Grace M Aldrovandi
Affiliation: University of Southern California
- Immunomodulatory factors in cervicovaginal secretions from pregnant and non-pregnant women: a cross-sectional studyJan Walter
Department of Plant Pathology and Microbiology, University of California, Riverside, USA
BMC Infect Dis 11:263. 2011....
- Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected womenGrace M Aldrovandi
Saban Research Institute of Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California 90027, USA
Pediatrics 124:e1189-97. 2009..Nucleoside reverse transcriptase inhibitor ARV agents can inhibit DNA polymerase gamma, impairing mitochondrial DNA (mtDNA) synthesis and resulting in depletion or dysfunction...
- Morphologic and metabolic abnormalities in vertically HIV-infected children and youthGrace M Aldrovandi
Saban Research Institute of Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California, USA
AIDS 23:661-72. 2009..To compare the distribution of lipid and glucose abnormalities and altered fat distribution among vertically HIV-infected patients and controls...
- What infants and breasts can teach us about natural protection from HIV infectionGrace M Aldrovandi
Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
J Infect Dis 202:S366-70. 2010..In this review, we discuss the advantages and disadvantages of mother‐to‐child HIV transmission as a model in which to elucidate correlates of immune protection...
- Reuse of single-dose nevirapine in subsequent pregnancies for the prevention of mother-to-child HIV transmission in Lusaka, Zambia: a cohort studyJan Walter
Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA
BMC Infect Dis 8:172. 2008..The effects of these mutations on the efficacy of SDNVP use in a subsequent pregnancy are not well understood...
- High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmissionJan Walter
Children s Hospital Los Angeles, University of Southern California, 4546 Sunset Boulevard, Los Angeles, CA 90027, USA
J Infect Dis 200:1498-502. 2009..IL-15-mediated immunity may protect against HIV transmission during breast-feeding...
- Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodiesKyle J Nakamura
Department of Pediatrics, Children s Hospital of Los Angeles, Los Angeles, CA, USA
AIDS 27:337-46. 2013..To assess the neutralization potency and coverage of a panel of second-generation bNAbs, we cloned and phenotypically characterized 227 primary HIV-1 envelopes from 23 mother-to-child transmission (MTCT) pairs...
- 4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphismsKyle J Nakamura
Department of Pediatrics, Childrens Hospital of Los Angeles, Los Angeles, California, United States of America
PLoS ONE 5:e9786. 2010..Our data provide important caveats for vaccine development targeting the MPER. Naturally occurring Env variants described in our study also represent unique tools for probing the structure-function of HIV-1 envelope...
- Review of HIV antiretroviral drug resistanceTempe K Chen
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Pediatr Infect Dis J 27:749-52. 2008
- Using cluster heat maps to investigate relationships between body composition and laboratory measurements in HIV-infected and HIV-uninfected children and young adultsJane C Lindsey
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA
J Acquir Immune Defic Syndr 59:325-8. 2012..Of these, 1 cluster had more participants with higher body fat and insulin resistance, which are risk factors for future cardiovascular disease, and the other had relatively normal measurements on all outcomes...
- Detection of low levels of human immunodeficiency virus (HIV) may be critical for early diagnosis of pediatric HIV infection by use of dried blood spotsJan Walter
Childrens Hospital Los Angeles, University of Southern California, 4546 Sunset Boulevard, Los Angeles, CA 90027, USA
J Clin Microbiol 47:2989-91. 2009..The codetection of DNA and RNA did not result in an overall higher sensitivity compared to that of DNA alone. Discordant results were associated with low levels of HIV DNA, indicating that the sample amount may be critical...
- Advances in basic science understanding of mother-to-child HIV-1 transmissionJan Walter
aChildren s Hospital Los Angeles, University of Southern California, Los Angeles, California, USA bGertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
Curr Opin HIV AIDS 3:146-50. 2008..The present review summarizes and discusses studies on the mechanisms underlying mother-to-child HIV transmission published in 2006-2007...
- 2050: Ending the odyssey of the great white plague. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo MolteniMandeep S Jassal
Division of Pediatric Pulmonology, Children s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, United States
Pharmacol Res 64:176-9. 2011..All such endeavors will require not only more focused research initiatives, but greater institutional support from the pharmaceutical industry, non-governmental organizations and national health sectors...