegre

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Mechanisms of CTLA-4-Ig in tolerance induction
    M L Alegre
    Department of Medicine, Section of Rheumatology, University of Chicago, IL 60637, USA
    Curr Pharm Des 12:149-60. 2006
  2. ncbi request reprint Toll-like receptors (TLRs) in transplantation
    Maria Luisa Alegre
    Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL60637, USA
    Front Biosci (Elite Ed) 1:36-43. 2009
  3. pmc Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance
    Maria Luisa Alegre
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Transplantation 87:S77-9. 2009
  4. ncbi request reprint T-cell regulation by CD28 and CTLA-4
    M L Alegre
    Department of Medicine, Section of Rheumatology and Committee in Immunology, Chicago, Illinois 60637, USA
    Nat Rev Immunol 1:220-8. 2001
  5. ncbi request reprint Expression and function of CTLA-4 in Th1 and Th2 cells
    M L Alegre
    Howard Hughes Medical Institute, University of Chicago, IL 60637, USA
    J Immunol 161:3347-56. 1998
  6. ncbi request reprint Costimulatory molecules as targets for the induction of transplantation tolerance
    Maria Luisa Alegre
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Curr Mol Med 6:843-57. 2006
  7. pmc Toll-like receptor signaling in transplantation
    Maria Luisa Alegre
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Curr Opin Organ Transplant 13:358-65. 2008
  8. ncbi request reprint Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts
    Ping Zhou
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Am J Transplant 3:139-47. 2003
  9. ncbi request reprint Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells
    Kwang Woo Hwang
    Department of Medicine and Committee in Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 169:633-7. 2002
  10. ncbi request reprint Overexpression of program death-1 in T cells has mild impact on allograft survival
    Luqiu Chen
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Transpl Int 21:21-9. 2008

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Mechanisms of CTLA-4-Ig in tolerance induction
    M L Alegre
    Department of Medicine, Section of Rheumatology, University of Chicago, IL 60637, USA
    Curr Pharm Des 12:149-60. 2006
    ..In this review, we will focus on the current knowledge of the mechanisms of action of CTLA-4 and CTLA-4-Ig...
  2. ncbi request reprint Toll-like receptors (TLRs) in transplantation
    Maria Luisa Alegre
    Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL60637, USA
    Front Biosci (Elite Ed) 1:36-43. 2009
    ..In this review, we will summarize the results published to date on the role of TLRs in experimental and clinical transplantation...
  3. pmc Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance
    Maria Luisa Alegre
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Transplantation 87:S77-9. 2009
    ..Therefore, transiently targeting these innate, proinflammatory pathways may have therapeutic value to promote transplantation tolerance...
  4. ncbi request reprint T-cell regulation by CD28 and CTLA-4
    M L Alegre
    Department of Medicine, Section of Rheumatology and Committee in Immunology, Chicago, Illinois 60637, USA
    Nat Rev Immunol 1:220-8. 2001
    ....
  5. ncbi request reprint Expression and function of CTLA-4 in Th1 and Th2 cells
    M L Alegre
    Howard Hughes Medical Institute, University of Chicago, IL 60637, USA
    J Immunol 161:3347-56. 1998
    ..We conclude that CTLA-4 can function to suppress the production of cytokines produced by both Th1 and Th2 cells...
  6. ncbi request reprint Costimulatory molecules as targets for the induction of transplantation tolerance
    Maria Luisa Alegre
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Curr Mol Med 6:843-57. 2006
    ..In this review, we will summarize the different reagents used to target costimulatory molecules, their effects, and the possible reasons limiting their efficacy in higher order mammals...
  7. pmc Toll-like receptor signaling in transplantation
    Maria Luisa Alegre
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Curr Opin Organ Transplant 13:358-65. 2008
    ..This review summarizes recent advances in the role of endogenous and exogenous Toll-like receptor ligands in the activation and inhibition of immune responses in transplantation...
  8. ncbi request reprint Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts
    Ping Zhou
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Am J Transplant 3:139-47. 2003
    ....
