Howard J Aizenstein

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint The BOLD hemodynamic response in healthy aging
    Howard J Aizenstein
    University of Pittsburgh School of Medicine, PA, USA
    J Cogn Neurosci 16:786-93. 2004
  2. ncbi request reprint Prefrontal and striatal activation during sequence learning in geriatric depression
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 58:290-6. 2005
  3. ncbi request reprint Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning
    Howard J Aizenstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Neurobiol Aging 27:741-51. 2006
  4. pmc Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:30-42. 2009
  5. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
  6. pmc The default mode network in late-life anxious depression
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Am J Geriatr Psychiatry 19:980-3. 2011
  7. pmc Slower gait, slower information processing and smaller prefrontal area in older adults
    Caterina Rosano
    Department of Epidemiology, Graduate School of Public Health, 130 N Bellefield Avenue, Pittsburgh, PA 15213, USA
    Age Ageing 41:58-64. 2012
  8. pmc Conflict-related activity in the caudal anterior cingulate cortex in the absence of awareness
    Stefan Ursu
    Department of Psychiatry, University of California, Davis, Sacramento, CA 95817, USA
    Biol Psychol 80:279-86. 2009
  9. pmc Three-dimensional surface mapping of the caudate nucleus in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:4-12. 2009
  10. pmc Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 57:761-7. 2005

Detail Information

Publications52

  1. ncbi request reprint The BOLD hemodynamic response in healthy aging
    Howard J Aizenstein
    University of Pittsburgh School of Medicine, PA, USA
    J Cogn Neurosci 16:786-93. 2004
    ..g., inclusion of low-significance and/or negative voxels) underscores the importance of ROI selection criteria in the interpretation of fMRI studies using elderly populations...
  2. ncbi request reprint Prefrontal and striatal activation during sequence learning in geriatric depression
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 58:290-6. 2005
    ..The aim of the present study was to test this hypothesis with the use of functional magnetic resonance imaging (fMRI) tasks that are known to engage the prefrontal and neostriatal cognitive circuits...
  3. ncbi request reprint Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning
    Howard J Aizenstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Neurobiol Aging 27:741-51. 2006
    ..Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness...
  4. pmc Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:30-42. 2009
    ..To characterize the functional neuroanatomy of late-life depression (LLD) by probing for both episodic and persistent alterations in the executive-control circuit of elderly adults...
  5. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
    ....
  6. pmc The default mode network in late-life anxious depression
    Carmen Andreescu
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Am J Geriatr Psychiatry 19:980-3. 2011
    ..The aim of this exploratory study is to examine the default mode network (DMN) functional connectivity pattern in elderly depressed subjects with and without comorbid anxiety...
  7. pmc Slower gait, slower information processing and smaller prefrontal area in older adults
    Caterina Rosano
    Department of Epidemiology, Graduate School of Public Health, 130 N Bellefield Avenue, Pittsburgh, PA 15213, USA
    Age Ageing 41:58-64. 2012
    ..Understanding slowing gait could help improve function in older age. We examine whether the association between smaller PFAv and slower gait is explained by lower performance on numerous neuropsychological tests...
  8. pmc Conflict-related activity in the caudal anterior cingulate cortex in the absence of awareness
    Stefan Ursu
    Department of Psychiatry, University of California, Davis, Sacramento, CA 95817, USA
    Biol Psychol 80:279-86. 2009
    ..These results suggest that the performance monitoring function of the cACC extends beyond detection of errors made with or without awareness, and involves detection of multiple responses even when they are outside of awareness...
  9. pmc Three-dimensional surface mapping of the caudate nucleus in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:4-12. 2009
    ....
  10. pmc Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 57:761-7. 2005
    ....
  11. pmc A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Disabil Rehabil 34:1848-52. 2012
    ..We evaluated the feasibility of a cognitive stimulation program (CSP) to improve neuropsychological test performance in HIV disease...
  12. ncbi request reprint Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adults
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennysylvania, USA
    J Neuroimaging 17:148-55. 2007
    ....
  13. pmc Pathways linking late-life depression to persistent cognitive impairment and dementia
    Meryl A Butters
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Dialogues Clin Neurosci 10:345-57. 2008
    ....
  14. pmc Amyloid imaging in mild cognitive impairment subtypes
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
    Ann Neurol 65:557-68. 2009
    ....
  15. pmc In vivo assessment of amyloid-β deposition in nondemented very elderly subjects
    Chester A Mathis
    Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Neurol 73:751-61. 2013
    ....
  16. pmc Functional connectivity measured with magnetoencephalography identifies persons with HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Imaging Behav 6:366-73. 2012
    ....
  17. pmc Patterns of focal gray matter atrophy are associated with bradykinesia and gait disturbances in older adults
    Caterina Rosano
    Department of Epidemiology, Graduate School of Public Health, 130 North Bellefield Street, Room 512, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 67:957-62. 2012
    ..Identify the neuroimaging correlates of parkinsonian signs in older adults living in the community...
