Roger Albin

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc The role of serotonin in sleep disordered breathing associated with Parkinson disease: a correlative [11C]DASB PET imaging study
    Irene M Lelieveld
    Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 7:e40166. 2012
  2. pmc Assessing mild cognitive impairment with amyloid and dopamine terminal molecular imaging
    Roger L Albin
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    J Nucl Med 54:887-93. 2013
  3. ncbi request reprint Initial agonist treatment of Parkinson disease: a critique
    Roger L Albin
    Department of Neurology, Geriatric Research, Education, and Clinical Center, Ann Arbor VAMC, University of Michigan, Ann Arbor, USA
    Neurology 60:390-4. 2003
  4. ncbi request reprint Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia
    Roger L Albin
    Geriatrics Research, Education Clinical Center, Ann Arbor VAMC and Department of Neurology, University of Michigan 41809 0585, USA
    Ann Neurol 53:528-32. 2003
  5. ncbi request reprint Spared caudal brainstem SERT binding in early Parkinson's disease
    Roger L Albin
    Geriatrics Research, Education, and Clinical Center, Ann Arbor VA, Ann Arbor, MI, USA
    J Cereb Blood Flow Metab 28:441-4. 2008
  6. ncbi request reprint Dominant ataxias and Friedreich ataxia: an update
    Roger L Albin
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Opin Neurol 16:507-14. 2003
  7. ncbi request reprint Increased ventral striatal monoaminergic innervation in Tourette syndrome
    R L Albin
    Department of Neurology, The University of Michigan Medical School, Ann Arbor, USA
    Neurology 61:310-5. 2003
  8. ncbi request reprint Parkinson's disease: background, diagnosis, and initial management
    Roger L Albin
    Geriatrics Research, Education, and Clinical Center, Veterans Administration Medical Center, Ann Arbor, MI 48109 0585, USA
    Clin Geriatr Med 22:735-51, v. 2006
  9. pmc Sham surgery controls are mitigated trolleys
    R L Albin
    4412D Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    J Med Ethics 31:149-52. 2005
  10. pmc Normal dopaminergic nigrostriatal innervation in SPG3A hereditary spastic paraplegia
    Roger L Albin
    Geriatrics Research, Education, and Clinical Center, Ann Arbor VAHS, Ann Arbor, Michigan 48109 2200, USA
    J Neurogenet 22:289-94. 2008

Research Grants

  1. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 1999
  2. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2002
  3. Michigan Parkinson's Disease Clinical Center
    Roger Albin; Fiscal Year: 2002
  4. Michigan Parkinson's Disease Clinical Center
    Roger Albin; Fiscal Year: 2007
  5. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2000
  6. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2000
  7. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2001
  8. Evaluating Striatal Function in a Murine HD Model
    Roger Albin; Fiscal Year: 2007

Detail Information

Publications54

  1. pmc The role of serotonin in sleep disordered breathing associated with Parkinson disease: a correlative [11C]DASB PET imaging study
    Irene M Lelieveld
    Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 7:e40166. 2012
    ..Neither serotoninergic nor dopaminergic neuron degeneration is likely to play a major role in SDB observed in PD patients...
  2. pmc Assessing mild cognitive impairment with amyloid and dopamine terminal molecular imaging
    Roger L Albin
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    J Nucl Med 54:887-93. 2013
    ..We evaluated PET-based classification of neurodegenerative pathology in mild cognitive impairment (MCI)...
  3. ncbi request reprint Initial agonist treatment of Parkinson disease: a critique
    Roger L Albin
    Department of Neurology, Geriatric Research, Education, and Clinical Center, Ann Arbor VAMC, University of Michigan, Ann Arbor, USA
    Neurology 60:390-4. 2003
    ..The basic science supporting these rationales is equivocal. The clinical evidence for advantages of initial agonist treatment is incomplete. More data are required to determine the optimal initial treatment for PD...
