Shahab A Akhter

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report
    Elaine Lin
    Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA
    J Med Case Reports 4:246. 2010
  2. doi request reprint The heart and pericardium
    Shahab A Akhter
    Section of Cardiac and Thoracic Surgery, The University of Chicago, 5841 South Maryland Avenue, MC 5040, Chicago, IL 60637, USA
    Thorac Surg Clin 21:205-17, viii. 2011
  3. pmc Reversal of impaired myocardial beta-adrenergic receptor signaling by continuous-flow left ventricular assist device support
    Shahab A Akhter
    Department of Surgery, Section of Cardiac and Thoracic Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Heart Lung Transplant 29:603-9. 2010
  4. doi request reprint Technique for left ventricular apical cannulation for short-term mechanical circulatory support
    Shahab A Akhter
    Section of Cardiac and Thoracic Surgery, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Ann Thorac Surg 89:994-5. 2010
  5. pmc Activation of JAK-STAT and nitric oxide signaling as a mechanism for donor heart dysfunction
    Christian F Bulcao
    Department of Surgery, Section of Cardiothoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Heart Lung Transplant 29:346-51. 2010
  6. doi request reprint Inhibition of protein kinase C alpha improves myocardial beta-adrenergic receptor signaling and ventricular function in a model of myocardial preservation
    Karen M D'Souza
    Department of Surgery, Section of Cardiothoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Thorac Cardiovasc Surg 135:172-9, 179.e1. 2008
  7. doi request reprint Acute beta-blockade prevents myocardial beta-adrenergic receptor desensitization and preserves early ventricular function after brain death
    Prakash K Pandalai
    Department of Surgery, Section of Cardiothoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Thorac Cardiovasc Surg 135:792-8. 2008
  8. pmc G protein-coupled receptor kinase-2 is a novel regulator of collagen synthesis in adult human cardiac fibroblasts
    Karen M D'Souza
    Department of Surgery, Section of Cardiac and Thoracic Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Biol Chem 286:15507-16. 2011
  9. pmc High-molecular-weight polyethylene glycol protects cardiac myocytes from hypoxia- and reoxygenation-induced cell death and preserves ventricular function
    Ricky Malhotra
    Department of Surgery and the Bioengineering Institute for Advanced Surgery and Endoscopy, University of Chicago, Chicago, Illinois, USA
    Am J Physiol Heart Circ Physiol 300:H1733-42. 2011
  10. pmc Uncoupling of myocardial beta-adrenergic receptor signaling during coronary artery bypass grafting: the role of GRK2
    Christian F Bulcao
    Department of Surgery, Section of Cardiothoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Ann Thorac Surg 86:1189-94. 2008

