H S Akiskal

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The bipolar spectrum--the shaping of a new paradigm in psychiatry
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, VA Psychiatry Service 116 A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Curr Psychiatry Rep 4:1-3. 2002
  2. ncbi request reprint The distinct temperament profiles of bipolar I, bipolar II and unipolar patients
    Hagop S Akiskal
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression, Clinical Studies, Rockville, MD, USA
    J Affect Disord 92:19-33. 2006
  3. ncbi request reprint Does the FDA proposed list of possible correlates of suicidality associated with antidepressants apply to an adult private practice population?
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, CA, USA
    J Affect Disord 94:105-10. 2006
  4. pmc Clinical presentations of substance abuse in bipolar heroin addicts at time of treatment entry
    Icro Maremmani
    Vincent P, Dole Dual Diagnosis Unit, Santa Chiara University Hospital, Department of Neurosciences, University of Pisa, Pisa, EU, Italy
    Ann Gen Psychiatry 11:23. 2012
  5. pmc How possible is the development of an operational psychometric method to assess the presence of the 5-HTTLPR s allele? Equivocal preliminary findings
    Xenia Gonda
    Department of Pharmacodynamics, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    Ann Gen Psychiatry 9:21. 2010
  6. ncbi request reprint Bipolar II with and without cyclothymic temperament: "dark" and "sunny" expressions of soft bipolarity
    Hagop S Akiskal
    International Mood Center, UCSD Department of Psychiatry, 9500 Gilman Drive, La Jolla, San Diego, CA 92093 0603, USA
    J Affect Disord 73:49-57. 2003
  7. ncbi request reprint Validating 'hard' and 'soft' phenotypes within the bipolar spectrum: continuity or discontinuity?
    Hagop S Akiskal
    University of California at San Diego and VA Psychiatry Service 116A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 73:1-5. 2003
  8. ncbi request reprint Proposed multidimensional structure of mania: beyond the euphoric-dysphoric dichotomy
    H S Akiskal
    International Mood Center, University of California at San Diego, La Jolla, CA, USA
    J Affect Disord 73:7-18. 2003
  9. ncbi request reprint The DSM-IV and ICD-10 categories of recurrent [major] depressive and bipolar II disorders: evidence that they lie on a dimensional spectrum
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, VA Psychiatry Service, 116A, 3350 La Jolla Village Drive, 92161, USA
    J Affect Disord 92:45-54. 2006
  10. ncbi request reprint Psychopathologic correlates of suicidal ideation in major depressive outpatients: is it all due to unrecognized (bipolar) depressive mixed states?
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, Calif 92161, USA
    Psychopathology 38:273-80. 2005

Collaborators

Detail Information

Publications95

  1. ncbi request reprint The bipolar spectrum--the shaping of a new paradigm in psychiatry
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, VA Psychiatry Service 116 A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Curr Psychiatry Rep 4:1-3. 2002
  2. ncbi request reprint The distinct temperament profiles of bipolar I, bipolar II and unipolar patients
    Hagop S Akiskal
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression, Clinical Studies, Rockville, MD, USA
    J Affect Disord 92:19-33. 2006
    ....
  3. ncbi request reprint Does the FDA proposed list of possible correlates of suicidality associated with antidepressants apply to an adult private practice population?
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, CA, USA
    J Affect Disord 94:105-10. 2006
    ..In this report we examine the relevance of the "FDA list" for adults...
  4. pmc Clinical presentations of substance abuse in bipolar heroin addicts at time of treatment entry
    Icro Maremmani
    Vincent P, Dole Dual Diagnosis Unit, Santa Chiara University Hospital, Department of Neurosciences, University of Pisa, Pisa, EU, Italy
    Ann Gen Psychiatry 11:23. 2012
    ..abstract:..
  5. pmc How possible is the development of an operational psychometric method to assess the presence of the 5-HTTLPR s allele? Equivocal preliminary findings
    Xenia Gonda
    Department of Pharmacodynamics, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    Ann Gen Psychiatry 9:21. 2010
    ..The aim of the current study was to develop a psychometric tool that could at least partially substitute for laboratory testing and could predict the presence of the s allele...
  6. ncbi request reprint Bipolar II with and without cyclothymic temperament: "dark" and "sunny" expressions of soft bipolarity
    Hagop S Akiskal
    International Mood Center, UCSD Department of Psychiatry, 9500 Gilman Drive, La Jolla, San Diego, CA 92093 0603, USA
    J Affect Disord 73:49-57. 2003
    ..Our aim in the present analyses is to further test the hypothesis that such patients-assigned to CT on the basis of clinical interview-represent a more "unstable" variant of BP-II...
  7. ncbi request reprint Validating 'hard' and 'soft' phenotypes within the bipolar spectrum: continuity or discontinuity?