  4. ncbi request reprint Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia
    Roger L Albin
    Geriatrics Research, Education Clinical Center, Ann Arbor VAMC and Department of Neurology, University of Michigan 41809 0585, USA
    Ann Neurol 53:528-32. 2003
    ..Striatal [(131)I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia...
  5. ncbi request reprint Spared caudal brainstem SERT binding in early Parkinson's disease
    Roger L Albin
    Geriatrics Research, Education, and Clinical Center, Ann Arbor VA, Ann Arbor, MI, USA
    J Cereb Blood Flow Metab 28:441-4. 2008
    ..There was no asymmetry of diminished SERT binding. DASB binding in the medulla was relatively spared, inconsistent with the description of early prominent pathologic study in these caudal brainstem nuclei...
  6. ncbi request reprint Dominant ataxias and Friedreich ataxia: an update
    Roger L Albin
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Opin Neurol 16:507-14. 2003
    ..This has resulted also in more rational classification schemes. Research on identified loci has begun to yield insights into the pathogenesis of neuronal dysfunction and neurodegeneration in these diseases...
  7. ncbi request reprint Increased ventral striatal monoaminergic innervation in Tourette syndrome
    R L Albin
    Department of Neurology, The University of Michigan Medical School, Ann Arbor, USA
    Neurology 61:310-5. 2003
    ..Excessive striatal dopaminergic innervation is suggested to underlie Tourette syndrome (TS). Prior imaging and postmortem studies yield conflicting data...
  8. ncbi request reprint Parkinson's disease: background, diagnosis, and initial management
    Roger L Albin
    Geriatrics Research, Education, and Clinical Center, Veterans Administration Medical Center, Ann Arbor, MI 48109 0585, USA
    Clin Geriatr Med 22:735-51, v. 2006
    ..Parkinson's disease is the most common disabling movement disorder. This article reviews the major clinical features, differential diagnosis, approach to diagnosis, and initial management of Parkinson's disease...
  9. pmc Sham surgery controls are mitigated trolleys
    R L Albin
    4412D Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    J Med Ethics 31:149-52. 2005
    ..I argue that sham surgery controls satisfy criteria derived from the trolley problem and are morally permissible...
  10. pmc Normal dopaminergic nigrostriatal innervation in SPG3A hereditary spastic paraplegia
    Roger L Albin
    Geriatrics Research, Education, and Clinical Center, Ann Arbor VAHS, Ann Arbor, Michigan 48109 2200, USA
    J Neurogenet 22:289-94. 2008
    ..This major difference between human SPG3A/atlastin-1 mutations and the Drosophila atl(l) phenotype has several possible explanations...
  11. pmc Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome
    R L Albin
    Geriatrics Research, Education, and Clinical Center, Ann Arbor VAMC, Ann Arbor, MI, USA
    Neurology 72:1390-6. 2009
    ..Prior molecular imaging studies of nigrostriatal dopaminergic terminal markers report conflicting results. Our goal was to characterize the distribution of nigrostriatal dopaminergic terminals in subjects with TS...
  12. pmc Sham surgery controls: intracerebral grafting of fetal tissue for Parkinson's disease and proposed criteria for use of sham surgery controls
    R L Albin
    Department of Neurology, University of Michigan, 4412D Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    J Med Ethics 28:322-5. 2002
    ..Sham surgery controls, however, should be employed only when absolutely necessary. I suggest criteria for appropriate use of sham surgery controls...
  13. ncbi request reprint Decreased striatal dopaminergic innervation in REM sleep behavior disorder
    R L Albin
    Department of Neurology, University of Michigan, Ann Arbor, USA
    Neurology 55:1410-2. 2000
    ..In subjects with RBD, there were significant reductions in striatal [11C]dihydrotetrabenazine binding, particularly in the posterior putamen...
