Donna Albertson

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
    S S Kwek
    Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Oncogene 28:1892-903. 2009
  2. pmc Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene
    A M Snijders
    Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Oncogene 28:625-37. 2009
  3. ncbi ESR1 amplification in breast cancer: controversy resolved?
    Donna G Albertson
    J Pathol 227:1-3. 2012
  4. pmc Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility
    David A Quigley
    Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA
    Genome Biol 12:R5. 2011
  5. pmc Genome position and gene amplification
    Pavla Gajduskova
    Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Genome Biol 8:R120. 2007
  6. pmc Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells
    Nicole E Willmarth
    Department of Cellular and Molecular Biology, The University of Michigan, Ann Arbor, Michigan, USA
    Breast Cancer Res 6:R531-9. 2004
  7. pmc Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers
    Christina Yau
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Breast Cancer Res 9:R59. 2007
  8. pmc Breast tumor copy number aberration phenotypes and genomic instability
    Jane Fridlyand
    Department of Epidemiology and Biostatistics, University of California San Francisco, CA 94143, USA
    BMC Cancer 6:96. 2006
  9. ncbi Genomic microarrays in human genetic disease and cancer
    Donna G Albertson
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Hum Mol Genet 12:R145-52. 2003
  10. ncbi Chromosome aberrations in solid tumors
    Donna G Albertson
    Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0808, USA
    Nat Genet 34:369-76. 2003

Research Grants

  1. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2006
  2. INDENTIFICATION OF ONCOGENES ON 20Q
    Donna Albertson; Fiscal Year: 1999
  3. Amplicons in Oral Dysplasia
    Donna Albertson; Fiscal Year: 2009
  4. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2007
  5. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2007
  6. Microarray-Based Scanning of the Mouse Genome
    Donna Albertson; Fiscal Year: 2007
  7. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2006
  8. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2005
  9. Amplicons in Oral Dysplasia
    Donna G Albertson; Fiscal Year: 2010
  10. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2004

Detail Information

Publications69

  1. pmc Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
    S S Kwek
    Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Oncogene 28:1892-903. 2009
    ....
  2. pmc Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene
    A M Snijders
    Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Oncogene 28:625-37. 2009
    ..Thus, upregulated GLI2 expression is sufficient to induce a number of the acquired characteristics of tumor cells; however, the stroma, in a tissue-specific manner, determines whether certain GLI2 oncogenic traits are expressed...
  3. ncbi ESR1 amplification in breast cancer: controversy resolved?
    Donna G Albertson
    J Pathol 227:1-3. 2012
    ..This story has important lessons for translational cancer research, and in particular FISH studies of gene copy number...
  4. pmc Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility
    David A Quigley
    Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA
    Genome Biol 12:R5. 2011
    ..Whether germline variants affect gene expression in tumors that have undergone somatic alterations, and the extent to which these variants influence tumor progression, is unknown...
  5. pmc Genome position and gene amplification
    Pavla Gajduskova
    Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Genome Biol 8:R120. 2007
    ....
  6. pmc Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells
    Nicole E Willmarth
    Department of Cellular and Molecular Biology, The University of Michigan, Ann Arbor, Michigan, USA
    Breast Cancer Res 6:R531-9. 2004
    ....
  7. pmc Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers
    Christina Yau
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Breast Cancer Res 9:R59. 2007
    ..Except for inherited forms of breast cancer, however, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior...
  8. pmc Breast tumor copy number aberration phenotypes and genomic instability
    Jane Fridlyand
    Department of Epidemiology and Biostatistics, University of California San Francisco, CA 94143, USA
    BMC Cancer 6:96. 2006
    ..g. those involved in mitosis, replication, repair, and telomeres) are rarely mutated in chromosomally unstable sporadic tumors, even though such mutations are associated with some heritable cancer prone syndromes...
  9. ncbi Genomic microarrays in human genetic disease and cancer
    Donna G Albertson
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Hum Mol Genet 12:R145-52. 2003
    ..Here we discuss the performance characteristics of different array platforms and review some of the recent applications of array CGH in cancer and medical genetics...
  10. ncbi Chromosome aberrations in solid tumors
    Donna G Albertson
    Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0808, USA
    Nat Genet 34:369-76. 2003
    ....
