KURT ALBERTINE

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Progress in understanding the pathogenesis of BPD using the baboon and sheep models
    Kurt H Albertine
    Department of Pediatrics, University of Utah, School of Medicine, Williams Building, P O Box 581289, Salt Lake City, UT 84158 1289 Department of Medicine, University of Utah, School of Medicine, Williams Building, P O Box 581289, Salt Lake City, UT 84158 1289 Department of Neurobiology and Anatomy, University of Utah, School of Medicine, Williams Building, P O Box 581289, Salt Lake City, UT 84158 1289 Electronic address
    Semin Perinatol 37:60-8. 2013
  2. pmc Brain injury in chronically ventilated preterm neonates: collateral damage related to ventilation strategy
    Kurt H Albertine
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158, USA
    Clin Perinatol 39:727-40. 2012
  3. pmc Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization
    Kurt H Albertine
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84158, USA
    Am J Physiol Lung Cell Mol Physiol 299:L59-72. 2010
  4. pmc Nasal ventilation alters mesenchymal cell turnover and improves alveolarization in preterm lambs
    Brent Reyburn
    Department of Pediatrics, Division of Neonatology, University of Utah Health Sciences Center, Williams Building, PO Box 581289, Salt Lake City, UT 84158, USA
    Am J Respir Crit Care Med 178:407-18. 2008
  5. ncbi request reprint Analysis of cell type and radiographic presentation as predictors of the clinical course of patients with bronchioalveolar cell carcinoma
    K H Albertine
    Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA
    Chest 113:997-1006. 1998
  6. pmc Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome
    Kurt H Albertine
    Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City 84132, USA
    Am J Pathol 161:1783-96. 2002
  7. ncbi request reprint DNA oxidation or apoptosis: will the real culprit of dna damage in hyperoxic lung injury please stand up?
    Kurt H Albertine
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84143 2202, USA
    Am J Respir Cell Mol Biol 26:381-3. 2002
  8. ncbi request reprint Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Drive, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1370-84. 2007
  9. ncbi request reprint Pulmonary vascular dysfunction in preterm lambs with chronic lung disease
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Dr, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 285:L76-85. 2003
  10. pmc Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Building, Room 1225, 269 Campus Drive, Stanford, CA 94305 5162, USA
    Am J Respir Crit Care Med 172:899-906. 2005

Research Grants

  1. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    KURT ALBERTINE; Fiscal Year: 2001
  2. VITAMIN A EFFECTS ON ALVEOLAR FORMATION
    KURT ALBERTINE; Fiscal Year: 2002
  3. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2009

