Schahram Akbarian

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling
    Jianhong Li
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurochem 90:1117-31. 2004
  2. ncbi request reprint Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia
    Schahram Akbarian
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry and Bioinformatics Unit, Information Services, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Arch Gen Psychiatry 62:829-40. 2005
  3. ncbi request reprint Chromatin immunoprecipitation in postmortem brain
    Hsien Sung Huang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
    J Neurosci Methods 156:284-92. 2006
  4. ncbi request reprint Epigenetics of schizophrenia
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Curr Top Behav Neurosci 4:611-28. 2010
  5. pmc GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia
    Hsien Sung Huang
    Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 2:e809. 2007
  6. pmc DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
    Kimberly D Siegmund
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 2:e895. 2007
  7. ncbi request reprint Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, Worcester, 01604, USA
    Brain Res Rev 52:293-304. 2006
  8. pmc Epigenetic regulation in human brain-focus on histone lysine methylation
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusettsm USA
    Biol Psychiatry 65:198-203. 2009
  9. ncbi request reprint The molecular pathology of Rett syndrome: synopsis and update
    Schahram Akbarian
    Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Neuromolecular Med 8:485-94. 2006
  10. ncbi request reprint Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons
    Schahram Akbarian
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Neurosci 22:4153-62. 2002

Research Grants

  1. Treating Depression with Histone Deacetylase Inhibitors
    Schahram Akbarian; Fiscal Year: 2006
  2. DOPAMINERGIC SIGNALING MODIFIES STRATIAL HISTONES
    Schahram Akbarian; Fiscal Year: 2007
  3. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2007
  4. Chromatin Alterations in Rett Syndrome
    Schahram Akbarian; Fiscal Year: 2009
  5. DOPAMINERGIC SIGNALING MODIFIES STRATIAL HISTONES
    Schahram Akbarian; Fiscal Year: 2009
  6. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2005
  7. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2009
  8. Small RNA regulation of BDNF expression in schizophrenia
    Schahram Akbarian; Fiscal Year: 2009
  9. Small RNA regulation of BDNF expression in schizophrenia
    Schahram Akbarian; Fiscal Year: 2010
  10. Remodeling Neuronal Chromatin in Mouse Models for Depression
    Schahram Akbarian; Fiscal Year: 2010

