Research Topics
Species | Howard J AizensteinSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Prefrontal and striatal activation during sequence learning in geriatric depressionHoward J Aizenstein
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 58:290-6. 2005..The aim of the present study was to test this hypothesis with the use of functional magnetic resonance imaging (fMRI) tasks that are known to engage the prefrontal and neostriatal cognitive circuits...- The BOLD hemodynamic response in healthy agingHoward J Aizenstein
University of Pittsburgh School of Medicine, PA, USA
J Cogn Neurosci 16:786-93. 2004..g., inclusion of low-significance and/or negative voxels) underscores the importance of ROI selection criteria in the interpretation of fMRI studies using elderly populations... - Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learningHoward J Aizenstein
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Neurobiol Aging 27:741-51. 2006..Moreover, these changes are observed during an implicit task, and thus do not seem to be mediated by awareness... 
Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomenaHoward J Aizenstein
Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 17:30-42. 2009..To characterize the functional neuroanatomy of late-life depression (LLD) by probing for both episodic and persistent alterations in the executive-control circuit of elderly adults...- Patterns of mild cognitive impairment after treatment of depression in the elderlyRishi K Bhalla
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 17:308-16. 2009.... - The default mode network in late-life anxious depressionCarmen Andreescu
Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
Am J Geriatr Psychiatry 19:980-3. 2011..The aim of this exploratory study is to examine the default mode network (DMN) functional connectivity pattern in elderly depressed subjects with and without comorbid anxiety... - Slower gait, slower information processing and smaller prefrontal area in older adultsCaterina Rosano
Department of Epidemiology, Graduate School of Public Health, 130 N Bellefield Avenue, Pittsburgh, PA 15213, USA
Age Ageing 41:58-64. 2012..Understanding slowing gait could help improve function in older age. We examine whether the association between smaller PFAv and slower gait is explained by lower performance on numerous neuropsychological tests... - Conflict-related activity in the caudal anterior cingulate cortex in the absence of awarenessStefan Ursu
Department of Psychiatry, University of California, Davis, Sacramento, CA 95817, USA
Biol Psychol 80:279-86. 2009..These results suggest that the performance monitoring function of the cACC extends beyond detection of errors made with or without awareness, and involves detection of multiple responses even when they are outside of awareness... - Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairmentCaterina Rosano
School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 57:761-7. 2005..76, p = .02) but not with changes in accuracy rates. CONCLUSIONS: PPC and dlPFC may show early functional changes associated with MCI... - Three-dimensional surface mapping of the caudate nucleus in late-life depressionMeryl A Butters
Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 17:4-12. 2009.... - A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV diseaseJames T Becker
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Disabil Rehabil 34:1848-52. 2012..We evaluated the feasibility of a cognitive stimulation program (CSP) to improve neuropsychological test performance in HIV disease... - Amyloid imaging in mild cognitive impairment subtypesDavid A Wolk
Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
Ann Neurol 65:557-68. 2009.... - Pathways linking late-life depression to persistent cognitive impairment and dementiaMeryl A Butters
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
Dialogues Clin Neurosci 10:345-57. 2008.... - Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adultsCaterina Rosano
School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennysylvania, USA
J Neuroimaging 17:148-55. 2007.... - Patterns of focal gray matter atrophy are associated with bradykinesia and gait disturbances in older adultsCaterina Rosano
Department of Epidemiology, Graduate School of Public Health, 130 North Bellefield Street, Room 512, Pittsburgh, PA 15213, USA
J Gerontol A Biol Sci Med Sci 67:957-62. 2012..Identify the neuroimaging correlates of parkinsonian signs in older adults living in the community... - Regional brain activation during concurrent implicit and explicit sequence learningHoward J Aizenstein
University of Pittsburgh Medical School, Department of Psychiatry, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Cereb Cortex 14:199-208. 2004..Our results suggest a relative dissociation of the brain regions engaged during ESL and ISL, whereby ESL and ISL can be viewed as partially distinct but overlapping parallel processes... - A fully automated method for quantifying and localizing white matter hyperintensities on MR imagesMinjie Wu
Department of Electrical and Computer Engineering, University of Pittsburgh, USA
Psychiatry Res 148:133-42. 2006..Given the emergence of large NeuroImage databases, techniques, such as that described here, will allow for a better understanding of the relationship between WMHs and neuropsychiatric disorders... 
