ELAINE ALARID

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc The proteasome inhibitor bortezomib induces an inhibitory chromatin environment at a distal enhancer of the estrogen receptor-α gene
    Ginny L Powers
    Department of Oncology, McArdle Laboratories for Cancer Research and University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 8:e81110. 2013
  2. pmc Proteasome inhibition represses ERalpha gene expression in ER+ cells: a new link between proteasome activity and estrogen signaling in breast cancer
    G L Powers
    Department of Oncology, University of Wisconsin Madison, Madison, WI 53705, USA
    Oncogene 29:1509-18. 2010
  3. pmc Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor
    Stephanie J Ellison-Zelski
    Department of Oncology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Cancer 9:263. 2010
  4. pmc Amping up estrogen receptors in breast cancer
    Amy M Fowler
    Department of Oncology, University of Wisconsin Madison, Madison, WI 53706, USA
    Breast Cancer Res 9:305. 2007
  5. pmc Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1
    Prashant Rajbhandari
    Department of Oncology and UW Carbone Comprehensive Cancer Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    Mol Cell Biol 32:445-57. 2012
  6. ncbi request reprint Thyroid hormone is an inhibitor of estrogen-induced degradation of estrogen receptor-alpha protein: estrogen-dependent proteolysis is not essential for receptor transactivation function in the pituitary
    Elaine T Alarid
    Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Endocrinology 144:3469-76. 2003
  7. pmc One-step purification of nucleic acid for gene expression analysis via Immiscible Filtration Assisted by Surface Tension (IFAST)
    Scott M Berry
    Department of Biomedical Engineering, University of Wisconsin Madison, 1111 Highland Ave, Rm 6009, Madison, WI 53705, USA
    Lab Chip 11:1747-53. 2011
  8. ncbi request reprint Lives and times of nuclear receptors
    Elaine T Alarid
    Department of Physiology, University of Wisconsin Madison, 120 Service Memorial Institute, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Mol Endocrinol 20:1972-81. 2006
  9. ncbi request reprint Ligand-specific regulation of proteasome-mediated proteolysis of estrogen receptor-alpha
    Mara T Preisler-Mashek
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Am J Physiol Endocrinol Metab 282:E891-8. 2002
  10. pmc Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor alpha N terminus
    Christopher C Valley
    Department of Physiology, 1300 University Ave, 120 SMI, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Cell Biol 25:5417-28. 2005

Research Grants

Collaborators

  • Kun Ping Lu
  • Amy M Fowler
  • ADRIAN VINCENT LEE
  • Natalia M Solodin
  • Prashant Rajbhandari
  • Christopher C Valley
  • Ginny L Powers
  • Stephanie J Ellison-Zelski
  • Scott M Berry
  • G L Powers
  • Amy L Weinberg
  • Mara T Preisler-Mashek
  • Brant Bickford
  • Sandra Z Haslam
  • John L Markley
  • Kelley J Kadunc
  • Sarata C Sahu
  • Greg Finn
  • Kiran K Singarapu
  • Anastasia Kariagina
  • David J Beebe
  • A J Casa
  • S J Ellison-Zelski
  • Stephanie J Ellison
  • Damien Carter
  • Michael K Fritsch
  • Minna Ahonen
  • Fern E Murdoch
  • Mara T Mashek
  • Lindsay Hill
  • Raphaël Métivier
  • Natalia Solodin
  • Bethany L Stark
  • Michael K Tyriver

