David Alberts

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Folate and colorectal neoplasia: relation between plasma and dietary markers of folate and adenoma recurrence
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson 85724 5024, USA
    Am J Clin Nutr 79:691-7. 2004
  2. ncbi request reprint Efficacy and safety of liposomal anthracyclines in phase I/II clinical trials
    David S Alberts
    The Arizona Cancer Center, Tucson, AZ, USA
    Semin Oncol 31:53-90. 2004
  3. pmc Difluoromethylornithine: the proof is in the polyamines
    Joanne M Jeter
    Department of Medicine, The University of Arizona Cancer Center, Tucson, Arizona 85719, USA
    Cancer Prev Res (Phila) 5:1341-4. 2012
  4. doi request reprint Phase II trial of nab-paclitaxel in the treatment of recurrent or persistent advanced cervix cancer: A gynecologic oncology group study
    David S Alberts
    The University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Gynecol Oncol 127:451-5. 2012
  5. pmc Estimation of colorectal adenoma recurrence with dependent censoring
    Chiu Hsieh Hsu
    Division of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ 85724, USA
    BMC Med Res Methodol 9:66. 2009
  6. ncbi request reprint Fecal bile acid concentrations in a subpopulation of the wheat bran fiber colon polyp trial
    David S Alberts
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 12:197-200. 2003
  7. ncbi request reprint Randomized phase 3 trial of interferon gamma-1b plus standard carboplatin/paclitaxel versus carboplatin/paclitaxel alone for first-line treatment of advanced ovarian and primary peritoneal carcinomas: results from a prospectively designed analysis of prog
    David S Alberts
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Gynecol Oncol 109:174-81. 2008
  8. ncbi request reprint Randomized trial of adjuvant intraperitoneal alpha-interferon in stage III ovarian cancer patients who have no evidence of disease after primary surgery and chemotherapy: An intergroup study
    David S Alberts
    Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Gynecol Oncol 100:133-8. 2006
  9. ncbi request reprint Safety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin
    David Alberts
    Department of Medicine, Arizona Cancer Center, College of Medicine, College of Public Health, University of Arizona, Tucson, Arizona 85724 05024, USA
    Clin Cancer Res 10:1875-80. 2004
  10. ncbi request reprint Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence
    David S Alberts
    Department of Medicine, Arizona Cancer Center, College of Public Health, University of Arizona, Tucson, AZ, USA
    J Natl Cancer Inst 97:846-53. 2005

Research Grants

  1. Colorectal Screening Capacity Building Conference
    David Alberts; Fiscal Year: 2003
  2. CANCER PREVENTION AND CONTROL TRAINING GRANT
    David Alberts; Fiscal Year: 2007
  3. Arizona Cancer Center Support Grant
    David Alberts; Fiscal Year: 2007
  4. CANCER PREVENTION AND CONTROL TRAINING GRANT
    David Alberts; Fiscal Year: 2008
  5. CHEMOPREVENTION OF SKIN CANCER PROGRAM PROJECT
    David Alberts; Fiscal Year: 2008
  6. Arizona Cancer Center Support Grant
    David Alberts; Fiscal Year: 2007
  7. Arizona Cancer Center Support Grant
    David Alberts; Fiscal Year: 2008
  8. Arizona Cancer Center Support Grant
    David Alberts; Fiscal Year: 2008

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint Folate and colorectal neoplasia: relation between plasma and dietary markers of folate and adenoma recurrence
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson 85724 5024, USA
    Am J Clin Nutr 79:691-7. 2004
    ..The results of epidemiologic studies indicate that higher intakes or blood concentrations of folate are associated with a lower risk of colorectal neoplasia; however, only one study assessed the role of homocysteine...
  2. ncbi request reprint Efficacy and safety of liposomal anthracyclines in phase I/II clinical trials
    David S Alberts
    The Arizona Cancer Center, Tucson, AZ, USA
    Semin Oncol 31:53-90. 2004
    ....
  3. pmc Difluoromethylornithine: the proof is in the polyamines
    Joanne M Jeter
    Department of Medicine, The University of Arizona Cancer Center, Tucson, Arizona 85719, USA
    Cancer Prev Res (Phila) 5:1341-4. 2012
    ....
  4. doi request reprint Phase II trial of nab-paclitaxel in the treatment of recurrent or persistent advanced cervix cancer: A gynecologic oncology group study
    David S Alberts
    The University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Gynecol Oncol 127:451-5. 2012
    ..The Gynecologic Oncology Group has studied >20 cytotoxic drugs or drug combinations in the second-line, phase II setting of advanced, drug resistant cervix cancer...
  5. pmc Estimation of colorectal adenoma recurrence with dependent censoring
    Chiu Hsieh Hsu
    Division of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ 85724, USA
    BMC Med Res Methodol 9:66. 2009
    ..The censoring could be dependent of risk of recurrence if the reasons of having early colonoscopy are associated with recurrence. This can complicate estimation of the recurrence rate...
  6. ncbi request reprint Fecal bile acid concentrations in a subpopulation of the wheat bran fiber colon polyp trial
    David S Alberts
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 12:197-200. 2003
    ..Thus, the inability of the high WBF intervention to reduce colorectal adenoma recurrence may be a consequence of its lack of effect on fecal aqueous-phase secondary bile acid concentrations...