  14. pmc Comparing fludeoxyglucose F18-PET assessment of regional cerebral glucose metabolism and [11C]dihydrotetrabenazine-PET in evaluation of early dementia and mild cognitive impairment
    Roger L Albin
    VA Ann Arbor Health System Geriatrics Research, Education, and Clinical Center, and Department of Neurology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Arch Neurol 67:440-6. 2010
    ....
  15. ncbi request reprint Rapid loss of striatal VMAT2 binding associated with onset of Lewy body dementia
    Roger Albin
    Department of Neurology, Geriatric Research, Ann Arbor, Michigan
    Mov Disord 21:287-8. 2006
  16. ncbi request reprint Vesicular neurotransmitter transporters in Huntington's disease: initial observations and comparison with traditional synaptic markers
    M Suzuki
    Department of Radiology (Division of Nuclear Medicine, The University of Michigan, Ann Arbor, Michigan, USA
    Synapse 41:329-36. 2001
    ..There is also markedly reduced expression of ChAT by surviving cholinergic striatal interneurons...
  17. doi request reprint Reliability of repeated cognitive assessment of dementia using a brief computerized battery
    Dustin Hammers
    Neuropsychology Section, Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Am J Alzheimers Dis Other Demen 26:326-33. 2011
    ..The aim of this study was to evaluate the short-term stability and reliability of a brief computerized cognitive battery in established dementia types...
  18. pmc History of falls in Parkinson disease is associated with reduced cholinergic activity
    N I Bohnen
    Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor 48105 9755, USA
    Neurology 73:1670-6. 2009
    ..To investigate the relationships between history of falls and cholinergic vs dopaminergic denervation in patients with Parkinson disease (PD)...
  19. pmc Astrocytic redox remodeling by amyloid beta peptide
    Sanjay K Garg
    Department of Biochemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Antioxid Redox Signal 14:2385-97. 2011
    ..Our study suggests that the alterations in astrocytic redox status could compromise the neuroprotective potential of astrocytes and may be a potential new target for therapeutic intervention in Alzheimer's disease...
  20. pmc Impact of belief in neuroprotection on therapeutic intervention in Parkinson's disease
    Rodger J Elble
    Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Mov Disord 25:1082-6. 2010
    ..We found the investigators' level of confidence in these agents had no effect on the time to symptomatic therapy or on the change in UPDRS during 12 months of treatment...
  21. ncbi request reprint Myofibrillogenesis regulator 1 gene mutations cause paroxysmal dystonic choreoathetosis
    Shirley Rainier
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Neurol 61:1025-9. 2004
    ..Previously, we and others identified a locus for autosomal dominant PDC on chromosome 2q33-2q35...
  22. ncbi request reprint Tetrahydro-9-aminoacridine (THA) interacts with the phencyclidine (PCP) receptor site
    R L Albin
    Department of Neurology, University of Michigan, Ann Arbor 48104
    Neurosci Lett 88:303-7. 1988
    ..THA may exert some of its clinical effects through interaction with the PCP receptor, and may have mixed agonist-antagonist properties...
  23. ncbi request reprint Receptor binding techniques
    K A Frey
    University of Michigan, Ann Arbor, Michigan, USA
    Curr Protoc Neurosci . 2001
    ..Quantification of the assay results can be accomplished by autoradiography or film densitometry. Finally, methods and considerations for analysis of the resulting data are presented...
  24. ncbi request reprint Chronic intrastriatal administration of quinolinic acid produces transient nocturnal hypermotility in the rat
    T J Bazzett
    Department of Neurology, University of Michigan, Ann Arbor 48104 1687, USA
    Brain Res Bull 39:69-73. 1996
    ..With continued exposure, this behavioral effect may then diminish as a result of subsequent widespread striatal cell death...
  25. ncbi request reprint Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation
    S Minoshima
    Department of Internal Medicine, University of Michigan Medical School, Geriatrics Research, Education, and Clinical Center, Ann Arbor, USA
    Ann Neurol 50:358-65. 2001
    ..In these patients, occipital hypometabolism preceded some clinical features of DLB. Occipital hypometabolism is a potential antemortem marker to distinguish DLB versus AD...