    Hagop S Akiskal
    University of California at San Diego and VA Psychiatry Service 116A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 73:1-5. 2003
    ..The emerging concept of the bipolar spectrum represents a provocative working hypothesis to account for these conditions...
  8. ncbi request reprint Proposed multidimensional structure of mania: beyond the euphoric-dysphoric dichotomy
    H S Akiskal
    International Mood Center, University of California at San Diego, La Jolla, CA, USA
    J Affect Disord 73:7-18. 2003
    ..The few available studies have reported at least two factors, which consist of euphoric versus dysphoric-hostile subtypes. Our objective was to replicate and further enrich this literature...
  9. ncbi request reprint The DSM-IV and ICD-10 categories of recurrent [major] depressive and bipolar II disorders: evidence that they lie on a dimensional spectrum
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, VA Psychiatry Service, 116A, 3350 La Jolla Village Drive, 92161, USA
    J Affect Disord 92:45-54. 2006
    ..We used the ongoing Ravenna-San Diego Collaboration database to examine this question with respect to major depressive disorder (MDD) and bipolar II (BP-II)...
  10. ncbi request reprint Psychopathologic correlates of suicidal ideation in major depressive outpatients: is it all due to unrecognized (bipolar) depressive mixed states?
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, Calif 92161, USA
    Psychopathology 38:273-80. 2005
    ..Recent transatlantic concern about suicidality in patients receiving antidepressants prompted us to examine the psychopathologic correlates of suicidal ideation occurring in clinically depressed patients...
  11. ncbi request reprint Toward a clinical delineation of dysphoric hypomania - operational and conceptual dilemmas
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, La Jolla, 92161, USA
    Bipolar Disord 7:456-64. 2005
    ..Analogous to the DSM-IV approach in the diagnosis of manic mixed state, in this exploratory study we operationalized DH as coexisting full syndromal hypomanic and major depressive states...
  12. ncbi request reprint Family history validation of the bipolar nature of depressive mixed states
    Hagop S Akiskal
    VA Medical Center, University of California at San Diego, VA Psychiatry Service 116 A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 73:113-22. 2003
    ..Our aims were to find the sensitivity and specificity of DMX for the diagnosis of bipolar II disorder, and validate it against familial bipolarity...
  13. ncbi request reprint TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament
    Hagop S Akiskal
    Department of Psychiatry, International Mood Center, University of California, San Diego, VA Psychiatry 116A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 85:45-52. 2005
    ..Further item wording and selection were achieved at a later stage through an iterative process that incorporated feedback from clinicians, researchers, and research volunteers...
  14. ncbi request reprint Validating affective temperaments in their subaffective and socially positive attributes: psychometric, clinical and familial data from a French national study
    Hagop S Akiskal
    International Mood Center, VA Psychiatry Service, VA Hospital, University of California at San Diego, 3350 La Jolla Village Dr 116 A, San Diego, CA 92161, USA
    J Affect Disord 85:29-36. 2005
    ..In this report we focus on the utility of the affective temperament scales (ATS) in delineating this spectrum in its clinical as well as socially desirable expressions...
  15. ncbi request reprint Searching for behavioral indicators of bipolar II in patients presenting with major depressive episodes: the "red sign," the "rule of three" and other biographic signs of temperamental extravagance, activation and hypomania
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, V A Hospital 3350, La Jolla Village Dr 116 A, San Diego CA 92161, USA
    J Affect Disord 84:279-90. 2005
    ....
  16. ncbi request reprint Validating Kraepelin's two types of depressive mixed states: "depression with flight of ideas" and "excited depression"
    Hagop S Akiskal
    International Mood Center, University of Californai at San Diego, and VA Psychiatry Service CA 92161, USA
    World J Biol Psychiatry 5:107-13. 2004
    ....
  17. ncbi request reprint The dark side of bipolarity: detecting bipolar depression in its pleomorphic expressions
    Hagop S Akiskal
    VA Psychiatry Service 116A, International Mood Center, University of Caifornia, 3550 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 84:107-15. 2005
    ....
  18. ncbi request reprint Validating the soft bipolar spectrum in the French National EPIDEP Study: the prominence of BP-II 1/2
    H S Akiskal
    Department of Psychiatry and International Mood Center, University of California at San Diego, VA Hospital San Diego, CA 92161, USA
    J Affect Disord 96:207-13. 2006
    ..In this report we test aspects of a bipolar schema proposed earlier by Akiskal and Pinto [Akiskal, H.S., Pinto, O., 1999. The evolving bipolar spectrum: Prototypes I, II, III, IV. Psychiatr. Clin. North Am. 22: 517-534.]...