  7. ncbi request reprint Randomized phase 3 trial of interferon gamma-1b plus standard carboplatin/paclitaxel versus carboplatin/paclitaxel alone for first-line treatment of advanced ovarian and primary peritoneal carcinomas: results from a prospectively designed analysis of prog
    David S Alberts
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Gynecol Oncol 109:174-81. 2008
    ..This trial was designed to evaluate IFN-gamma 1b plus carboplatin and paclitaxel in treatment-naive ovarian cancer (OC) and primary peritoneal carcinoma (PPC) patients...
  8. ncbi request reprint Randomized trial of adjuvant intraperitoneal alpha-interferon in stage III ovarian cancer patients who have no evidence of disease after primary surgery and chemotherapy: An intergroup study
    David S Alberts
    Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Gynecol Oncol 100:133-8. 2006
    ..Despite the improvement in progression-free and overall survival in patients with advanced ovarian cancer associated with platinum-taxane chemotherapy, strategies are needed to prevent the greater than 70% recurrence rate...
  9. ncbi request reprint Safety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin
    David Alberts
    Department of Medicine, Arizona Cancer Center, College of Medicine, College of Public Health, University of Arizona, Tucson, Arizona 85724 05024, USA
    Clin Cancer Res 10:1875-80. 2004
    ..We hypothesized that dose escalation of vitamin A to 50000 or 75000 IU/day would be both safe and more efficacious in skin cancer chemoprevention...
  10. ncbi request reprint Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence
    David S Alberts
    Department of Medicine, Arizona Cancer Center, College of Public Health, University of Arizona, Tucson, AZ, USA
    J Natl Cancer Inst 97:846-53. 2005
    ..We conducted a phase III, double-blind placebo-controlled trial of UDCA to evaluate its ability to prevent colorectal adenoma recurrence...
  11. pmc Randomized trial of pegylated liposomal doxorubicin (PLD) plus carboplatin versus carboplatin in platinum-sensitive (PS) patients with recurrent epithelial ovarian or peritoneal carcinoma after failure of initial platinum-based chemotherapy (Southwest Onc
    David S Alberts
    University of Arizona Cancer Center, Tucson, AZ 85724 5024, USA
    Gynecol Oncol 108:90-4. 2008
    ....
  12. ncbi request reprint Long-term follow-up of a phase II trial of oral altretamine for consolidation of clinical complete remission in women with stage III epithelial ovarian cancer in the Southwest Oncology Group
    D S Alberts
    University of Arizona Cancer Center, 1515 North Campbell Avenue, PO Box 245024, Tucson, AZ 85724 5024, USA
    Int J Gynecol Cancer 14:224-8. 2004
    ....
  13. ncbi request reprint Karyometry of the colonic mucosa
    David S Alberts
    Arizona Cancer Center, College of Medicine, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 16:2704-16. 2007
    ..The study summarizes results of karyometric measurements in epithelial cells of the colorectal mucosa to document evidence of a field effect of preneoplastic development among patients with colorectal adenocarcinoma or adenoma...
  14. pmc Proceedings of a GOG workshop on intraperitoneal therapy for ovarian cancer
    D S Alberts
    University of Arizona, Arizona Cancer Center, 1515 N Campbell Avenue, POB 245024, Tucson, AZ 85724 5024, and Case Western Reserve University Hospital, USA
    Gynecol Oncol 103:783-92. 2006
    ..The proceedings of this workshop summarize both research trial results and practical implementation issues associated with intraperitoneal therapy discussed at this workshop...
  15. ncbi request reprint Phase II trial of imatinib mesylate in recurrent, biomarker positive, ovarian cancer (Southwest Oncology Group Protocol S0211)
    D S Alberts
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724 5024, USA
    Int J Gynecol Cancer 17:784-8. 2007
    ..We conclude that imatinib mesylate as a single agent does not appear to have useful clinical activity in c-Kit and/or PDGFR positive, recurrent ovarian cancer in heavily pretreated patients with ovarian cancer...
  16. ncbi request reprint Maximizing the delivery of intraperitoneal therapy while minimizing drug toxicity and maintaining quality of life
    David S Alberts
    Arizona Cancer Center, Tucson, AZ 85274, USA
    Semin Oncol 33:S8-17. 2006
    ..Mitigating drug toxicities with the use of cytoprotectants such as amifostine and preventing infection with the use of agents, such as amifostine and pegfilgrastim, are discussed in detail...
  17. ncbi request reprint Phase I pharmacokinetic trial and correlative in vitro phase II tumor kinetic study of Apomine (SR-45023A), a novel oral biphosphonate anticancer drug
    D S Alberts
    Section of Hematology and Oncology, College of Medicine, University of Arizona, Tucson, Arizona, USA
    Clin Cancer Res 7:1246-50. 2001
    ..To study the human pharmacokinetics and in vitro cytotoxicity of Apomine, an p.o. administered, nonmyelosuppressive agent that selectively inhibits cell proliferation and induces tumor cell apoptosis through the farnesoid X receptor...
  18. ncbi request reprint Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine
    D S Alberts
    Arizona Cancer Center, University of Arizona, Tucson 85724, USA
    Cancer Epidemiol Biomarkers Prev 9:1281-6. 2000
    ..Topical DFMO for 6 months can reduce the number of AK lesions and skin spermidine concentrations in high-risk participants and deserves additional study as a skin cancer chemopreventive agent...
  19. ncbi request reprint Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network
    D S Alberts
    Arizona Cancer Center, Department of Medicine, University of Arizona, Tucson 85724 5024, USA
    N Engl J Med 342:1156-62. 2000
    ..We conducted a randomized trial to determine whether dietary supplementation with wheat-bran fiber reduces the rate of recurrence of colorectal adenomas...
  20. ncbi request reprint In vitro phase II comparison of the cytotoxicity of a novel platinum analog, nedaplatin (254-S), with that of cisplatin and carboplatin against fresh, human ovarian cancers
    D S Alberts
    Department of Medicine, University of Arizona, College of Medicine, Tucson 85724, USA
    Cancer Chemother Pharmacol 39:493-7. 1997
    ..To compare the in vitro cytotoxicity of nedaplatin, an investigational platinum analog, with that of the standard platinum agents, cisplatin and carboplatin, against fresh human, epithelial ovarian cancers...
  21. ncbi request reprint Karyometry in rectal mucosa of patients with previous colorectal adenomas
    James Ranger-Moore
    Department of Public Health and Optical Sciences Center, University of Arizona, Tucson, Arizona 85724, USA
    Anal Quant Cytol Histol 27:134-42. 2005
    ..To determine whether karyometric measurements taken in biopsies from histologically normal-appearing rectal mucosa could serve as a biomarker for the risk of recurrence of polyps...
  22. pmc Progression of skin lesions from normal skin to squamous cell carcinoma
    Robert S Krouse
    Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona, USA
    Anal Quant Cytol Histol 31:17-25. 2009
    ..To assess the changes in the nuclear chromatin pattern concomitant with progressive sun damage in skin biopsies ranging from sun-exposed, normal-appearing skin to squamous cell carcinoma (SCC)...
  23. ncbi request reprint Second order discriminant analysis in chemopreventive efficacy measurement
    Peter H Bartels
    Department of Medicine, Optical Sciences Center, University of Arizona, Tucson, Arizona 85721, USA
    Anal Quant Cytol Histol 27:15-26. 2005
    ....
  24. ncbi request reprint Skin cancer chemoprevention: strategies to save our skin
    Janine G Einspahr
    Arizona Cancer Center, University of Arizona, P O Box 245024, Tucson, AZ 85724, USA
    Recent Results Cancer Res 163:151-64; discussion 264-6. 2003
    ..Our goal is to develop agents for use in combination and/or incorporation into sunscreens to improve chemoprevention efficacy and reduce skin cancer incidence...
  25. pmc Knowledge discovery processing and data mining in karyometry
    Peter H Bartels
    College of Optical Sciences and Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724 5024, USA
    Anal Quant Cytol Histol 31:125-36. 2009
    ..To present the rationale for applying different sequences of multivariate analysis algorithms to determine if and where, in the large and high-dimensional data space, events have led to change in karyometric features...
  26. pmc Chemopreventive efficacy of topical difluoromethylornithine and/or triamcinolone in the treatment of actinic keratoses analyzed by karyometry
    Peter Bartels
    College of Optical Sciences, University of Arizona, Tucson, Arizona 85724 5024, USA
    Anal Quant Cytol Histol 31:355-66. 2009
    ..To determine whether low-dose topical applications of difluoromethylornithine (DFMO) with or without Triamcinolone (Fougena, Melville, New York, U.S.A.) to moderately sun-damaged skin with actinic skin keratoses are efficacious...
  27. ncbi request reprint Role of pegylated liposomal doxorubicin in ovarian cancer
    J Tate Thigpen
    Division of Oncology, Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Gynecol Oncol 96:10-8. 2005
    ..The plethora of agents currently available present difficult choices for physicians. The present effort seeks to examine the role of one of these agents, pegylated liposomal doxorubicin...
  28. pmc Physical activity as a determinant of fecal bile acid levels
    Betsy C Wertheim
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 18:1591-8. 2009
    ..However, this effect may be limited to individuals with lower triglyceride levels...
  29. ncbi request reprint Karyometry of nuclei from actinic keratosis and squamous cell cancer of the skin
    James Ranger-Moore
    College of Public Health, Arizona Cancer Center, University of Arizona, Tucson, AZ 85721, USA
    Anal Quant Cytol Histol 25:353-61. 2003
    ....
  30. ncbi request reprint Reliability and validity of a histologic score as a marker for skin cancer chemoprevention studies
    Paul Bozzo
    Arizona Cancer Center, Departments of Pathology and Medicine, University of Arizona, P O Box 245024, Tucson, Arizona 85724 5024, USA
    Anal Quant Cytol Histol 25:285-92. 2003
    ..To develop a reliable and valid scoring system for grading skin biopsies from actinic keratosis (AK) and sun-damaged skin for use in evaluating the efficacy of skin cancer chemopreventive agents...
  31. ncbi request reprint Karyometry in endometrial adenocarcinoma of different grades
    Francisco A R Garcia
    Arizona Cancer Center, Optical Sciences Center, Department of Pathology, University of Arizona, Tucson 85721, USA
    Anal Quant Cytol Histol 24:93-102. 2002
    ..To characterize nuclei from adenocarcinoma of the endometrium of different grades in order to establish whether significantly different nuclear subpopulations exist...
  32. pmc Limits of detection of chemopreventive efficacy: karyometry of skin biopsies
    Peter H Bartels
    College of Optical Sciences and Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 17:1689-95. 2008
    ..This study was designed to establish estimates of the smallest effects due to chemopreventive intervention detectable by karyometry in skin biopsies...
  33. pmc Using optical coherence tomography to evaluate skin sun damage and precancer
    Vrushali R Korde
    College of Optical Sciences, The University of Arizona, Tucson, Arizona 85721, USA
    Lasers Surg Med 39:687-95. 2007
    ..Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK)...
  34. pmc A pooled analysis of advanced colorectal neoplasia diagnoses after colonoscopic polypectomy
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Gastroenterology 136:832-41. 2009
    ..Limited data exist regarding the actual risk of developing advanced adenomas and cancer after polypectomy or the factors that determine risk...
  35. ncbi request reprint Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression
    A C Goulet
    Department of Pathology, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Biol Ther 2:713-8. 2003
    ..Collectively, these data suggest that COX-2 may play a functional role in metastases of melanoma, and treatment with COX-2 inhibitors may be efficacious for malignant melanoma...
  36. ncbi request reprint Statistical analysis of chemopreventive efficacy of vitamin A in sun-exposed, normal skin
    Peter H Bartels
    Optical Sciences Center, University of Arizona, Tucson, USA
    Anal Quant Cytol Histol 24:185-97. 2002
    ..To develop numeric, statistically secured measures of chemopreventive efficacy and to derive procedures with high sensitivity of detection...
  37. ncbi request reprint Karyometry of breast epithelial cells acquired by random periareolar fine needle aspiration in women at high risk for breast cancer
    Peter H Bartels
    Optical Sciences Center, Division of Epidemiology and Biostatistics, Department of Medicine, University of Arizona, Tucson, Arizona, USA
    Anal Quant Cytol Histol 29:63-70. 2007
    ..To establish whether karyometry was likely to detect change in the proportion of abnormal cells in random periareolar fine needle aspiration (RPFNA) specimens from high-risk women in a 6-month prevention trial with an aromatase inhibitor...
  38. ncbi request reprint Prediction of the need for red cell transfusion in newly diagnosed ovarian cancer patients undergoing platinum-based treatment
    David Heddens
    Arizona Cancer Center, Tucson, AZ, USA
    Gynecol Oncol 86:239-43. 2002
    ..The objective of this study was to develop a predictive algorithm for the likelihood of red blood cell transfusion in women with ovarian cancer undergoing platinum-based chemotherapy...
  39. ncbi request reprint Intake of supplemental and total fiber and risk of colorectal adenoma recurrence in the wheat bran fiber trial
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 87516, USA
    Cancer Epidemiol Biomarkers Prev 11:906-14. 2002
    ....
  40. ncbi request reprint Carcinogenesis and the hypothesis of phylogenetic reversion
    Peter H Bartels
    Optical Sciences Center and Arizona Cancer Center, Division of Epidemiology and Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Anal Quant Cytol Histol 28:243-52. 2006
    ..Its use can monitor the impact of chemopreventive agents on the earliest events in progression to cancer...
  41. ncbi request reprint Development of a questionnaire and a database for assessing dietary d-limonene intake
    Iman A Hakim
    Arizona Cancer Center and College of Public Health, The University of Arizona, 1515 North Campbell Avenue, Tucson 85724, USA
    Public Health Nutr 5:939-45. 2002
    ..d-Limonene is a natural component of a variety of foods and beverages and is found mainly in citrus fruits. However, d-limonene is not assessed by any nationally available analysis database...
  42. doi request reprint Cross-validation of murine UV signal transduction pathways in human skin
    Janine G Einspahr
    Department of Medicine, University of Arizona, Tucson, AZ, USA
    Photochem Photobiol 84:463-76. 2008
    ..Validation of murine models in human skin will aid in development of effective skin cancer chemoprevention and prevention strategies...
  43. ncbi request reprint Modulation of human glutathione s-transferases by polyphenon e intervention
    H H Sherry Chow
    Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 16:1662-6. 2007
    ..We conducted this clinical study to determine the effect of repeated green tea polyphenol administration on a major group of detoxification enzymes, glutathione S-transferases (GST)...
  44. ncbi request reprint Adherence assessment using medication weight in a phase IIb clinical trial of difluoromethylornithine for the chemoprevention of skin cancer
    Lisa M Hess
    Arizona Cancer Center, University of Arizona, P O Box 245024, 1515 North Campbell Avenue, 2964A1 Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 14:2579-83. 2005
    ..This study evaluates the association between participant self-reported study diary records and the weight of the medication vessel at each study visit, in the setting of a phase IIb topical chemoprevention trial...
  45. pmc Association between body size and colorectal adenoma recurrence
    Elizabeth T Jacobs
    Mel and Enid Zuckerman Arizona College of Public Health, University of Arizona, Tucson, Arizona 85724 5024, USA
    Clin Gastroenterol Hepatol 5:982-90. 2007
    ..Therefore, we sought to evaluate the effect of anthropometric measures of obesity on adenoma after polypectomy...