Detail Information

Publications53

  1. ncbi request reprint Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling
    Jianhong Li
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurochem 90:1117-31. 2004
    ..Blockade of D2-like receptors induces H3 phospho-acetylation, H3pS10-acK14, through cAMP-dependent PKA, and post-synaptic NMDA receptor signaling...
  2. ncbi request reprint Chromatin alterations associated with down-regulated metabolic gene expression in the prefrontal cortex of subjects with schizophrenia
    Schahram Akbarian
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry and Bioinformatics Unit, Information Services, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Arch Gen Psychiatry 62:829-40. 2005
    ..Cellular metabolism regulates chromatin structure, including covalent histone modifications, which are epigenetic regulators of gene expression...
  3. ncbi request reprint Chromatin immunoprecipitation in postmortem brain
    Hsien Sung Huang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
    J Neurosci Methods 156:284-92. 2006
    ..Therefore, immunoprecipitation of micrococcal nuclease-digested tissue extracts is a feasible approach to profile histone methylation at defined genomic loci in postmortem brain...
  4. ncbi request reprint Epigenetics of schizophrenia
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Curr Top Behav Neurosci 4:611-28. 2010
    ..from diseased and control brain tissue is likely to provide valuable insight into the genomic risk architecture of schizophrenia, particularly in the large majority of cases for which a straightforward genetic cause still remains elusive,..
  5. pmc GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia
    Hsien Sung Huang
    Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 2:e809. 2007
    ..These results suggest that chromatin remodeling mechanisms are involved in dysregulated GABAergic gene expression in schizophrenia...
  6. pmc DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
    Kimberly D Siegmund
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 2:e895. 2007
    ..Therefore, DNA methylation is dynamically regulated in the human cerebral cortex throughout the lifespan, involves differentiated neurons, and affects a substantial portion of genes predominantly by an age-related increase...
  7. ncbi request reprint Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, Worcester, 01604, USA
    Brain Res Rev 52:293-304. 2006
    ..We propose an integrative model, with multiple molecular and cellular mechanisms contributing to transcriptional dysregulation of GAD67 and cortical dysfunction in psychosis...
  8. pmc Epigenetic regulation in human brain-focus on histone lysine methylation
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusettsm USA
    Biol Psychiatry 65:198-203. 2009
    ..Together, these findings emphasize the potential significance of histone lysine methylation for orderly brain development and also as a molecular toolbox to study chromatin function in postmortem tissue...
  9. ncbi request reprint The molecular pathology of Rett syndrome: synopsis and update
    Schahram Akbarian
    Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Neuromolecular Med 8:485-94. 2006
    ..Further studies are necessary to elucidate the molecular pathology of both loss-of-function and gain-of-function mutations in MECP2...
  10. ncbi request reprint Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons
    Schahram Akbarian
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Neurosci 22:4153-62. 2002
    ..Therefore, a BDNF-signaling pathway originating from non-noradrenergic sources is essential for opiate-induced molecular adaptations of the noradrenergic system...
  11. pmc The molecular pathology of schizophrenia--focus on histone and DNA modifications
    Schahram Akbarian
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmonst Street, Worcester, MA 01604, United States
    Brain Res Bull 83:103-7. 2010
    ....
  12. pmc Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B
    Yan Jiang
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurosci 30:7152-67. 2010
    ....
  13. doi request reprint Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia
    Nikolaos Mellios
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    Biol Psychiatry 65:1006-14. 2009
    ..However, it remains unclear if these mechanisms are important determinants for dysregulated NPY and SST expression in prefrontal cortex (PFC) of subjects with schizophrenia...
  14. pmc Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia
    Rahul Bharadwaj
    Graduate School of Biomedical Sciences and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Neurosci 33:11839-51. 2013
    ..More broadly, the findings presented here draw a connection between noncoding DNA, spatial genome architecture, and neuronal plasticity in development and disease. ..
  15. pmc Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex
    Iris Cheung
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Proc Natl Acad Sci U S A 107:8824-9. 2010
    ....
  16. pmc Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors
    Frederick A Schroeder
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Neuropsychopharmacology 33:2981-92. 2008
    ....
  17. pmc Human-specific histone methylation signatures at transcription start sites in prefrontal neurons
    Hennady P Shulha
    Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Biol 10:e1001427. 2012
    ....
  18. doi request reprint Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons
    Hennady P Shulha
    Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Arch Gen Psychiatry 69:314-24. 2012
    ..Neuronal dysfunction in cerebral cortex and other brain regions could contribute to the cognitive and behavioral defects in autism...
  19. pmc Cingulate white matter neurons in schizophrenia and bipolar disorder
    Caroline M Connor
    Program in Neurobiology, Graduate School of Biomedical Sciences, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    Biol Psychiatry 66:486-93. 2009
    ....
  20. pmc Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia
    Nikolaos Mellios
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, MA, USA
    Schizophr Bull 38:433-43. 2012
    ..These preliminary findings point to the possibility that disease-related changes in the expression of small noncoding RNAs such as miR-30b in schizophrenia could be influenced by gender and potentially regulated by estrogen signaling...
  21. ncbi request reprint Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters
    Hsien Sung Huang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurosci 27:11254-62. 2007
    ....
  22. pmc Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice
    Yan Jiang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA 01604, USA
    Neuropharmacology 60:1088-97. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  23. pmc Epigenetics in the nervous system
    Yan Jiang
    Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurosci 28:11753-9. 2008
    ..Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions...
  24. pmc Isolation of neuronal chromatin from brain tissue
    Yan Jiang
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA
    BMC Neurosci 9:42. 2008
    ....
  25. pmc Coordinated cell type-specific epigenetic remodeling in prefrontal cortex begins before birth and continues into early adulthood
    Hennady P Shulha
    Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Genet 9:e1003433. 2013
    ....
  26. ncbi request reprint Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain
    Florian Stadler
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurochem 94:324-36. 2005
    ....
  27. ncbi request reprint A simple method for improving the specificity of anti-methyl histone antibodies
    Caroline Connor
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA
    Epigenetics 5:392-5. 2010
    ....