  19. ncbi request reprint TEMPS-I: delineating the most discriminant traits of the cyclothymic, depressive, hyperthymic and irritable temperaments in a nonpatient population
    H S Akiskal
    International Mood Center, Department of Psychiatry, University of California, San Diego, USA
    J Affect Disord 51:7-19. 1998
    ..Although most personality constructs have been standardized in population studies, cyclothymic, depressive, irritable and hyperthymic temperaments putatively linked to mood disorders have been classically derived from clinical observations...
  20. ncbi request reprint The evolving bipolar spectrum. Prototypes I, II, III, and IV
    H S Akiskal
    Department of Psychiatry, University of California at San Diego, La Jolla, USA
    Psychiatr Clin North Am 22:517-34, vii. 1999
    ....
  21. doi request reprint The field of affectiveology at the new millennium: clinically relevant advances as reflected in books (1998-2007)
    Hagop Akiskal
    International Mood Center, University of California at San Diego, La Jolla, CA 92161, USA
    J Affect Disord 107:1-4. 2008
    ..I may have had some penchant for the unusual--and in this sense this is a very personal list--but my intention was to highlight new developments which are shaping our field...
  22. ncbi request reprint Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders
    H S Akiskal
    International Mood Center, University of California at San Diego, La Jolla, CA, USA
    J Affect Disord 59:S5-S30. 2000
    ....
  23. ncbi request reprint Dysthymia and cyclothymia in psychiatric practice a century after Kraepelin
    H S Akiskal
    VA Psychiatry Service 116A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 62:17-31. 2001
    ....
  24. ncbi request reprint Toward a refined phenomenology of mania: combining clinician-assessment and self-report in the French EPIMAN study
    H S Akiskal
    International Mood Center, University of California at San Diego, VA Psychiatry Service 116A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 67:89-96. 2001
    ..The present analyses sought to examine to what extent patient reports could improve formal diagnostic criteria for mania--and be validated against the Carroll-Klein (CK) psychobiological model of bipolarity...
  25. ncbi request reprint Special issue on circular insanity and beyond: historic contributions of French psychiatry to contemporary concepts and research on bipolar disorder
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, CA, USA
    J Affect Disord 96:141-3. 2006
    ....
  26. ncbi request reprint [Widening the borders of the bipolar disorder: validation of the concept of bipolar spectrum]
    Hagop S Akiskal
    International Mood Center, Department of Psychiatry, University of California at San Diego, San Diego, CA, USA
    Vertex 17:340-6. 2006
    ..In the last decades, a great body of data justifies considerable widening beyond the conservative positions of current nosological classifications, such as DSM IV and ICD10...
  27. ncbi request reprint Bipolar II and anxious reactive "comorbidity": toward better phenotypic characterization suitable for genotyping
    Hagop S Akiskal
    Department of Psychiatry at the University of California at San Diego, and Veterans Administration Medical Center, La Jolla, CA, USA
    J Affect Disord 96:239-47. 2006
    ..This association has genetic-familial implications, which we believe must be incorporated in refining the BP-II phenotype suitable for genotyping purposes...
  28. ncbi request reprint Validating the bipolar spectrum in the French National EPIDEP Study: overview of the phenomenology and relative prevalence of its clinical prototypes
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, La Jolla, CA 92161, USA
    J Affect Disord 96:197-205. 2006
    ..The protocol was developed in 1994 and implemented in 1995; publication of its first data began in 1998. This report provides the complete data set of the EPIDEP...
  29. ncbi request reprint Atypical depression: a variant of bipolar II or a bridge between unipolar and bipolar II?
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, V A Hospital, 3350 La Jolla Village Dr 116 A, La Jolla, San Diego, CA 92161, USA
    J Affect Disord 84:209-17. 2005
    ..Accordingly, we undertook a full scale validation of such a link in a large clinical sample of BP-II and unipolar (UP) major depressive disorder (MDD)...
  30. ncbi request reprint Gender, temperament, and the clinical picture in dysphoric mixed mania: findings from a French national study (EPIMAN)
    H S Akiskal
    International Mood Center, University of California at San Diego, La Jolla 92161, USA
    J Affect Disord 50:175-86. 1998
    ....
  31. ncbi request reprint Agitated "unipolar" depression re-conceptualized as a depressive mixed state: implications for the antidepressant-suicide controversy
    Hagop S Akiskal
    Department of Psychiatry and International Mood Center, University of California, La Jolla, CA, USA
    J Affect Disord 85:245-58. 2005
    ..S., Mallya, G., 1987. Criteria for the "soft" bipolar spectrum: treatment implications. Psychopharmacol Bull. 23, 68-73]...