  26. ncbi request reprint Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice
    S J Tallaksen-Greene
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neuroscience 131:843-52. 2005
    ..HdhCAG(150) knockin mice may be a model of early pathologic changes in HD...
  27. ncbi request reprint Embryonic stem cells expressing expanded CAG repeats undergo aberrant neuronal differentiation and have persistent Oct-4 and REST/NRSF expression
    Matthew T Lorincz
    Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Mol Cell Neurosci 26:135-43. 2004
    ..This novel model will allow analysis of the molecular pathogenesis of neuronal degeneration and can be used to rapidly screen therapeutic interventions for these fatal diseases...
  28. ncbi request reprint Hprt(CAG)146 mice: age of onset of behavioral abnormalities, time course of neuronal intranuclear inclusion accumulation, neurotransmitter marker alterations, mitochondrial function markers, and susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridi
    Sara J Tallaksen-Greene
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 0585, USA
    J Comp Neurol 465:205-19. 2003
    ..Hprt(CAG)146 mice did not exhibit increased susceptibility to the mitochondrial toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Hprt(CAG)146 mice are a useful model for studying polyglutamine repeat disorders...
  29. ncbi request reprint An advance in molecular imaging of dementias
    Roger L Albin
    Lancet Neurol 6:288-9. 2007
  30. doi request reprint Mortalin: a protein associated with progression of Parkinson disease?
    Min Shi
    Department of Pathology, University of Washington, School of Medicine, Seattle, Washington, USA
    J Neuropathol Exp Neurol 67:117-24. 2008
    ..Of those, mortalin, a mitochondrial protein, was decreased in the advanced PD cases and was further validated to be decreased using independent techniques. These results suggest a role for mortalin in PD progression...
  31. ncbi request reprint Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease
    Mary Y Heng
    Neuroscience Graduate Program and Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:8989-98. 2007
    ..The Hdh(CAG)150 knock-in mouse is a valid model to evaluate early events in the pathogenesis of neurodegeneration in HD...
  32. ncbi request reprint Brain imaging to assess the effects of dopamine agonists on progression of Parkinson disease
    Roger L Albin
    JAMA 288:311-2; author reply 312-3. 2002
  33. ncbi request reprint Striatal monoaminergic terminals in Lewy body and Alzheimer's dementias
    Masahiko Suzuki
    Department of Radiology Nuclear Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0028, USA
    Ann Neurol 51:767-71. 2002
    ..We conclude that dementia with Lewy bodies may be distinguished from Alzheimer's disease by postmortem examination or by future in vivo measurements of the striatal vesicular monoamine transporter type 2...
  34. ncbi request reprint Cholinergic vesicular transporters in progressive supranuclear palsy
    Masahiko Suzuki
    Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, USA
    Neurology 58:1013-8. 2002
    ..To determine the status of cholinergic and monoaminergic vesicular transporter binding sites in progressive supranuclear palsy (PSP)...
  35. ncbi request reprint Neuroimaging of Tourette syndrome
    Kirk A Frey
    Department of Neurology, The University of Michigan, Ann Arbor, MI 48109 0028, USA
    J Child Neurol 21:672-7. 2006
    ..Although the available data have important limitations, an encouraging convergence of findings implicates abnormal function in the Tourette syndrome striatum and in associated limbic and frontal cortical systems...
  36. ncbi request reprint 11C-DTBZ and 18F-FDG PET measures in differentiating dementias
    Robert A Koeppe
    Division of Nuclear Medicine, Department of Radiology, University of Michigan School of Medicine, 3480 Kresge III, Box 0552, Ann Arbor, MI 48109, USA
    J Nucl Med 46:936-44. 2005
    ....
