Abeer M Al-Ghananeem

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. doi request reprint Gamma scintigraphy for testing bioequivalence: a case study on two cromolyn sodium nasal spray preparations
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 927 Rose Street, Lexington, KY 40536, USA
    Int J Pharm 357:70-6. 2008
  2. ncbi request reprint Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and delivery
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
    Molecules 12:373-88. 2007
  3. doi request reprint Pharmacokinetics of lofexidine hydrochloride in healthy volunteers
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    J Pharm Sci 98:319-26. 2009
  4. pmc Intratumoral delivery of Paclitaxel in solid tumor from biodegradable hyaluronan nanoparticle formulations
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 927 Rose Street, Lexington, Kentucky 40536 0082, USA
    AAPS PharmSciTech 10:410-7. 2009
  5. ncbi request reprint Scopolamine sublingual spray: an alternative route of delivery for the treatment of motion sickness
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Drug Dev Ind Pharm 33:577-82. 2007
  6. doi request reprint Urine and plasma pharmacokinetics of lofexidine after oral delivery in opiate-dependent patients
    Abeer M Al Ghananeem
    Department of Pharmaceutical Sciences, University of Kentucky, Lexington, 40536 0082, USA
    Am J Drug Alcohol Abuse 35:311-5. 2009
  7. doi request reprint Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS viruses
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
    J Drug Target 18:381-8. 2010
  8. pmc Formulation-based approach to support early drug discovery and development efforts: a case study with enteric microencapsulation dosage form development for a triarylmethane derivative TRAM-34; a novel potential immunosuppressant
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Drug Dev Ind Pharm 36:563-9. 2010
  9. doi request reprint Bioavailability of Δ⁹-tetrahydrocannabinol following intranasal administration of a mucoadhesive gel spray delivery system in conscious rabbits
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, University of Kentucky, Lexington, 40536 0082, USA
    Drug Dev Ind Pharm 37:329-34. 2011
  10. ncbi request reprint A novel chemical delivery system comprising an ocular sustained release formulation of a 3alpha, 17alpha, 21-trihydroxy-5beta-pregnan-20-one-BIS-5-fluorouracil [correction of flourouracil] codrug
    Michelle Howard-Sparks
    College of Pharmacy, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Drug Dev Ind Pharm 33:677-82. 2007