  32. ncbi request reprint Familiality of temperament in bipolar disorder: support for a genetic spectrum
    Lynn Evans
    Department of Psychiatry, UCSD, School of Medicine, University of California, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    J Affect Disord 85:153-68. 2005
    ..We predicted that a gradient of scores would be observed from those with BP to those with major depression to unaffected relatives to controls...
  33. ncbi request reprint The theoretical underpinnings of affective temperaments: implications for evolutionary foundations of bipolar disorder and human nature
    Kareen K Akiskal
    International Mood Center, La Jolla, CA, USA
    J Affect Disord 85:231-9. 2005
    ..Finally, we outline a hypothesis on the evolutionary function of anxious-depressive traits for women...
  34. pmc A genome-wide association study of bipolar disorder and comorbid migraine
    K J Oedegaard
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Genes Brain Behav 9:673-80. 2010
    ..These data suggest that genetic variants in the KIAA0564 gene region may predispose to migraine headaches in subgroups of patients with both BPAD and ADHD...
  35. doi request reprint Residual symptom recovery from major affective episodes in bipolar disorders and rapid episode relapse/recurrence
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 65:386-94. 2008
    ..Both bipolar disorder type I and type II are characterized by frequent affective episode relapse and/or recurrence. An increasingly important goal of therapy is reducing chronicity by preventing or delaying additional episodes...
  36. ncbi request reprint [Temperament and affective disorders. The TEMPS-A Scale as a convergence of European and US-American concepts]
    H S Akiskal
    International Mood Centre, Department of Psychiatry, University of California at San Diego, USA
    Nervenarzt 73:262-71. 2002
    ..Clinical description and scientific implications are described in the light of recent work by Akiskal and the German version of the TEMPS-A scale, a self-report questionnaire for assessing temperament...
  37. ncbi request reprint A case series on the hypothesized connection between dementia and bipolar spectrum disorders: bipolar type VI?
    Bernardo Ng
    International Mood Center, and Department of Psychiatry, University of California, San Diego, CA, USA
    J Affect Disord 107:307-15. 2008
    ....
  38. doi request reprint A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11
    K J Oedegaard
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    J Affect Disord 122:14-26. 2010
    ..Together these data suggest that some genes may predispose to both bipolar disorder and migraine...
  39. ncbi request reprint Does incomplete recovery from first lifetime major depressive episode herald a chronic course of illness?
    L L Judd
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0603, USA
    Am J Psychiatry 157:1501-4. 2000
    ..This study investigated the influence of incomplete recovery from first lifetime major depressive episodes on long-term outcome...
  40. ncbi request reprint TEMPS-A: progress towards validation of a self-rated clinical version of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire
    Hagop S Akiskal
    International Mood Center, La Jolla, CA 92161, USA
    J Affect Disord 85:3-16. 2005
    ..Our aim was to validate the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) in a clinical population...
  41. ncbi request reprint The long-term natural history of the weekly symptomatic status of bipolar I disorder
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 59:530-7. 2002
    ..To our knowledge, this is the first prospective natural history study of weekly symptomatic status of patients with bipolar I disorder (BP-I) during long-term follow-up...
  42. doi request reprint The relationship of bulimia and anorexia nervosa with bipolar disorder and its temperamental foundations
    Anna V Lunde
    Department of Clinical Psychiatry Risskov, Aarhus University Hospital, Denmark International Mood Center, University of California, La Jolla, CA, USA
    J Affect Disord 115:309-14. 2009
    ..In the present report we extend this relationship to broader definitions of bipolarity...
  43. ncbi request reprint Charting patients' course: a comparison of statistics used to summarize patient course in longitudinal and repeated measures studies
    S Arndt
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    J Psychiatr Res 34:105-13. 2000
    ..Kendall's tau appears to offer more statistical power to detect change in course, yet its average type I error rate was comparable to the other indices...
  44. pmc Bipolar disorder with frequent mood episodes in the national comorbidity survey replication (NCS-R)
    A A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Mol Psychiatry 15:1075-87. 2010
    ..Whether these indicators of severity merely reflect attenuated effects of rapid cycling or independent effects of sub-threshold rapid cycling warrants further study given the high proportion of lifetime cases who met criteria for FME...
  45. ncbi request reprint Validating antidepressant-associated hypomania (bipolar III): a systematic comparison with spontaneous hypomania (bipolar II)
    Hagop S Akiskal
    International Mood Center, University of California at San Diego and VA Psychiatry Service 116 A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 73:65-74. 2003
    ..According to DSM-IV and ICD-10, hypomania which occurs solely during antidepressant treatment does not belong to the category of bipolar II (BP-II)...
  46. ncbi request reprint A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0603, USA
    Arch Gen Psychiatry 60:261-9. 2003
    ..This is the first prospective longitudinal study, to our knowledge, of the natural history of the weekly symptomatic status of bipolar II disorder (BP-II)...