  37. ncbi request reprint The mind's eye, looking inward? In search of executive control in internal attention shifting
    William J Gehring
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
    Psychophysiology 40:572-85. 2003
    ..Bottom-up processes may include priming on no-switch trials and conflict on switch trials. Top-down processes may control conflict, subvocal rehearsal, and the contents of working memory...
  38. ncbi request reprint Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease
    Nicolaas I Bohnen
    Department of Radiology, Division of Nuclear Medicine, The University of Michigan Medical School, Ann Arbor, 48109 0028, USA
    J Cereb Blood Flow Metab 26:1198-212. 2006
    ..We conclude that (+)-[(11)C]DTBZ-PET imaging displays many properties necessary of a PD biomarker...
  39. ncbi request reprint Treatment effects on nigrostriatal projection integrity in partial 6-OHDA lesions: comparison of L-DOPA and pramipexole
    Elyse S Kemmerer
    Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA
    Exp Neurol 183:81-6. 2003
    ..There was no treatment effect on VMAT2 expression in the partially lesioned striatum and thus no differential effect of indirect versus direct dopamimetic treatment on nigrostriatal integrity...
  40. ncbi request reprint Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Na(v)1.6)
    Jennifer A Kearney
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Hum Mol Genet 11:2765-75. 2002
    ..medJ mice provide a model for the physiological effects of sodium channel deficiency and the molecular mechanism of bigenic disease...
  41. ncbi request reprint Genetics of subthalamic nucleus in development and disease
    Steven T Philips
    Department of Pediatrics, The University of Michigan, Ann Arbor, MI 48109, USA
    Exp Neurol 192:320-30. 2005
    ..In this report, we discuss recent evidence for transcription factor mediated regulation of STN development. We also review STN developmental neurobiology and known patterns of gene expression in the developing and mature STN...
  42. ncbi request reprint Practice Parameters for Parkinson disease: signposts for clinical research
    Roger L Albin
    Neurology 66:966-7. 2006
  43. ncbi request reprint Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse
    Jamee M Bomar
    Mental Health Research Institute, 205 Zina Pitcher Place, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Nat Genet 35:264-9. 2003
    ..Three-dimensional protein structural modeling predicts that the caytaxin ligand is more polar than vitamin E. Identification of the caytaxin ligand may help develop a therapy for Cayman ataxia...
  44. ncbi request reprint mGluRs: a target for pharmacotherapy in Parkinson disease
    Jennifer A Feeley Kearney
    Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
    Exp Neurol 184:S30-6. 2003
    ..Agents active at Group III mGluRs may also be useful for treatment of parkinsonism...
  45. ncbi request reprint Neuroimaging in dementia with Lewy bodies: metabolism, neurochemistry, and morphology
    Satoshi Minoshima
    Departments of Radiology, University of Washington School of Medicine, Seattle, Washington 98195 6004, USA
    J Geriatr Psychiatry Neurol 15:200-9. 2002
    ....
  46. pmc Optimal frequency for measuring health care resource utilization in Parkinson's disease using participant recall: the FS-TOO resource utilization substudy
    Patrick D Mauldin
    Department of Clinical Pharmacy and Outcomes Sciences, Medical University of South Carolina, and the Ralph H Johnson VA Medical Center, Charleston, South Carolina 29425, USA
    Clin Ther 30:1553-7. 2008
    ....
  47. doi request reprint Dopamine and epilepsy: hints of complex subcortical roles
    Sheryl R Haut
    Neurology 71:784-5. 2008
  48. ncbi request reprint A mutation in the human neurofilament M gene in Parkinson's disease that suggests a role for the cytoskeleton in neuronal degeneration
    Christian Lavedan
    Novartis Pharmaceuticals Corporation, Pharmacogenetics, 9 W Watkins Mill Road, Gaithersburg, MD 20878, USA
    Neurosci Lett 322:57-61. 2002
    ..This finding suggests, for the first time, that aberrations in neuronal molecules involved in the cytoskeleton could lead to the development of the pathology seen in PD...