Neuroimaging differences between older adults with maintained versus declining cognition over a 10-year periodCaterina Rosano
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 12513, United States
Neuroimage 62:307-13. 2012..This study aims to identify the neuroimaging correlates of maintenance of higher global cognition as measured by the Modified Mini Mental State Test (3 MS) score...- fMRI activation in late-life anxious depression: a potential biomarkerCarmen Andreescu
Department of Psychiatry, The Advanced Center in Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine and the John A Hartford Center of Excellence in Geriatric Psychiatry, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 24:820-8. 2009..Subjects were trained on the Preparing to Overcome Prepotency (POP) task, which is an executive control task that reliably activates the lateral prefrontal cortex-anterior cingulate cortex (ACC) cognitive control circuit... - Concurrent validity of a computer-based cognitive screening tool for use in adults with HIV diseaseJames T Becker
Department of Psychiatry, University of Pittsburgh, Pennsylvania, USA
AIDS Patient Care STDS 25:351-7. 2011..A larger trial to obtain risk-group appropriate normative data will be necessary to make the instrument useful in both clinical practice and research (e.g., clinical trials)... - fMRI correlates of white matter hyperintensities in late-life depressionHoward J Aizenstein
Department of Psychiatry, University of Pittsburgh, USA
Am J Psychiatry 168:1075-82. 2011..This study used an emotional faces paradigm that has been shown to engage the affective limbic brain regions... - Striatal outcome processing in healthy agingKarin M Cox
Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Cogn Affect Behav Neurosci 8:304-17. 2008..In sum, our data suggest that the signaling of outcome valence remains relatively stable into late adulthood, although more research is needed to understand some subtle changes that might occur across the life span... - Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV diseaseJames T Becker
Department of Psychiatry, University of Pittsburgh, United States Department of Neurology, University of Pittsburgh, United States
J Neurosci Methods 206:176-82. 2012..The stability of the wide-band MEG frequency profiles over 24 weeks supports the utility of MEG as a biomarker. The links between the MEG profile, serostatus, and cognition suggest further research on its potential in HAND is needed... - Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjectsShannon B Juengst
Department of Psychiatry, University of Pittsburgh School of Medicine, United States
J Neurosci Methods 163:208-12. 2007..The HRF of MNCD/HAD subjects did not return to baseline after 16s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies... - Optimum template selection for atlas-based segmentationMinjie Wu
Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuroimage 34:1612-8. 2007..Moreover, the improved accuracy of atlas-based segmentation using optimum templates approaches the accuracy of manual tracing, and thus is valid for automated brain imaging analyses... - Functional connectivity measured with magnetoencephalography identifies persons with HIV diseaseJames T Becker
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Brain Imaging Behav 6:366-73. 2012.... - Acute 5-HT reuptake blockade potentiates human amygdala reactivityKristin L Bigos
Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA
Neuropsychopharmacology 33:3221-5. 2008.... - Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtypeGina Perez-Madriñan
Dept of Psychiatry, Univ of Pittsburgh, PA, USA
Am J Geriatr Psychiatry 12:449-56. 2004..We hypothesized that these two groups differed in their patterns of cognitive impairment, compared with AD subjects without psychosis... - Delays in auditory-cued step initiation are related to increased volume of white matter hyperintensities in older adultsPatrick J Sparto
Department of Physical Therapy, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA 15260, USA
Exp Brain Res 188:633-40. 2008.... - Amygdalae morphometry in late-life depressionRobert J Tamburo
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 24:837-46. 2009.... - Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depressionJack R Cornelius
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
Addict Behav 35:644-6. 2010..70, df = 5, p < 0.05, two-tailed). These findings are consistent with the reports by Phan et al. (2008) and Hariri et al. (2009) suggesting that cannabinoids have an inhibitory effect on threat-related amygdala reactivity... - Gain in adiposity across 15 years is associated with reduced gray matter volume in healthy womenIsabella Soreca
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychosom Med 71:485-90. 2009..Cross-sectional results indicate that reduced GMV may be associated with excess body weight... - Aortic pulse wave velocity predicts focal white matter hyperintensities in a biracial cohort of older adultsCaterina Rosano