  18. ncbi request reprint Regional brain activation during concurrent implicit and explicit sequence learning
    Howard J Aizenstein
    University of Pittsburgh Medical School, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Cereb Cortex 14:199-208. 2004
    ..Our results suggest a relative dissociation of the brain regions engaged during ESL and ISL, whereby ESL and ISL can be viewed as partially distinct but overlapping parallel processes...
  19. pmc A fully automated method for quantifying and localizing white matter hyperintensities on MR images
    Minjie Wu
    Department of Electrical and Computer Engineering, University of Pittsburgh, USA
    Psychiatry Res 148:133-42. 2006
    ..Given the emergence of large NeuroImage databases, techniques, such as that described here, will allow for a better understanding of the relationship between WMHs and neuropsychiatric disorders...
  20. pmc Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 71:207-15. 2013
    ..IO was developed using full-dynamic atrophy-corrected PiB PET data obtained from a group of control subjects with a fairly distinct separation between PiB-positive [PiB(+)] and PiB-negative [PiB(-)] subjects...
  21. doi request reprint Long-term survival in adults 65 years and older with white matter hyperintensity: association with performance on the digit symbol substitution test
    Caterina Rosano
    MPH, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Avenue, Room 467, Pittsburgh, PA 15213
    Psychosom Med 75:624-31. 2013
    ..The increased risk is attenuated for those with higher DSST. Assessment of cognitive function with DSST may improve risk stratification of individuals with WMH. ..
  22. pmc Neuroimaging differences between older adults with maintained versus declining cognition over a 10-year period
    Caterina Rosano
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 12513, United States
    Neuroimage 62:307-13. 2012
    ..This study aims to identify the neuroimaging correlates of maintenance of higher global cognition as measured by the Modified Mini Mental State Test (3 MS) score...
  23. pmc fMRI correlates of white matter hyperintensities in late-life depression
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, USA
    Am J Psychiatry 168:1075-82. 2011
    ..This study used an emotional faces paradigm that has been shown to engage the affective limbic brain regions...
  24. pmc Concurrent validity of a computer-based cognitive screening tool for use in adults with HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, Pennsylvania, USA
    AIDS Patient Care STDS 25:351-7. 2011
    ..A larger trial to obtain risk-group appropriate normative data will be necessary to make the instrument useful in both clinical practice and research (e.g., clinical trials)...
  25. pmc fMRI activation in late-life anxious depression: a potential biomarker
    Carmen Andreescu
    Department of Psychiatry, The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 24:820-8. 2009
    ..Subjects were trained on the Preparing to Overcome Prepotency (POP) task, which is an executive control task that reliably activates the lateral prefrontal cortex-anterior cingulate cortex (ACC) cognitive control circuit...
  26. pmc Striatal outcome processing in healthy aging
    Karin M Cox
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Cogn Affect Behav Neurosci 8:304-17. 2008
    ..In sum, our data suggest that the signaling of outcome valence remains relatively stable into late adulthood, although more research is needed to understand some subtle changes that might occur across the life span...
  27. pmc Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease
    James T Becker
    Department of Psychiatry, University of Pittsburgh, United States Department of Neurology, University of Pittsburgh, United States
    J Neurosci Methods 206:176-82. 2012
    ..The stability of the wide-band MEG frequency profiles over 24 weeks supports the utility of MEG as a biomarker. The links between the MEG profile, serostatus, and cognition suggest further research on its potential in HAND is needed...
  28. ncbi request reprint Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjects
    Shannon B Juengst
    Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Neurosci Methods 163:208-12. 2007
    ..The HRF of MNCD/HAD subjects did not return to baseline after 16s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies...
  29. ncbi request reprint Optimum template selection for atlas-based segmentation
    Minjie Wu
    Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroimage 34:1612-8. 2007
    ..Moreover, the improved accuracy of atlas-based segmentation using optimum templates approaches the accuracy of manual tracing, and thus is valid for automated brain imaging analyses...
  30. pmc Aortic pulse wave velocity predicts focal white matter hyperintensities in a biracial cohort of older adults
    Caterina Rosano
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Hypertension 61:160-5. 2013
    ....
  31. doi request reprint White matter hyperintensities, exercise, and improvement in gait speed: does type of gait rehabilitation matter?
    Neelesh K Nadkarni
    Division of Geriatric Medicine and Gerontology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    J Am Geriatr Soc 61:686-93. 2013
    ..To examine whether white matter hyperintensities (WMHs) on brain magnetic resonance imaging (MRI) in tracts in older adults with mobility impairment are linked to outcomes of gait rehabilitation interventions...
  32. ncbi request reprint Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtype
    Gina Perez-Madriñan
    Dept of Psychiatry, Univ of Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 12:449-56. 2004
    ..We hypothesized that these two groups differed in their patterns of cognitive impairment, compared with AD subjects without psychosis...
  33. pmc Acute 5-HT reuptake blockade potentiates human amygdala reactivity
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA
    Neuropsychopharmacology 33:3221-5. 2008
    ....