  9. ncbi request reprint Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells
    Kwang Woo Hwang
    Department of Medicine and Committee in Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 169:633-7. 2002
    ..Furthermore, CTLA-4(+/+) T cells that had encountered 7M-expressing tumors in vivo acquired defects in cytokine production and cytotoxicity. Thus, deliberate ligation of CTLA-4 in vivo potently inhibits allogeneic T cell responses...
  10. ncbi request reprint Overexpression of program death-1 in T cells has mild impact on allograft survival
    Luqiu Chen
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Transpl Int 21:21-9. 2008
    ..We conclude that genetic engineering of T cells to express PD-1 constitutively has only a mild impact on allograft survival...
  11. ncbi request reprint CTLA-4 engagement regulates NF-kappaB activation in vivo
    Helena Harlin
    Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, Ill 60637 USA
    Eur J Immunol 32:2095-104. 2002
    ..Thus, impaired NF-kappaB activity in T cells prevents specific aspects of the CTLA-4(-/-) phenotype, suggesting that inhibition of NF-kappaB activation is one of the key biochemical events regulated by CTLA-4 ligation in vivo...
  12. ncbi request reprint Secondary lymphoid organs are important but not absolutely required for allograft responses
    Ping Zhou
    Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA
    Am J Transplant 3:259-66. 2003
    ..These results suggest that immunologic events capable of leading to allograft rejection can successfully occur at sites other than classical secondary lymphoid organs...
  13. ncbi request reprint Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation
    Dongdong Li
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 173:7135-9. 2004
    ..These observations indicate that CD28 and CTLA-4 tightly regulate Cbl-b expression which is critical for establishing the threshold for T cell activation...
  14. pmc Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection
    Sumit K Subudhi
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 113:694-700. 2004
    ..Ig fusion protein augmented naive T cell priming both in vitro and in vivo. Our results demonstrate that B7-H1 can provide positive costimulation for naive T cells to promote allograft rejection and autoimmune disease pathogenesis...
  15. ncbi request reprint TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism
    Helena Harlin
    Committee on Immunology and Department of Medicine, Section of Rheumatology, University of Chicago, IL 60637, USA
    J Immunol 169:2451-9. 2002
    ..Inasmuch as IL-13 can promote airway inflammation and cancer progression, production of IL-13 in a TCR-independent manner has important pathological implications in vivo...
  16. ncbi request reprint Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice
    Kwang Woo Hwang
    Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 173:5415-24. 2004
    ..Thus, restoring CTLA-4 expression in T cells may be an attractive strategy to control clinical autoimmune diseases in which CTLA-4 expression is reduced...
  17. ncbi request reprint Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL
    Ping Zhou
    Department of Medicine, Section of Rheumatology, Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 174:3447-53. 2005
    ..Together, these results suggest that the death of alloreactive T cells may be partly responsible for the transplantation tolerance observed in mice with defective T cell-intrinsic NF-kappaB activation...
  18. pmc Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes
    Tongmin Wang
    Section of Transplantation, Department of Surgery, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 180:5991-9. 2008
    ..Our results indicate that bacterial exposure at the time of transplantation can antagonize tolerogenic regimens by enhancing alloantigen-specific immune responses independently of the generation of cross-reactive memory T cells...
  19. pmc T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b
    Guilin Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Ave, MC 5100, Suite S 521, Chicago, IL 60637, USA
    Mol Cell Biol 28:2470-80. 2008
    ....
  20. pmc Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration
    Fabiola V Rivas
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 24:1628-39. 2004
    ..Our results imply a novel role for the actin cytoskeleton in modulating the duration of Ca(2+)-NFAT signaling and indicate that actin dynamics regulate features of T-cell activation downstream of receptor clustering...
  21. ncbi request reprint Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance
    P Zhou
    Section of Transplantation, Departments of Surgery, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 165:5580-7. 2000
    ..These data suggest that the balance of type 1 and type 2 T lymphocyte differentiation is not critical for acute rejection but influences the robust tolerance induced by CD28/B7 blockade in this model...
  22. pmc TLR signals promote IL-6/IL-17-dependent transplant rejection
    Luqiu Chen
    Department of Medicine, Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 182:6217-25. 2009
    ..Thus, proinflammatory signals at the time of transplantation can change the quality of the effector immune response and reveal a pathogenic function for IL-6 and IL-17 in wild-type recipients...