Collaborators

Detail Information

Publications35

  1. pmc Progress in understanding the pathogenesis of BPD using the baboon and sheep models
    Kurt H Albertine
    Department of Pediatrics, University of Utah, School of Medicine, Williams Building, P O Box 581289, Salt Lake City, UT 84158 1289 Department of Medicine, University of Utah, School of Medicine, Williams Building, P O Box 581289, Salt Lake City, UT 84158 1289 Department of Neurobiology and Anatomy, University of Utah, School of Medicine, Williams Building, P O Box 581289, Salt Lake City, UT 84158 1289 Electronic address
    Semin Perinatol 37:60-8. 2013
    ..The models' are valuable because they contribute to better understanding of the underlying molecular pathogenic mechanisms. An epigenetic hypothesis is proposed as a pathogenic mechanism for BPD and its persistent pulmonary morbidities...
  2. pmc Brain injury in chronically ventilated preterm neonates: collateral damage related to ventilation strategy
    Kurt H Albertine
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158, USA
    Clin Perinatol 39:727-40. 2012
    ..Evidence is introduced from the 2 large-animal, physiologic models of evolving neonatal chronic lung disease that suggest that an epigenetic mechanism may underlie the collateral damage...
  3. pmc Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization
    Kurt H Albertine
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84158, USA
    Am J Physiol Lung Cell Mol Physiol 299:L59-72. 2010
    ..We conclude that vitamin A treatment partially improves lung development in chronically ventilated preterm neonates by modulating expression of tropoelastin, deposition of elastin, and expression of vascular growth factors...
  4. pmc Nasal ventilation alters mesenchymal cell turnover and improves alveolarization in preterm lambs
    Brent Reyburn
    Department of Pediatrics, Division of Neonatology, University of Utah Health Sciences Center, Williams Building, PO Box 581289, Salt Lake City, UT 84158, USA
    Am J Respir Crit Care Med 178:407-18. 2008
    ..In normally developing lungs, by comparison, remodeling of the immature parenchymal architecture is characterized by thinning of the future alveolar walls, a process predicated on cell loss through apoptosis...
  5. ncbi request reprint Analysis of cell type and radiographic presentation as predictors of the clinical course of patients with bronchioalveolar cell carcinoma
    K H Albertine
    Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA
    Chest 113:997-1006. 1998
    ....
  6. pmc Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome
    Kurt H Albertine
    Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City 84132, USA
    Am J Pathol 161:1783-96. 2002
    ....
  7. ncbi request reprint DNA oxidation or apoptosis: will the real culprit of dna damage in hyperoxic lung injury please stand up?
    Kurt H Albertine
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84143 2202, USA
    Am J Respir Cell Mol Biol 26:381-3. 2002
  8. ncbi request reprint Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Drive, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1370-84. 2007
    ..These changes, coupled with increased lung elastase activity measured in preterm lambs after MV for 1-3 days, likely contribute to CLD...
  9. ncbi request reprint Pulmonary vascular dysfunction in preterm lambs with chronic lung disease
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Bldg, Rm 1225, 269 Campus Dr, Stanford, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 285:L76-85. 2003
    ....
  10. pmc Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs
    Richard D Bland
    Department of Pediatrics, Stanford University School of Medicine, CCSR Building, Room 1225, 269 Campus Drive, Stanford, CA 94305 5162, USA
    Am J Respir Crit Care Med 172:899-906. 2005
    ..Inhaled nitric oxide (iNO) can reverse neonatal pulmonary hypertension and bronchoconstriction and reduce proliferation of cultured arterial and airway smooth muscle cells...
  11. ncbi request reprint Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease
    Donald C McCurnin
    Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA
    Am J Physiol Lung Cell Mol Physiol 288:L450-9. 2005
    ..Thus, in the baboon model of CLD, iNO improves early pulmonary function and alters lung growth and extracellular matrix deposition. As such, NO biosynthetic pathway dysfunction may contribute to the pathogenesis of CLD...
  12. ncbi request reprint Impaired alveolar development and abnormal lung elastin in preterm lambs with chronic lung injury: potential benefits of retinol treatment
    Richard D Bland
    Department of Pediatrics, Stanford University, Palo Alto, Calif, USA
    Biol Neonate 84:101-2. 2003
  13. ncbi request reprint Design and utility of a web-based computer-assisted instructional tool for neuroanatomy self-study and review for physical and occupational therapy graduate students
    K Bo Foreman
    Division of Physical and Occupational Therapy at The University of Utah, College of Health, UT, USA
    Anat Rec B New Anat 285:26-31. 2005
    ..We conclude that the design of a CAI tool, with minimal limitations, provides a useful ancillary tool for human neuroanatomy instruction...
  14. ncbi request reprint TK3 eBook software to author, distribute, and use electronic course content for medical education
    David A Morton
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Adv Physiol Educ 31:55-61. 2007
    ..In conclusion, the present study demonstrated that eBooks provide a convenient method for authoring, distributing, and using course content but that students preferred paper to take notes during lecture...
  15. pmc Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates
    Christian C Yost
    Department of Pediatrics Neonatology, University of Utah, Salt Lake City, USA
    Blood 113:6419-27. 2009
    ..Impaired NET formation may be a critical facet of a common developmental immunodeficiency that predisposes newborn infants to infection...
  16. pmc IUGR decreases PPARĪ³ and SETD8 Expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementation
    Lisa A Joss-Moore
    University of Utah, Division of Neonatology, Salt Lake City, UT 84108, USA
    Early Hum Dev 86:785-91. 2010
    ..These outcomes are offset by maternal DHA. We speculate that maintenance of the epigenetic milieu may be one role of PPARĪ³ in the lung and suggests a novel benefit of maternal DHA supplementation in IUGR...
  17. ncbi request reprint Characterization of bleomycin lung injury by nuclear magnetic resonance: correlation between NMR relaxation times and lung water and collagen content
    Antonio G Cutillo
    Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    Magn Reson Med 47:246-56. 2002