  46. ncbi request reprint Fatty acid composition of red blood cell membranes and risk of squamous cell carcinoma of the skin
    Robin B Harris
    Division of Cancer Prevention and Control, Arizona Cancer Center, P O Box 245024, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 14:906-12. 2005
    ..49; 95% CI, 0.30-0.81) were associated with reduced SCC risk. More studies are needed to elucidate the function of RBC fatty acids so that recommendations can be made to alter the human diet for cancer prevention...
  47. ncbi request reprint Risk group, skin lesion history, and sun sensitivity reliability in squamous cell skin cancer progression
    Mary C Clouser
    Mel and Enid Zuckerman College of Public Health, University of Arizona, 1430 East Fort Lowell, Suite 301, Tucson, AZ 85719, USA
    Cancer Epidemiol Biomarkers Prev 15:2292-7. 2006
    ..In all comparisons, women had higher kappa values than men. These results suggest that self-reported measures of skin cancer risk are reasonably reliable for use in screening subjects into studies...
  48. pmc Serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    J Steroid Biochem Mol Biol 103:752-6. 2007
    ..In summary, the results of this study show a moderate, nonsignificant inverse association between serum 25(OH)D levels and reduced risk for colorectal adenoma recurrence, particularly among women...
  49. ncbi request reprint Meat intake, preparation methods, mutagens and colorectal adenoma recurrence
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Carcinogenesis 28:2019-27. 2007
    ..07-2.82) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (OR = 1.68; 95% CI = 1.03-2.75). Our results support a meat mutagen exposure hypothesis as a potential mechanism for recurrence of clinically significant adenomatous polyps...
  50. ncbi request reprint Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals
    H H Sherry Chow
    Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Clin Cancer Res 11:4627-33. 2005
    ..We conducted this clinical study to test the hypothesis that the oral bioavailability of green tea catechins can be enhanced when consumed in the absence of food...
  51. ncbi request reprint Fiber, sex, and colorectal adenoma: results of a pooled analysis
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Am J Clin Nutr 83:343-9. 2006
    ..Evidence for an association between dietary fiber and colorectal neoplasia has been equivocal, and some data suggest that there may be sex differences in response to fiber...
  52. ncbi request reprint Karyometry of infiltrating breast lesions
    Denise H Frank
    Department of Medicine, Optical Sciences Center, University of Arizona, Tucson, Arizona 85724 5024, USA
    Anal Quant Cytol Histol 27:195-201. 2005
    ..To characterize nuclei from well-differentiated, moderately differentiated and poorly differentiated lesions of invasive breast cancer by karyometry and to test the hypothesis that these diagnostic categories form homogeneous sets...
  53. ncbi request reprint Folate fortification, plasma folate, homocysteine and colorectal adenoma recurrence
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Int J Cancer 119:1440-6. 2006
    ..Our finding, suggesting that multivitamins or supplemental folate only benefit individuals with lower plasma folate concentrations, should be taken into consideration when designing and interpreting results of intervention studies...
  54. ncbi request reprint Preneoplastic changes in ovarian tissues
    Molly A Brewer
    Department of Obstetrics and Gynecology, Arizona Cancer Center, Tucson, Arizona 85724 5024, USA
    Anal Quant Cytol Histol 26:207-16. 2004
    ..To test whether histologically normal epithelium within ovarian inclusion cysts and stroma exhibit changes in nuclear chromatin pattern that indicate the presence of occult ovarian lesions...
  55. ncbi request reprint Determination of celecoxib in human plasma using solid-phase extraction and high-performance liquid chromatography
    H H Sherry Chow
    Arizona Cancer Center, The University of Arizona, 1515 N Campbell Avenue, Tucson, AZ 85724 5024, USA
    J Pharm Biomed Anal 34:167-74. 2004
    ..S.D. for the assay was less than 12 and 5%, respectively. This assay has been applied to the analysis of celecoxib levels in plasma samples collected from healthy participants entered into a Phase II clinical study...
  56. pmc Overexpression of tumor vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer
    Setsuko K Chambers
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724 5024, USA
    Clin Cancer Res 16:5320-8. 2010
    ..This phase II trial evaluated bevacizumab plus erlotinib in platinum-resistant ovarian cancer; exploratory biomarker analyses, including that of tumor vascular endothelial growth factor A (VEGF-A), were also done...
  57. ncbi request reprint Current application of selective COX-2 inhibitors in cancer prevention and treatment
    M Suzanne Stratton
    Arizona Cancer Center, Tucson 85719, USA
    Oncology (Williston Park) 16:37-51. 2002
    ..These COX-2 data have contributed to initiation of clinical trials testing COX-2 inhibitors for the chemoprevention of a wide variety of cancers that overexpress COX-2...
  58. ncbi request reprint Association between Cyclooxygenase expression and colorectal adenoma characteristics
    Janine G Einspahr
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Res 63:3891-3. 2003
    ....
  59. pmc Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene
    Maria Elena Martinez
    Arizona Cancer Center, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 100:7859-64. 2003
    ....
  60. ncbi request reprint Nutrition and diet in the development of gastrointestinal cancer
    Cynthia A Thomson
    Arizona Cancer Center, University of Arizona, 1515 N Campbell Avenue, PO Box 245024, Tucson, AZ 85724 5024, USA
    Curr Oncol Rep 5:192-202. 2003
    ..Finally, the evidence for a relationship between pancreatic cancer and diet remains sparse and warrants additional investigation...