  23. pmc Role of T-cell-specific nuclear factor κB in islet allograft rejection
    Delia Lozano Porras
    Department of Medicine, Committee on Immunology, University of Chicago, Gwen Knapp Center for Lupus and Immunology Research, Chicago, IL 60637, USA
    Transplantation 93:976-82. 2012
    ..Nuclear factor κB (NF-κB) is a transcription factor important for survival and differentiation of T cells. In this study, we tested whether NF-κB in T cells is required for the rejection of islet allografts...
  24. ncbi request reprint Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice
    G L Szot
    Ben May Institute for Cancer Research, The University of Chicago, IL 60637, USA
    Am J Transplant 1:38-46. 2001
    ..These results may help to explain the failure to promote graft tolerance in some preclinical and clinical settings...
  25. pmc Microbes and allogeneic transplantation
    Maria Luisa Alegre
    1 Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 2 Section of Transplantation, Department of Surgery, University of Chicago, Chicago, IL 3 Address for Correspondence Maria Luisa Alegre, M D, Ph D, Section of Rheumatology, Department of Medicine, University of Chicago, 924 East 57th Street, JFK R312, Chicago, IL
    Transplantation 97:5-11. 2014
    ..Here, we discuss known and hypothesized mechanisms for how infections or microbiota-derived signals may affect local or systemic alloimmunity and briefly review data on downstream effects of antibiotics and vaccinations. ..
  26. ncbi request reprint Cellular mechanisms underlying acute graft rejection: time for reassessment
    Maria Luisa Alegre
    Department of Medicine, Section of Rheumatology, University of Chicago, 5841 S Maryland Avenue, Room N005C, MC 0930, Chicago, IL 60637, USA
    Curr Opin Immunol 19:563-8. 2007
    ..The redundancy of rejection mechanisms explains the difficulty to induce transplantation tolerance and to develop reliable biomarkers for prediction of allograft outcome...
  27. pmc Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28
    H Lin
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Exp Med 188:199-204. 1998
    ..Thus, the negative regulatory role of CTLA4 extends beyond its potential ability to prevent CD28 activation through ligand competition. Even in the absence of CD28, CTLA4 plays an inhibitory role in the regulation of allograft rejection...
  28. pmc Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells
    James P O'Keefe
    Committee on Cancer Biology and Department of Pathology, University of Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 101:9351-6. 2004
    ....
  29. pmc Bacterial infections, alloimmunity, and transplantation tolerance
    Emily B Ahmed
    Department of Surgery, The University of Chicago, Chicago, IL 60637, USA
    Transplant Rev (Orlando) 25:27-35. 2011
    ....
  30. pmc High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner
    Luciana L Molinero
    Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 186:4609-17. 2011
    ..Thus, NF-κB helps T cells control their differentiation fate in a cell-intrinsic manner and prevents peripheral iTreg development under conditions of high Ag load that may require more vigorous effector T cell responses...
  31. ncbi request reprint The balance of immune responses: costimulation verse coinhibition
    Sumit K Subudhi
    Department of Pathology, University of Chicago, 5841 S Maryland, Chicago, IL 60637, USA
    J Mol Med (Berl) 83:193-202. 2005
    ..This cautions against using clinical immunotherapeutic reagents targeted against these molecules until we gain a better understanding of the circumstances that regulate the outcomes of the T cell response...
  32. pmc T cell receptor/CARMA1/NF-κB signaling controls T-helper (Th) 17 differentiation
    Luciana L Molinero
    Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 109:18529-34. 2012
    ..Our results demonstrate that TCR/CARMA1/NF-κB controls completion of Th17 differentiation by enabling chromatin accessibility of Th17 effector molecule loci...
  33. pmc Role of T cell-nuclear factor κB in transplantation
    Luciana L Molinero
    Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637, USA
    Transplant Rev (Orlando) 26:189-200. 2012
    ..Targeted inhibition of NF-κB in selected cell types may promote graft survival with fewer adverse effects compared with global immunosuppressive therapies...
  34. doi request reprint Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome
    Sangeeta M Bhorade
    Section of Pulmonary, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Transplantation 90:540-6. 2010
    ..Studies in animal models suggest that intragraft T regulatory cells (Tregs) are important in maintaining transplantation tolerance, and FoxP3 is the protoypic Treg marker...
