Research Topics
Genomes and Genes | Schahram AkbarianSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signalingJianhong Li
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
J Neurochem 90:1117-31. 2004..Blockade of D2-like receptors induces H3 phospho-acetylation, H3pS10-acK14, through cAMP-dependent PKA, and post-synaptic NMDA receptor signaling...- Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophreniaSchahram Akbarian
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry and Bioinformatics Unit, Information Services, University of Massachusetts Medical School, Worcester, MA 01604, USA
Arch Gen Psychiatry 62:829-40. 2005..Cellular metabolism regulates chromatin structure, including covalent histone modifications, which are epigenetic regulators of gene expression... - Chromatin immunoprecipitation in postmortem brainHsien Sung Huang
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
J Neurosci Methods 156:284-92. 2006..Therefore, immunoprecipitation of micrococcal nuclease-digested tissue extracts is a feasible approach to profile histone methylation at defined genomic loci in postmortem brain... - Epigenetics of schizophreniaSchahram Akbarian
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
Curr Top Behav Neurosci 4:611-28. 2010..from diseased and control brain tissue is likely to provide valuable insight into the genomic risk architecture of schizophrenia, particularly in the large majority of cases for which a straightforward genetic cause still remains elusive,.. - The molecular pathology of Rett syndrome: synopsis and updateSchahram Akbarian
Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
Neuromolecular Med 8:485-94. 2006..Further studies are necessary to elucidate the molecular pathology of both loss-of-function and gain-of-function mutations in MECP2... 
Epigenetic regulation in human brain-focus on histone lysine methylationSchahram Akbarian
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusettsm USA
Biol Psychiatry 65:198-203. 2009..Together, these findings emphasize the potential significance of histone lysine methylation for orderly brain development and also as a molecular toolbox to study chromatin function in postmortem tissue...- Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disordersSchahram Akbarian
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, Worcester, 01604, USA
Brain Res Rev 52:293-304. 2006..We propose an integrative model, with multiple molecular and cellular mechanisms contributing to transcriptional dysregulation of GAD67 and cortical dysfunction in psychosis... - The molecular pathology of schizophrenia--focus on histone and DNA modificationsSchahram Akbarian
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmonst Street, Worcester, MA 01604, United States
Brain Res Bull 83:103-7. 2010.... - Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neuronsSchahram Akbarian
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
J Neurosci 22:4153-62. 2002..Therefore, a BDNF-signaling pathway originating from non-noradrenergic sources is essential for opiate-induced molecular adaptations of the noradrenergic system... - Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2BYan Jiang
Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
J Neurosci 30:7152-67. 2010.... 
Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophreniaNikolaos Mellios
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
Biol Psychiatry 65:1006-14. 2009..However, it remains unclear if these mechanisms are important determinants for dysregulated NPY and SST expression in prefrontal cortex (PFC) of subjects with schizophrenia...- Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortexIris Cheung
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
Proc Natl Acad Sci U S A 107:8824-9. 2010.... - Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviorsFrederick A Schroeder
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
Neuropsychopharmacology 33:2981-92. 2008.... - Human-specific histone methylation signatures at transcription start sites in prefrontal neuronsHennady P Shulha
Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS Biol 10:e1001427. 2012.... - Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neuronsHennady P Shulha
Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Arch Gen Psychiatry 69:314-24. 2012..Neuronal dysfunction in cerebral cortex and other brain regions could contribute to the cognitive and behavioral defects in autism... - Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promotersHsien Sung Huang
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
J Neurosci 27:11254-62. 2007.... - Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient miceYan Jiang
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, USA
Neuropharmacology 60:1088-97. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'... - Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophreniaNikolaos Mellios
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, MA, USA
Schizophr Bull 38:433-43. 2012..These preliminary findings point to the possibility that disease-related changes in the expression of small noncoding RNAs such as miR-30b in schizophrenia could be influenced by gender and potentially regulated by estrogen signaling... - Isolation of neuronal chromatin from brain tissueYan Jiang
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA
BMC Neurosci 9:42. 2008.... - Cingulate white matter neurons in schizophrenia and bipolar disorderCaroline M Connor
Program in Neurobiology, Graduate School of Biomedical Sciences, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
Biol Psychiatry 66:486-93. 2009.... - Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brainFlorian Stadler
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
J Neurochem 94:324-36. 2005.... - A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortexNikolaos Mellios
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, 303 Belmont Street, Worcester, MA 01604, USA
Hum Mol Genet 17:3030-42. 2008..Collectively, our data highlight the multiple layers of regulation governing the developmental expression of BDNF in human PFC and suggest that miRNAs are involved in the fine-tuning of this neurotrophin particularly in adulthood... - Epigenetics in the nervous systemYan Jiang
Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
J Neurosci 28:11753-9. 2008..Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions... - A simple method for improving the specificity of anti-methyl histone antibodiesCaroline Connor
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA
Epigenetics 5:392-5. 2010.... - The neurobiology of Rett syndromeSchahram Akbarian
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester 01613, USA
Neuroscientist 9:57-63. 2003..Rett syndrome is not accompanied by a neurodegenerative process and thus perhaps may be amenable to therapeutic intervention at the time of symptom expression... - Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenomeCaroline M Connor