Collaborators

Detail Information

Publications22

  1. doi request reprint Gamma scintigraphy for testing bioequivalence: a case study on two cromolyn sodium nasal spray preparations
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 927 Rose Street, Lexington, KY 40536, USA
    Int J Pharm 357:70-6. 2008
    ....
  2. ncbi request reprint Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and delivery
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
    Molecules 12:373-88. 2007
    ..This present article reviews the progress in ocular prodrug and codrug design and delivery in light of ocular metabolic activities...
  3. doi request reprint Pharmacokinetics of lofexidine hydrochloride in healthy volunteers
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    J Pharm Sci 98:319-26. 2009
    ....
  4. pmc Intratumoral delivery of Paclitaxel in solid tumor from biodegradable hyaluronan nanoparticle formulations
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 927 Rose Street, Lexington, Kentucky 40536 0082, USA
    AAPS PharmSciTech 10:410-7. 2009
    ..9-fold larger than the baseline volume at 57 days post-drug administration. Intratumoral administration of paclitaxel-loaded hyaluronan nanoparticles could be a promising treatment modality for solid mammary tumors...
  5. ncbi request reprint Scopolamine sublingual spray: an alternative route of delivery for the treatment of motion sickness
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Drug Dev Ind Pharm 33:577-82. 2007
    ....
  6. doi request reprint Urine and plasma pharmacokinetics of lofexidine after oral delivery in opiate-dependent patients
    Abeer M Al Ghananeem
    Department of Pharmaceutical Sciences, University of Kentucky, Lexington, 40536 0082, USA
    Am J Drug Alcohol Abuse 35:311-5. 2009
    ..To date, there have been no published studies on lofexidine appearance and excretion in urine of opioid dependent subjects...
  7. doi request reprint Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS viruses
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
    J Drug Target 18:381-8. 2010
    ..n. dosing was 2.1 and 1.9 in CSF and brain, respectively. Thus, both the i.n. route of administration and formulation of ddI in chitosan nanoparticles increased delivery of ddI to CSF and brain...
  8. pmc Formulation-based approach to support early drug discovery and development efforts: a case study with enteric microencapsulation dosage form development for a triarylmethane derivative TRAM-34; a novel potential immunosuppressant
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Drug Dev Ind Pharm 36:563-9. 2010
    ..Enteric microencapsulation of the potential immunosuppressant TRAM-34 was investigated as a means of enhancing oral drug delivery and minimizing or eliminating hydrolysis of pyrazole-substituted triarylmethane to the respective alcohol...
  9. doi request reprint Bioavailability of Δ⁹-tetrahydrocannabinol following intranasal administration of a mucoadhesive gel spray delivery system in conscious rabbits
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, University of Kentucky, Lexington, 40536 0082, USA
    Drug Dev Ind Pharm 37:329-34. 2011
    ..A further aim was to investigate the effect of nasally administered chitosan-based nasal bioadhesive gel on THC bioavailability as a formulation strategy to decrease normal mucociliary drug clearance...
  10. ncbi request reprint A novel chemical delivery system comprising an ocular sustained release formulation of a 3alpha, 17alpha, 21-trihydroxy-5beta-pregnan-20-one-BIS-5-fluorouracil [correction of flourouracil] codrug
    Michelle Howard-Sparks
    College of Pharmacy, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Drug Dev Ind Pharm 33:677-82. 2007
    ....
  11. pmc Development of a GC-MS assay for the determination of fentanyl pharmacokinetics in rabbit plasma after sublingual spray delivery
    Ahmad H Malkawi
    College of Pharmacy, University of Kentucky, Lexington, Kentucky, 40536 0082, USA
    AAPS J 10:261-7. 2008
  12. pmc Effect of pH on sublingual absorption of oxycodone hydrochloride
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, USA
    AAPS PharmSciTech 7:E23. 2006
    ..The formulation pH had no significant influence on oxycodone bioavailability (P < .05). A sublingual spray dosage form of oxycodone hydrochloride would be a good alternative for fast onset pain management, especially in children...
  13. ncbi request reprint A pharmacokinetic study on Z-(+/-)-2-(1-benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a novel radio-sensitization agent
    Abeer M Al-Ghananeem
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Cancer Chemother Pharmacol 60:915-9. 2007
    ..2.2]octane-3-ol (BMABO), a novel radio-sensitization agent, after oral delivery...
  14. doi request reprint Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokers
    Ahmad H Malkawi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    J Pharm Biomed Anal 49:129-32. 2009
    ..6-81.1 ng/ml). The concentrations of cotinine in CSF samples suggests that nicotine easily passes into the CSF, which makes it an excellent CSF marker for tobacco-smoke exposure...
  15. ncbi request reprint An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma
    Ahmad H Malkawi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    J Pharm Biomed Anal 45:120-4. 2007
    ....
  16. ncbi request reprint Neonatal exposure to drugs in breast milk
    Patrick J McNamara
    College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
    Pharm Res 21:555-66. 2004
    ..g., colostrum vs. mature milk, fore vs. hind milk) and infant clearance (e.g., ontogeny of elimination pathways, pharmacogenetics) and their role in modulating exposure are also discussed...
  17. pmc Targeted brain delivery of 17 beta-estradiol via nasally administered water soluble prodrugs
    Abeer M Al-Ghananeem
    Division of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    AAPS PharmSciTech 3:E5. 2002
    ..These prodrugs are capable of producing high levels of estradiol in the CSF and as a result may have a significant value in the treatment of Alzheimer's disease...
  18. ncbi request reprint Synthesis and stability of two indomethacin prodrugs
    Shyamala Chandrasekaran
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Bioorg Med Chem Lett 16:1874-9. 2006
    ..2h in 80% buffered plasma. In contrast, the amide conjugate 12 appeared to be stable over the entire pH range studied with the only observed degradation being cleavage of the indolic N-4-chlorobenzoyl moiety...
  19. ncbi request reprint Evaluation of O(3alpha)-, O(21)-di-(N(1)-methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl) 17alpha-hydroxy-5beta-pregnan-20-one as a novel potential antiangiogenic codrug
    Michelle Howard-Sparks
    College of Pharmacy, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Enzyme Inhib Med Chem 20:417-28. 2005
    ..In the hydrolysis studies 5FU was released at a faster rate than THS with an unknown intermediate observed by HPLC, a rationale and proposed structure and mechanism of the unknown THS derivative is provided...
  20. doi request reprint Advances in brain targeting and drug delivery of anti-HIV therapeutic agents
    Abeer M Al-Ghananeem
    Sullivan University, College of Pharmacy, Department of Pharmaceutical Sciences, 2100 Gardiner Lane West Campus, Louisville, KY 40205, USA
    Expert Opin Drug Deliv 10:973-85. 2013
    ..Therefore, in order to increase the efficacy of anti-HIV drugs, novel drug delivery methodologies that can exhibit activity in the CNS are most needed and warranted...
  21. ncbi request reprint Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners
    Peter A Crooks
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, 40536 0082, USA
    Bioorg Med Chem Lett 16:4291-5. 2006
    ..Morphine-3-O-propionyl-6-O-sulfate had four times greater affinity than morphine at the mu-opiate receptor and was the most selective compound at this receptor subtype...
  22. ncbi request reprint Novel antiglaucoma prodrugs and codrugs of ethacrynic acid
    Grazyna Cynkowska
    New England Eye Center, Boston, MA 02111, USA
    Bioorg Med Chem Lett 15:3524-7. 2005
    ....