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
Hypertension 61:160-5. 2013.... - Lower Digit Symbol Substitution Score in the Oldest Old is Related to Magnetization Transfer and Diffusion Tensor Imaging of the White MatterVijay K Venkatraman
Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh Pittsburgh, PA, USA
Front Aging Neurosci 3:11. 2011..Since processing slowing is a potent index of mortality and disability, these indices may serve as biomarkers in prevention or treatment trials of disability... - Brain activity during bladder filling is related to white matter structural changes in older women with urinary incontinenceStasa D Tadic
Division of Geriatric Medicine and Institute on Aging, University of Pittsburgh, Pittsburgh, PA, USA
Neuroimage 51:1294-302. 2010.... - Quantitative comparison of AIR, SPM, and the fully deformable model for atlas-based segmentation of functional and structural MR imagesMinjie Wu
Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Hum Brain Mapp 27:747-54. 2006.... - A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adultsCaterina Rosano
School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA
J Gerontol A Biol Sci Med Sci 62:1048-55. 2007..This study examined the association between gray matter volumes of regions related to motor control, gait, and balance and whether this association is independent of burden of white matter hyperintensities... - Association of small vessel ischemic white matter changes with BOLD fMRI imaging in the elderlyMeenal J Patel
Department of Bioengineering, University of Pittsburgh, PA, USA
Psychiatry Res 204:117-22. 2012.... - Trajectories of treatment response in late-life depression: psychosocial and clinical correlatesAriel G Gildengers
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Clin Psychopharmacol 25:S8-13. 2005..Further study focusing on risk factors associated with slower response may help optimize treatment in elderly patients who do not respond quickly to first-line therapies... - Prevalence of cognitive disorders differs as a function of age in HIV virus infectionJames T Becker
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
AIDS 18:S11-8. 2004..However, HIV viral load at study entry was significantly higher among those participants who had developed cognitive impairment one year later. CONCLUSION: Age is a significant risk modifier for prevalent neuropsychological disorder... - Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigreesWilliam E Klunk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 27:6174-84. 2007..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms... - 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDSPaul M Thompson
Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Neuroimage 31:12-23. 2006..We (1) identified regions with greatest differences between AIDS patients and healthy controls and (2) correlated specific 3D patterns of structural differences with measures of immune system deterioration and cognitive decline... - Tracking Alzheimer's diseasePaul M Thompson
Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Ann N Y Acad Sci 1097:183-214. 2007..Strengths and weaknesses of these different imaging measures for basic neuroscience and drug trials are discussed... - 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometryMing Chang Chiang
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Neuroimage 34:44-60. 2007..To perform TBM, we developed a new MRI-based analysis technique that uses fluid image warping, and a new alpha-entropy-based information-theoretic measure of image correspondence, called the Jensen-Rényi divergence (JRD)... - Automated ROI-based brain parcellation analysis of frontal and temporal brain volumes in schizophreniaPilar Lopez-Garcia
Department of Psychiatry, School of Medicine, University of California, Davis, United States
Psychiatry Res 147:153-61. 2006..The automated ROI-based method can be used as a valid and efficient tool for quantification of regional gray matter volume in schizophrenia in multiple ROIs across the brains of large numbers of subjects... - Ventricular volume and dementia progression in the Cardiovascular Health StudyOwen T Carmichael
Neurology Department, University of California, Davis, CA 95616, USA
Neurobiol Aging 28:389-97. 2007..Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology... - Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte declinePaul M Thompson
Laboratory of Neuro Imaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095 1769, USA
Proc Natl Acad Sci U S A 102:15647-52. 2005..They provide an approach to gauge the impact of AIDS on the living brain and show that the brain is still vulnerable to infection even when patients are receiving antiretroviral therapy... - Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementiaOwen T Carmichael
Neurology and Computer Science Departments, Center for Neuroscience, University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
Alzheimer Dis Assoc Disord 21:14-24. 2007..Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes...