Grace M Aldrovandi

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc 4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms
    Kyle J Nakamura
    Department of Pediatrics, Childrens Hospital of Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9786. 2010
  2. pmc Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission
    Laura Heath
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e10213. 2010
  3. pmc Pregnancy loss and role of infant HIV status on perinatal mortality among HIV-infected women
    Hae Young Kim
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    BMC Pediatr 12:138. 2012
  4. pmc Immunomodulatory factors in cervicovaginal secretions from pregnant and non-pregnant women: a cross-sectional study
    Jan Walter
    Department of Plant Pathology and Microbiology, University of California, Riverside, USA
    BMC Infect Dis 11:263. 2011
  5. pmc Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected women
    Grace M Aldrovandi
    Saban Research Institute of Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California 90027, USA
    Pediatrics 124:e1189-97. 2009
  6. pmc Morphologic and metabolic abnormalities in vertically HIV-infected children and youth
    Grace M Aldrovandi
    Saban Research Institute of Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California, USA
    AIDS 23:661-72. 2009
  7. pmc What infants and breasts can teach us about natural protection from HIV infection
    Grace M Aldrovandi
    Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Infect Dis 202:S366-70. 2010
  8. pmc Reuse of single-dose nevirapine in subsequent pregnancies for the prevention of mother-to-child HIV transmission in Lusaka, Zambia: a cohort study
    Jan Walter
    Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA
    BMC Infect Dis 8:172. 2008
  9. pmc Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding
    Lars Bode
    Division of Neonatology and the Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of California, San Diego, CA, USA
    Am J Clin Nutr 96:831-9. 2012
  10. pmc Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodies
    Kyle J Nakamura
    Department of Pediatrics, Children s Hospital of Los Angeles, Los Angeles, CA, USA
    AIDS 27:337-46. 2013

Collaborators

Detail Information

Publications19

  1. pmc 4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms
    Kyle J Nakamura
    Department of Pediatrics, Childrens Hospital of Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9786. 2010
    ..Our data provide important caveats for vaccine development targeting the MPER. Naturally occurring Env variants described in our study also represent unique tools for probing the structure-function of HIV-1 envelope...
  2. pmc Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission
    Laura Heath
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e10213. 2010
    ..The basis of this restriction and the genetic relationship between breast milk and blood variants are not well established...
  3. pmc Pregnancy loss and role of infant HIV status on perinatal mortality among HIV-infected women
    Hae Young Kim
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    BMC Pediatr 12:138. 2012
    ..Here we examine risk factors for these adverse pregnancy outcomes in a cohort of HIV-infected women in Zambia considering the impact of infant HIV status...
  4. pmc Immunomodulatory factors in cervicovaginal secretions from pregnant and non-pregnant women: a cross-sectional study
    Jan Walter
    Department of Plant Pathology and Microbiology, University of California, Riverside, USA
    BMC Infect Dis 11:263. 2011
    ....
  5. pmc Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected women
    Grace M Aldrovandi
    Saban Research Institute of Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California 90027, USA
    Pediatrics 124:e1189-97. 2009
    ..Nucleoside reverse transcriptase inhibitor ARV agents can inhibit DNA polymerase gamma, impairing mitochondrial DNA (mtDNA) synthesis and resulting in depletion or dysfunction...
  6. pmc Morphologic and metabolic abnormalities in vertically HIV-infected children and youth
    Grace M Aldrovandi
    Saban Research Institute of Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California, USA
    AIDS 23:661-72. 2009
    ..To compare the distribution of lipid and glucose abnormalities and altered fat distribution among vertically HIV-infected patients and controls...
  7. pmc What infants and breasts can teach us about natural protection from HIV infection
    Grace M Aldrovandi
    Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Infect Dis 202:S366-70. 2010
    ..In this review, we discuss the advantages and disadvantages of mother‐to‐child HIV transmission as a model in which to elucidate correlates of immune protection...
  8. pmc Reuse of single-dose nevirapine in subsequent pregnancies for the prevention of mother-to-child HIV transmission in Lusaka, Zambia: a cohort study
    Jan Walter
    Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA
    BMC Infect Dis 8:172. 2008
    ..The effects of these mutations on the efficacy of SDNVP use in a subsequent pregnancy are not well understood...
  9. pmc Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding
    Lars Bode
    Division of Neonatology and the Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of California, San Diego, CA, USA
    Am J Clin Nutr 96:831-9. 2012
    ..The inefficiency of HIV breast-milk transmission may be caused by the presence of immunologically active factors, including human milk oligosaccharides (HMOs)...
  10. pmc Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodies
    Kyle J Nakamura
    Department of Pediatrics, Children s Hospital of Los Angeles, Los Angeles, CA, USA
    AIDS 27:337-46. 2013
    ..To assess the neutralization potency and coverage of a panel of second-generation bNAbs, we cloned and phenotypically characterized 227 primary HIV-1 envelopes from 23 mother-to-child transmission (MTCT) pairs...
  11. pmc High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission
    Jan Walter
    Children s Hospital Los Angeles, University of Southern California, 4546 Sunset Boulevard, Los Angeles, CA 90027, USA
    J Infect Dis 200:1498-502. 2009
    ..IL-15-mediated immunity may protect against HIV transmission during breast-feeding...
  12. pmc Human milk galectin-3 binding protein and breast-feeding-associated HIV transmission
    Christina S Chan
    From the Divisions of Neonatology and Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of California, San Diego, CA Gertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY Lusaka District Health Management Team University Teaching Hospital, University of Zambia, Lusaka, Zambia Center for International Health and Development, Boston University School of Public Health, Boston, MA and Department of Pediatrics, Children s Hospital Los Angeles, University of Southern California, Los Angeles, CA
    Pediatr Infect Dis J 32:e473-5. 2013
    ..This suggests that although milk galectin-3 binding protein is a marker of advanced maternal disease, it does not independently modify transmission risk. ..
  13. pmc Review of HIV antiretroviral drug resistance
    Tempe K Chen
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Pediatr Infect Dis J 27:749-52. 2008
  14. pmc Detection of low levels of human immunodeficiency virus (HIV) may be critical for early diagnosis of pediatric HIV infection by use of dried blood spots
    Jan Walter
    Childrens Hospital Los Angeles, University of Southern California, 4546 Sunset Boulevard, Los Angeles, CA 90027, USA
    J Clin Microbiol 47:2989-91. 2009
    ..The codetection of DNA and RNA did not result in an overall higher sensitivity compared to that of DNA alone. Discordant results were associated with low levels of HIV DNA, indicating that the sample amount may be critical...
  15. pmc Using cluster heat maps to investigate relationships between body composition and laboratory measurements in HIV-infected and HIV-uninfected children and young adults
    Jane C Lindsey
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA
    J Acquir Immune Defic Syndr 59:325-8. 2012
    ..Of these, 1 cluster had more participants with higher body fat and insulin resistance, which are risk factors for future cardiovascular disease, and the other had relatively normal measurements on all outcomes...
  16. pmc Immunology of pediatric HIV infection
    Nicole H Tobin
    Children s Hospital Los Angeles, Los Angeles, CA, USA
    Immunol Rev 254:143-69. 2013
    ....
  17. ncbi request reprint Advances in basic science understanding of mother-to-child HIV-1 transmission
    Jan Walter
    aChildren s Hospital Los Angeles, University of Southern California, Los Angeles, California, USA bGertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Curr Opin HIV AIDS 3:146-50. 2008
    ..The present review summarizes and discusses studies on the mechanisms underlying mother-to-child HIV transmission published in 2006-2007...
  18. doi request reprint Are infants unique in their ability to be "functionally cured" of HIV-1?
    Nicole H Tobin
    Department of Pediatrics, Children s Hospital Los Angeles, 4650 Sunset Blvd, MS 51, Los Angeles, CA, 90027, USA
    Curr HIV/AIDS Rep 11:1-10. 2014
    ..We will also compare the path to infant "cure" to cures in adults. ..
  19. doi request reprint 2050: Ending the odyssey of the great white plague. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni
    Mandeep S Jassal
    Division of Pediatric Pulmonology, Children s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, United States
    Pharmacol Res 64:176-9. 2011
    ..All such endeavors will require not only more focused research initiatives, but greater institutional support from the pharmaceutical industry, non-governmental organizations and national health sectors...