  47. ncbi request reprint Proposed endophenotypes of dysthymia: evolutionary, clinical and pharmacogenomic considerations
    A B Niculescu
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Mol Psychiatry 6:363-6. 2001
    ..It would also expand the pool of subjects that may be enrolled in genetic and pharmacogenomic research studies...
  48. ncbi request reprint Can temperament identify affectively ill patients who engage in lethal or near-lethal suicidal behavior? A 14-year prospective study
    Jack D Maser
    Department of Psychiatry, University of California San Diego, USA
    Suicide Life Threat Behav 32:10-32. 2002
    ..Such temperament attributes as impulsivity and assertiveness were the best prospective predictors of completed suicides beyond 12 months with a sensitivity level of 74% and specificity level of 82%...
  49. ncbi request reprint Psychosocial disability and work role function compared across the long-term course of bipolar I, bipolar II and unipolar major depressive disorders
    Lewis L Judd
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0603, USA
    J Affect Disord 108:49-58. 2008
    ....
  50. ncbi request reprint Depressive episodes and symptoms dominate the longitudinal course of bipolar disorder
    Lewis L Judd
    Department of Psychiatry, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Curr Psychiatry Rep 5:417-8. 2003
  51. ncbi request reprint Long-term symptomatic status of bipolar I vs. bipolar II disorders
    Lewis L Judd
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression Clinical Studies, San Diego, La Jolla, CA, USA
    Int J Neuropsychopharmacol 6:127-37. 2003
    ..However the genetic variation underlying such a putative spectrum remains to be clarified...
  52. ncbi request reprint The prevalence, clinical relevance, and public health significance of subthreshold depressions
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Psychiatr Clin North Am 25:685-98. 2002
    ..This conceptualization in turn dictates a public health approach, which emphasizes that treatment of MDD even at the deceptively mild levels of symptoms should be initiated or maintained...
  53. ncbi request reprint Optimizing the detection of bipolar II disorder in outpatient private practice: toward a systematization of clinical diagnostic wisdom
    Hagop S Akiskal
    International Mood Center, University of California, San Diego, USA
    J Clin Psychiatry 66:914-21. 2005
    ..quot;..
  54. pmc A factor analysis of different temperament domains in a border region in rural Southern California
    Alvaro Camacho
    Sun Valley Behavioral and Research Center, Imperial, CA, USA
    J Affect Disord 126:46-8. 2010
    ..Understanding of these temperaments can help understanding psychiatric status and therapeutic needs of a patient population. As the Latino population grows providers need to become more familiar with their psychiatric status...
  55. ncbi request reprint Spectrum concepts in major mental disorders
    Jack D Maser
    Psychiatry Service, Veterans Affairs San Diego Healthcare System, USA
    Psychiatr Clin North Am 25:xi-xiii. 2002
  56. ncbi request reprint Proposal for a bipolar-stimulant spectrum: temperament, diagnostic validation and therapeutic outcomes with mood stabilizers
    Alvaro Camacho
    International Mood Center, Department of Psychiatry, University of California, San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0603R, USA
    J Affect Disord 85:217-30. 2005
    ..Accordingly, if bipolarity is ever considered in this interface, it usually pertains to syndromal bipolar I disorder...
  57. ncbi request reprint Dissociative experiences differentiate bipolar-II from unipolar depressed patients: the mediating role of cyclothymia and the Type A behaviour speed and impatience subscale
    Ketil J Oedegaard
    Department of Clinical Medicine, Section for Psychiatry, Faculty of Medicine, University of, Bergen, Bergen, Norway
    J Affect Disord 108:207-16. 2008
    ..Dissociative symptoms are often seen in patients with mood disorders, but there is little information on possible association with subgroups and temperamental features of these disorders...
  58. ncbi request reprint The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    J Affect Disord 73:123-31. 2003
    ..In the present secondary analyses of the US National Epidemiological Catchment Area (ECA) database, we provide further clarification on this fundamental public health issue...
  59. ncbi request reprint Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 62:1322-30. 2005
    ..Evidence of psychosocial disability in bipolar disorder is based primarily on bipolar I disorder (BP-I) and does not relate disability to affective symptom severity and polarity or to bipolar II disorder (BP-II)...
  60. ncbi request reprint Continuous distribution of atypical depressive symptoms between major depressive and bipolar II disorders: dose-response relationship with bipolar family history
    Hagop S Akiskal
    International Mood Center, University of California at San Diego, San Diego, CA, USA
    Psychopathology 41:39-42. 2008
    ..Despite the categorical position of formal diagnostic approaches (i.e. ICD-10 and DSM-IV) to mood disorders, atypical depression (AD) occupies an ambiguous position between major depressive (MDD) and bipolar II (BP-II) disorders...