  61. ncbi request reprint Reducing the risk of colorectal cancer by intervening in the process of carcinogenesis: a status report
    David S Alberts
    Cancer Prevention and Control, Arizona Cancer Center, University of Arizona, Tucson 85724, USA
    Cancer J 8:208-21. 2002
    ..Celecoxib has been approved for the management of familial adenomatous polyposis and is under investigation for the management of sporadic colorectal polyps and for its potential as a chemopreventive agent for other cancers...
  62. pmc Gender modifies the effect of ursodeoxycholic acid in a randomized controlled trial in colorectal adenoma patients
    Patricia A Thompson
    Arizona Cancer Center, 1515 North Campbell Avenue, P O Box 245024, Tucson, AZ 85724, USA
    Cancer Prev Res (Phila) 2:1023-30. 2009
    ..We re-evaluated the effect of UDCA in men and women separately, based on sex-specific differences in bile acid metabolism and suspected variation in etiologic factors contributing to colorectal cancer risk...
  63. pmc Sulindac and sulindac metabolites in nipple aspirate fluid and effect on drug targets in a phase I trial
    Patricia A Thompson
    Arizona Cancer Center, University of Arizona, Tucson, 85724 5024, USA
    Cancer Prev Res (Phila) 3:101-7. 2010
    ..038). These results are the first to show partitioning of sulindac and metabolites to human breast tissue and the first evidence for a potential dose-dependent effect of sulindac on growth differentiation factor 15 levels in NAF...
  64. pmc A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer
    Steven P Stratton
    Department of Medicine, University of Arizona, Tucson, 85724, USA
    Cancer Prev Res (Phila) 3:160-9. 2010
    ..These results suggest that whereas our karyometric analyses can detect a modest effect of POH in sun-damaged skin, improved delivery into the epidermis may be necessary...
  65. doi request reprint Digital image analysis of breast epithelial cells collected by random periareolar fine-needle aspirates (RPFNA) from women at high risk for breast cancer taking hormone replacement and the aromatase inhibitor, letrozole, for six months
    Denise H Frank
    University of Arizona, Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
    Breast Cancer Res Treat 115:661-8. 2009
    ..Correlation with long term clinical outcome is needed to validate meaningful combinations of informative biomarkers...
  66. ncbi request reprint Accuracy of self-reported smoking status among participants in a chemoprevention trial
    Maria Elena Martinez
    Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Prev Med 38:492-7. 2004
    ..Degree of misreporting among participants in chemoprevention trials is unknown. We assessed the level of discrepancy between self-reported smoking exposure and plasma cotinine among participants in a chemoprevention trial...
  67. ncbi request reprint Chemoprevention of human skin cancer
    Janine G Einspahr
    Arizona Cancer Center, University of Arizona, 1515, North Campbell Avenue, Tucson 85724, USA
    Crit Rev Oncol Hematol 41:269-85. 2002
    ....
  68. pmc Dose response of retinol and isotretinoin in the prevention of nonmelanoma skin cancer recurrence
    Mary C Clouser
    Mel and Enid Zuckerman College of Public Health, Tucson, Arizona, USA
    Nutr Cancer 62:1058-66. 2010
    ..These analyses confirm the results of the original intent to treat analyses and raise an interesting question related to the potential for increased risk for patients in the first quartile of retinol dose...
  69. ncbi request reprint Longitudinal changes in body weight and body composition among women previously treated for breast cancer consuming a high-vegetable, fruit and fiber, low-fat diet
    Cynthia A Thomson
    Dept of Nutritional Sciences, The University of Arizona, Tucson, AZ 85721 0038, USA
    Eur J Nutr 44:18-25. 2005
    ..Whether a plant-based diet without specific energy goals will result in weight loss or changes in body composition in women who have been diagnosed with breast cancer has not been fully explored...
  70. ncbi request reprint Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer
    Steven P Stratton
    Arizona Cancer Center and Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    Nutr Cancer 60:325-30. 2008
    ..However, there was no significant difference between lesions appearing on the POH treated forearm vs. the placebo-treated forearm...
  71. pmc Factors associated with osteonecrosis of the jaw among bisphosphonate users
    Lisa M Hess
    College of Medicine, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Am J Med 121:475-483.e3. 2008
    ..It is unclear if the risk factors associated with osteonecrosis of the jaw among cancer patients taking bisphosphonates also are possible risk factors among patients receiving these medications for other indications...
  72. ncbi request reprint Karyometric analysis of actinic damage in unexposed and sun-exposed skin and in actinic keratoses in untreated individuals
    James Ranger-Moore
    Arizona Cancer Center, University of Arizona, 1515 North Campbell Avenue, P O Box 245024, Tucson, Arizona 85724 05024, USA
    Anal Quant Cytol Histol 26:155-65. 2004
    ..To assess the ability of karyometric analysis to demonstrate progression of actinic damage as a function of sun exposure in individuals with actinic keratoses (AKs) and to evaluate the stability of that assessment over a 3-month period...
  73. pmc Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics
    Janine G Einspahr
    Department of Medicine, Arizona Cancer Center, P O Box 245024, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 15:1443-50. 2006
    ....