  35. pmc Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model
    T Wang
    Department of Surgery, The University of Chicago, IL, USA
    Am J Transplant 10:1524-33. 2010
    ..In conclusion, these studies demonstrate that the proinflammatory effects of infections can induce the loss of tolerance and acute rejection of accepted allografts...
  36. ncbi request reprint CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease
    T Kouki
    Thyroid Study Unit, Department of Medicine, University of Chicago, Chicago, IL 60637 Fujita Health University, Aichi, Japan
    J Immunol 165:6606-11. 2000
    ..019). CTLA-4 polymorphism affects the inhibitory function of CTLA-4. The G allele is associated with reduced control of T cell proliferation and thus contributes to the pathogenesis of GD and presumably of other autoimmune diseases...
  37. ncbi request reprint Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts
    M L Alegre
    Ben May Institute, Department of Pathology, Pritzker School of Medicine, University of Chicago, IL 60637
    J Immunol 153:2738-49. 1994
    ..Thus, this hu-Spl-SCID model may be useful for the study of immunosuppressive therapies in a preclinical in vivo setting...
  38. ncbi request reprint Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases
    E Chuang
    Gwen Knapp Center for Lupus and Immunology Research, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 162:1270-7. 1999
    ..The association of CTLA-4 with Src kinases and with SHP-2 results in the formation of a CTLA-4 complex with the potential to regulate T cell activation...
  39. pmc Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A
    Christopher P Montgomery
    Department of Pediatrics, University of Chicago, Chicago Illinois, USA
    Infect Immun 82:2125-34. 2014
    ..aureus SSTI. These findings also highlight the importance of the mouse genetic background in the development of protective immunity against S. aureus SSTI. ..
  40. pmc Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells
    Michelle L Miller
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637 and
    Proc Natl Acad Sci U S A 111:7397-402. 2014
    ..Our results reveal an evolutionarily conserved role of NF-κB in T cells before antigenic stimulation and identify a novel molecular pathway that controls T-cell homeostasis. ..
  41. doi request reprint The multiple facets of toll-like receptors in transplantation biology
    Maria Luisa Alegre
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA
    Transplantation 86:1-9. 2008
    ..We then discuss the involvement of TLRs in the different phases of the rejection phenomenon and the impact of TLR-mediated events on regulatory circuits which dampen alloimmune responses...
  42. pmc Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations
    Nadera J Sweiss
    Sarcoidosis and Scleroderma Clinic, Section of Rheumatology, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 5:e9088. 2010
    ..The goal of this study was to evaluate lymphocyte subsets in peripheral blood in a cohort of sarcoidosis patients to determine the prevalence, severity, and clinical features associated with lymphopenia in major lymphocyte subsets...
  43. pmc Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells
    Michael I Zimmer
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:1909-14. 2009
    ..Collectively, results from these studies demonstrate a role for polymorphisms in influencing the development and function of CD1d-restricted T cells...
  44. doi request reprint Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-kappaB signaling
    Luciana Lorena Molinero
    Department of Medicine, Section of Rheumatology, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Transpl Int 22:845-52. 2009
    ..These results indicate that T-cell inhibition of NF-kappaB results in cardiac allograft acceptance because of increased susceptibility to Fas-mediated cell death...
  45. ncbi request reprint Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase
    T F Gajewski
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 166:3900-7. 2001
    ..Thus, the biochemical mechanism explaining the differential inhibitory effect of CTLA-4 on naive and primed CD8(+) T cells remains unclear...
  46. ncbi request reprint Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
    E Chuang
    Gwen Knapp Center for Lupus and Immunology Research, Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
    J Immunol 159:144-51. 1997
    ..Together these data suggest that the interaction of CTLA-4 with AP50 plays an important role in regulating the cell surface expression of CTLA-4...
  47. pmc Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells
    L L Molinero
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Am J Transplant 8:21-31. 2008
    ..The combined blockade of T-cell-NF-kappaB with that of alternative pathways allowing activation of NF-kappaB-impaired T cells may be an effective strategy for tolerance induction to highly immunogenic organs...