Collaborators

Detail Information

Publications17

  1. pmc Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report
    Elaine Lin
    Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA
    J Med Case Reports 4:246. 2010
    ..However, the signs, symptoms and laboratory findings of pericarditis related to chronic lymphocytic leukemia can mimic tuberculosis...
  2. doi request reprint The heart and pericardium
    Shahab A Akhter
    Section of Cardiac and Thoracic Surgery, The University of Chicago, 5841 South Maryland Avenue, MC 5040, Chicago, IL 60637, USA
    Thorac Surg Clin 21:205-17, viii. 2011
    ..As cardiac and thoracic surgery continue to get more specialized and the procedures become less invasive, it is essential for the cardiothoracic surgeon to have a thorough working knowledge of cardiothoracic anatomy...
  3. pmc Reversal of impaired myocardial beta-adrenergic receptor signaling by continuous-flow left ventricular assist device support
    Shahab A Akhter
    Department of Surgery, Section of Cardiac and Thoracic Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Heart Lung Transplant 29:603-9. 2010
    ..This study was conducted to determine if left ventricular (LV) beta-AR signaling could be restored after continuous-flow LV assist device (LVAD) support...
  4. doi request reprint Technique for left ventricular apical cannulation for short-term mechanical circulatory support
    Shahab A Akhter
    Section of Cardiac and Thoracic Surgery, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Ann Thorac Surg 89:994-5. 2010
    ..We describe a simple and reliable technique for left ventricular apical cannulation for this device, which also facilitates decannulation without the use of cardiopulmonary bypass...
  5. pmc Activation of JAK-STAT and nitric oxide signaling as a mechanism for donor heart dysfunction
    Christian F Bulcao
    Department of Surgery, Section of Cardiothoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Heart Lung Transplant 29:346-51. 2010
    ..We investigated the potential role of myocardial interleukin (IL)-6 signaling through the JAK2-STAT3 pathway, which can lead to the generation of nitric oxide (NO) and decreased cardiac myocyte contractility...
  6. doi request reprint Inhibition of protein kinase C alpha improves myocardial beta-adrenergic receptor signaling and ventricular function in a model of myocardial preservation
    Karen M D'Souza
    Department of Surgery, Section of Cardiothoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Thorac Cardiovasc Surg 135:172-9, 179.e1. 2008
    ....
  7. doi request reprint Acute beta-blockade prevents myocardial beta-adrenergic receptor desensitization and preserves early ventricular function after brain death
    Prakash K Pandalai
    Department of Surgery, Section of Cardiothoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Thorac Cardiovasc Surg 135:792-8. 2008
    ..We hypothesized that acute beta-blockade can prevent myocardial beta-adrenergic receptor desensitization after brain death through attenuation of G protein-coupled receptor kinase 2 activity, resulting in improved cardiac function...
  8. pmc G protein-coupled receptor kinase-2 is a novel regulator of collagen synthesis in adult human cardiac fibroblasts
    Karen M D'Souza
    Department of Surgery, Section of Cardiac and Thoracic Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Biol Chem 286:15507-16. 2011
    ..GRK2 appears to play a significant role in regulating collagen synthesis in adult human CF, and increased activity of this kinase may be an important mechanism of maladaptive ventricular remodeling as mediated by cardiac fibroblasts...
  9. pmc High-molecular-weight polyethylene glycol protects cardiac myocytes from hypoxia- and reoxygenation-induced cell death and preserves ventricular function
    Ricky Malhotra
    Department of Surgery and the Bioengineering Institute for Advanced Surgery and Endoscopy, University of Chicago, Chicago, Illinois, USA
    Am J Physiol Heart Circ Physiol 300:H1733-42. 2011
    ....
  10. pmc Uncoupling of myocardial beta-adrenergic receptor signaling during coronary artery bypass grafting: the role of GRK2
    Christian F Bulcao
    Department of Surgery, Section of Cardiothoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Ann Thorac Surg 86:1189-94. 2008
    ....
  11. pmc G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C
    Ricky Malhotra
    Department of Surgery, Section of Cardiac and Thoracic Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Biol Chem 285:13748-60. 2010
    ..Cross-talk between hypertrophic signaling at the level of PKC and beta-AR signaling regulated by GRK2 may be an important mechanism in the transition from compensatory ventricular hypertrophy to heart failure...
  12. doi request reprint GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension
    Lin Piao
    Section of Cardiology, Department of Medicine, University of Chicago Medical Center, University of Chicago, Chicago, IL 60637, USA
    Circulation 126:2859-69. 2012
    ..The implications of right ventricular (RV) adrenergic remodeling for inotrope selection and the therapeutic benefit of interrupting Gβγ-GRK2 interaction, using gallein, were tested...
  13. pmc Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury
    Jay L Koyner
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Clin J Am Soc Nephrol 5:2154-65. 2010
    ..The diagnostic and prognostic utility of novel and traditional AKI biomarkers was evaluated during a prospective study of 123 adults undergoing cardiac surgery...
  14. ncbi request reprint Acute Kidney Injury and Mortality following Ventricular Assist Device Implantation
    Abhijit Naik
    Section of Nephrology, University of Chicago, Chicago, Ill, USA
    Am J Nephrol 39:195-203. 2014
    ..85 (1.06-3.21), p = 0.03] independently predicted 365-day mortality. Conclusion: AKI is common following VAD implantation and is an independent predictor of 30-day and 1-year all-cause mortality. © 2014 S. Karger AG, Basel. ..
  15. ncbi request reprint Restoration of myocardial beta-adrenergic receptor signaling after left ventricular assist device support
    Prakash K Pandalai
    Department of Surgery, Section of Cardiothoracic Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0558, USA
    J Thorac Cardiovasc Surg 131:975-80. 2006
    ....
  16. ncbi request reprint Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury
    Shahab A Akhter
    Department of Surgery, University of Cincinnati College of Medicine, Ohio, USA
    Am J Physiol Heart Circ Physiol 290:H1427-32. 2006
    ..Thus genetic variation of the human beta(1)-AR may play a role in cardiac functional recovery after ischemic injury...
  17. ncbi request reprint Effects of alpha1-adrenergic stimulation on normal and hypertrophied mouse hearts. Relation to caveolin-3 expression
    Natalia N Petrashevskaya
    Department of Surgery, Cardiovascular Research Center, Institute of Molecular Pharmacology and Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati OH 45267 0828, USA
    Cardiovasc Res 63:561-72. 2004
    ..We compared protein-kinase C (PKC)-dependent regulation of positive inotropic effect via alpha1-adrenoreceptor (ADR)/Gq protein in hyperdynamic versus hypertrophied myocardium...