    ..CPMG-T(2) and Hahn-T(2) measurements can be valuable as a potentially noninvasive method for characterizing bleomycin-induced lung injury and pathologically related lung disorders...
  18. ncbi request reprint Urorectal septum malformation sequence: Insights into pathogenesis
    Teri Jo Mauch
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Anat Rec 268:405-10. 2002
    ..We summarize the relevant literature and propose a molecular model for the pathogenesis of the URSMS, in which alterations in sonic hedgehog and homeobox genes lead to caudal mesodermal deficiency during blastogenesis...
  19. pmc A methodology and implementation for annotating digital images for context-appropriate use in an academic health care environment
    Patricia A Goede
    Department of Radiology, University of Utah Health Sciences Center, Salt Lake City, UT 84132 2202, USA
    J Am Med Inform Assoc 11:29-41. 2004
    ..The annotation methodology is the foundation for a Windows implementation that allows annotated elements to be represented as structured eXtensible Markup Language and stored separate from the image(s)...
  20. ncbi request reprint Novel application of a fibrin cell block method to evaluate melanocytic cell populations
    Scott R Florell
    Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Pigment Cell Res 16:662-9. 2003
    ..Preparation of a FCB followed by immunohistochemical staining is an easy and inexpensive way to confirm melanocytic lineage, estimate population purity, and provide a permanent archive of cultured cells...
  21. doi request reprint Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung
    Donald McCurnin
    Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA
    Pediatrics 121:945-56. 2008
    ..The goal was to study the pulmonary, biochemical, and morphologic effects of a persistent patent ductus arteriosus in a preterm baboon model of bronchopulmonary dysplasia...
  22. doi request reprint Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development
    Shibin Yu
    Department of Pediatrics, University of Utah, Salt Lake City, UT 84112, USA
    Dev Biol 347:92-108. 2010
    ....
  23. ncbi request reprint Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiency
    Xingrao Ke
    Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, 30 North 1900 East, Rm 2A100, Salt Lake City, UT 84132 2202, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1038-45. 2005
    ....
  24. ncbi request reprint Endotoxin contamination of ovalbumin suppresses murine immunologic responses and development of airway hyper-reactivity
    Junji Watanabe
    Department of Pathology, University of Utah, Salt Lake City, UT 84112 5330, USA
    J Biol Chem 278:42361-8. 2003
    ....
  25. ncbi request reprint Temporal correlation of measurements of airway hyperresponsiveness in ovalbumin-sensitized mice
    Kurt H Albertine
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84132 2202, USA
    Am J Physiol Lung Cell Mol Physiol 283:L219-33. 2002
    ..We conclude that, although ovalbumin treatment changed lung function in mice, correlation between noninvasive and invasive measures of peak airway hyperresponsiveness was inconsistent...
  26. ncbi request reprint Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density
    Alfred P McQueen
    Division of Cardiology, The University of Utah, Salt Lake City, UT, USA
    J Mol Cell Cardiol 39:882-92. 2005
    ..Thus, absence of insulin receptor signaling in the cardiac myocyte worsens catecholamine-mediated myocardial injury, at least in part, via mechanisms that tend to impair myocardial blood flow and increase ischemic injury...
  27. ncbi request reprint Vasculogenesis drives pulmonary vascular growth in the developing chick embryo
    Ann Anderson-Berry
    Department of Pediatrics, University of Utah, School of Medicine, Salt Lake City, UT 84158, USA
    Dev Dyn 233:145-53. 2005
    ..Pulmonary blood vessel formation occurred continuously throughout the embryonic period studied. Our results show that vasculogenesis is the main process by which the pulmonary vasculature forms in the developing chick embryo...
  28. pmc mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets
    Andrew S Weyrich
    Department of Internal Medicine, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Blood 109:1975-83. 2007
    ....
  29. pmc Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt Univ School of Medicine, T 1218 Medical Center North, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 294:L874-81. 2008
    ..Levels of intra-alveolar TFPI in ARDS are not sufficient to block intra-alveolar TF procoagulant activity due to truncation and inactivation of intra-alveolar TFPI...
  30. pmc Blunted hypoxic pulmonary vasoconstriction in experimental neonatal chronic lung disease
    Gloria Juliana Rey-Parra
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Am J Respir Crit Care Med 178:399-406. 2008
    ....
  31. pmc The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor
    Julie A Bastarache
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, T1218 Medical Center North, Nashville, Tennessee 37232 2650, USA
    Thorax 62:608-16. 2007
    ..A study was undertaken to test the hypothesis that the alveolar epithelium can initiate intra-alveolar coagulation by expressing active tissue factor (TF)...
  32. ncbi request reprint Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat
    Man Yi
    Lung Biology Programme, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Am J Respir Crit Care Med 170:1188-96. 2004
    ..These data suggest that exposure of the neonatal lung to moderate hyperoxia may enhance postnatal lung growth, provided postnatal pulmonary inflammation is suppressed...
  33. ncbi request reprint Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome
    Akitoshi Ishizaka
    Department of Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582 Japan
    Am J Physiol Lung Cell Mol Physiol 286:L1088-94. 2004
    ....
  34. ncbi request reprint An exciting centennial year for The Anatomical Record
    Kurt H Albertine
    Anat Rec (Hoboken) 290:141-4. 2007
  35. ncbi request reprint The anatomical record: a tradition of reporting what is new about things that are very, very old
    Jeffrey T Laitman
    Anat Rec A Discov Mol Cell Evol Biol 288:1121-2. 2006

Research Grants9

  1. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    KURT ALBERTINE; Fiscal Year: 2001
    ....
  2. VITAMIN A EFFECTS ON ALVEOLAR FORMATION
    KURT ALBERTINE; Fiscal Year: 2002
    ..The experiments also should help establish the molecular basis for the potentially therapeutic benefit of retinoids. ..
  3. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2009
    ..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..