  48. ncbi request reprint Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial
    Tammy O Utset
    Section of Rheumatology, The Ben May Institute for Cancer Research, Chicago, Illinois, USA
    J Rheumatol 29:1907-13. 2002
    ..We hypothesized that this Mab may be safe and efficacious in the treatment of type 1 T lymphocyte mediated chronic autoimmune diseases such as psoriatic arthritis (PsA)...
  49. pmc Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues
    James C Lo
    Committee on Immunology and Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Blood 107:1048-55. 2006
    ....
  50. pmc The impact of infection and tissue damage in solid-organ transplantation
    Anita S Chong
    Department of Surgery, The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA
    Nat Rev Immunol 12:459-71. 2012
    ....
  51. ncbi request reprint Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
    Tomas Vilimas
    Department of Medicine, Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue Chicago, Illinois 60637, USA
    Nat Med 13:70-7. 2007
    ..These findings identify NF-kappaB as one of the major mediators of Notch1-induced transformation and suggest that the NF-kappaB pathway is a potential target of future therapies of T-ALL...
  52. ncbi request reprint Impaired negative selection in CD28-deficient mice
    P J Noel
    Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA
    Cell Immunol 187:131-8. 1998
    ..In contrast to its role in T cell activation and survival in the peripheral immune system, the CD28 receptor appears to participate in the intracellular signaling events that result in negative selection in the thymus...
  53. ncbi request reprint CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway
    Z Guo
    Department of Surgery, University of Chicago, Illinois 60637, USA
    Transplantation 71:1351-4. 2001
    ..Disruption of the CD40/CD154 pathway inhibits rejection in numerous models. The importance of this pathway on intestinal allograft rejection was examined in this study...
  54. pmc Lessons and limits of mouse models
    Anita S Chong
    Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, Illinois 60637
    Cold Spring Harb Perspect Med 3:a015495. 2013
    ....
  55. doi request reprint Post-transplant dynamics of pulmonary microbiota
    Valeriy Poroyko
    1 Department of Medicine, University of Chicago, Chicago, Illinois and
    Ann Am Thorac Soc 11:S74. 2014
    ..Our findings provide novel approaches to address the relationship between microbial communities and BOS development after lung transplantation. ..
  56. pmc Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells
    Shannon K O'Neill
    Department of Medicine, Section of Rheumatology, and The Knapp Center for Lupus Research, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:6262-7. 2009
    ..These results indicate that B cell anergy is reinforced by the exclusion of both TLRs and their BCR captured ligands from subcellular environments necessary for TLR activation...
  57. pmc CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells
    Luciana L Molinero
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 182:6736-43. 2009
    ..These data suggest a modified model of nTreg development in which TCR-CBM-dependent signals are essential to commit immature thymocytes to the nTreg lineage...
  58. ncbi request reprint Tissue distribution, regulation and intracellular localization of murine CD1 molecules
    M Mandal
    Gwen Knapp Center for Lupus and Immunology Research, Department of Pathology, University of Chicago, IL 60637, USA
    Mol Immunol 35:525-36. 1998
    ..Localization in endocytic compartments indicates that murine CD1 may be capable of binding endocytosed antigens...
  59. pmc Transplantation tolerance and its outcome during infections and inflammation
    Anita S Chong
    Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL, USA
    Immunol Rev 258:80-101. 2014
    ..Understanding the mechanisms by which infections prevent and destabilize tolerance can lead to therapies that promote stable life-long tolerance in transplant recipients. ..
  60. ncbi request reprint Role of bacterial infections in allograft rejection
    Emily B Ahmed
    Department of Surgery, University of Chicago, Chicago, IL 60637, USA
    Expert Rev Clin Immunol 4:281-93. 2008
    ..This review seeks to explore the clinical and scientific literature examining the role of bacterial infections in transplant rejection...
  61. ncbi request reprint CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo
    Qizhi Tang
    Diabetes Center and Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 170:1510-6. 2003
    ....
  62. ncbi request reprint Modulation of tryptophan catabolism by regulatory T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 4:1206-12. 2003
    ..Thus, regulation of immunosuppressive tryptophan catabolism in dendritic cells might represent a major mechanism of action of T(R) cells...