EUGENE ALBRECHT

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Prematurely elevating estradiol in early baboon pregnancy suppresses uterine artery remodeling and expression of extravillous placental vascular endothelial growth factor and α1β1 and α5β1 integrins
    Thomas W Bonagura
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Endocrinology 153:2897-906. 2012
  2. ncbi request reprint Regulation of placental vascular endothelial growth/permeability factor expression and angiogenesis by estrogen during early baboon pregnancy
    Eugene D Albrecht
    Department of Obstetrics, Gynecology, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 89:5803-9. 2004
  3. ncbi request reprint Suppression of extravillous trophoblast invasion of uterine spiral arteries by estrogen during early baboon pregnancy
    E D Albrecht
    Department of Obstetrics, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Placenta 27:483-90. 2006
  4. ncbi request reprint Expression of estrogen receptors alpha and beta in the fetal baboon testis and epididymis
    Eugene D Albrecht
    Departments of Obstetrics, Gynecology, Reproductive Sciences, and Physiology, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biol Reprod 70:1106-13. 2004
  5. pmc Regulation of placental villous angiopoietin-1 and -2 expression by estrogen during baboon pregnancy
    Eugene D Albrecht
    Department of Obstetrics, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Mol Reprod Dev 75:504-11. 2008
  6. ncbi request reprint Effect of estrogen on angiogenesis in co-cultures of human endometrial cells and microvascular endothelial cells
    Eugene D Albrecht
    Department of Obstetrics, Gynecology and Reproductive Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Hum Reprod 18:2039-47. 2003
  7. ncbi request reprint Identification and developmental expression of the estrogen receptor alpha and beta in the baboon fetal adrenal gland
    E D Albrecht
    Department of Obstetrics, Gynecology, Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore 21201, USA
    Endocrinology 140:5953-61. 1999
  8. pmc Estrogen promotes germ cell and seminiferous tubule development in the baboon fetal testis
    Eugene D Albrecht
    Department of Obstetrics, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biol Reprod 81:406-14. 2009
  9. ncbi request reprint Estrogen elicits cortical zone-specific effects on development of the primate fetal adrenal gland
    Eugene D Albrecht
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Bressler Research Laboratories 11 019, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
    Endocrinology 146:1737-44. 2005
  10. pmc Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy
    Eugene D Albrecht
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Int J Dev Biol 54:397-408. 2010