  61. ncbi request reprint The clinical and public health relevance of current research on subthreshold depressive symptoms to elderly patients
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0603, USA
    Am J Geriatr Psychiatry 10:233-8. 2002
  62. ncbi request reprint Reassessing carbamazepine in the treatment of bipolar disorder: clinical implications of new data
    Hagop S Akiskal
    University of California, San Diego, USA
    CNS Spectr 10:suppl 1-11; discuss 12-3; quiz 14-5. 2005
    ..Further efforts are needed to update physicians on the use of carbamazepine relative to other medications in the treatment of bipolar disorder...
  63. ncbi request reprint Suggestive linkage of a chromosomal locus on 18p11 to cyclothymic temperament in bipolar disorder families
    Lynn M Evans
    Department of Psychiatry, Columbia University, New York, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 147:326-32. 2008
    ..The temperament-based cyclothymic trait yielded a higher peak LOD score and a lower P-value than analyses using traditional, categorical phenotypes in a separate analysis including these same families...
  64. ncbi request reprint Bipolar disorders and affective temperaments: a national family study testing the "endophenotype" and "subaffective" theses using the TEMPS-A Buenos Aires
    Gustavo H Vazquez
    Department of Neuroscience, University of Palermo, Buenos Aires, Argentina
    J Affect Disord 108:25-32. 2008
    ....
  65. pmc Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication
    Kathleen R Merikangas
    Intramural Research Program, Section on Developmental Genetic Epidemiology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:543-52. 2007
    ..There is growing recognition that bipolar disorder (BPD) has a spectrum of expression that is substantially more common than the 1% BP-I prevalence traditionally found in population surveys...
  66. ncbi request reprint Is the bipolar spectrum the psychopathological substrate of suicidality in heroin addicts?
    Icro Maremmani
    Santa Chiara University Hospital, Department of Psychiatry, University of Pisa, Pisa, Italy
    Psychopathology 40:269-77. 2007
    ..To describe the prevalence and the risk factors of suicidal ideation in a cohort of Italian opioid addicts presenting for treatment...
  67. ncbi request reprint Factors associated with rapid cycling in bipolar I manic patients: findings from a French national study
    Jean Michel Azorin
    University of Aix Marseille II, and Department of Adult Psychiatry, Sainte Marguerite Hospital, Marseille Cedex 09, France
    CNS Spectr 13:780-7. 2008
    ..Despite numerous explanatory hypotheses, few studies have involved a large national clinical sample examining risk factors in the occurrence of rapid cycling during the course of bipolar illness...
  68. ncbi request reprint TEMPS-A (Rome): psychometric validation of affective temperaments in clinically well subjects in mid- and south Italy
    Maurizio Pompili
    Department of Psychiatry, Sant Andrea Hospital, University of Rome La Sapienza, Rome, Italy
    J Affect Disord 107:63-75. 2008
    ..In Italian, the TEMPS has previously been validated in its original 32-item version, the TEMPS-I (Pisa), one which did not yet include an anxious subscale...
  69. ncbi request reprint A study of affective temperaments in Hungary: internal consistency and concurrent validity of the TEMPS-A against the TCI and NEO-PI-R
    Sandor Rozsa
    Department of Personality and Health Psychology, Lorand Eotvos University, Budapest, Hungary
    J Affect Disord 106:45-53. 2008
    ..We were particularly interested in concurrent validation against the TCI and the NEO-PI-R, the most important of the new personality instruments...
  70. ncbi request reprint Validation of a severity threshold for the Mania Rating Scale: a receiver-operating characteristic analysis
    Jean Michel Azorin
    Sainte Marguerite Hospital, University of Marseilles, Marseilles, France
    Psychopathology 40:453-60. 2007
    ..The aim of this study was to determine a cutoff score on the Mania Rating Scale (MRS), which easily allows identification of severe mania in a population of manic patients to be included in clinical trials of antimanic drugs...
  71. ncbi request reprint Post-traumatic stress disorder among adolescents with bipolar disorder and its relationship to suicidality
    Steven C Dilsaver
    Mental Health Mental Retardation Clinic, Rio Grande City, TX, USA
    Bipolar Disord 9:649-55. 2007
    ..The impetus for the study was born of clinical impressions derived in the course of routine clinical practice...
  72. ncbi request reprint How best to identify a bipolar-related subtype among major depressive patients without spontaneous hypomania: superiority of age at onset criterion over recurrence and polarity?
    Franco Benazzi
    Hecker Psychiatry Research Center, Department of Psychiatry, National Health Service, Forli, Italy
    J Affect Disord 107:77-88. 2008
    ..History of high depressive recurrence (without history of mania/hypomania) has been proposed as a mood subtype close to bipolar disorders. Herein we test whether this is the best approach to this question...