  28. pmc The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism
    Chunxing Yang
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e15878. 2010
    ....
  29. pmc A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex
    Nikolaos Mellios
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, 303 Belmont Street, Worcester, MA 01604, USA
    Hum Mol Genet 17:3030-42. 2008
    ..Collectively, our data highlight the multiple layers of regulation governing the developmental expression of BDNF in human PFC and suggest that miRNAs are involved in the fine-tuning of this neurotrophin particularly in adulthood...
  30. ncbi request reprint The neurobiology of Rett syndrome
    Schahram Akbarian
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester 01613, USA
    Neuroscientist 9:57-63. 2003
    ..Rett syndrome is not accompanied by a neurodegenerative process and thus perhaps may be amenable to therapeutic intervention at the time of symptom expression...
  31. pmc Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome
    Caroline M Connor
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, MA 01604, USA
    Schizophr Res 140:175-84. 2012
    ..We conclude that prenatal poly IC is associated with cognitive deficits later in life, but without robust alterations in epigenetic regulation of gene expression in the cerebral cortex...
  32. ncbi request reprint Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse
    Frederick A Schroeder
    Brudnick Neuropsychiatric Research Institute, Worcester, Massachusetts, USA
    Biol Psychiatry 62:55-64. 2007
    ..We investigated whether the histone deacetylase inhibitor sodium butyrate (SB) administered as single drug or in combination with the selective serotonin reuptake inhibitor (SSRI) fluoxetine exerts antidepressant-like effects in mice...
  33. doi request reprint RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder
    Hsien Sung Huang
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, Worcester, Massachusetts, USA
    Autism Res 3:153-61. 2010
    ..Taken together, these findings suggest a potential role for the RPP25 gene transcript in the neurobiology of developmental brain disorders...
  34. pmc Prefrontal cortical dysfunction after overexpression of histone deacetylase 1
    Mira Jakovcevski
    Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester Massachusetts
    Biol Psychiatry 74:696-705. 2013
    ..However, it remains unclear whether upregulated expression of Hdac1 in the PFC could affect cognition and behavior...
  35. pmc Epigenetics in the human brain
    Isaac Houston
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Neuropsychopharmacology 38:183-97. 2013
    ....
  36. pmc Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain
    Matthew Tudor
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, MA 02142, USA
    Proc Natl Acad Sci U S A 99:15536-41. 2002
    ..This result suggests that Mecp2 deficiency leads to subtle gene expression changes in mutant brains which may be associated with the phenotypic changes observed...
  37. pmc Epigenetic mechanisms in neurological disease
    Mira Jakovcevski
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Med 18:1194-204. 2012
    ....
  38. ncbi request reprint rAAV9--a human-derived adeno-associated virus vector for efficient transgene expression in mouse cingulate cortex
    Mira Jakovcevski
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Cold Spring Harb Protoc 2010:pdb.prot5417. 2010
    ..Here, we introduce a protocol for efficient, AAV9-serotype-mediated gene delivery in juvenile (postnatal day 21) and young adult PFC, resulting in long-lasting transgene expression...
  39. pmc White matter neuron alterations in schizophrenia and related disorders
    Caroline M Connor
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Int J Dev Neurosci 29:325-34. 2011
    ..These could include the 22q11 deletion (Velocardiofacial/DiGeorge) syndrome, which in some cases is associated with neuronal ectopias in white matter...
  40. ncbi request reprint DNA methylation changes in schizophrenia and bipolar disorder
    Caroline M Connor
    Program in Neurobiology, Graduate School of Biomedical Sciences, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    Epigenetics 3:55-8. 2008
    ..Additional work will be necessary to clarify the origin and timing of these methylation changes in psychosis and to determine the specific cell types affected in the diseased brain...
  41. ncbi request reprint Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals
    Brian Bates
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Neurobiol Dis 9:24-37. 2002
    ..We conclude that endogenous NT-3 enhanced neuronal injury during acute stroke, possible by increasing oxygen-radical mediated cell death...
  42. pmc Epigenetic determinants of healthy and diseased brain aging and cognition
    Schahram Akbarian
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    JAMA Neurol 70:711-8. 2013
    ....
  43. pmc Balancing histone methylation activities in psychiatric disorders
    Cyril Jayakumar Peter
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01604, USA
    Trends Mol Med 17:372-9. 2011
    ....
  44. doi request reprint The histone deacetylase inhibitor, sodium butyrate, alleviates cognitive deficits in pre-motor stage PD
    Pallavi Rane
    Center for Comparative NeuroImaging, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Neuropharmacology 62:2409-12. 2012
    ..The results indicated that the sodium butyrate treatment not only effectively alleviated the set-shifting deficits, but also improved the attentional set formation in the treated rats...
  45. pmc Advancing drug discovery for schizophrenia
    Stephen R Marder
    Semel Institute for Neuroscience at the University of California, Los Angeles, California, USA
    Ann N Y Acad Sci 1236:30-43. 2011
    ....
  46. doi request reprint Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction
    Edward I Ginns
    Lysosomal Disorders Treatment and Research Program, Clinical Labs, University of Massachusetts Medical School, Worcester, MA 01545, USA Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01545, USA Clinical Neuroscience Branch, IRP, NIMH, Bethesda, MD 20892, USA
    Mol Genet Metab 111:152-62. 2014
    ....
  47. pmc Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology
    Tsuyoshi Udagawa
    1 Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA 2 3
    Nat Med 19:1473-7. 2013
    ..Our results suggest that disruption of translational homeostasis is causal for FXS and that the maintenance of this homeostasis by FMRP and CPEB1 is necessary for normal neurologic function. ..
  48. ncbi request reprint Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia
    Katherine A Albert
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, USA
    Arch Gen Psychiatry 59:705-12. 2002
    ..Thus, DARPP-32 occupies a key regulatory position, and may play an important role in the pathophysiological changes in dopamine and glutamate function reported in patients with schizophrenia...
  49. ncbi request reprint Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice
    Maribel Rios
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Neurobiol 66:408-20. 2006
    ....
  50. pmc NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis
    Kazuhiro Shimazu
    Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Learn Mem 13:307-15. 2006
    ..In addition to identifying a novel role for NT-3 in adult NPC differentiation in vivo, our study provides a potential link between neurogenesis, dentate LTP, and spatial memory...
  51. ncbi request reprint Diseases of the mind and brain: Rett's syndrome, part II
    Schahram Akbarian
    Am J Psychiatry 159:1294. 2002
  52. ncbi request reprint Clinical experts on Rett disorder
    Schahram Akbarian
    Pediatr Rehabil 5:117-8. 2002
  53. ncbi request reprint Diseases of the mind and brain: Rett's syndrome
    Schahram Akbarian
    Am J Psychiatry 159:1103. 2002