Research Grants

Collaborators

Detail Information

Publications41

  1. pmc Prematurely elevating estradiol in early baboon pregnancy suppresses uterine artery remodeling and expression of extravillous placental vascular endothelial growth factor and α1β1 and α5β1 integrins
    Thomas W Bonagura
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Endocrinology 153:2897-906. 2012
    ....
  2. ncbi request reprint Regulation of placental vascular endothelial growth/permeability factor expression and angiogenesis by estrogen during early baboon pregnancy
    Eugene D Albrecht
    Department of Obstetrics, Gynecology, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 89:5803-9. 2004
    ..It is concluded that estrogen has an important role in stimulating trophoblast VEG/PF expression and consequently villous placental angiogenesis to promote fetal growth and development in early primate pregnancy...
  3. ncbi request reprint Suppression of extravillous trophoblast invasion of uterine spiral arteries by estrogen during early baboon pregnancy
    E D Albrecht
    Department of Obstetrics, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Placenta 27:483-90. 2006
    ..Consequently, we propose that the estrogen-dependent restraint of spiral artery invasion/remodeling ensures optimal blood flow dynamics across the uteroplacental vascular bed to promote normal fetal growth and development...
  4. ncbi request reprint Expression of estrogen receptors alpha and beta in the fetal baboon testis and epididymis
    Eugene D Albrecht
    Departments of Obstetrics, Gynecology, Reproductive Sciences, and Physiology, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biol Reprod 70:1106-13. 2004
    ....
  5. pmc Regulation of placental villous angiopoietin-1 and -2 expression by estrogen during baboon pregnancy
    Eugene D Albrecht
    Department of Obstetrics, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Mol Reprod Dev 75:504-11. 2008
    ..We propose that the estrogen-dependent differential regulation of these angioregulatory factors underpins the unique pattern of neovascularization established within the villous placenta during primate pregnancy...
  6. ncbi request reprint Effect of estrogen on angiogenesis in co-cultures of human endometrial cells and microvascular endothelial cells
    Eugene D Albrecht
    Department of Obstetrics, Gynecology and Reproductive Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Hum Reprod 18:2039-47. 2003
    ....
  7. ncbi request reprint Identification and developmental expression of the estrogen receptor alpha and beta in the baboon fetal adrenal gland
    E D Albrecht
    Department of Obstetrics, Gynecology, Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore 21201, USA
    Endocrinology 140:5953-61. 1999
    ..The presence of the estrogen receptor provides a mechanism for mediating the action of estrogen in modulating ACTH-dependent and cortical zone-specific development and function of the primate fetal adrenal gland...
  8. pmc Estrogen promotes germ cell and seminiferous tubule development in the baboon fetal testis
    Eugene D Albrecht
    Department of Obstetrics, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biol Reprod 81:406-14. 2009
    ..We conclude that endogenous estrogen promotes fetal testis development and that the changes in the germ cell population in the estrogen-deprived baboon fetus may impair spermatogenesis and fertility in adulthood...
  9. ncbi request reprint Estrogen elicits cortical zone-specific effects on development of the primate fetal adrenal gland
    Eugene D Albrecht
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Bressler Research Laboratories 11 019, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
    Endocrinology 146:1737-44. 2005
    ....
  10. pmc Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy
    Eugene D Albrecht
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Int J Dev Biol 54:397-408. 2010
    ..This review will describe the developmental processes required for placental vascularization and fetal follicular maturation and recent studies which show that estrogen has an important role in regulating these events...
  11. ncbi request reprint Steroid hormone regulation of angiogenesis in the primate endometrium
    Eugene D Albrecht
    Department of Obstetrics, Gynecology and Reproductive Sciences, The Center for Studies in Reproduction, The University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Front Biosci 8:d416-29. 2003
    ..Finally, further study is needed of cell-specific responsivity and function in the human endometrium with respect to steroid hormone regulation of angiogenesis...
  12. ncbi request reprint Developmental regulation of baboon fetal ovarian maturation by estrogen
    Nicholas C Zachos
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk 23501 1980, USA
    Biol Reprod 67:1148-56. 2002
    ..We propose that estrogen plays an integral role in regulating, and perhaps programming, primate fetal ovarian development...
  13. pmc Placental villous vascular endothelial growth factor expression and vascularization after estrogen suppression during the last two-thirds of baboon pregnancy
    Victoria A Robb
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, MD, USA
    Endocrine 31:260-7. 2007
    ....
  14. ncbi request reprint Expression of vascular endothelial growth/permeability factor by endometrial glandular epithelial and stromal cells in baboons during the menstrual cycle and after ovariectomy
    Andrea L Niklaus
    Department of Obstetrics, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore 21201, USA
    Endocrinology 143:4007-17. 2002
    ....
  15. pmc Uterine and fetal blood flow indexes and fetal growth assessment after chronic estrogen suppression in the second half of baboon pregnancy
    Graham W Aberdeen
    Dept of Obstetrics, Gynecology and Reproductive Sciences, Univ of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Heart Circ Physiol 298:H881-9. 2010
    ..This suggests that elevated levels of endogenous estrogen are not required to maintain low impedance blood flow within the uteroplacental vascular bed during the second half of nonhuman primate pregnancy...
  16. ncbi request reprint Effect of estrogen on vascular endothelial growth/permeability factor expression by glandular epithelial and stromal cells in the baboon endometrium
    Andrea L Niklaus
    Departments of Obstetrics, Gynecology, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Biol Reprod 68:1997-2004. 2003
    ..01) and VEG/PF protein expression to normal. In summary, estrogen has a significant role in regulating and maintaining VEG/PF expression by glandular epithelial and stromal cells of the endometrium during the menstrual cycle...
  17. pmc Regulation of baboon fetal pituitary prolactin expression by estrogen
    Gerald J Pepe
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23501 1980, USA
    Biol Reprod 80:1189-95. 2009
    ....
  18. ncbi request reprint Estrogen modulates developmentally regulated gene expression in the fetal baboon liver
    Miriam D Rosenthal
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23501 1980, USA
    Endocrine 23:219-28. 2004
    ..We suggest, therefore, that estrogen regulates normal development of the primate fetal liver...
  19. pmc Developmental regulation of the expression of the transferrin receptor and Ki67 in oocytes of the baboon fetal ovary by estrogen
    Marcia G Burch
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23501 1980, USA
    Endocrine 35:177-83. 2009
    ..Collectively, these results and our previous studies further define the essential role of estrogen in regulating development of follicles comprised of healthy oocytes by the baboon fetal ovary...
  20. ncbi request reprint Fetal lung maturation in estrogen-deprived baboons
    Gerald J Pepe
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23501 1980, USA
    J Clin Endocrinol Metab 88:471-7. 2003
    ....
  21. ncbi request reprint Functional differentiation of the placental syncytiotrophoblast: Effect of estrogen on chorionic somatomammotropin expression during early primate pregnancy
    Biljana Musicki
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Studies in Reproduction, The University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:4316-23. 2003
    ....
  22. pmc Divergent regulation of angiopoietin-1 and -2, Tie-2, and thrombospondin-1 expression by estrogen in the baboon endometrium
    Thomas W Bonagura