  11. ncbi Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene
    D G Albertson
    1 Cancer Research Institute, University of California, San Francisco, Box 0808, San Francisco, California, USA
    Nat Genet 25:144-6. 2000
    ..The putative oncogene ZNF217 (ref. 5) mapped to one peak, and CYP24 (encoding vitamin D 24 hydroxylase), whose overexpression is likely to lead to abrogation of growth control mediated by vitamin D, mapped to the other...
  12. ncbi Gene amplification in cancer
    Donna G Albertson
    Cancer Research Institute and Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Genet 22:447-55. 2006
    ..Clinically, amplification has prognostic and diagnostic usefulness, and is a mechanism of acquired drug resistance...
  13. ncbi Profiling breast cancer by array CGH
    Donna G Albertson
    Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Breast Cancer Res Treat 78:289-98. 2003
    ..The capabilities of this new technology are reviewed. Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed...
  14. ncbi Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors
    Joris A Veltman
    Cancer Center, University of California San Francisco, California 94143 0808, USA
    Cancer Res 63:2872-80. 2003
    ....
  15. ncbi Genome-wide-array-based comparative genomic hybridization reveals genetic homogeneity and frequent copy number increases encompassing CCNE1 in fallopian tube carcinoma
    Antoine M Snijders
    Cancer Research Institute, University of California San Francisco, San Francisco, CA, USA
    Oncogene 22:4281-6. 2003
    ..The FTC were remarkably homogeneous, with some recurrent aberrations occurring in more than 70% of samples, which suggests a stereotyped pattern of tumor evolution...
  16. ncbi FBXW7 and DNA copy number instability
    Kristin N Byrd
    Cancer Research Institute, University of California San Francisco, Box 0808, San Francisco, CA 94143 0808, USA
    Breast Cancer Res Treat 109:47-54. 2008
    ..Taken together these studies suggest that FBXW7 deficiency is unlikely to contribute to the extensive copy number aberrations associated with breast and possibly other tumor types...
  17. ncbi Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer
    J E Vivienne Watson
    Collins Lab, UCSF Comprehensive Cancer Center, University of California, 2340 Sutter Street, San Francisco, USA
    Oncogene 23:3487-94. 2004
    ....
  18. ncbi Array comparative genomic hybridization and its applications in cancer
    Daniel Pinkel
    Department of Laboratory Medicine and Comprehensive Cancer Center, University of California San Francisco, Box 0808, San Francisco, California 94143, USA
    Nat Genet 37:S11-7. 2005
    ..Here, we discuss the state of the art of array comparative genomic hybridization and its applications in cancer, emphasizing general concepts rather than specific results...
  19. ncbi Array comparative genomic hybridization identifies genetic subgroups in grade 4 human astrocytoma
    Anjan Misra
    Brain Tumor Research Center, Department of Neurosurgery, University of California San Francisco, San Francisco, California, USA
    Clin Cancer Res 11:2907-18. 2005
    ..The significance of these genetic groups to therapeutics needs further study...
  20. ncbi Comparative genomic hybridization
    Daniel Pinkel
    Comprehensive Cancer Center, Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA
    Annu Rev Genomics Hum Genet 6:331-54. 2005
    ..In this review we discuss the state of the art of array CGH and its applications in medical genetics and cancer, emphasizing general concepts rather than specific results...
  21. ncbi Additional patient with del(12)(q21.2q22): further evidence for a candidate region for cardio-facio-cutaneous syndrome?
    Katherine A Rauen
    Division of Medical Genetics, Department of Pediatrics, University of California San Francisco, San Francisco, California, USA
    Am J Med Genet 110:51-6. 2002
    ..The region 12q21.2 --> q22 remains a possible candidate region for CFC syndrome. Additional characterization of these and other CFC patients may confirm and further refine this candidate region...
  22. ncbi Interstitial deletion of chromosome 12q: genotype-phenotype correlation of two patients utilizing array comparative genomic hybridization
    Ophir D Klein
    Department of Pediatrics, Division of Medical Genetics, University of California San Francisco, San Francisco, California 94115, USA
    Am J Med Genet A 138:349-54. 2005
    ....
  23. pmc Fully automatic quantification of microarray image data
    Ajay N Jain
    Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Genome Res 12:325-32. 2002
    ..The software, called, runs on Windows platforms and is available free of charge for academic use...
  24. ncbi Genomic and transcriptional aberrations linked to breast cancer pathophysiologies
    Koei Chin
    Comprehensive Cancer Center, 2340 Sutter Street, University of California, San Francisco, San Francisco, California 94143
    Cancer Cell 10:529-41. 2006
    ..Nine of these (FGFR1, IKBKB, ERBB2, PROCC, ADAM9, FNTA, ACACA, PNMT, and NR1D1) are considered druggable. Low-level CNAs appear to contribute to cancer progression by altering RNA and cellular metabolism...