Research Grants22

  1. Treating Depression with Histone Deacetylase Inhibitors
    Schahram Akbarian; Fiscal Year: 2006
    ..abstract_text> ..
  2. DOPAMINERGIC SIGNALING MODIFIES STRATIAL HISTONES
    Schahram Akbarian; Fiscal Year: 2007
    ....
  3. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2007
    ....
  4. Chromatin Alterations in Rett Syndrome
    Schahram Akbarian; Fiscal Year: 2009
    ..It is expected that these approaches will provide a clear and comprehensive picture on the developmental regulation of histone modifications in cortical neurons, including potential changes in MECP2-deficient brain. ..
  5. DOPAMINERGIC SIGNALING MODIFIES STRATIAL HISTONES
    Schahram Akbarian; Fiscal Year: 2009
    ....
  6. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2005
    ....
  7. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2009
    ....
  8. Small RNA regulation of BDNF expression in schizophrenia
    Schahram Akbarian; Fiscal Year: 2009
    ....
  9. Small RNA regulation of BDNF expression in schizophrenia
    Schahram Akbarian; Fiscal Year: 2010
    ....
  10. Remodeling Neuronal Chromatin in Mouse Models for Depression
    Schahram Akbarian; Fiscal Year: 2010
    ..Then, indirectly, the chromatin changes brought about by Setdb1 result in certain adaptations in the communication between nerve cells, ultimately resulting in an antidepressant-like effect. ..
  11. Treating Depression with Histone Deacetylase Inhibitors
    Schahram Akbarian; Fiscal Year: 2005
    ..abstract_text> ..
  12. DOPAMINERGIC SIGNALING MODIFIES STRATIAL HISTONES
    Schahram Akbarian; Fiscal Year: 2005
    ....
  13. Chromatin Alterations in Rett Syndrome
    Schahram Akbarian; Fiscal Year: 2006
    ..It is expected that these approaches will provide a clear and comprehensive picture on the developmental regulation of histone modifications in cortical neurons, including potential changes in MECP2-deficient brain. ..
  14. DOPAMINERGIC SIGNALING MODIFIES STRATIAL HISTONES
    Schahram Akbarian; Fiscal Year: 2006
    ....
  15. Chromatin Pathology in Cerebral Cortex of Schizophrenics
    Schahram Akbarian; Fiscal Year: 2006
    ..Finally, the proposed studies will provide the framework for future proposals designed to map histone modification patterns across entire chromosomes in human brain, including alterations in major psychiatric disease. ..
  16. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2006
    ....
  17. Chromatin Alterations in Rett Syndrome
    Schahram Akbarian; Fiscal Year: 2007
    ..It is expected that these approaches will provide a clear and comprehensive picture on the developmental regulation of histone modifications in cortical neurons, including potential changes in MECP2-deficient brain. ..
  18. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2009
    ....