  74. ncbi request reprint Strategies for skin cancer prevention
    Robin B Harris
    Division of Cancer Prevention and Control, Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Int J Dermatol 43:243-51. 2004
  75. ncbi request reprint Dietary change in an intervention trial of wheat bran fiber and colorectal adenoma recurrence
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724 5024, USA
    Ann Epidemiol 14:280-6. 2004
    ..The objectives of this study were to determine whether participants in the Wheat Bran Fiber (WBF) trial exhibited changes in diet over time, and whether these changes were differential by assigned treatment group...
  76. pmc Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study
    H H Sherry Chow
    Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA
    Cancer Prev Res (Phila) 3:1168-75. 2010
    ..Further clinical development of resveratrol for cancer prevention should consider evaluation of lower doses of resveratrol to minimize adverse metabolic drug interactions...
  77. pmc Chemoprevention of human actinic keratoses by topical DL-alpha-tocopherol
    Janet A Foote
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Cancer Prev Res (Phila) 2:394-400. 2009
    ....
  78. pmc Analysis of colorectal adenoma recurrence data subject to informative censoring
    Chiu Hsieh Hsu
    Arizona Cancer Center, College of Medicine, University of Arizona, PO Box 245024, 1515 N Campbell, Tucson, AZ 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 18:712-7. 2009
    ..The method described here is illustrated with an example from a colon polyp prevention study...
  79. pmc Vitamin D insufficiency in southern Arizona
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Am J Clin Nutr 87:608-13. 2008
    ..Vitamin D deficiency or insufficiency has been observed among populations in the northern United States. However, data on the prevalence of vitamin D deficiency in areas of high sun exposure, such as Arizona, are limited...
  80. doi request reprint Plasma insulin-like growth factor I is inversely associated with colorectal adenoma recurrence: a novel hypothesis
    Elizabeth T Jacobs
    Arizona Cancer Center, Arizona College of Public Health, University of Arizona P O Box 245024, Tucson, AZ 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 17:300-5. 2008
    ..02) than for nonadvanced recurrence (P(trend) = 0.10). These results suggest that, once an adenoma is removed, higher IGF-I levels reduce the odds of the formation of new lesions in the colorectum...
  81. ncbi request reprint Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression
    Janine G Einspahr
    Department of Medicine, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Cancer 110:2519-27. 2007
    ..Tumor angiogenesis likely plays a critical role in early development of melanoma, and intermediate biomarkers of angiogenesis could be useful as chemoprevention and prognostic markers...
  82. ncbi request reprint Effects of repeated green tea catechin administration on human cytochrome P450 activity
    H H Sherry Chow
    Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 15:2473-6. 2006
    ..We conducted this clinical study to determine the effect of repeated green tea catechin administration on human cytochrome P450 (CYP) enzyme activities...
  83. ncbi request reprint Calcium, vitamin D, and risk of adenoma recurrence (United States)
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson 85724 4024, USA
    Cancer Causes Control 13:213-20. 2002
    ..We investigated the role of dietary and supplemental sources of calcium and vitamin D in the etiology of adenoma recurrence...
  84. ncbi request reprint Baseline dietary fiber intake and colorectal adenoma recurrence in the wheat bran fiber randomized trial
    Elizabeth T Jacobs
    Arizona Cancer Center and Nutritional Sciences Interdisciplinary Program, University of Arizona, Tucson 85716, USA
    J Natl Cancer Inst 94:1620-5. 2002
    ..Therefore, we examined whether baseline fiber intake affected colorectal adenoma recurrence or modified the effect of treatment group in the WBF trial participants...
  85. ncbi request reprint Effects of a high-selenium yeast supplement on celecoxib plasma levels: a randomized phase II trial
    Denise H Frank
    Arizona Cancer Center, and Section of Hematology and Oncology, Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Epidemiol Biomarkers Prev 13:299-303. 2004
    ..In future Phase III chemoprevention trials of celecoxib, weight gain should be carefully monitored, and participants should be made aware of this potential side effect before study entry...
  86. ncbi request reprint Karyometric image analysis for intraepithelial and invasive cervical lesions
    Francisco A Garcia
    Division of Gynecology, Department of Obstetrics and Gynecology, University of Arizona, Tucson, Arizona 85721
    Anal Quant Cytol Histol 26:141-50. 2004
    ..To derive an objective, numeric measure for the progression of intraepithelial and invasive squamous cell cervical lesions...
  87. ncbi request reprint Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers
    Robert T Dorr
    Department of Medicine, Cancer Center Division, University of Arizona, Tucson, AZ, USA
    Arch Dermatol 140:827-35. 2004
    ..Three phase 1 clinical trials of a superpotent melanotropic peptide, melanotan-1 (MT-1, or [Nle(4)-D-Phe(7)]alpha-melanocyte-stimulating hormone) were performed to demonstrate safety for MT-1 therapy combined with UV-B light or sunlight...
  88. ncbi request reprint Wheat bran fiber supplementation and bone loss among older people
    Zhao Chen
    Arizona Cancer Center, Tucson, USA
    Nutrition 20:747-51. 2004
    ..The purpose of this study was to investigate the effect of wheat bran fiber (WBF) supplementation on bone loss in older people...