  25. pmc High-resolution mapping of genotype-phenotype relationships in cri du chat syndrome using array comparative genomic hybridization
    Xiaoxiao Zhang
    Comprehensive Cancer Center and Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Hum Genet 76:312-26. 2005
    ..However, MR increased as deletions that included MRI extended progressively into MRII and MRIII, and MR became profound when all three regions were deleted...
  26. ncbi Xq chromosome duplication in males: clinical, cytogenetic and array CGH characterization of a new case and review
    Sabrina F Cheng
    Department of Pediatrics, Division of Medical Genetics, University of California San Francisco, San Francisco, California, USA
    Am J Med Genet A 135:308-13. 2005
    ..Mental, psychomotor and growth retardation, as well as, craniofacial anomalies, muscle hypotonia, hypoplastic genitalia, cryptorchidism, feeding difficulties, and endocrine dysfunction are all significant issues in these individuals...
  27. ncbi Detection of single clone deletions using array CGH: identification of submicroscopic deletions in the 22q11.2 deletion syndrome as a model system
    Taku A Tokuyasu
    Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    Am J Med Genet A 143:925-32. 2007
    ..We demonstrate that such technology is ideally suited for microdeletion syndromes such as 22q11.2...
  28. ncbi Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors
    Pamela L Paris
    Comprehensive Cancer Center, University of California at San Francisco, 94115, USA
    Hum Mol Genet 13:1303-13. 2004
    ..Moreover, comparison with an independent set of metastases revealed approximately 40 candidate markers associated with metastatic potential. Copy number aberrations at these loci may define metastatic genotypes...
  29. pmc High-resolution analysis of paraffin-embedded and formalin-fixed prostate tumors using comparative genomic hybridization to genomic microarrays
    Pamela L Paris
    Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94115, USA
    Am J Pathol 162:763-70. 2003
    ..We present a straightforward protocol and demonstrate the utility of archived tissue for array comparative genomic hybridization with a 2400 element BAC array that provides high-resolution detection of both deletions and amplifications...
  30. ncbi Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells
    Ami S Bhatt
    University of California at San Francisco, School of Medicine, 513 Parnassus Ave, Box 0454, San Francisco, CA 94143, USA
    Biol Chem 384:257-66. 2003
    ..However, the significant correlation between MT-SP1 and uPAR transcript levels in this initial study suggests further work to establish the role of MT-SP1 as a possible prognostic, diagnostic or therapeutic target for breast cancer...
  31. ncbi Specific keynote: genome copy number abnormalities in ovarian cancer
    Joe W Gray
    University of California, Los Angeles, USA
    Gynecol Oncol 88:S16-21; discussion S22-4. 2003
  32. ncbi Chromosomal instability in microsatellite-unstable and stable colon cancer
    Karolin Trautmann
    Comprehensive Cancer Center, Department of Medicine, University of California San Francisco, San Francisco, California 94143 0808, USA
    Clin Cancer Res 12:6379-85. 2006
    ....
  33. ncbi Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors
    Christopher S Hackett
    Department of Neurology, University of California, San Francisco, California 94143 0114, USA
    Cancer Res 63:5266-73. 2003
    ..These data demonstrate conservation of many genetic changes in murine and human neuroblastoma and suggest that further delineation of genetic abnormalities in murine tumors may identify genes important in human disease...
  34. ncbi Duplication of distal 20q: clinical, cytogenetic and array CGH. Characterization of a new case
    Alejandro Iglesias
    Division of Genetics, Department of Pediatrics, Beth Israel Medical Center, New York, and Division of Medical Genetics, Department of Pediatrics, Division of Medical Genetics, University of California, San Francisco, USA
    Clin Dysmorphol 15:19-23. 2006
    ..This case further highlights the utility of array CGH in characterizing aneusomies and, in particular, for accurate breakpoint designation and quantitation of ambiguous rearrangements...
  35. ncbi Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma
    Antoine M Snijders
    Cancer Research Institute, University of California San Francisco, Box 0808, San Francisco, CA 94143 0808, USA
    Oncogene 24:4232-42. 2005
    ..Deregulation of these and other members of the hedgehog and notch pathways (HHIP, SMO, DLL1, NOTCH4) implicates deregulation of developmental and differentiation pathways, cell fate misspecification, in oral SCC development...
