Simon Akerman

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Pearls and pitfalls in experimental in vivo models of migraine: dural trigeminovascular nociception
    Simon Akerman
    Headache Group, Department of Neurology, University of California, CA 94158, USA
    Cephalalgia 33:577-92. 2013
  2. doi request reprint A translational in vivo model of trigeminal autonomic cephalalgias: therapeutic characterization
    Simon Akerman
    Headache Group, Department of Neurology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USA
    Brain 135:3664-75. 2012
  3. doi request reprint Inhibition of trigeminovascular dural nociceptive afferents by Ca(2+)-activated K(+) (MaxiK/BK(Ca)) channel opening
    Simon Akerman
    UCSF Headache Group, Department of Neurology, University of California, San Francisco, CA 94115, USA
    Pain 151:128-36. 2010
  4. doi request reprint Olvanil acts on transient receptor potential vanilloid channel 1 and cannabinoid receptors to modulate neuronal transmission in the trigeminovascular system
    Jan Hoffmann
    UCSF Headache Program, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
    Pain 153:2226-32. 2012
  5. doi request reprint Acid-sensing ion channel 1: A novel therapeutic target for migraine with aura
    Philip R Holland
    Headache Group, Department of Neurology, University of California at San Francisco, San Francisco, CA Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom
    Ann Neurol 72:559-63. 2012
  6. doi request reprint Trigeminocervical complex responses after lesioning dopaminergic A11 nucleus are modified by dopamine and serotonin mechanisms
    Annabelle R Charbit
    Headache Group Department of Neurology, University of California San Francisco, San Francisco, CA 94115, USA
    Pain 152:2365-76. 2011
  7. doi request reprint Oxygen inhibits neuronal activation in the trigeminocervical complex after stimulation of trigeminal autonomic reflex, but not during direct dural activation of trigeminal afferents
    Simon Akerman
    Headache Group, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0114, USA
    Headache 49:1131-43. 2009
  8. doi request reprint TRPV1 receptor blockade is ineffective in different in vivo models of migraine
    Oliver Summ
    University of California, USA
    Cephalalgia 31:172-80. 2011
  9. doi request reprint Dopamine: what's new in migraine?
    Annabelle R Charbit
    Headache Group Department of Neurology, University of California, San Francisco, San Francisco, California 94115, USA
    Curr Opin Neurol 23:275-81. 2010
  10. pmc A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches
    Oliver Summ
    Headache Group, Department of Neurology, University of California, 1701 Divisadero St, Suite 480, San Francisco, CA 94115, USA
    J Headache Pain 11:477-83. 2010

Collaborators

Detail Information

Publications14

  1. doi request reprint Pearls and pitfalls in experimental in vivo models of migraine: dural trigeminovascular nociception
    Simon Akerman
    Headache Group, Department of Neurology, University of California, CA 94158, USA
    Cephalalgia 33:577-92. 2013
    ....
  2. doi request reprint A translational in vivo model of trigeminal autonomic cephalalgias: therapeutic characterization
    Simon Akerman
    Headache Group, Department of Neurology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USA
    Brain 135:3664-75. 2012
    ....
  3. doi request reprint Inhibition of trigeminovascular dural nociceptive afferents by Ca(2+)-activated K(+) (MaxiK/BK(Ca)) channel opening
    Simon Akerman
    UCSF Headache Group, Department of Neurology, University of California, San Francisco, CA 94115, USA
    Pain 151:128-36. 2010
    ..06, P<0.05). The data taken together indicate that the MaxiK/BK(Ca) channel may represent a novel therapeutic target in migraine...
  4. doi request reprint Olvanil acts on transient receptor potential vanilloid channel 1 and cannabinoid receptors to modulate neuronal transmission in the trigeminovascular system
    Jan Hoffmann
    UCSF Headache Program, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
    Pain 153:2226-32. 2012
    ..Curiously, TRPV1 receptor agonism may have anti-nociceptive properties through central mechanisms that would be of considerable interest to elucidate...
  5. doi request reprint Acid-sensing ion channel 1: A novel therapeutic target for migraine with aura
    Philip R Holland
    Headache Group, Department of Neurology, University of California at San Francisco, San Francisco, CA Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom
    Ann Neurol 72:559-63. 2012
    ..Migraine with aura is a severe debilitating neurological disorder with few relatively specific therapeutic options...
  6. doi request reprint Trigeminocervical complex responses after lesioning dopaminergic A11 nucleus are modified by dopamine and serotonin mechanisms
    Annabelle R Charbit
    Headache Group Department of Neurology, University of California San Francisco, San Francisco, CA 94115, USA
    Pain 152:2365-76. 2011
    ..The data suggest that the serotonergic and dopaminergic antinociceptive pathways act simultaneously on neurons in the trigeminocervical complex, and both amine systems need to be functioning for trigeminal sensitization to be reversed...
  7. doi request reprint Oxygen inhibits neuronal activation in the trigeminocervical complex after stimulation of trigeminal autonomic reflex, but not during direct dural activation of trigeminal afferents
    Simon Akerman
    Headache Group, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0114, USA
    Headache 49:1131-43. 2009
    ..To understand the mechanism of action of oxygen treatment in cluster headache...
  8. doi request reprint TRPV1 receptor blockade is ineffective in different in vivo models of migraine
    Oliver Summ
    University of California, USA
    Cephalalgia 31:172-80. 2011
    ..Due to a possible role of TRPV1 receptors in cortical spreading depression (CSD), an experimental phenomenon sharing many features with migraine aura, we also utilized a model of mechanically induced CSD...
  9. doi request reprint Dopamine: what's new in migraine?
    Annabelle R Charbit
    Headache Group Department of Neurology, University of California, San Francisco, San Francisco, California 94115, USA
    Curr Opin Neurol 23:275-81. 2010
    ..Recent data offer some new perspective on a possible role for dopaminergic mechanisms in migraine. This review aims to summarize our current understanding of dopamine in migraine...
  10. pmc A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches
    Oliver Summ
    Headache Group, Department of Neurology, University of California, 1701 Divisadero St, Suite 480, San Francisco, CA 94115, USA
    J Headache Pain 11:477-83. 2010
    ....
  11. doi request reprint Neurons of the dopaminergic/calcitonin gene-related peptide A11 cell group modulate neuronal firing in the trigeminocervical complex: an electrophysiological and immunohistochemical study
    Annabelle R Charbit
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    J Neurosci 29:12532-41. 2009
    ..Exploration of dopaminergic influences and mechanisms in migraine may open up an almost untapped opportunity to pursue potential new therapeutic options for the disorder...
  12. pmc Endocannabinoids in the Brainstem Modulate Dural Trigeminovascular Nociceptive Traffic via CB1 and "Triptan" Receptors: Implications in Migraine
    Simon Akerman
    Headache Group, Department of Neurology, University of California, San Francisco, San Francisco, California 94158
    J Neurosci 33:14869-77. 2013
    ....
  13. doi request reprint Mechanically-induced cortical spreading depression associated regional cerebral blood flow changes are blocked by Na+ ion channel blockade
    Simon Akerman
    Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco CA 94143 0114, USA
    Brain Res 1229:27-36. 2008
    ....
  14. doi request reprint Diencephalic and brainstem mechanisms in migraine
    Simon Akerman
    Headache Group, Department of Neurology, University of California, San Francisco, California 94115, USA
    Nat Rev Neurosci 12:570-84. 2011
    ....