Affiliation: University of Utah
- Utility of large-animal models of BPD: chronically ventilated preterm lambsKurt H Albertine
Department of Pediatrics, University of Utah, School of Medicine, Salt Lake City, Utah Department of Medicine, University of Utah, School of Medicine, Salt Lake City, Utah and Department of Neurobiology and Anatomy, University of Utah, School of Medicine, Salt Lake City, Utah
Am J Physiol Lung Cell Mol Physiol 308:L983-L1001. 2015..The new insights that are being gained from our preterm lamb model may have important translational implications about the pathogenesis and treatment of BPD in preterm human infants. ..
- Progress in understanding the pathogenesis of BPD using the baboon and sheep modelsKurt H Albertine
Department of Pediatrics, University of Utah, School of Medicine, Salt Lake City, UT 84158 1289, USA
Semin Perinatol 37:60-8. 2013..The models' are valuable because they contribute to better understanding of the underlying molecular pathogenic mechanisms. An epigenetic hypothesis is proposed as a pathogenic mechanism for BPD and its persistent pulmonary morbidities...
- Brain injury in chronically ventilated preterm neonates: collateral damage related to ventilation strategyKurt H Albertine
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158, USA
Clin Perinatol 39:727-40. 2012..Evidence is introduced from the 2 large-animal, physiologic models of evolving neonatal chronic lung disease that suggest that an epigenetic mechanism may underlie the collateral damage...
- Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarizationKurt H Albertine
Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84158, USA
Am J Physiol Lung Cell Mol Physiol 299:L59-72. 2010..We conclude that vitamin A treatment partially improves lung development in chronically ventilated preterm neonates by modulating expression of tropoelastin, deposition of elastin, and expression of vascular growth factors...
- Nasal ventilation alters mesenchymal cell turnover and improves alveolarization in preterm lambsBrent Reyburn
Department of Pediatrics, Division of Neonatology, University of Utah Health Sciences Center, Williams Building, PO Box 581289, Salt Lake City, UT 84158, USA
Am J Respir Crit Care Med 178:407-18. 2008..In normally developing lungs, by comparison, remodeling of the immature parenchymal architecture is characterized by thinning of the future alveolar walls, a process predicated on cell loss through apoptosis...
- Analysis of cell type and radiographic presentation as predictors of the clinical course of patients with bronchioalveolar cell carcinomaK H Albertine
Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA
Chest 113:997-1006. 1998....
- DNA oxidation or apoptosis: will the real culprit of dna damage in hyperoxic lung injury please stand up?Kurt H Albertine
Department of Pediatrics, University of Utah, Salt Lake City, Utah 84143 2202, USA
Am J Respir Cell Mol Biol 26:381-3. 2002
- Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndromeKurt H Albertine
Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City 84132, USA
Am J Pathol 161:1783-96. 2002....
- Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung diseaseRichard D Bland
Department of Pediatrics, Stanford University School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Drive, Stanford, CA 94305 5162, USA
Am J Physiol Lung Cell Mol Physiol 292:L1370-84. 2007..These changes, coupled with increased lung elastase activity measured in preterm lambs after MV for 1-3 days, likely contribute to CLD...
- Pulmonary vascular dysfunction in preterm lambs with chronic lung diseaseRichard D Bland
Department of Pediatrics, Stanford University School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Dr, Stanford, CA 94305 5162, USA
Am J Physiol Lung Cell Mol Physiol 285:L76-85. 2003....
- Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambsRichard D Bland
Department of Pediatrics, Stanford University School of Medicine, CCSR Building, Room 1225, 269 Campus Drive, Stanford, CA 94305 5162, USA
Am J Respir Crit Care Med 172:899-906. 2005..Inhaled nitric oxide (iNO) can reverse neonatal pulmonary hypertension and bronchoconstriction and reduce proliferation of cultured arterial and airway smooth muscle cells...
- Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung diseaseDonald C McCurnin
Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA
Am J Physiol Lung Cell Mol Physiol 288:L450-9. 2005..Thus, in the baboon model of CLD, iNO improves early pulmonary function and alters lung growth and extracellular matrix deposition. As such, NO biosynthetic pathway dysfunction may contribute to the pathogenesis of CLD...
- Impaired alveolar development and abnormal lung elastin in preterm lambs with chronic lung injury: potential benefits of retinol treatmentRichard D Bland
Department of Pediatrics, Stanford University, Palo Alto, Calif, USA
Biol Neonate 84:101-2. 2003
- Urorectal septum malformation sequence: Insights into pathogenesisTeri Jo Mauch
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA
Anat Rec 268:405-10. 2002..We summarize the relevant literature and propose a molecular model for the pathogenesis of the URSMS, in which alterations in sonic hedgehog and homeobox genes lead to caudal mesodermal deficiency during blastogenesis...
- IUGR decreases PPARγ and SETD8 Expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementationLisa A Joss-Moore
University of Utah, Division of Neonatology, Salt Lake City, UT 84108, USA
Early Hum Dev 86:785-91. 2010..These outcomes are offset by maternal DHA. We speculate that maintenance of the epigenetic milieu may be one role of PPARγ in the lung and suggests a novel benefit of maternal DHA supplementation in IUGR...
- Novel application of a fibrin cell block method to evaluate melanocytic cell populationsScott R Florell
Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Pigment Cell Res 16:662-9. 2003..Preparation of a FCB followed by immunohistochemical staining is an easy and inexpensive way to confirm melanocytic lineage, estimate population purity, and provide a permanent archive of cultured cells...
- Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonatesChristian C Yost
Department of Pediatrics Neonatology, University of Utah, Salt Lake City, USA
Blood 113:6419-27. 2009..Impaired NET formation may be a critical facet of a common developmental immunodeficiency that predisposes newborn infants to infection...
- A methodology and implementation for annotating digital images for context-appropriate use in an academic health care environmentPatricia A Goede
Department of Radiology, University of Utah Health Sciences Center, Salt Lake City, UT 84132 2202, USA
J Am Med Inform Assoc 11:29-41. 2004..The annotation methodology is the foundation for a Windows implementation that allows annotated elements to be represented as structured eXtensible Markup Language and stored separate from the image(s)...
- Design and utility of a web-based computer-assisted instructional tool for neuroanatomy self-study and review for physical and occupational therapy graduate studentsK Bo Foreman
Division of Physical and Occupational Therapy at The University of Utah, College of Health, UT, USA
Anat Rec B New Anat 285:26-31. 2005..We conclude that the design of a CAI tool, with minimal limitations, provides a useful ancillary tool for human neuroanatomy instruction...
- TK3 eBook software to author, distribute, and use electronic course content for medical educationDavid A Morton
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Adv Physiol Educ 31:55-61. 2007..In conclusion, the present study demonstrated that eBooks provide a convenient method for authoring, distributing, and using course content but that students preferred paper to take notes during lecture...
- Characterization of bleomycin lung injury by nuclear magnetic resonance: correlation between NMR relaxation times and lung water and collagen contentAntonio G Cutillo
Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
Magn Reson Med 47:246-56. 2002..CPMG-T(2) and Hahn-T(2) measurements can be valuable as a potentially noninvasive method for characterizing bleomycin-induced lung injury and pathologically related lung disorders...
- Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lungDonald McCurnin
Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA
Pediatrics 121:945-56. 2008..The goal was to study the pulmonary, biochemical, and morphologic effects of a persistent patent ductus arteriosus in a preterm baboon model of bronchopulmonary dysplasia...
- Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung developmentShibin Yu
Department of Pediatrics, University of Utah, Salt Lake City, UT 84112, USA
Dev Biol 347:92-108. 2010....
- Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiencyXingrao Ke
Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, 30 North 1900 East, Rm 2A100, Salt Lake City, UT 84132 2202, USA
Am J Physiol Regul Integr Comp Physiol 288:R1038-45. 2005....
- Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary densityAlfred P McQueen
Division of Cardiology, The University of Utah, Salt Lake City, UT, USA
J Mol Cell Cardiol 39:882-92. 2005..Thus, absence of insulin receptor signaling in the cardiac myocyte worsens catecholamine-mediated myocardial injury, at least in part, via mechanisms that tend to impair myocardial blood flow and increase ischemic injury...
- Temporal correlation of measurements of airway hyperresponsiveness in ovalbumin-sensitized miceKurt H Albertine
Department of Pediatrics, University of Utah, Salt Lake City, Utah 84132 2202, USA
Am J Physiol Lung Cell Mol Physiol 283:L219-33. 2002..We conclude that, although ovalbumin treatment changed lung function in mice, correlation between noninvasive and invasive measures of peak airway hyperresponsiveness was inconsistent...
- mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human plateletsAndrew S Weyrich
Department of Internal Medicine, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Blood 109:1975-83. 2007....
- Vasculogenesis drives pulmonary vascular growth in the developing chick embryoAnn Anderson-Berry
Department of Pediatrics, University of Utah, School of Medicine, Salt Lake City, UT 84158, USA
Dev Dyn 233:145-53. 2005..Pulmonary blood vessel formation occurred continuously throughout the embryonic period studied. Our results show that vasculogenesis is the main process by which the pulmonary vasculature forms in the developing chick embryo...
- Endotoxin contamination of ovalbumin suppresses murine immunologic responses and development of airway hyper-reactivityJunji Watanabe
Department of Pathology, University of Utah, Salt Lake City, UT 84112 5330, USA
J Biol Chem 278:42361-8. 2003....
- Blunted hypoxic pulmonary vasoconstriction in experimental neonatal chronic lung diseaseGloria Juliana Rey-Parra
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Am J Respir Crit Care Med 178:399-406. 2008....
- Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activityJulie A Bastarache
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt Univ School of Medicine, T 1218 Medical Center North, Nashville, TN 37232 2650, USA
Am J Physiol Lung Cell Mol Physiol 294:L874-81. 2008..Levels of intra-alveolar TFPI in ARDS are not sufficient to block intra-alveolar TF procoagulant activity due to truncation and inactivation of intra-alveolar TFPI...
- Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal ratMan Yi
Lung Biology Programme, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
Am J Respir Crit Care Med 170:1188-96. 2004..These data suggest that exposure of the neonatal lung to moderate hyperoxia may enhance postnatal lung growth, provided postnatal pulmonary inflammation is suppressed...
- The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factorJulie A Bastarache
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, T1218 Medical Center North, Nashville, Tennessee 37232 2650, USA
Thorax 62:608-16. 2007..A study was undertaken to test the hypothesis that the alveolar epithelium can initiate intra-alveolar coagulation by expressing active tissue factor (TF)...
- Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndromeAkitoshi Ishizaka
Department of Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582 Japan
Am J Physiol Lung Cell Mol Physiol 286:L1088-94. 2004....
- The anatomical record: a tradition of reporting what is new about things that are very, very oldJeffrey T Laitman
Anat Rec A Discov Mol Cell Evol Biol 288:1121-2. 2006
- An exciting centennial year for The Anatomical RecordKurt H Albertine
Anat Rec (Hoboken) 290:141-4. 2007
- Stretch and Vitamin A Effects on Alveolar FormationKURT ALBERTINE; Fiscal Year: 2009..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..