  36. ncbi Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors
    Giuseppe Zardo
    Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94115, USA
    Nat Genet 32:453-8. 2002
    ..Our results show that most aberrant methylation events are focal and independent of deletions, and the rare convergence of these mechanisms can pinpoint biallelic gene inactivation without the use of positional cloning...
  37. pmc Mapping segmental and sequence variations among laboratory mice using BAC array CGH
    Antoine M Snijders
    Cancer Research Institute, University of California San Francisco, San Francisco, California 94143, USA
    Genome Res 15:302-11. 2005
    ..1) distinguish homozygous and heterozygous regions of the genome in interspecific backcross mice, providing an efficient method for genotyping progeny of backcrosses...
  38. ncbi Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway
    Pierre P Massion
    UCSF Comprehensive Cancer Center, University of California, San Francisco, California 94143 0808, USA
    Cancer Res 62:3636-40. 2002
    ..75), suggesting that these copy number increases contribute to activation of PI3K signaling in SqCas of the lung...
  39. ncbi Shaping of tumor and drug-resistant genomes by instability and selection
    Antoine M Snijders
    Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0808, USA
    Oncogene 22:4370-9. 2003
    ....
  40. ncbi Therapy-induced malignant neoplasms in Nf1 mutant mice
    Richard C Chao
    Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143, USA
    Cancer Cell 8:337-48. 2005
    ..Nf1(+/-) mice provide a tractable model for investigating the pathogenesis of common mutagen-induced cancers and for testing preventive strategies...
  41. doi High-efficiency microarray printer using fused-silica capillary tube printing pins
    Steve M Clark
    University of California San Francisco, Box 0808, San Francisco, California 94143, USA
    Anal Chem 80:7639-42. 2008
    ....
  42. ncbi BAC microarray-based comparative genomic hybridization
    Antoine M Snijders
    Comprehensive Cancer Center, University of California, San Francisco, USA
    Methods Mol Biol 256:39-56. 2004
  43. ncbi Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability
    Antoine M Snijders
    Cancer Research Institute, University of California San Francisco, San Francisco, CA, USA
    Genes Chromosomes Cancer 47:71-83. 2008
    ..On the other hand, it appears that loss of BLM function suppresses the mismatch repair mutator mechanism in mismatch repair and BLM deficient HCT116 BLM-/- cells...
  44. ncbi Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3
    Tsui Ting Ching
    The Brain Tumor Research Center, Department of Neurological Surgery and the Biomedical Sciences Program, University of California San Francisco, San Franciso, California 94143, USA
    Nat Genet 37:645-51. 2005
    ..Defects in SHANK3 seem to underlie human 22q13 deletion syndrome. Furthermore, these patterns for SHANK3 are conserved in mice and rats...
  45. ncbi Ring 21 chromosome and a satellited 1p in the same patient: novel origin for an ectopic NOR
    Anita Ki
    Division of Medical Genetics and Department of Pathology, Children s Hospital and Research Center, Oakland, California, USA
    Am J Med Genet A 120:365-9. 2003
    ..This represents a novel mechanism for the origin of ectopic NORs. In addition, this study illustrates the importance of FISH analysis with telomeric and subtelomeric probes for characterization of chromosomes with ectopic NORs...
  46. pmc A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
    Hiroshi Okabe
    Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, California, United States of America UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 1:e128. 2006
    ..Thus, FBXW8 plays an essential role in cancer cell proliferation through proteolysis of cyclin D1. It may present new opportunities to develop therapies targeting destruction of cyclin D1 or its regulator E3 ligase selectively...
  47. ncbi Genomic profiling of gastric cancer predicts lymph node status and survival
    Marjan M Weiss
    Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
    Oncogene 22:1872-9. 2003
    ..The possibility to discriminate between patients with a high risk of lymph node metastasis could clinically be helpful for selecting patients for extended lymph node resection...
  48. ncbi Deletion of chromosome 11q predicts response to anthracycline-based chemotherapy in early breast cancer
    Joan Climent
    Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, and Department of Hematology and Medical Oncology, Hospital Clinico, University of Valencia, Spain
    Cancer Res 67:818-26. 2007
    ..However, these initial findings should be evaluated in randomized clinical trials...