  89. ncbi request reprint Selenium and colorectal adenoma: results of a pooled analysis
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, P O Box 245024, Tucson, AZ 85724 5024, USA
    J Natl Cancer Inst 96:1669-75. 2004
    ..Secondary analyses of data from a large randomized clinical trial have suggested that intake of the trace element selenium reduces risk of colorectal neoplasia, but epidemiologic studies have not shown a consistent protective association...
  90. ncbi request reprint Exploratory study of ovarian intraepithelial neoplasia
    Molly A Brewer
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Arizona Cancer Center, Room 1968G, 1515 North Campbell Avenue, Tucson, AZ 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 14:299-305. 2005
    ....
  91. ncbi request reprint Results of a phase I multiple-dose clinical study of ursodeoxycholic Acid
    Lisa M Hess
    Arizona Cancer Center, University of Arizona Health Sciences Center, 1515 North Campbell Avenue, POB 245024, Tucson, AZ 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 13:861-7. 2004
    ....
  92. ncbi request reprint Dietary factors and biomarkers involved in the methylenetetrahydrofolate reductase genotype-colorectal adenoma pathway
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Gastroenterology 131:1706-16. 2006
    ..We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal adenoma recurrence and conducted analyses to investigate their joint effects with plasma and dietary markers of folate status...
  93. ncbi request reprint Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer
    Janine G Einspahr
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Clin Cancer Res 8:149-55. 2002
    ....
  94. ncbi request reprint Reproducibility and expression of skin biomarkers in sun-damaged skin and actinic keratoses
    Janine G Einspahr
    Department of Medicine, College of Public Health, University of Arizona, Tucson, AZ, USA
    Cancer Epidemiol Biomarkers Prev 15:1841-8. 2006
    ..To explore p53 and proliferating cell nuclear antigen (PCNA) expression and polyamine content as biomarkers in skin cancer chemoprevention trials, we evaluated their expression in early stages of UV-induced squamous cell tumorigenesis...
  95. ncbi request reprint Diet and biomarkers of oxidative damage in women previously treated for breast cancer
    Cynthia A Thomson
    Department of Nutritional Sciences, The University of Arizona, Tucson 85721 0038, USA
    Nutr Cancer 51:146-54. 2005
    ..The results of this nested case-controlled study provide potential mechanisms by which a high fruit and vegetable, low-fat diet might reduce the recurrence rate of or early-stage breast cancer...
  96. ncbi request reprint Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis
    Warner B Bair
    Department of Radiation Oncology, The University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Cancer Epidemiol Biomarkers Prev 11:1645-52. 2002
    ....
  97. ncbi request reprint Correlation of p53 immunostaining in primary and residual ovarian cancer at the time of positive second-look laparotomy and its prognostic role: a Southwest Oncology Group ancillary study
    Debra Hawes
    University of Southern California, Los Angeles, CA 90033, USA
    Gynecol Oncol 87:17-23. 2002
    ....
  98. ncbi request reprint Paclitaxel and carboplatin with amifostine in advanced, recurrent, or refractory endometrial adenocarcinoma: a phase II study of the Southwest Oncology Group
    Sidney A Scudder
    University of California Davis Medical Center, Sacramento, CA 95817, USA
    Gynecol Oncol 96:610-5. 2005
    ..To evaluate the toxicity of amifostine when used in combination with carboplatin and paclitaxel...
  99. ncbi request reprint Intraperitoneal therapy for stage III ovarian cancer: a therapy whose time has come!
    David S Alberts
    J Clin Oncol 20:3944-6. 2002
  100. ncbi request reprint Selenium supplementation and colorectal adenomas: an analysis of the nutritional prevention of cancer trial
    Mary E Reid
    Department of Epidemiology, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 118:1777-81. 2006
    ....
  101. ncbi request reprint Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis
    John L Clifford
    Departments of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:2067-72. 2002
    ..Our previous preliminary studies suggested suppression of some or all of the ISGF-3 proteins in skin SCC...

Research Grants8

  1. Colorectal Screening Capacity Building Conference
    David Alberts; Fiscal Year: 2003
    ..Continued capacity building and future collaboration will also be woven into this conference to serve as a stone to build upon in the future. ..
  2. CANCER PREVENTION AND CONTROL TRAINING GRANT
    David Alberts; Fiscal Year: 2007
    ....
  3. Arizona Cancer Center Support Grant
    David Alberts; Fiscal Year: 2007
    ..The renewal outlined in this application is critical to keep us working to accomplish our mission. ..
  4. CANCER PREVENTION AND CONTROL TRAINING GRANT
    David Alberts; Fiscal Year: 2008
    ....
  5. CHEMOPREVENTION OF SKIN CANCER PROGRAM PROJECT
    David Alberts; Fiscal Year: 2008
    ..abstract_text> ..
  6. Arizona Cancer Center Support Grant
    David Alberts; Fiscal Year: 2007
    ..The renewal outlined in this application is critical to keep us working to accomplish our mission. ..
  7. Arizona Cancer Center Support Grant
    David Alberts; Fiscal Year: 2008
    ..The renewal outlined in this application is critical to keep us working to accomplish our mission. ..
  8. Arizona Cancer Center Support Grant
    David Alberts; Fiscal Year: 2008
    ..The renewal outlined in this application is critical to keep us working to accomplish our mission. ..