  73. ncbi request reprint Factor structure of hypomania: interrelationships with cyclothymia and the soft bipolar spectrum
    Elie G Hantouche
    Psychiatry Department, Mood Center, Pitie Salpetriere Hospital, Paris, France
    J Affect Disord 73:39-47. 2003
    ..In this report we focus on the factor structure of hypomania and its relationships with cyclothymic temperament in unipolar (UP) and bipolar II (BP-II) spectrum (soft bipolar) patients...
  74. ncbi request reprint Affective temperaments in clinically-well subjects in Turkey: initial psychometric data on the TEMPS-A
    Simavi Vahip
    Affective Disorder Unit, Department of Psychiatry, Psikiyatri Anabilim Dali, Tip Fakultesi, Ege University, Bornova 35100, Izmir, Turkey
    J Affect Disord 85:113-25. 2005
    ..The questionnaire is a self-report 110-item measure that postulates five affective temperaments-the depressive, cyclothymic, irritable, hyperthymic, and anxious-which embody both strengths and liabilities along affective lines...
  75. ncbi request reprint The proposed factor structure of temperament and personality in Japan: combining traits from TEMPS-A and MPT
    Tsuyoshi Akiyama
    Department of Neuropsychiatry, Kanto Medical Center NTT EC, Tokyo, Japan
    J Affect Disord 85:93-100. 2005
    ..This research investigates the construct validity of these temperaments through factor analysis...
  76. ncbi request reprint Reliability and validity of TEMPS-A in a Japanese non-clinical population: application to unipolar and bipolar depressives
    Satoko Matsumoto
    Department of Mental Health, School of Health Sciences, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Affect Disord 85:85-92. 2005
    ..In Japan, TEMPS-A has gathered much attention, because Kraepelin's concepts on "fundamental states" of mood disorder and temperaments have been widely respected...
  77. ncbi request reprint Factorial structure and internal consistency of the German TEMPS-A scale: validation against the NEO-FFI questionnaire
    Raffaela Bloink
    University Hospital for Psychiatry and Psychotherapy, Martin Luther University Halle Wittenberg, 06097 Halle Saale, Germany
    J Affect Disord 85:77-83. 2005
    ..Therefore, the relationship between the TEMPS-A and the well-established personality questionnaire NEO-FFI, whose factors show theoretical overlap with temperaments, was investigated...
  78. ncbi request reprint Distribution and gender effects of the subscales of a German version of the temperament autoquestionnaire briefTEMPS-M in a university student population
    Andreas Erfurth
    Department of Psychiatry, Munster University Hospital, Albert Schweitzer Str 11, 48129 Munster, Germany
    J Affect Disord 85:71-6. 2005
    ..This paper examines the distribution of the temperamental characteristics and gender effects of a new autoquestionnaire developed by Akiskal et al. (TEMPS-A) in its German briefTEMPS-M version...
  79. ncbi request reprint Studies on a German (Münster) version of the temperament auto-questionnaire TEMPS-A: construction and validation of the briefTEMPS-M
    Andreas Erfurth
    Department of Psychiatry, Munster University Hospital, Albert Schweitzer Str 11, 48129 Munster, Germany
    J Affect Disord 85:53-69. 2005
    ..It is the aim of the present analyses to validate a brief German version of TEMPS-A...
  80. ncbi request reprint High rate of unrecognized bipolar mixed states among destitute Hispanic adolescents referred for "major depressive disorder"
    Steven C Dilsaver
    Mental Health and Mental Retardation Clinic, Rio Grande City, TX, USA
    J Affect Disord 84:179-86. 2005
    ....
  81. ncbi request reprint A downscaled practical measure of mood lability as a screening tool for bipolar II
    Franco Benazzi
    Outpatient Psychiatry Center Ravenna and Forli, Italy and the Department of Psychiatry, National Health Service, Forli, Italy
    J Affect Disord 84:225-32. 2005
    ..Accordingly, the aim of the present analyses was to test if a practical measure of mood lability was unique to BPII, in comparison with major depressive disorder (MDD)...
  82. ncbi request reprint Temperament in the clinical differentiation of depressed bipolar and unipolar major depressive patients
    Mauro V Mendlowicz
    Institute of Psychiatry, Federal University of Rio de Janeiro IPUB UFRJ, Rio de Janeiro, Brazil
    J Affect Disord 84:219-23. 2005
    ..To examine differences in temperament profiles between patients with recurrent unipolar and bipolar depression...
  83. ncbi request reprint A comparison of recovered bipolar patients, healthy relatives of bipolar probands, and normal controls using the short TEMPS-A
    Mauro V Mendlowicz
    Institute of Psychiatry, Federal University of Rio de Janeiro IPUB UFRJ, Brazil
    J Affect Disord 85:147-51. 2005
    ....