Detail Information

Publications16

  1. pmc The proteasome inhibitor bortezomib induces an inhibitory chromatin environment at a distal enhancer of the estrogen receptor-α gene
    Ginny L Powers
    Department of Oncology, McArdle Laboratories for Cancer Research and University of Wisconsin Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 8:e81110. 2013
    ....
  2. pmc Proteasome inhibition represses ERalpha gene expression in ER+ cells: a new link between proteasome activity and estrogen signaling in breast cancer
    G L Powers
    Department of Oncology, University of Wisconsin Madison, Madison, WI 53705, USA
    Oncogene 29:1509-18. 2010
    ..These results reveal a novel link between proteasome activity and expression of ERalpha in breast cancer and uncover distinct roles of the chymotrypsin-like activity of the proteasome in the regulation of the ERalpha pathway...
  3. pmc Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor
    Stephanie J Ellison-Zelski
    Department of Oncology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Cancer 9:263. 2010
    ..Here, we expand our previous studies to elucidate the function of Sin3A in the control of gene expression and growth of breast cancer cells...
  4. pmc Amping up estrogen receptors in breast cancer
    Amy M Fowler
    Department of Oncology, University of Wisconsin Madison, Madison, WI 53706, USA
    Breast Cancer Res 9:305. 2007
    ....
  5. pmc Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1
    Prashant Rajbhandari
    Department of Oncology and UW Carbone Comprehensive Cancer Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    Mol Cell Biol 32:445-57. 2012
    ....
  6. ncbi request reprint Thyroid hormone is an inhibitor of estrogen-induced degradation of estrogen receptor-alpha protein: estrogen-dependent proteolysis is not essential for receptor transactivation function in the pituitary
    Elaine T Alarid
    Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Endocrinology 144:3469-76. 2003
    ....
  7. pmc One-step purification of nucleic acid for gene expression analysis via Immiscible Filtration Assisted by Surface Tension (IFAST)
    Scott M Berry
    Department of Biomedical Engineering, University of Wisconsin Madison, 1111 Highland Ave, Rm 6009, Madison, WI 53705, USA
    Lab Chip 11:1747-53. 2011
    ..The IFAST technology thus significantly enhances researchers' abilities to isolate and analyze nucleic acids, a process which is critical and ubiquitous in an extensive array of scientific fields...
  8. ncbi request reprint Lives and times of nuclear receptors
    Elaine T Alarid
    Department of Physiology, University of Wisconsin Madison, 120 Service Memorial Institute, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Mol Endocrinol 20:1972-81. 2006
    ..Here, we review our current understanding of the mechanism and relevance of proteolysis to receptor function based on general concepts that have emerged from analyses of liganded members of the nuclear receptor family...
  9. ncbi request reprint Ligand-specific regulation of proteasome-mediated proteolysis of estrogen receptor-alpha
    Mara T Preisler-Mashek
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Am J Physiol Endocrinol Metab 282:E891-8. 2002
    ....
  10. pmc Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor alpha N terminus
    Christopher C Valley
    Department of Physiology, 1300 University Ave, 120 SMI, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Cell Biol 25:5417-28. 2005
    ....
  11. ncbi request reprint Increases in estrogen receptor-alpha concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen
    Amy M Fowler
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin, USA
    FASEB J 18:81-93. 2004
    ..Further, they describe a potential mechanism whereby increases in ERalpha concentration may provide a proliferative advantage by augmenting ERalpha function regardless of ligand status...
  12. ncbi request reprint Altered target gene regulation controlled by estrogen receptor-alpha concentration
    Amy M Fowler
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Endocrinol 20:291-301. 2006
    ..Together these results demonstrate that the concentration of receptor in breast cancer cells can influence the pattern of target gene expression through a noncanonical activation mechanism...
  13. ncbi request reprint Temporal variation in estrogen receptor-alpha protein turnover in the presence of estrogen
    Christopher C Valley
    McArdle Laboratories for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin Madison, 1400 University Avenue, Madison, Wisconsin 53706, USA
    J Mol Endocrinol 40:23-34. 2008
    ..This temporal control of proteolysis allows for the establishment of steady-state levels of receptor and provides a protective mechanism against loss of hormone responsiveness...
  14. ncbi request reprint Nuclear receptor and transcriptional complex cycles
    Amy M Fowler
    University of Wisconsin Madison, Department of Physiology, 1300 University Avenue, Madison, WI 53706, USA
    Sci STKE 2004:tr11. 2004
    ..The associated table describes the proteins and multimolecular complexes that participate in the nuclear receptor-chromatin cycles...
  15. ncbi request reprint Dynamic control of nuclear receptor transcription
    Amy M Fowler
    Department of Physiology, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Sci STKE 2004:pe51. 2004
    ..These conceptual and technical achievements integrate kinetic and combinatorial regulation into a new dynamic model of nuclear receptor-mediated transcription...
  16. ncbi request reprint The DNA binding domain of estrogen receptor alpha is required for high-affinity nuclear interaction induced by estradiol
    Amy L Weinberg
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biochemistry 46:8933-42. 2007
    ....

Research Grants5

  1. MECHANISM OF ESTROGEN RECEPTOR DOWN REGULATION
    ELAINE ALARID; Fiscal Year: 2002
    ..The attainment of a faculty position within this department will be a critical step toward her goal to contribute to the scientific community as both a researcher and a mentor. ..
  2. Proteolytic Regulation of Estrogen Receptor-alpha
    ELAINE ALARID; Fiscal Year: 2004
    ..Understanding the relationship between receptor proteolysis and transcription will likely contribute to the identification of novel targets for therapeutic intervention of ERalpha-dependent malignancies. ..
  3. Proteolytic Regulation of Estrogen Receptor-alpha
    ELAINE ALARID; Fiscal Year: 2005
    ..Understanding the relationship between receptor proteolysis and transcription will likely contribute to the identification of novel targets for therapeutic intervention of ERalpha-dependent malignancies. ..
  4. Proteolytic Regulation of Estrogen Receptor-alpha
    ELAINE ALARID; Fiscal Year: 2006
    ..Understanding the relationship between receptor proteolysis and transcription will likely contribute to the identification of novel targets for therapeutic intervention of ERalpha-dependent malignancies. ..
  5. Proteolytic Regulation of Estrogen Receptor-alpha
    ELAINE ALARID; Fiscal Year: 2007
    ..Understanding the relationship between receptor proteolysis and transcription will likely contribute to the identification of novel targets for therapeutic intervention of ERalpha-dependent malignancies. ..