  49. pmc Large-scale variation among human and great ape genomes determined by array comparative genomic hybridization
    Devin P Locke
    Department of Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Genome Res 13:347-57. 2003
    ..In contrast to previous cytogenetic and comparative mapping studies, these results indicate extensive local repatterning of hominoid chromosomes in euchromatic regions through a duplication-driven mechanism of genome evolution...
  50. ncbi Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization
    Marjan M Weiss
    Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 200:320-6. 2003
    ..In the present study, an amplicon at 20q13.2 has been narrowed down to 800 kb which is likely to harbour one or more putative oncogenes relevant to gastric carcinogenesis, for which ZNF217 and CYP24 are good candidates...
  51. doi Conflicting evidence on the frequency of ESR1 amplification in breast cancer
    Donna G Albertson
    Nat Genet 40:821-2. 2008
  52. doi The BAC resource: tools for array CGH and FISH
    Norma J Nowak
    Roswell Park Cancer Institute and SUNY at Buffalo, Buffalo, New York, USA
    Curr Protoc Hum Genet . 2005
    ..The BAC clones through their sequence allow the extent and gene content of numerical aberrations to be delineated by aCGH, and also provide cytogeneticists with tools for subsequent validation or fine mapping studies...
  53. ncbi MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma
    Dolors Sanchez-Izquierdo
    Department of Hematology and Medical Oncology, Hospital Clinico, University of Valencia, Spain
    Blood 101:4539-46. 2003
    ..Together, these data implicate MALT1 as a dominant oncogene that may play a role in the pathogenesis of B-NHL...
  54. pmc A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    Richard M Neve
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94270, USA
    Cancer Cell 10:515-27. 2006
    ..We show, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations...
  55. ncbi Discovery of previously unidentified genomic disorders from the duplication architecture of the human genome
    Andrew J Sharp
    Department of Genome Sciences and the Howard Hughes Medical Institute, University of Washington School of Medicine, 1705 NE Pacific St, Seattle, Washington 98195, USA
    Nat Genet 38:1038-42. 2006
    ..In common with the 17q21.31 deletion, these breakpoint regions are sites of copy number polymorphism in controls, indicating that these may be inherently unstable genomic regions...
  56. ncbi Construction and application of a full-coverage, high-resolution, human chromosome 8q genomic microarray for comparative genomic hybridization
    Mark van Duin
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Cytometry A 63:10-9. 2005
    ..A high-resolution contig array was developed specifically for chromosome 8q because this chromosome arm is frequently altered in many human cancers...
  57. ncbi Current status and future prospects of array-based comparative genomic hybridisation
    Antoine M Snijders
    University of California Comprehensive Cancer Center, USA
    Brief Funct Genomic Proteomic 2:37-45. 2003
    ..This paper reviews these approaches and presents some of the recently-developed applications of this new technology in both research and clinical settings...
  58. pmc Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH
    José M Lage
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Genome Res 13:294-307. 2003
    ..Gene-dosage alterations of threefold or more can be observed with high reproducibility with as few as 1000 cells of starting material...
  59. pmc Segmental duplications and copy-number variation in the human genome
    Andrew J Sharp
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Am J Hum Genet 77:78-88. 2005
    ..Our specialized segmental duplication BAC microarray and associated database of structural polymorphisms will provide an important resource for the future characterization of human genomic disorders...
  60. ncbi A tiling resolution DNA microarray with complete coverage of the human genome
    Adrian S Ishkanian
    British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Nat Genet 36:299-303. 2004
    ..Our submegabase resolution tiling set for array CGH (SMRT array) allows comprehensive assessment of genomic integrity and thereby the identification of new genes associated with disease...
  61. ncbi Regional copy number-independent deregulation of transcription in cancer
    Nicolas Stransky
    UMR 144 Centre National de la Recherche Scientifique CNRS Institut Curie, 75248 Paris Cedex 05, France
    Nat Genet 38:1386-96. 2006
    ..We validated one candidate region experimentally, demonstrating histone methylation leading to the loss of expression of neighboring genes without DNA methylation...
  62. ncbi Evaluation of genetic patterns in different tumor areas of intermediate-grade prostatic adenocarcinomas by high-resolution genomic array analysis
    Herman van Dekken
    Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Genes Chromosomes Cancer 39:249-56. 2004
    ..The patterns of imbalance could be found to coincide in the G3 and G4 areas of the majority of cancers. Array-based CGH can be used as a tool for the evaluation of genetic patterns in prostate cancer...