  34. pmc Delays in auditory-cued step initiation are related to increased volume of white matter hyperintensities in older adults
    Patrick J Sparto
    Department of Physical Therapy, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA 15260, USA
    Exp Brain Res 188:633-40. 2008
    ....
  35. pmc Association of small vessel ischemic white matter changes with BOLD fMRI imaging in the elderly
    Meenal J Patel
    Department of Bioengineering, University of Pittsburgh, PA, USA
    Psychiatry Res 204:117-22. 2012
    ....
  36. pmc Amygdalae morphometry in late-life depression
    Robert J Tamburo
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 24:837-46. 2009
    ....
  37. pmc Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression
    Jack R Cornelius
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    Addict Behav 35:644-6. 2010
    ..70, df = 5, p < 0.05, two-tailed). These findings are consistent with the reports by Phan et al. (2008) and Hariri et al. (2009) suggesting that cannabinoids have an inhibitory effect on threat-related amygdala reactivity...
  38. pmc Gain in adiposity across 15 years is associated with reduced gray matter volume in healthy women
    Isabella Soreca
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychosom Med 71:485-90. 2009
    ..Cross-sectional results indicate that reduced GMV may be associated with excess body weight...
  39. ncbi request reprint A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adults
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 62:1048-55. 2007
    ..This study examined the association between gray matter volumes of regions related to motor control, gait, and balance and whether this association is independent of burden of white matter hyperintensities...
  40. pmc Lower Digit Symbol Substitution Score in the Oldest Old is Related to Magnetization Transfer and Diffusion Tensor Imaging of the White Matter
    Vijay K Venkatraman
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh Pittsburgh, PA, USA
    Front Aging Neurosci 3:11. 2011
    ..Since processing slowing is a potent index of mortality and disability, these indices may serve as biomarkers in prevention or treatment trials of disability...
  41. pmc Quantitative comparison of AIR, SPM, and the fully deformable model for atlas-based segmentation of functional and structural MR images
    Minjie Wu
    Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Hum Brain Mapp 27:747-54. 2006
    ....
  42. pmc Brain activity during bladder filling is related to white matter structural changes in older women with urinary incontinence
    Stasa D Tadic
    Division of Geriatric Medicine and Institute on Aging, University of Pittsburgh, Pittsburgh, PA, USA
    Neuroimage 51:1294-302. 2010
    ....
  43. ncbi request reprint Prevalence of cognitive disorders differs as a function of age in HIV virus infection
    James T Becker
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    AIDS 18:S11-8. 2004
    ..The purpose of this report is to describe the prevalence and incidence of cognitive impairment in HIV-infected individuals enrolled in a community-based study...
  44. ncbi request reprint Trajectories of treatment response in late-life depression: psychosocial and clinical correlates
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:S8-13. 2005
    ..Further study focusing on risk factors associated with slower response may help optimize treatment in elderly patients who do not respond quickly to first-line therapies...
  45. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...
  46. ncbi request reprint 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS
    Paul M Thompson
    Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 31:12-23. 2006
    ..We (1) identified regions with greatest differences between AIDS patients and healthy controls and (2) correlated specific 3D patterns of structural differences with measures of immune system deterioration and cognitive decline...
  47. pmc Ventricular volume and dementia progression in the Cardiovascular Health Study
    Owen T Carmichael
    Neurology Department, University of California, Davis, CA 95616, USA
    Neurobiol Aging 28:389-97. 2007
    ..Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology...
  48. pmc Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline
    Paul M Thompson
    Laboratory of Neuro Imaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095 1769, USA
    Proc Natl Acad Sci U S A 102:15647-52. 2005
    ..They provide an approach to gauge the impact of AIDS on the living brain and show that the brain is still vulnerable to infection even when patients are receiving antiretroviral therapy...
  49. ncbi request reprint Automated ROI-based brain parcellation analysis of frontal and temporal brain volumes in schizophrenia
    Pilar Lopez-Garcia
    Department of Psychiatry, School of Medicine, University of California, Davis, United States
    Psychiatry Res 147:153-61. 2006
    ..The automated ROI-based method can be used as a valid and efficient tool for quantification of regional gray matter volume in schizophrenia in multiple ROIs across the brains of large numbers of subjects...
  50. pmc 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry
    Ming Chang Chiang
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 34:44-60. 2007
    ..To perform TBM, we developed a new MRI-based analysis technique that uses fluid image warping, and a new alpha-entropy-based information-theoretic measure of image correspondence, called the Jensen-Rényi divergence (JRD)...
  51. pmc Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia
    Owen T Carmichael
    Neurology and Computer Science Departments, Center for Neuroscience, University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
    Alzheimer Dis Assoc Disord 21:14-24. 2007
    ..Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes...
  52. pmc Tracking Alzheimer's disease
    Paul M Thompson
    Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Ann N Y Acad Sci 1097:183-214. 2007
    ..Strengths and weaknesses of these different imaging measures for basic neuroscience and drug trials are discussed...