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Mol Reprod Dev 77:430-8. 2010
    ..In summary, estrogen induced a rapid, divergent, and cell-specific change in expression of angiostimulatory and angioinhibitory growth factors in the endometrium of the nonhuman primate...
  23. ncbi request reprint Regulation of baboon fetal ovarian folliculogenesis by estrogen
    Gerald J Pepe
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23501 1980, USA
    Mol Cell Endocrinol 247:41-6. 2006
    ..These findings demonstrate a need for translational research studies of the impact of impairment of estrogen action/availability on reproductive function in adulthood...
  24. ncbi request reprint Developmental regulation of follicle-stimulating hormone receptor messenger RNA expression in the baboon fetal ovary
    Nicholas C Zachos
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk 23501, USA
    Biol Reprod 68:1911-7. 2003
    ..e., increased number of granulosa cells and oocytes)...
  25. ncbi request reprint Regulation of oocyte microvilli development in the baboon fetal ovary by estrogen
    Nicholas C Zachos
    Department of Physiological Sciences, Eastern Virginia Medical School, P O Box 1980, Norfolk, VA 23501 1980, USA
    Endocrinology 145:959-66. 2004
    ....
  26. ncbi request reprint Expression of estrogen receptors alpha and beta in the baboon fetal ovary
    Gerald J Pepe
    Department of Physiological Sciences, Eastern Virginia Medical School, 700 Olney Road, Norfolk, VA 23501 1980, USA
    Biol Reprod 66:1054-60. 2002
    ..Because placental estrogen production and secretion into the baboon fetus increases markedly during advancing pregnancy, we propose that estrogen plays an integral role in programming fetal ovarian development in the primate...
  27. ncbi request reprint Up-regulation of alpha-inhibin expression in the fetal ovary of estrogen-suppressed baboons is associated with impaired fetal ovarian folliculogenesis
    Reinhart B Billiar
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23501 1980, USA
    Biol Reprod 68:1989-96. 2003
    ..Therefore, we propose that estrogen regulates fetal ovarian follicular development by controlling alpha-inhibin expression and, thus, the intraovarian inhibin:activin ratio...
  28. ncbi request reprint Acute temporal regulation of vascular endothelial growth/permeability factor expression and endothelial morphology in the baboon endometrium by ovarian steroids
    Eugene D Albrecht
    Department of Obstetrics, Gynecology, Reproductive Sciences and Physiology, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:2844-52. 2003
    ..6 +/- 4.6 nm at 0 h to 101.1 +/- 6.4 nm at 6 h, whereas vehicle or progesterone had no effect. We suggest that estrogen has a major role in regulating VEG/PF synthesis and early events in angiogenesis in the primate endometrium...
  29. ncbi request reprint Acute temporal regulation of placental vascular endothelial growth/permeability factor expression in baboons by estrogen
    Victoria A Robb
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Biol Reprod 71:1694-8. 2004
    ..We propose that estrogen regulates VEG/PF expression within the placenta in a cell-specific manner, providing a paracrine system to promote vascularization of the villous placenta during the first half of primate pregnancy...
  30. pmc Suppression of extravillous trophoblast vascular endothelial growth factor expression and uterine spiral artery invasion by estrogen during early baboon pregnancy
    Thomas W Bonagura
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Bressler Research Laboratories 11 019, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
    Endocrinology 149:5078-87. 2008
    ..We suggest that VEGF mediates the decline in EVT vessel invasion induced by estrogen in early primate pregnancy...
  31. pmc Oocytes of baboon fetal primordial ovarian follicles express estrogen receptor beta mRNA
    Silvina M Bocca
    Department of Obstetrics, The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, VA 23501, USA
    Endocrine 33:254-60. 2008
    ..We conclude that oocytes of the fetal baboon ovary express ERbeta mRNA, thereby providing a mechanism by which estrogen regulates oocyte function, e.g. microvillus development...
  32. ncbi request reprint Estrogen suppression induces papillary gingival overgrowth in pregnant baboons
    Mark A Reynolds
    Department of Periodontics, University of Maryland, Dental School, Baltimore, MD 21201, USA
    J Periodontol 75:693-701. 2004
    ..Currently, few experimental animal models similar to humans are available to examine regulatory pathways involving sex steroids and the periodontium...
  33. ncbi request reprint Developmental regulation of the sodium/hydrogen ion exchangers and their regulatory factors in baboon placental syncytiotrophoblast
    Gerald J Pepe
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23501 1980, USA
    Endocrinology 147:2986-96. 2006
    ..We conclude that the subcellular distribution and levels of key components of the Na+/H+ system in the baboon syncytiotrophoblast are developmentally regulated...
  34. pmc Vascular endothelial growth factor mediates the estrogen-induced breakdown of tight junctions between and increase in proliferation of microvessel endothelial cells in the baboon endometrium
    Graham W Aberdeen
    Department of Obstetrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Endocrinology 149:6076-83. 2008
    ..Therefore, we propose that VEGF mediates the estrogen-induced increase in microvessel permeability and endothelial cell proliferation as early steps in angiogenesis in the primate endometrium...
  35. ncbi request reprint Localization and developmental expression of the activin signal transduction proteins Smads 2, 3, and 4 in the baboon fetal ovary
    Reinhart B Billiar
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    Biol Reprod 70:586-92. 2004
    ....
  36. ncbi request reprint Developmental expression of cell cycle regulators in the baboon fetal adrenal gland
    Adina Dumitrescu
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Endocrinol 192:237-47. 2007
    ....
  37. pmc Regulation of expression of microvillus membrane proteins by estrogen in baboon fetal ovarian oocytes
    Nicholas C Zachos
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    Biol Reprod 79:1160-8. 2008
    ..Therefore, we propose that development of oocyte microvilli requires expression of alpha-actinin and that expression of alpha-actinin and localization of ezrin-phosphate and SLC9A3R1 to the oocyte membrane are regulated by estrogen...
  38. pmc Estrogen stimulates the human endometrium to express a factor(s) that promotes vascular smooth muscle cell migration as an early step in microvessel remodeling
    Jeffery S Babischkin
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Bressler Research Laboratories, Baltimore, MD 21201, USA
    Endocrine 35:81-8. 2009
    ..It is concluded, therefore, that estrogen stimulates endometrial secretion of a factor(s) that promotes VSMC migration as an early step in vessel remodeling within the endometrium...
  39. pmc Impact of estradiol on gamma-aminobutyric acid- and glutamate-mediated calcium responses of fetal baboon (Papio anubis) hippocampal and cortical neurons
    Joseph L Nunez
    Department of Physiology, University of Maryland, Baltimore, Baltimore, Maryland 21201, USA
    Endocrinology 149:6433-43. 2008
    ..Along with documenting a prominent role for 17beta-estradiol in maturation of the GABAergic system, these findings increase our understanding of neuronal differentiation and maturation in the fetal primate brain...
  40. ncbi request reprint Development of a coculture system and use of confocal laser fluorescent microscopy to study human microvascular endothelial cell and mural cell interaction
    Marcia G Burch
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Microvasc Res 70:43-52. 2005
    ..We propose that this system will greatly facilitate study of remodeling of the microvasculature in various organ systems...
  41. ncbi request reprint Methoxychlor and its metabolites inhibit growth and induce atresia of baboon antral follicles
    Rupesh K Gupta
    Department of Veterinary Biosciences, University of Illinois Urbana Champaign, Urbana, Illinois 61802, USA
    Toxicol Pathol 35:649-56. 2007
    ..These data suggest that MXC and its metabolites inhibit growth and induce atresia of baboon antral follicles, and that primate follicles are more sensitive to MXC than rodent follicles...