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, MA 01604, USA
Schizophr Res 140:175-84. 2012..We conclude that prenatal poly IC is associated with cognitive deficits later in life, but without robust alterations in epigenetic regulation of gene expression in the cerebral cortex... - RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorderHsien Sung Huang
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, Massachusetts, USA
Autism Res 3:153-61. 2010..Taken together, these findings suggest a potential role for the RPP25 gene transcript in the neurobiology of developmental brain disorders... - GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophreniaHsien Sung Huang
Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS ONE 2:e809. 2007..These results suggest that chromatin remodeling mechanisms are involved in dysregulated GABAergic gene expression in schizophrenia... - The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanismChunxing Yang
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS ONE 5:e15878. 2010.... - Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouseFrederick A Schroeder
Brudnick Neuropsychiatric Research Institute, Worcester, Massachusetts, USA
Biol Psychiatry 62:55-64. 2007..We investigated whether the histone deacetylase inhibitor sodium butyrate (SB) administered as single drug or in combination with the selective serotonin reuptake inhibitor (SSRI) fluoxetine exerts antidepressant-like effects in mice... - Epigenetics in the human brainIsaac Houston
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
Neuropsychopharmacology 38:183-97. 2013.... - Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brainMatthew Tudor
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, MA 02142, USA
Proc Natl Acad Sci U S A 99:15536-41. 2002..This result suggests that Mecp2 deficiency leads to subtle gene expression changes in mutant brains which may be associated with the phenotypic changes observed... - Coordinated Cell Type-Specific Epigenetic Remodeling in Prefrontal Cortex Begins before Birth and Continues into Early AdulthoodHennady P Shulha
Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS Genet 9:e1003433. 2013.... - Epigenetic mechanisms in neurological diseaseMira Jakovcevski
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Med 18:1194-204. 2012.... - rAAV9--a human-derived adeno-associated virus vector for efficient transgene expression in mouse cingulate cortexMira Jakovcevski
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
Cold Spring Harb Protoc 2010:pdb.prot5417. 2010..Here, we introduce a protocol for efficient, AAV9-serotype-mediated gene delivery in juvenile (postnatal day 21) and young adult PFC, resulting in long-lasting transgene expression... - White matter neuron alterations in schizophrenia and related disordersCaroline M Connor
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
Int J Dev Neurosci 29:325-34. 2011..These could include the 22q11 deletion (Velocardiofacial/DiGeorge) syndrome, which in some cases is associated with neuronal ectopias in white matter... - Balancing histone methylation activities in psychiatric disordersCyril Jayakumar Peter
Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
Trends Mol Med 17:372-9. 2011.... - The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PDPallavi Rane
Center for Comparative NeuroImaging, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Neuropharmacology 62:2409-12. 2012..The results indicated that the sodium butyrate treatment not only effectively alleviated the set-shifting deficits, but also improved the attentional set formation in the treated rats... - Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicalsBrian Bates
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Neurobiol Dis 9:24-37. 2002..We conclude that endogenous NT-3 enhanced neuronal injury during acute stroke, possible by increasing oxygen-radical mediated cell death... - DNA methylation changes in schizophrenia and bipolar disorderCaroline M Connor
Program in Neurobiology, Graduate School of Biomedical Sciences, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
Epigenetics 3:55-8. 2008..Additional work will be necessary to clarify the origin and timing of these methylation changes in psychosis and to determine the specific cell types affected in the diseased brain... - Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant miceMaribel Rios
Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Neurobiol 66:408-20. 2006.... - Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophreniaKatherine A Albert
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, USA
Arch Gen Psychiatry 59:705-12. 2002..CONCLUSIONS: Our findings are consistent with a selective reduction in DARPP-32 levels in schizophrenic subjects. This may be involved in the prefrontal dysfunction associated with schizophrenia... - Clinical experts on Rett disorderSchahram Akbarian
Pediatr Rehabil 5:117-8. 2002 - NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesisKazuhiro Shimazu
Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Learn Mem 13:307-15. 2006..In addition to identifying a novel role for NT-3 in adult NPC differentiation in vivo, our study provides a potential link between neurogenesis, dentate LTP, and spatial memory... - Diseases of the mind and brain: Rett's syndrome, part IISchahram Akbarian
Am J Psychiatry 159:1294. 2002 - Diseases of the mind and brain: Rett's syndromeSchahram Akbarian
Am J Psychiatry 159:1103. 2002
Research Grants
- Chromatin Alterations in Rett SyndromeSchahram Akbarian; Fiscal Year: 2009..It is expected that these approaches will provide a clear and comprehensive picture on the developmental regulation of histone modifications in cortical neurons, including potential changes in MECP2-deficient brain. ..
- DOPAMINERGIC SIGNALING MODIFIES STRATIAL HISTONESSchahram Akbarian; Fiscal Year: 2009....
- Small RNA regulation of BDNF expression in schizophreniaSchahram Akbarian; Fiscal Year: 2010....
- Remodeling Neuronal Chromatin in Mouse Models for DepressionSchahram Akbarian; Fiscal Year: 2010..Then, indirectly, the chromatin changes brought about by Setdb1 result in certain adaptations in the communication between nerve cells, ultimately resulting in an antidepressant-like effect. ..
- EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICSSchahram Akbarian; Fiscal Year: 2007....
- Treating Depression with Histone Deacetylase InhibitorsSchahram Akbarian; Fiscal Year: 2006..abstract_text> ..
- Chromatin Pathology in Cerebral Cortex of SchizophrenicsSchahram Akbarian; Fiscal Year: 2006..Finally, the proposed studies will provide the framework for future proposals designed to map histone modification patterns across entire chromosomes in human brain, including alterations in major psychiatric disease. ..
- DOPAMINERGIC SIGNALING MODIFIES STRATIAL HISTONESSchahram Akbarian; Fiscal Year: 2007....
- EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICSSchahram Akbarian; Fiscal Year: 2009....