  84. ncbi request reprint Affective temperament traits measured by TEMPS-I and emotional-behavioral problems in clinically-well children, adolescents, and young adults
    Salvatore Signoretta
    Institute of Behavioral Sciences, Carrara, Italy
    J Affect Disord 85:169-80. 2005
    ..The identification of specific temperament dimensions as correlates or risk factors for psychopathology in infancy, childhood and adolescence might provide key information to elucidate causal mechanisms that underlie these relationships...
  85. ncbi request reprint Temperament profiles in physicians, lawyers, managers, industrialists, architects, journalists, and artists: a study in psychiatric outpatients
    Kareen K Akiskal
    International Mood Center, San Diego USA and French Depressive and Manic Depressive Association, Rennes, France
    J Affect Disord 85:201-6. 2005
    ..With the possible exception of cyclothymia in artists, there is a paucity of data in the literature on the temperament in different professions...
  86. ncbi request reprint Dose-response relationship between number of comorbid anxiety disorders in adolescent bipolar/unipolar disorders, and psychosis, suicidality, substance abuse and familiality
    Steven C Dilsaver
    Rio Grande City Community Mental Health Mental Retardation Clinic, Rio Grande City, TX, USA
    J Affect Disord 96:249-58. 2006
    ....
  87. ncbi request reprint Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: I. Clinical implications
    Diogo R Lara
    Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Affect Disord 94:67-87. 2006
    ..We submit this proposed schema represented herein as a heuristic attempt to build bridges between basic and clinical science...
  88. ncbi request reprint Toward a unitary perspective on the bipolar spectrum and substance abuse: opiate addiction as a paradigm
    Icro Maremmani
    Santa Chiara University Hospital, Psychiatric Unit 1, University of Pisa, Italy, EU
    J Affect Disord 93:1-12. 2006
    ..We therefore submit that the present conceptualization of the link between bipolar spectrum and addictive disorders has not only heuristic and scientific values, but also an important message for the clinician...
  89. ncbi request reprint The soft bipolar spectrum redefined: focus on the cyclothymic, anxious-sensitive, impulse-dyscontrol, and binge-eating connection in bipolar II and related conditions
    Giulio Perugi
    Institute of Behavioral Sciences G De Lisio, Viale Monzone 3, 54031 Carrara, Italy
    Psychiatr Clin North Am 25:713-37. 2002
    ....
  90. ncbi request reprint The comparative clinical phenotype and long term longitudinal episode course of bipolar I and II: a clinical spectrum or distinct disorders?
    Lewis L Judd
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression Clinical Studies, USA
    J Affect Disord 73:19-32. 2003
    ....
  91. ncbi request reprint Refining the evaluation of bipolar II: beyond the strict SCID-CV guidelines for hypomania
    Franco Benazzi
    Department of Psychiatry, National Health Service, Forli, Italy
    J Affect Disord 73:33-8. 2003
    ..Our objective was to further refine the strict SCID-CV guidelines for hypomania in depressed outpatients...
  92. ncbi request reprint Bulimia nervosa in atypical depression: the mediating role of cyclothymic temperament
    Giulio Perugi
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, Psychiatry Section, University of Pisa, Pisa, Italy
    J Affect Disord 92:91-7. 2006
    ....
  93. ncbi request reprint Biphasic course in bipolar II outpatients: prevalence and clinical correlates of a cyclic pattern described by Baillarger and Falret in hospitalised patients in 1854
    Franco Benazzi
    E Hecker Outpatient Psychiatry Center, Via Pozzetto 17, 48010 Castiglione di Cervia, Ravenna, Italy
    J Affect Disord 96:183-7. 2006
    ..These patients would probably have today met the criteria for bipolar I. Our aim was to find the prevalence and clinical correlates of biphasic course in bipolar II (BP II) in contemporary ambulatory patients...
  94. ncbi request reprint Psychometric delineation of the most discriminant symptoms of depressive mixed states
    Franco Benazzi
    Hecker Psychiatry Research Center, Ravenna, Italy
    Psychiatry Res 141:81-8. 2006
    ..Beyond its diagnostic significance, the foregoing signs and symptoms are among the clinical features the FDA lists as presaging "suicidality" on antidepressant monotherapy...
  95. ncbi request reprint Bipolar II vs. unipolar depression: psychopathologic differentiation by dimensional measures
    Elie G Hantouche
    Adult Psychiatry, Mood Center, Psychiatry Department, Pitié Salpêtrière Hôpital, 47 bd de l Hopital, 75013 Paris, France
    J Affect Disord 84:127-32. 2005
    ..UP MDD in a large national sample...