  49. ncbi request reprint Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia
    James G Alb
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7090, USA
    J Biol Chem 278:33501-18. 2003
    ..Taken together, the data suggest an unanticipated role for PITP alpha in with glucose homeostasis and in mammalian endoplasmic reticulum functions that interface with transport of specific luminal lipid cargoes...
  50. ncbi request reprint Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context
    Walker S Jackson
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Mol Genet 12:1621-9. 2003
    ..Furthermore, the signals did not alter the relative regional distribution of NIIs, suggesting that factors other than nuclear access dictate the regional specificity of NII formation in this mouse model...
  51. pmc Abnormalities of germ cell maturation and sertoli cell cytoskeleton in androgen receptor 113 CAG knock-in mice reveal toxic effects of the mutant protein
    Zhigang Yu
    Department of Pathology, University of Michigan Medical School, 1301 Catherine, 4233 Medical Science 1, Ann Arbor, Michigan 48109, USA
    Am J Pathol 168:195-204. 2006
    ..Our data demonstrate that toxic effects of the mutant protein mediate aspects of the Kennedy disease phenotype previously attributed to a loss of AR function...
  52. ncbi request reprint Recent advances in Tourette syndrome research
    Roger L Albin
    Geriatrics Research, Education, and Clinical Center, Ann Arbor VAMC, Department of Neurology, University of Michigan, MI 48109, USA
    Trends Neurosci 29:175-82. 2006
    ..These lines of research have provided new pieces to the TS puzzle, and their increasing convergence is showing how those pieces can be put together...
  53. ncbi request reprint Neurobiology of basal ganglia and Tourette syndrome: striatal and dopamine function
    Roger L Albin
    Department of Neurology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Adv Neurol 99:99-106. 2006
  54. ncbi request reprint Proteomics identification of proteins in human cortex using multidimensional separations and MALDI tandem mass spectrometer
    Sheng Pan
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 6:1818-23. 2007
    ..Finally 140 proteins found in the cortical proteome were present in the proteome of cerebrospinal fluid, providing tissue-specific candidates for biomarker discovery in body fluid...

Research Grants9

  1. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 1999
    ..These experiments will establish HPRT-CAG mice as important tools for understanding neurodegeneration in CAG repeat diseases and enable accurate preclinical evaluation of interventions for CAG repeat diseases. ..
  2. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2002
    ..These experiments will establish HPRT-CAG mice as important tools for understanding neurodegeneration in CAG repeat diseases and enable accurate preclinical evaluation of interventions for CAG repeat diseases. ..
  3. Michigan Parkinson's Disease Clinical Center
    Roger Albin; Fiscal Year: 2002
    ..The use of DTBZ-PET will be enhanced by sharing of subjects from other PDCCs within Michigan to ensure efficient use of PET imaging. ..
  4. Michigan Parkinson's Disease Clinical Center
    Roger Albin; Fiscal Year: 2007
    ..The use of DTBZ-PET will be enhanced by sharing of subjects from other PDCCs within Michigan to ensure efficient use of PET imaging. ..
  5. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2000
    ..These experiments will establish HPRT-CAG mice as important tools for understanding neurodegeneration in CAG repeat diseases and enable accurate preclinical evaluation of interventions for CAG repeat diseases. ..
  6. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2000
    ..These experiments will establish HPRT-CAG mice as important tools for understanding neurodegeneration in CAG repeat diseases and enable accurate preclinical evaluation of interventions for CAG repeat diseases. ..
  7. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2001
    ..These experiments will establish HPRT-CAG mice as important tools for understanding neurodegeneration in CAG repeat diseases and enable accurate preclinical evaluation of interventions for CAG repeat diseases. ..
  8. Evaluating Striatal Function in a Murine HD Model
    Roger Albin; Fiscal Year: 2007
    ..Validation of these methods will provide new and useful behavioral tools for evaluating murine disease models. ..