  63. ncbi High-resolution genomic profiling of occult micrometastatic tumor cells
    Jurgen Kraus
    Institut fur Humangenetik, Technische Universitat Munchen, Munich, Germany
    Genes Chromosomes Cancer 36:159-66. 2003
    ..Thus, occult micrometastatic cells are now amenable to detailed analyses of their genome. Markers for prognosis and treatment decisions can now be established...
  64. ncbi Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations
    Jose A Martinez-Climent
    Department of Hematology and Medical Oncology, Hospital Clinico, University of Valencia, Spain
    Blood 101:3109-17. 2003
    ..This process is associated with the acquisition of a variable spectrum of genomic imbalances affecting recurrent chromosomal areas that harbor overexpressed or underexpressed genes targeted upon transformation...
  65. ncbi Altered promoter usage characterizes monoallelic transcription arising with ERBB2 amplification in human breast cancers
    Christopher C Benz
    Buck Institute for Age Research, Novato, CA 94945, USA
    Genes Chromosomes Cancer 45:983-94. 2006
    ....
  66. ncbi Genomic analysis of tumors by array comparative genomic hybridization: more is better
    Donna G Albertson
    Cancer Res 66:3955-6; author reply 3956. 2006
  67. pmc Linkage disequilibrium and heritability of copy-number polymorphisms within duplicated regions of the human genome
    Devin P Locke
    Department of Genome Sciences, University of Washington and Howard Hughes Medical Institute, Seattle, WA 98195, USA
    Am J Hum Genet 79:275-90. 2006
    ..Our results underscore the need for complete maps of genetic variation in duplication-rich regions of the genome...
  68. ncbi ErbB2 activation of ESX gene expression
    Richard M Neve
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Oncogene 21:3934-8. 2002
    ..These results indicate that the ESX promoter represents a transcriptional target of ErbB2, and ESX expression may represent a downstream mediator of ErbB2 signaling and ErbB2-induced gene expression...
  69. pmc Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 436:123-7. 2005
    ..These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation...

Research Grants22

  1. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2006
    ..abstract_text> ..
  2. INDENTIFICATION OF ONCOGENES ON 20Q
    Donna Albertson; Fiscal Year: 1999
  3. Amplicons in Oral Dysplasia
    Donna Albertson; Fiscal Year: 2009
    ..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..
  4. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2007
    ..abstract_text> ..
  5. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2007
    ..In addition, these studies will determine which mouse models most closely resemble different subtypes of ER negative tumors at the molecular level, thereby enhancing their utility as preclinical models. ..
  6. Microarray-Based Scanning of the Mouse Genome
    Donna Albertson; Fiscal Year: 2007
    ..New approaches for hybridization and analysis will be developed to extend the dynamic range of the expression measurements so we can obtain data from mRNAs expressed at very low abundances. ..
  7. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2006
    ..In addition, these studies will determine which mouse models most closely resemble different subtypes of ER negative tumors at the molecular level, thereby enhancing their utility as preclinical models. ..
  8. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2005
    ..abstract_text> ..
  9. Amplicons in Oral Dysplasia
    Donna G Albertson; Fiscal Year: 2010
    ..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..
  10. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2004
    ..In addition, these studies will determine which mouse models most closely resemble different subtypes of ER negative tumors at the molecular level, thereby enhancing their utility as preclinical models. ..
  11. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2004
    ..abstract_text> ..
  12. Amplicon Profiling by Array CGH
    Donna Albertson; Fiscal Year: 2004
    ..abstract_text> ..
  13. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2003
    ..In addition, these studies will determine which mouse models most closely resemble different subtypes of ER negative tumors at the molecular level, thereby enhancing their utility as preclinical models. ..
  14. High Resolution Genomic Analysis of Amplicon Structure
    Donna Albertson; Fiscal Year: 2003
    ..abstract_text> ..
  15. Genomic and Functional Analysis of Oral Cancer Development
    Donna Albertson; Fiscal Year: 2009
    ..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..
  16. Genomic and Functional Analysis of Oral Cancer Development
    Donna Albertson; Fiscal Year: 2007
    ..The most fundamental way to make progress toward improving diagnosis and treatment of oral cancer is to elucidate the specific genes and the interactions among genes that become abnormal as cancer develops. ..
  17. Genomic Analysis of ER Negative Breast Cancer
    Donna Albertson; Fiscal Year: 2005
    ..In addition, these studies will determine which mouse models most closely resemble different subtypes of ER negative tumors at the molecular level, thereby enhancing their utility as preclinical models. ..