Research Grants32

  1. MATERNAL-FETAL STEROID REGULATION IN PREGNANT BABOONS
    EUGENE ALBRECHT; Fiscal Year: 1980
    ..Baboon neonates delivered from untreated and MER-25-treated mothers will be infused with (3H)P5/(14C)P4 and (3H)F/(14C)E, respectively, to determine the contribution of p (Text Truncated - Exceeds Capacity) ..
  2. REGULATION OF FETAL/PLACENTAL DEVELOPMENT IN THE PRIMATE
    EUGENE ALBRECHT; Fiscal Year: 2000
    ....
  3. Regulation of Fetal-Placental Development in the Primate
    EUGENE ALBRECHT; Fiscal Year: 2005
    ..Completion of the proposed study will provide new insight into communication between the fetus and placenta and improve our knowledge of the regulation of fetal development and neonatal self-sufficiency. ..
  4. Regulation of Placental-Fetal Development During Primate Pregnancy
    EUGENE ALBRECHT; Fiscal Year: 2007
    ....
  5. MATERNAL-FETAL STEROID REGULATION
    EUGENE ALBRECHT; Fiscal Year: 1993
    ....
  6. MATERNAL-FETAL STEROID REGULATION
    EUGENE ALBRECHT; Fiscal Year: 1991
    ..This should eventually enable formulation of methods to reduce the incidence of abnormal human pregnancy and thus neonatal morbidity and mortality...
  7. Regulation of Placental-Fetal Development During Primate Pregnancy
    Eugene D Albrecht; Fiscal Year: 2010
    ....